ATE481088T1 - Embolisierung unter verwendung von poly-4- hydroxybutyrat-partikeln - Google Patents

Embolisierung unter verwendung von poly-4- hydroxybutyrat-partikeln

Info

Publication number
ATE481088T1
ATE481088T1 AT06719816T AT06719816T ATE481088T1 AT E481088 T1 ATE481088 T1 AT E481088T1 AT 06719816 T AT06719816 T AT 06719816T AT 06719816 T AT06719816 T AT 06719816T AT E481088 T1 ATE481088 T1 AT E481088T1
Authority
AT
Austria
Prior art keywords
poly
embolization
hydroxybutyrate
particles
hydroxybutyrate particles
Prior art date
Application number
AT06719816T
Other languages
English (en)
Inventor
David Martin
Donald Crabtree
Simon Williams
Original Assignee
Tepha Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tepha Inc filed Critical Tepha Inc
Application granted granted Critical
Publication of ATE481088T1 publication Critical patent/ATE481088T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/765Polymers containing oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/36Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
AT06719816T 2005-01-28 2006-01-27 Embolisierung unter verwendung von poly-4- hydroxybutyrat-partikeln ATE481088T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64805205P 2005-01-28 2005-01-28
PCT/US2006/003128 WO2006081517A2 (en) 2005-01-28 2006-01-27 Embolization using poly-4-hydroxybutyrate particles

Publications (1)

Publication Number Publication Date
ATE481088T1 true ATE481088T1 (de) 2010-10-15

Family

ID=36295572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06719816T ATE481088T1 (de) 2005-01-28 2006-01-27 Embolisierung unter verwendung von poly-4- hydroxybutyrat-partikeln

Country Status (8)

Country Link
US (1) US20060177513A1 (de)
EP (1) EP1845951B1 (de)
JP (1) JP2008528204A (de)
AT (1) ATE481088T1 (de)
CA (1) CA2596283C (de)
DE (1) DE602006016915D1 (de)
ES (1) ES2362221T3 (de)
WO (1) WO2006081517A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
JP5538217B2 (ja) * 2007-07-10 2014-07-02 ライフセル コーポレーション 組織修復用無細胞組織基質構成体
EP2306991B1 (de) * 2008-06-27 2019-12-25 Tepha, Inc. Verbesserte injektionsabgabe von mikroteilchen und zusammensetzungen dafür
US8246876B2 (en) * 2008-08-18 2012-08-21 Cook Medical Technologies Llc Embolization particles and method for making same
ES2659525T3 (es) * 2011-09-27 2018-03-16 Tepha, Inc. Hidrólisis controlada de poli-4-hidroxibutirato y copolímeros
CA2923753C (en) 2013-09-19 2021-10-12 Terumo Corporation Polymer particles
AU2014321278B2 (en) 2013-09-19 2016-11-10 Microvention, Inc. Polymer films
US9480780B2 (en) 2013-11-05 2016-11-01 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
AU2014346486B2 (en) 2013-11-08 2016-12-08 Terumo Corporation Polymer particles
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
ES2874090T3 (es) 2015-12-11 2021-11-04 Lifecell Corp Métodos y sistemas para el endurecimiento de tejidos para un procesamiento mejorado
US10201632B2 (en) 2016-09-28 2019-02-12 Terumo Corporation Polymer particles
WO2019112925A1 (en) 2017-12-04 2019-06-13 Tepha, Inc. Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants
EP4000604B1 (de) 2017-12-18 2023-08-23 C. R. Bard, Inc. Arzneimittelbeladene mikrokügelchenzusammensetzungen, embolisationszusammensetzungen und zugehörige verfahren
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
CN112807485A (zh) * 2020-12-23 2021-05-18 青岛科技大学 一种无干细胞和生长因子负载的可注射聚(4-羟基丁酸酯)(p4hb)多孔微球制剂
WO2022215653A1 (ja) 2021-04-06 2022-10-13 株式会社 フューエンス ポリヒドロキシアルカン酸(pha)を含む微粒子及びその製造方法
CN114366723B (zh) * 2021-12-06 2023-07-07 珠海麦得发生物科技股份有限公司 一种含盐酸吡柔比星的微球及其制备方法和应用

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4A (en) * 1836-08-10 Stock
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3982543A (en) * 1973-04-24 1976-09-28 American Cyanamid Company Reducing capillarity of polyglycolic acid sutures
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4849226A (en) * 1981-06-29 1989-07-18 Alza Corporation Method for increasing oxygen supply by administering vasodilator
US4435180A (en) * 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
DE3374698D1 (en) * 1982-08-27 1988-01-07 Ici Plc 3-hydroxybutyrate polymers
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
EP0145233B2 (de) * 1983-11-23 1991-11-06 Imperial Chemical Industries Plc Trennungsverfahrenfür ein 3-hydroxybutyrat-Polymer
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
GB8424950D0 (en) * 1984-10-03 1984-11-07 Ici Plc Non-woven fibrous materials
US4573995A (en) * 1984-10-09 1986-03-04 Alza Corporation Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
US4648978A (en) * 1985-04-24 1987-03-10 American Sterilizer Company Process for the continuous preparation of sterile, depyrogenated solutions
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
AU603076B2 (en) * 1985-12-09 1990-11-08 W.R. Grace & Co.-Conn. Polymeric products and their manufacture
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US5032638A (en) * 1986-09-05 1991-07-16 American Cyanamid Company Bioabsorbable coating for a surgical device
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
NL8603073A (nl) * 1986-12-02 1988-07-01 Rijksuniversiteit Werkwijze voor het bereiden van polyesters door fermentatie; werkwijze voor het bereiden van optisch actieve carbonzuren en esters; polyester omvattende voortbrengselen.
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5250430A (en) * 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) * 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5229279A (en) * 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5480794A (en) * 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5026381A (en) * 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US5041100A (en) * 1989-04-28 1991-08-20 Cordis Corporation Catheter and hydrophilic, friction-reducing coating thereon
EP0423484B1 (de) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Pressling mit retardierter Wirkstofffreisetzung
JPH0662839B2 (ja) * 1989-11-14 1994-08-17 工業技術院長 微生物分解性プラスチック成形物及びその製造方法
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IT1247157B (it) * 1991-02-11 1994-12-12 Fidia Spa Canali di guida biodegradabili e bioassorbibili da impiegare per la rigenerazione nervosa.
DE4113984C2 (de) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salze der 4-Hydroxy-Buttersäure
FR2676927B1 (fr) * 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5236431A (en) * 1991-07-22 1993-08-17 Synthes Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor
JP2777757B2 (ja) * 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
EP0560984B1 (de) * 1991-09-27 1999-05-26 Terumo Kabushiki Kaisha Flexibles teil zur medizinischen verwendung
WO1993006792A1 (en) * 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
JPH05194141A (ja) * 1992-01-14 1993-08-03 Mitsubishi Kasei Corp 化粧料
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
CH689767A5 (de) * 1992-03-24 1999-10-15 Balzers Hochvakuum Verfahren zur Werkstueckbehandlung in einer Vakuumatmosphaere und Vakuumbehandlungsanlage.
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5278256A (en) * 1992-09-16 1994-01-11 E. I. Du Pont De Nemours And Company Rapidly degradable poly (hydroxyacid) compositions
GB9223351D0 (en) * 1992-11-06 1992-12-23 Ici Plc Polyesters
GB9223350D0 (en) * 1992-11-06 1992-12-23 Ici Plc Polymer composition
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5412067A (en) * 1993-05-10 1995-05-02 Mitsui Toatsu Chemicals, Inc. Preparation process of polyester
US5874040A (en) * 1993-06-02 1999-02-23 Monsanto Company Processing of polyesters
AU7396294A (en) * 1993-06-25 1995-01-24 Alza Corporation Incorporating poly-n-vinyl amide in a transdermal system
DK0797988T3 (da) * 1993-07-19 2009-05-11 Univ British Columbia Anti-angiogene præparater og fremgangsmåder til anvendelse deraf
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
WO1995018781A1 (en) * 1994-01-06 1995-07-13 Metabolix, Inc. Methods for synthesizing oligomers containing hydroxy acid units
CZ221196A3 (en) * 1994-01-28 1997-01-15 Procter & Gamble Biologically degradable copolymer and plastic parts, which contain biologically degradable copolymers of 3-hydroxyhexanoate
ZA95627B (en) * 1994-01-28 1995-10-05 Procter & Gamble Biodegradable copolymers and plastic articles comprising biodegradable copolymers
ATE247933T1 (de) * 1994-06-06 2003-09-15 Univ Case Western Reserve Biomatrix für geweberegenaration
US5629077A (en) * 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
ES2141953T3 (es) * 1994-08-12 2000-04-01 Minnesota Mining & Mfg Composiciones de adhesivos sensibles a la presion de poli(beta-hidroxiorganoato).
US5599852A (en) * 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
AU706434B2 (en) * 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US5563239A (en) * 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5814071A (en) * 1994-11-10 1998-09-29 Innovasive Devices, Inc. Suture anchor assembly and methods
EP0723983B1 (de) * 1995-01-26 2001-08-08 Takasago International Corporation Biologisch abbaubare Zusammensetzung
US5879322A (en) * 1995-03-24 1999-03-09 Alza Corporation Self-contained transdermal drug delivery device
JP3586815B2 (ja) * 1995-03-24 2004-11-10 タキロン株式会社 セル構造体の製造方法
DE19539449A1 (de) * 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial
US5670161A (en) * 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5811272A (en) * 1996-07-26 1998-09-22 Massachusetts Institute Of Technology Method for controlling molecular weight of polyhydroxyalkanoates
ATE354600T1 (de) * 1997-05-12 2007-03-15 Metabolix Inc Polyhydroxyalkanoate für in vivo anwendungen
US6610764B1 (en) * 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6119567A (en) * 1997-07-10 2000-09-19 Ktm Industries, Inc. Method and apparatus for producing a shaped article
US5876455A (en) * 1997-07-24 1999-03-02 Harwin; Steven F. Bio-shim
CA2314151C (en) * 1997-12-22 2004-10-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6056970A (en) * 1998-05-07 2000-05-02 Genzyme Corporation Compositions comprising hemostatic compounds and bioabsorbable polymers
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
ATE376433T1 (de) * 1999-03-25 2007-11-15 Metabolix Inc Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
US7025980B1 (en) * 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
EP1216067B1 (de) * 1999-09-14 2006-04-19 Tepha, Inc. Polyhydroxyalkanoatzusammensetzung zur ausbesserung, zum aufbau und als viskositätszusatz von weichteilgewebe
US20020168518A1 (en) * 2001-05-10 2002-11-14 The Procter & Gamble Company Fibers comprising starch and polymers
US6770356B2 (en) * 2001-08-07 2004-08-03 The Procter & Gamble Company Fibers and webs capable of high speed solid state deformation
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
WO2003066733A1 (fr) * 2002-02-05 2003-08-14 Mitsui Chemicals, Inc. Composition de resine biodegradable et objet moule a base de cette composition
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US20050267516A1 (en) * 2004-06-01 2005-12-01 Farzad Soleimani Embolic protection device for the prevention of stroke

Also Published As

Publication number Publication date
CA2596283A1 (en) 2006-08-03
CA2596283C (en) 2011-11-01
US20060177513A1 (en) 2006-08-10
WO2006081517A2 (en) 2006-08-03
DE602006016915D1 (de) 2010-10-28
WO2006081517A3 (en) 2006-11-16
EP1845951A2 (de) 2007-10-24
EP1845951B1 (de) 2010-09-15
JP2008528204A (ja) 2008-07-31
ES2362221T3 (es) 2011-06-29

Similar Documents

Publication Publication Date Title
ATE481088T1 (de) Embolisierung unter verwendung von poly-4- hydroxybutyrat-partikeln
MX2007002470A (es) Fenilaminotiazoles sustituidos y su uso.
CY1118222T1 (el) Συνθεσεις λυασης φαινυλαλανινης αμμωνιας προκαρυωτικων και μεθοδοι αγωγης καρκινου χρησιμοποιωντας συνθεσεις εξ' αυτης
CY1112813T1 (el) 4-(4-κυανο-2-θειοαρυλ)διϋδροπυριμιδινονες και η χρηση αυτων
ATE554725T1 (de) Chirurgische artikel zur behandlung von beckenerkrankungen
ATE530142T1 (de) Chirurgische artikel zur behandlung von beckenerkrankungen
EA200601905A1 (ru) Микрокапсулы с замедленным высвобождением, основанные на сополимере лактида и гликолида, включающие полипептид и сахар
MX2011009539A (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso.
TW200728466A (en) Antibody molecules having specificity for human IL-6
DE502005008790D1 (de) Substituierte phenylaminopyrimidine
TW200736275A (en) Methods and compositions for treating allergic diseases
UA90048C2 (ru) Кондиционированная композиция и способ ее получения
ATE495739T1 (de) Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
EA200601904A1 (ru) Система отсроченного высвобождения лекарственного средства на основе полимеров
ATE489371T1 (de) Benzamidglucokinaseaktivatoren
WO2010021874A3 (en) Engineered anti-il-13 antibodies, compositions, methods and uses
NO20082986L (no) Nye, acylisk substituerte furopyrimidinderivater og anvendelse derav for behandling av kardiovaskulaere lidelser
WO2006078648A3 (en) Rhinovirus vaccines
EA201190312A1 (ru) Замещенные пиперидины
GB201101740D0 (en) Therapeutic agents with improved fibrinogen binding
DE602004017326D1 (de) Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
ATE455789T1 (de) Substituierte nonadepsipeptide
ATE524463T1 (de) 4-chromenonyl-1,4-dihydropyridincarbonitrile und ihre verwendung
EP1788004A4 (de) Neuartiges modifiziertes polymer, prozess zu dessen herstellung und verwendung des neuartigen modifizierten polymers
TW200738752A (en) Modulation of MDL-1 activity for treatment of inflammatory disease

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties