IL85953A - Subtilisin analogs having improved stability and method for preparing such analogs - Google Patents

Subtilisin analogs having improved stability and method for preparing such analogs

Info

Publication number
IL85953A
IL85953A IL85953A IL8595388A IL85953A IL 85953 A IL85953 A IL 85953A IL 85953 A IL85953 A IL 85953A IL 8595388 A IL8595388 A IL 8595388A IL 85953 A IL85953 A IL 85953A
Authority
IL
Israel
Prior art keywords
analogs
subtilisin
improved stability
preparing
asn
Prior art date
Application number
IL85953A
Other languages
English (en)
Other versions
IL85953A0 (en
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21891131&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL85953(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL85953A0 publication Critical patent/IL85953A0/xx
Publication of IL85953A publication Critical patent/IL85953A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
IL85953A 1987-04-10 1988-03-31 Subtilisin analogs having improved stability and method for preparing such analogs IL85953A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/036,872 US4914031A (en) 1987-04-10 1987-04-10 Subtilisin analogs

Publications (2)

Publication Number Publication Date
IL85953A0 IL85953A0 (en) 1988-09-30
IL85953A true IL85953A (en) 1993-01-31

Family

ID=21891131

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85953A IL85953A (en) 1987-04-10 1988-03-31 Subtilisin analogs having improved stability and method for preparing such analogs

Country Status (15)

Country Link
US (1) US4914031A (de)
EP (1) EP0309565B2 (de)
JP (1) JP2590247B2 (de)
KR (1) KR960006120B1 (de)
AT (1) ATE119941T1 (de)
AU (1) AU612653B2 (de)
CA (1) CA1316473C (de)
DE (1) DE3853328T3 (de)
DK (1) DK175576B1 (de)
FI (1) FI105695B (de)
HK (1) HK1007168A1 (de)
IL (1) IL85953A (de)
LV (1) LV11043B (de)
NO (1) NO179679C (de)
WO (1) WO1988008033A1 (de)

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JPS63502959A (ja) * 1986-02-12 1988-11-02 ジェネックス、コ−ポレ−ション 突然変異誘発及びスクリ−ニング方法並びに生成物
IE65767B1 (en) * 1986-04-30 1995-11-15 Genencor Int Non-human carbonyl hydrolase mutants DNA sequences and vectors encoding same and hosts transformed with said vectors
JPH0657151B2 (ja) * 1986-05-15 1994-08-03 昭和電工株式会社 酵素の安定化法
BR8805646A (pt) * 1987-02-27 1989-10-17 Gist Brocades Nv Processo para amplificacao de genes estaveis em adn cromossomico de microorganismos procarioticos
ATE371029T1 (de) * 1987-04-06 2007-09-15 Novozymes As Regelung von elektrostatischen interaktionen an metallionen-bindungsstellen zur stabilisierung von proteinen

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DE3853328T2 (de) 1995-07-27
AU1701688A (en) 1988-11-04
FI885719A0 (fi) 1988-12-09
EP0309565B1 (de) 1995-03-15
NO179679C (no) 1996-11-27
EP0309565A1 (de) 1989-04-05
DK686788A (da) 1988-12-09
NO179679B (no) 1996-08-19
DK686788D0 (da) 1988-12-09
KR960006120B1 (ko) 1996-05-09
EP0309565B2 (de) 2001-08-22
JP2590247B2 (ja) 1997-03-12
JPH01502957A (ja) 1989-10-12
IL85953A0 (en) 1988-09-30
KR890700668A (ko) 1989-04-26
EP0309565A4 (de) 1990-02-05
FI885719L (fi) 1988-12-09
DE3853328D1 (de) 1995-04-20
US4914031A (en) 1990-04-03
WO1988008033A1 (en) 1988-10-20
AU612653B2 (en) 1991-07-18
HK1007168A1 (en) 1999-04-01
FI105695B (fi) 2000-09-29
NO885484L (no) 1989-02-09
LV11043B (en) 1996-06-20
ATE119941T1 (de) 1995-04-15
NO885484D0 (no) 1988-12-09
DE3853328T3 (de) 2002-06-06
LV11043A (lv) 1996-02-20
DK175576B1 (da) 2004-12-13
CA1316473C (en) 1993-04-20

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