MX9705943A - Analogos de ligando mpl. - Google Patents

Analogos de ligando mpl.

Info

Publication number
MX9705943A
MX9705943A MX9705943A MX9705943A MX9705943A MX 9705943 A MX9705943 A MX 9705943A MX 9705943 A MX9705943 A MX 9705943A MX 9705943 A MX9705943 A MX 9705943A MX 9705943 A MX9705943 A MX 9705943A
Authority
MX
Mexico
Prior art keywords
mpl ligand
analogs
ligand analogs
mpl
amino acids
Prior art date
Application number
MX9705943A
Other languages
English (en)
Inventor
Steven G Elliott
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/388,779 external-priority patent/US5696250A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX9705943A publication Critical patent/MX9705943A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Los análogos de ligando de mpl tienen uno o más sitios de glicosilacion cambiados en comparacion con la secuencia de ligando de mpl que se presenta de manera natural de un numero correspondiente de aminoácidos. La invencion también se relaciona con secuencias de ADN que codifican para loa análogos de ligando de mpl, plásmidos recombinantes y células huésped para expresion análoga, y composiciones terapéuticas que incluyen tales análagos.
MX9705943A 1995-02-15 1996-02-13 Analogos de ligando mpl. MX9705943A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/388,779 US5696250A (en) 1995-02-15 1995-02-15 DNA encoding megakaryocyte growth and development factor analogs
US08/591,070 US5756083A (en) 1995-02-15 1996-02-09 Mpl ligand analogs
PCT/US1996/002492 WO1996025498A2 (en) 1995-02-15 1996-02-13 Mpl ligand analogs

Publications (1)

Publication Number Publication Date
MX9705943A true MX9705943A (es) 1997-10-31

Family

ID=27012437

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9705943A MX9705943A (es) 1995-02-15 1996-02-13 Analogos de ligando mpl.

Country Status (11)

Country Link
EP (1) EP0811064B1 (es)
JP (1) JP3836877B2 (es)
CN (1) CN1161468C (es)
AT (1) ATE323724T1 (es)
AU (1) AU691410B2 (es)
CA (1) CA2209298C (es)
DE (1) DE69636052T2 (es)
HK (2) HK1005807A1 (es)
MX (1) MX9705943A (es)
NZ (1) NZ303588A (es)
WO (1) WO1996025498A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241900B1 (en) 1994-01-03 2012-08-14 Genentech, Inc. mpl ligand
US8192955B1 (en) 1994-01-03 2012-06-05 Genentech, Inc. Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US8357513B1 (en) 1994-01-03 2013-01-22 Genentech, Inc. Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
HU230275B1 (hu) * 1996-09-13 2015-11-30 Shire Human Genetic Therapies, Inc Eljárás tisztított humán alfa-galaktozidáz-A készítmények előállítására, és a tisztított készítményeket tartalmazó gyógyászati készítmények, alfa-gal-A-deficienciából eredő rendellenességek kezelésében történő alkalmazásra
AU4344697A (en) * 1996-10-04 1998-04-24 Amgen, Inc. Pharmaceutical compositions containing an mpl ligand
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
AU7604400A (en) 1999-09-21 2001-04-24 Emory University Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
WO2005033135A1 (en) * 2003-10-09 2005-04-14 Daewoong Co., Ltd. Process for purifying human thrombopoietin with high content of sialic acid
US20110294733A1 (en) 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
JP2015513674A (ja) * 2012-02-27 2015-05-14 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． シアル酸定量のためのハイスループット方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19500030A1 (de) * 1994-01-03 1995-07-06 Genentech Inc Thrombopoietin
GB2285446B (en) * 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
EP0668352A1 (en) * 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
EP0755263A4 (en) * 1994-03-31 2005-02-09 Amgen Inc COMPOUNDS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND THEIR DIFFERENTIATION
AU4163196A (en) * 1994-11-30 1996-06-19 Zymogenetics Inc. Low molecular weight thrombopoietin
US6254870B1 (en) * 1995-02-03 2001-07-03 G. D. Searle & Co. Thrombopoietin: IL-3 fusion protein

Also Published As

Publication number Publication date
DE69636052T2 (de) 2007-04-12
AU4994696A (en) 1996-09-04
ATE323724T1 (de) 2006-05-15
HK1009151A1 (en) 1999-09-10
WO1996025498A2 (en) 1996-08-22
NZ303588A (en) 1999-02-25
AU691410B2 (en) 1998-05-14
WO1996025498A3 (en) 1997-03-20
HK1005807A1 (en) 1999-01-29
CA2209298A1 (en) 1996-08-22
DE69636052D1 (de) 2006-05-24
CN1182453A (zh) 1998-05-20
CA2209298C (en) 2001-12-18
EP0811064A2 (en) 1997-12-10
EP0811064B1 (en) 2006-04-19
JP3836877B2 (ja) 2006-10-25
CN1161468C (zh) 2004-08-11
JPH11500904A (ja) 1999-01-26

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees