MX351430B - Pre-concentrado lipídico de liberación sostenida de una sustancia farmacológicamente activa y una composición farmacéutica que comprende el mismo. - Google Patents
Pre-concentrado lipídico de liberación sostenida de una sustancia farmacológicamente activa y una composición farmacéutica que comprende el mismo.Info
- Publication number
- MX351430B MX351430B MX2014002131A MX2014002131A MX351430B MX 351430 B MX351430 B MX 351430B MX 2014002131 A MX2014002131 A MX 2014002131A MX 2014002131 A MX2014002131 A MX 2014002131A MX 351430 B MX351430 B MX 351430B
- Authority
- MX
- Mexico
- Prior art keywords
- concentrate
- pharmaceutical composition
- pharmacologically active
- sustained
- lipid pre
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un pre-concentrado lipídico de liberación sostenida que comprende: a) un éster de ácido graso insaturado y sorbitán que tiene una extremo superior polar con al menos dos o más grupos -OH(hidroxilo); b) un fosfolípido; y c) un endurecedor de cristal líquido, libre de un grupo ionizable, que tienen una porción hidrofóbica de 15 hasta 40 átomos de carbono con un grupo triacilo o una estructura con anillo de carbono. El pre-concentrado lipídico existe como una fase líquida en ausencia de un fluido acuoso y se forma en el interior de un cristal líquido en presencia de un fluido acuoso. También, se proporciona una composición farmacéutica que comprende además un ingrediente farmacológicamente activo más el pre-concentrado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20110087160 | 2011-08-30 | ||
PCT/KR2012/006855 WO2013032207A1 (en) | 2011-08-30 | 2012-08-28 | Sustained-release lipid pre-concentrate of pharmacologically active substance and pharmaceutical composition comprising the same |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014002131A MX2014002131A (es) | 2014-09-15 |
MX351430B true MX351430B (es) | 2017-10-13 |
Family
ID=47756584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002131A MX351430B (es) | 2011-08-30 | 2012-08-28 | Pre-concentrado lipídico de liberación sostenida de una sustancia farmacológicamente activa y una composición farmacéutica que comprende el mismo. |
Country Status (20)
Country | Link |
---|---|
US (1) | US9526787B2 (es) |
EP (1) | EP2750667B1 (es) |
JP (1) | JP5981997B2 (es) |
KR (1) | KR101494594B1 (es) |
CN (1) | CN103764127B (es) |
AU (1) | AU2012302422B2 (es) |
BR (1) | BR112014004967B1 (es) |
CA (1) | CA2845784C (es) |
DK (1) | DK2750667T3 (es) |
ES (1) | ES2661487T3 (es) |
HU (1) | HUE036150T2 (es) |
LT (1) | LT2750667T (es) |
MX (1) | MX351430B (es) |
NO (1) | NO2750667T3 (es) |
PL (1) | PL2750667T3 (es) |
PT (1) | PT2750667T (es) |
RU (1) | RU2632433C2 (es) |
SI (1) | SI2750667T1 (es) |
TR (1) | TR201802984T4 (es) |
WO (1) | WO2013032207A1 (es) |
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KR101383324B1 (ko) | 2011-11-10 | 2014-04-28 | 주식회사 종근당 | 신규한 유전자 전달용 조성물 |
EP3936133A1 (en) | 2011-11-23 | 2022-01-12 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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US8586103B2 (en) | 2008-02-08 | 2013-11-19 | Foresee Pharmaceuticals, Llc | Non-polymeric compositions for controlled drug delivery |
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MX2011010045A (es) | 2009-03-25 | 2011-10-11 | Novartis Ag | Composicion farmaceutica que contiene un farmaco y siarn. |
CN101904814A (zh) | 2009-06-04 | 2010-12-08 | 上海恒瑞医药有限公司 | 制备载药乳剂的方法 |
KR20110056042A (ko) | 2009-11-20 | 2011-05-26 | 주식회사유한양행 | 종양세포 표적지향을 위한 나노 입자 및 이의 제조방법 |
KR101319420B1 (ko) | 2011-03-18 | 2013-10-17 | 한남대학교 산학협력단 | 서방형 방출이 가능한 수용성 양이온 약물 전달 시스템 |
JP6054291B2 (ja) | 2011-05-31 | 2016-12-27 | 株式会社ナノエッグ | 親油性化合物を高濃度で含有する液晶組成物の製造方法及びその方法によって製造された液晶組成物 |
KR101383324B1 (ko) | 2011-11-10 | 2014-04-28 | 주식회사 종근당 | 신규한 유전자 전달용 조성물 |
KR101586791B1 (ko) | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | GnRH 유도체의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
KR101586789B1 (ko) | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
KR101586790B1 (ko) | 2012-12-28 | 2016-01-19 | 주식회사 종근당 | 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물 |
CN105143193B (zh) | 2013-01-31 | 2017-12-15 | 株式会社钟根堂 | 作为cetp抑制剂的联芳基或杂环联芳基取代的环己烯衍生化合物 |
KR101601035B1 (ko) | 2013-02-28 | 2016-03-08 | 주식회사 종근당 | 키토산 및 액상결정 형성 물질을 포함하는 유전자 전달용 조성물 |
WO2014178606A1 (en) | 2013-04-29 | 2014-11-06 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
-
2012
- 2012-08-27 KR KR20120093677A patent/KR101494594B1/ko active IP Right Grant
- 2012-08-28 PL PL12826818T patent/PL2750667T3/pl unknown
- 2012-08-28 RU RU2014112189A patent/RU2632433C2/ru active
- 2012-08-28 NO NO12826818A patent/NO2750667T3/no unknown
- 2012-08-28 DK DK12826818.2T patent/DK2750667T3/en active
- 2012-08-28 JP JP2014528270A patent/JP5981997B2/ja active Active
- 2012-08-28 AU AU2012302422A patent/AU2012302422B2/en active Active
- 2012-08-28 PT PT128268182T patent/PT2750667T/pt unknown
- 2012-08-28 US US14/241,696 patent/US9526787B2/en active Active
- 2012-08-28 ES ES12826818.2T patent/ES2661487T3/es active Active
- 2012-08-28 WO PCT/KR2012/006855 patent/WO2013032207A1/en active Application Filing
- 2012-08-28 CN CN201280041992.1A patent/CN103764127B/zh active Active
- 2012-08-28 SI SI201231230T patent/SI2750667T1/en unknown
- 2012-08-28 EP EP12826818.2A patent/EP2750667B1/en active Active
- 2012-08-28 BR BR112014004967-0A patent/BR112014004967B1/pt active IP Right Grant
- 2012-08-28 TR TR2018/02984T patent/TR201802984T4/tr unknown
- 2012-08-28 MX MX2014002131A patent/MX351430B/es active IP Right Grant
- 2012-08-28 LT LTEP12826818.2T patent/LT2750667T/lt unknown
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Also Published As
Publication number | Publication date |
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NO2750667T3 (es) | 2018-05-05 |
JP5981997B2 (ja) | 2016-08-31 |
CA2845784C (en) | 2016-11-22 |
PT2750667T (pt) | 2018-01-19 |
JP2014527545A (ja) | 2014-10-16 |
AU2012302422B2 (en) | 2015-10-08 |
NZ622165A (en) | 2015-10-30 |
CA2845784A1 (en) | 2013-03-07 |
SI2750667T1 (en) | 2018-04-30 |
AU2012302422A1 (en) | 2014-03-27 |
ES2661487T3 (es) | 2018-04-02 |
US9526787B2 (en) | 2016-12-27 |
KR20130024804A (ko) | 2013-03-08 |
US20140206616A1 (en) | 2014-07-24 |
RU2632433C2 (ru) | 2017-10-04 |
EP2750667A4 (en) | 2015-06-03 |
BR112014004967A2 (pt) | 2017-03-21 |
HUE036150T2 (hu) | 2018-06-28 |
RU2014112189A (ru) | 2015-10-10 |
PL2750667T3 (pl) | 2018-05-30 |
DK2750667T3 (en) | 2018-03-05 |
WO2013032207A1 (en) | 2013-03-07 |
EP2750667B1 (en) | 2017-12-06 |
BR112014004967B1 (pt) | 2022-03-15 |
KR101494594B1 (ko) | 2015-02-23 |
MX2014002131A (es) | 2014-09-15 |
EP2750667A1 (en) | 2014-07-09 |
TR201802984T4 (tr) | 2018-03-21 |
LT2750667T (lt) | 2018-03-26 |
CN103764127A (zh) | 2014-04-30 |
CN103764127B (zh) | 2017-08-22 |
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