EA201491005A1 - Устойчивые составы с контролируемым высвобождением - Google Patents
Устойчивые составы с контролируемым высвобождениемInfo
- Publication number
- EA201491005A1 EA201491005A1 EA201491005A EA201491005A EA201491005A1 EA 201491005 A1 EA201491005 A1 EA 201491005A1 EA 201491005 A EA201491005 A EA 201491005A EA 201491005 A EA201491005 A EA 201491005A EA 201491005 A1 EA201491005 A1 EA 201491005A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- low viscosity
- compositions
- carbon
- forming
- relates
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
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- Neurosurgery (AREA)
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- Ophthalmology & Optometry (AREA)
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- Obesity (AREA)
- Addiction (AREA)
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- Psychiatry (AREA)
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Abstract
Настоящее изобретение относится к композициям, образующим нежидкокристаллическую смесь с низкой вязкостью: а) от 25 до 55 мас.% по меньшей мере одного диацилглицерина и/или по меньшей мере одного токоферола; b) от 25 до 55 мас.% по меньшей мере одного фосфолипидного компонента, содержащего фосфолипиды, которые имеют: i) полярные концевые группы, содержащие более чем 50% фосфатидилэтаноламина, и ii) две ацильные цепи, каждая из которых независимо имеет от 16 до 20 атомов углерода, отличающиеся тем, что по меньшей мере одна ацильная цепь имеет по меньшей мере одну ненасыщенную связь в углеродной цепи иприсутствуют не более чем четыре ненасыщенные связи в двух углеродных цепях; с) от 5 до 25 мас.% по меньшей мере одного биосовместимого, кислородсодержащего, органического растворителя с низкой вязкостью; отличающаяся тем, что в смеси с низкой вязкостью растворяют или диспергируют от 0,1 до 10 мас.% по меньшей мере одного пептидного активного средства, содержащего по меньшей мере один агонист рецептора соматостатина; а также отличающаяся тем, что субстанция-кандидат образует или способна образовать по меньшей мере одну неламеллярную жидкокристаллическую фазовую структуру при контакте с жидкостью на водной основе. Изобретение также относится к способам обработки, включающим введение подобной композиции, и предварительно заполненному устройству для введения и наборам, содержащим составы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161566851P | 2011-12-05 | 2011-12-05 | |
| PCT/EP2012/073841 WO2013083459A1 (en) | 2011-12-05 | 2012-11-28 | Robust controlled-release peptide formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491005A1 true EA201491005A1 (ru) | 2014-11-28 |
| EA027924B1 EA027924B1 (ru) | 2017-09-29 |
Family
ID=47226199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201490921A EA028040B1 (ru) | 2011-12-05 | 2012-11-28 | Композиция-предшественник, которая образует жидкокристаллическую композицию in vivo, способ доставки биологически активного средства с ее использованием, способ ее получения и способ лечения путем ее введения |
| EA201491005A EA027924B1 (ru) | 2011-12-05 | 2012-11-28 | Композиция-прекурсор, содержащая агонист рецептора соматостатина, способ ее получения, способ лечения путем ее введения и содержащее ее предварительно заполненное устройство введения |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201490921A EA028040B1 (ru) | 2011-12-05 | 2012-11-28 | Композиция-предшественник, которая образует жидкокристаллическую композицию in vivo, способ доставки биологически активного средства с ее использованием, способ ее получения и способ лечения путем ее введения |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9585959B2 (ru) |
| EP (2) | EP2787974B1 (ru) |
| JP (2) | JP6081479B2 (ru) |
| KR (2) | KR101979051B1 (ru) |
| CN (2) | CN104093399B (ru) |
| AU (2) | AU2012348641B2 (ru) |
| BR (2) | BR112014013693B1 (ru) |
| CA (2) | CA2858227C (ru) |
| CL (1) | CL2014001472A1 (ru) |
| CO (1) | CO7000746A2 (ru) |
| DK (2) | DK2787974T3 (ru) |
| EA (2) | EA028040B1 (ru) |
| ES (2) | ES2645345T3 (ru) |
| HK (2) | HK1201722A1 (ru) |
| HR (1) | HRP20170954T1 (ru) |
| IL (2) | IL232789B (ru) |
| MX (2) | MX350929B (ru) |
| PE (1) | PE20141297A1 (ru) |
| PL (1) | PL2787975T3 (ru) |
| SG (1) | SG11201402673YA (ru) |
| SI (1) | SI2787974T1 (ru) |
| WO (2) | WO2013083459A1 (ru) |
| ZA (1) | ZA201403793B (ru) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06014095A (es) * | 2004-06-04 | 2007-08-07 | Camurus Ab | Formulaciones de deposito de lipidos. |
| GB0711656D0 (en) * | 2007-06-15 | 2007-07-25 | Camurus Ab | Formulations |
| MX361716B (es) * | 2011-05-25 | 2018-12-14 | Camurus Ab | Formulaciones peptidicas de liberacion controlada. |
| US11672843B2 (en) * | 2012-05-25 | 2023-06-13 | Camurus Ab | Somatostatin receptor agonist formulations |
| CN104661648B (zh) | 2012-07-26 | 2019-04-05 | 卡姆拉斯公司 | 阿片样物质制剂 |
| EP2823808A1 (en) * | 2013-07-09 | 2015-01-14 | Ipsen Pharma S.A.S. | Pharmaceutical composition for a sustained release of lanreotide |
| AU2014340095A1 (en) | 2013-10-22 | 2016-05-26 | Prolynx Llc | Conjugates of somatostatin and its analogs |
| WO2016092569A1 (en) * | 2014-12-10 | 2016-06-16 | Council Of Scientific & Industrial Research | A discontinuous reverse micellar composition in cubic fd3m phase for sustained release of therapeutic drugs |
| SG11201705155SA (en) * | 2014-12-23 | 2017-07-28 | Camurus Ab | Controlled-release formulations |
| GB201516554D0 (en) * | 2015-09-18 | 2015-11-04 | Camurus Ab | Controlled-release formulations |
| ITUB20160416A1 (it) * | 2016-01-28 | 2017-07-28 | Italfarmaco Spa | Uso di una formulazione a lento rilascio di octreotide per la prevenzione della formazione di seroma |
| CA3018670A1 (en) * | 2016-03-31 | 2017-10-05 | Sun Pharma Advanced Research Company Limited | Viscoelastic gel of liraglutide adapted for once-weekly or once bi-weekly administration |
| SI3512495T1 (sl) * | 2016-09-15 | 2023-01-31 | Camurus Ab | Formulacije prostaciklinskih analogov |
| EP3518978A1 (en) * | 2016-09-27 | 2019-08-07 | Camurus AB | Mixtures and formulations comprising an alkyl ammonium edta salt |
| WO2018217926A1 (en) | 2017-05-24 | 2018-11-29 | Vmr Products Llc | Flavor disk |
| WO2019182745A1 (en) | 2018-03-19 | 2019-09-26 | Bryn Pharma, LLC | Epinephrine spray formulations |
| JP2021523223A (ja) | 2018-05-01 | 2021-09-02 | チビ，インコーポレイティド | 眼への薬物の非侵襲的な持続型送達のための液体デポー |
| MX2020011535A (es) * | 2018-05-01 | 2020-11-24 | Chibi Inc | Formulacion de gotas para ojos y metodos para la liberacion sostenida de medicamento a la retina. |
| CN108498849B (zh) * | 2018-05-08 | 2021-04-30 | 武汉百纳礼康生物制药有限公司 | 一种液晶凝胶肝动脉栓塞剂及其制备方法 |
| CN109091451B (zh) * | 2018-09-10 | 2021-08-13 | 武汉百纳礼康生物制药有限公司 | 亲水性药物的油相液晶凝胶前体制剂及其制备方法 |
| US20220202898A1 (en) | 2019-05-29 | 2022-06-30 | Camurus Ab | Lipid-controlled release compositions |
| EP4103587A1 (en) | 2020-02-14 | 2022-12-21 | Immunor AS | Corona virus vaccine |
| US20230372317A1 (en) * | 2020-10-27 | 2023-11-23 | Pts Consulting, Llc | A liquid injectable composition of donepezil |
| CN113081954A (zh) * | 2021-05-25 | 2021-07-09 | 南昌大学第二附属医院 | 一种凝胶载药贴剂药物输送系统 |
| JPWO2023008498A1 (ru) * | 2021-07-27 | 2023-02-02 |
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| SE8206744D0 (sv) | 1982-11-26 | 1982-11-26 | Fluidcarbon International Ab | Preparat for kontrollerad avgivning av substanser |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5538739A (en) | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| CA2186750C (en) * | 1994-03-30 | 2008-08-05 | Jens Hansen | Use of fatty acid esters as bioadhesive substances |
| SE518578C2 (sv) * | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| DE69730093T2 (de) | 1996-10-31 | 2006-07-20 | Takeda Pharmaceutical Co. Ltd. | Zubereitung mit verzögerter Freisetzung |
| BE1011899A6 (fr) * | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
| JP3952617B2 (ja) | 1998-12-11 | 2007-08-01 | 株式会社日立製作所 | 内燃機関の排ガス浄化装置，排ガス浄化方法及び排ガス浄化触媒 |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| CA2542708A1 (en) * | 2003-10-24 | 2005-05-06 | University Of Saskatchewan | Dna delivery with gemini cationic surfactants |
| JP5600233B2 (ja) * | 2003-11-07 | 2014-10-01 | カムルス エービー | 脂質及びカチオン性ペプチドの組成物 |
| GB0401513D0 (en) | 2004-01-23 | 2004-02-25 | Camurus Ab | Compositions |
| EP1713446B1 (en) | 2004-01-23 | 2010-12-01 | Camurus Ab | Ternary non-lamellar lipid compositions |
| MXPA06014095A (es) * | 2004-06-04 | 2007-08-07 | Camurus Ab | Formulaciones de deposito de lipidos. |
| EP1765367A4 (en) * | 2004-06-15 | 2010-08-11 | Therapeutics Inc Encore | PHOSPHOLIPID COMPOSITIONS AND METHOD FOR THEIR PREPARATION AND USE |
| PL1848403T3 (pl) | 2005-01-14 | 2010-09-30 | Camurus Ab | Preparaty bioadhezyjne o działaniu miejscowym |
| PL1843746T3 (pl) * | 2005-01-14 | 2011-09-30 | Camurus Ab | Formulacje analogów somatostatyny |
| CA2595385C (en) | 2005-01-21 | 2011-01-25 | Camurus Ab | Pharmaceutical lipid compositions |
| DK1888031T3 (da) | 2005-06-06 | 2013-02-18 | Camurus Ab | GLP-1-analogformuleringer |
| GB0711656D0 (en) | 2007-06-15 | 2007-07-25 | Camurus Ab | Formulations |
| GB0716385D0 (en) * | 2007-08-22 | 2007-10-03 | Camurus Ab | Formulations |
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