YU8104A - Oligopeptidi osteogenog rasta kao stimulatori hematopoeze - Google Patents

Oligopeptidi osteogenog rasta kao stimulatori hematopoeze

Info

Publication number
YU8104A
YU8104A YU8104A YUP8104A YU8104A YU 8104 A YU8104 A YU 8104A YU 8104 A YU8104 A YU 8104A YU P8104 A YUP8104 A YU P8104A YU 8104 A YU8104 A YU 8104A
Authority
YU
Yugoslavia
Prior art keywords
gly
phe
oligopeptides
tyr
hematopoiesis
Prior art date
Application number
YU8104A
Other languages
English (en)
Inventor
Itai Bab
Michael Chorev
Arye Shteyer
Nura Muhlrad
Nura Mansur
Olga Gurevitch
Zvi Greenberg
Sergio Rosini
Silvia Trasciatti
Mario Petrini
Original Assignee
Yissum Research Development Company Of The Hebrew University Of Yerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Company Of The Hebrew University Of Yerusalem filed Critical Yissum Research Development Company Of The Hebrew University Of Yerusalem
Publication of YU8104A publication Critical patent/YU8104A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na farmaceutsku mešavinu koja uključuje kao delotvoran sastojak jedan oligopeptid koji je identičan ili analogan C terminalnom delu OGP, koji ima stimulativne efekte na produkciju hematopoetičkih ćelija. Najpoželjniji oligopeptidi koji su korišćeni su Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly ili Met-Tyr-GlyPhe-Gly-Gly. Preciznije, ovi oligopeptidi pojačavaju primanje grafta transplantirane kostne srži, hemopoetičku rekonstrukciju, re-populaciju kostne srži i mobilizaciju perifernih matičnih ćelija, najbolje posle hemioterapije ili zračenja. Ovaj pronalazak dalje obezbeđuje metode tretmana i upotrebe ovih oligopeptida za pripremu farmaceutskih mešavina.[The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analagous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.
YU8104A 2001-07-29 2001-07-29 Oligopeptidi osteogenog rasta kao stimulatori hematopoeze YU8104A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU8104 2001-07-29

Publications (1)

Publication Number Publication Date
YU8104A true YU8104A (sh) 2006-08-17

Family

ID=47750092

Family Applications (1)

Application Number Title Priority Date Filing Date
YU8104A YU8104A (sh) 2001-07-29 2001-07-29 Oligopeptidi osteogenog rasta kao stimulatori hematopoeze

Country Status (1)

Country Link
YU (1) YU8104A (sh)

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