MX350929B - Formulaciones peptidicas robustas de liberación controlada. - Google Patents

Formulaciones peptidicas robustas de liberación controlada.

Info

Publication number
MX350929B
MX350929B MX2014006624A MX2014006624A MX350929B MX 350929 B MX350929 B MX 350929B MX 2014006624 A MX2014006624 A MX 2014006624A MX 2014006624 A MX2014006624 A MX 2014006624A MX 350929 B MX350929 B MX 350929B
Authority
MX
Mexico
Prior art keywords
low viscosity
compositions
forming
acyl
chains
Prior art date
Application number
MX2014006624A
Other languages
English (en)
Other versions
MX2014006624A (es
Inventor
Tiberg Fredrik
Johnsson Markus
Original Assignee
Camurus Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47226199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX350929(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Camurus Ab filed Critical Camurus Ab
Publication of MX2014006624A publication Critical patent/MX2014006624A/es
Publication of MX350929B publication Critical patent/MX350929B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
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  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
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  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)

Abstract

La presente invención se refiere a composiciones que forman una mezcla de baja viscosidad de: a. el 25 al 50% en peso de al menos un diacilglicerol y/o al menos un tocoferol; b. el 25 al 55% en peso de la menos un componente fosfolípido que comprende fosfolípidos que tienen i. grupos de cabeza polar que comprenden más del 50% de fosfatidiletanolamina y ii. Dos cadenas de acilo, cada una de las cuales posee independientemente de 16 a 20 carbonos, donde al menos una cadena de acilo tiene al menos una insaturación en la cadena de carbono, y donde hay no más de cuatro insaturaciones en las dos cadenas de carbono; c. el 5 al 25% en peso de al menos un solvente biocompatible, orgánico, de baja viscosidad que contiene oxígeno; donde del 0,1 al 10% en peso de al menos un agente peptídico activo que comprende al menos un agente peptídico activo que comprende al menos un agonista del receptor de somatostatina está disuelto o disperso en la mezcla de baja viscosidad; y donde la preformulación forma, o tiene la capacidad de formar, al menos una estructura de fase cristalina líquida no laminar al entrar en contacto con un fluido acuoso. La invención se relaciona adicionalmente con métodos de tratamiento que comprenden la administración de tales composiciones y con dispositivos de administración precargados y kits que contienen las formulaciones.
MX2014006624A 2011-12-05 2012-11-28 Formulaciones peptidicas robustas de liberación controlada. MX350929B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161566851P 2011-12-05 2011-12-05
PCT/EP2012/073841 WO2013083459A1 (en) 2011-12-05 2012-11-28 Robust controlled-release peptide formulations

Publications (2)

Publication Number Publication Date
MX2014006624A MX2014006624A (es) 2014-09-22
MX350929B true MX350929B (es) 2017-09-26

Family

ID=47226199

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014006624A MX350929B (es) 2011-12-05 2012-11-28 Formulaciones peptidicas robustas de liberación controlada.
MX2014006625A MX352024B (es) 2011-12-05 2012-11-28 Formulaciones potentes de liberacion controlada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2014006625A MX352024B (es) 2011-12-05 2012-11-28 Formulaciones potentes de liberacion controlada.

Country Status (23)

Country Link
US (2) US9585959B2 (es)
EP (2) EP2787974B1 (es)
JP (2) JP6081480B2 (es)
KR (2) KR20140105527A (es)
CN (2) CN104093399B (es)
AU (2) AU2012348640B2 (es)
BR (2) BR112014013691A2 (es)
CA (2) CA2858227C (es)
CL (1) CL2014001472A1 (es)
CO (1) CO7000746A2 (es)
DK (2) DK2787975T3 (es)
EA (2) EA027924B1 (es)
ES (2) ES2629188T3 (es)
HK (2) HK1201722A1 (es)
HR (1) HRP20170954T1 (es)
IL (2) IL232789B (es)
MX (2) MX350929B (es)
PE (1) PE20141297A1 (es)
PL (1) PL2787975T3 (es)
SG (1) SG11201402673YA (es)
SI (1) SI2787974T1 (es)
WO (2) WO2013083459A1 (es)
ZA (1) ZA201403793B (es)

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IL232789B (en) 2019-11-28
EA027924B1 (ru) 2017-09-29
KR101979051B1 (ko) 2019-05-15
DK2787974T3 (en) 2017-07-17
PL2787975T3 (pl) 2018-01-31
IL232967A0 (en) 2014-07-31
CN104093399A (zh) 2014-10-08
JP2015505833A (ja) 2015-02-26
BR112014013693A2 (pt) 2020-06-30
CN104105479A (zh) 2014-10-15
HRP20170954T1 (hr) 2017-09-22
MX2014006624A (es) 2014-09-22
PE20141297A1 (es) 2014-10-09
KR20140111661A (ko) 2014-09-19
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