JP6054291B2 - 親油性化合物を高濃度で含有する液晶組成物の製造方法及びその方法によって製造された液晶組成物 - Google Patents
親油性化合物を高濃度で含有する液晶組成物の製造方法及びその方法によって製造された液晶組成物 Download PDFInfo
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- JP6054291B2 JP6054291B2 JP2013518120A JP2013518120A JP6054291B2 JP 6054291 B2 JP6054291 B2 JP 6054291B2 JP 2013518120 A JP2013518120 A JP 2013518120A JP 2013518120 A JP2013518120 A JP 2013518120A JP 6054291 B2 JP6054291 B2 JP 6054291B2
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- liquid crystal
- lipophilic compound
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- fatty acid
- acid
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- -1 alkali metal salt Chemical class 0.000 claims description 96
- 238000002360 preparation method Methods 0.000 claims description 36
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- 239000004094 surface-active agent Substances 0.000 claims description 28
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 22
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- 150000005215 alkyl ethers Chemical class 0.000 claims description 18
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- MHAJPDPJQMAIIY-UHFFFAOYSA-M hydroperoxide group Chemical group [O-]O MHAJPDPJQMAIIY-UHFFFAOYSA-M 0.000 claims description 3
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims description 3
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Description
(1)親油性化合物を含有する液晶組成物の製造方法であって、両親媒性分子及び水を添加及び混合することを含む液晶調製過程で、両親媒性分子としてイオン性の解離基を有する親油性化合物又は該親油性化合物と界面活性剤との組み合わせを添加及び混合する工程を含んでおり、その際、該親油性化合物をアルカリ金属塩又はアルカリ土類金属塩の形態で添加及び混合するか、又は該親油性化合物とアルカリ金属又はアルカリ土類金属の水酸化物又はリン酸化物とを反応させる処理を含んでいることを特徴とする、前記方法。
本調製例では、親油性化合物としてα‐リポ酸(製品名 α-リポ酸:立山化成社製)、非イオン界面活性剤としてポリオキシエチレンアルキルエーテル(製品名 NIKKOL BS−20:日光ケミカルズ社製)、多価アルコールとしてグリセリン(製品名 濃グリセリン:花王社製)、油分としてエチルヘキサン酸セチル(製品名 CIO:日光ケミカルズ社製)又はビタミンE(製品名 dl-α-トコフェロール:DSM社製)を用いて本発明の液晶を調製した例を示す。
本調製例では、親油性化合物としてフェルラ酸(製品名 フェルラ酸:築野食品工業社製)、非イオン界面活性剤としてポリオキシエチレンアルキルエーテル(製品名 NIKKOL BS−20:日光ケミカルズ社製)、多価アルコールとしてグリセリン(製品名 濃グリセリン:花王社製)を用いて本発明の液晶を調製した例を示す。
本調製例では、親油性化合物としてグリチルレチン酸(製品名 グリチルレチン酸:丸善製薬社製)、非イオン界面活性剤としてポリオキシエチレンアルキルエーテル(製品名 NIKKOL BS−20:日光ケミカルズ社製)、多価アルコールとしてグリセリン(製品名 濃グリセリン:花王社製)、油分としてエチルヘキサン酸セチル(製品名 CIO:日光ケミカルズ社製)を用いて本発明の液晶を調製した例を示す。
本調製例では、親油性化合物としてα‐リポ酸(製品名 α-リポ酸:立山化成社製)を用いて本発明の液晶を調製した例を示す。
本試験例では、実施例1の組成物中のα‐リポ酸の安定性を評価した。
Claims (10)
- 親油性化合物をその構造内に包接する単一のリオトロピック液晶である液晶組成物の製造方法であって、
両親媒性分子及び水を添加及び混合することを含む液晶調製過程で、両親媒性分子としてイオン性の解離基を有する親油性化合物又は該親油性化合物と界面活性剤との組み合わせを添加及び混合する工程を含んでおり、
その際、該親油性化合物をアルカリ金属塩又はアルカリ土類金属塩の形態で添加及び混合するか、又は該親油性化合物とアルカリ金属又はアルカリ土類金属の水酸化物又はリン酸化物とを反応させる処理を含んでおり、
ここで、前記両親媒性分子は、前記リオトロピック液晶の15〜70重量%(w/w)の量であり、
それにより、前記親油性化合物をその構造内に包接する単一のリオトロピック液晶を調製することを特徴とする、前記方法。 - イオン性の解離基は、カルボン酸基、スルホン酸基、スルフェン酸基、ヒドロぺルオキシド基よりなる群から選択される、請求項1記載の方法。
- イオン性の解離基を有する親油性化合物は、α‐リポ酸、フェルラ酸、グリチルレチン酸、ナプロキセン、メフェナム酸、ドコサヘキサエン酸、エイコサペンタエン酸、タミバロテン、クロロゲン酸、コレステリル硫酸よりなる群から選択される、請求項1記載の方法。
- イオン性の解離基を有する親油性化合物は、前記リオトロピック液晶中、7.2%〜50%(w/w)の量で配合される、請求項3記載の方法。
- 前記親油性化合物のアルカリ金属塩はナトリウム塩である、請求項1記載の方法。
- アルカリ金属の水酸化物は水酸化ナトリウムである、請求項1記載の方法。
- 界面活性剤は非イオン界面活性剤である、請求項1記載の方法。
- 非イオン界面活性剤は、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル類、プロピレングリコール脂肪酸エステル、モノグリセリン脂肪酸エステル、ジグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレン脂肪酸エステルよりなる群から選択される少なくとも1種である、請求項7記載の方法。
- 前記液晶調製過程は多価アルコールを混合することをさらに含んでいる、請求項1記載の方法。
- 前記液晶調製過程は油分を混合することをさらに含んでいる、請求項1記載の方法。
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