DK175576B1 - Subtilisinanaloger - Google Patents

Subtilisinanaloger Download PDF

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Publication number
DK175576B1
DK175576B1 DK198806867A DK686788A DK175576B1 DK 175576 B1 DK175576 B1 DK 175576B1 DK 198806867 A DK198806867 A DK 198806867A DK 686788 A DK686788 A DK 686788A DK 175576 B1 DK175576 B1 DK 175576B1
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DK
Denmark
Prior art keywords
subtilisin
asn
replaced
analog
ser218
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Application number
DK198806867A
Other languages
Danish (da)
English (en)
Other versions
DK686788A (da
DK686788D0 (da
Inventor
Yitzhak Stabinsky
Mark M Zukowski
Michael Levitt
Original Assignee
Amgen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21891131&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175576(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of DK686788A publication Critical patent/DK686788A/da
Publication of DK686788D0 publication Critical patent/DK686788D0/da
Application granted granted Critical
Publication of DK175576B1 publication Critical patent/DK175576B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198806867A 1987-04-10 1988-12-09 Subtilisinanaloger DK175576B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3687287 1987-04-10
US07/036,872 US4914031A (en) 1987-04-10 1987-04-10 Subtilisin analogs
PCT/US1988/001038 WO1988008033A1 (en) 1987-04-10 1988-03-28 Subtilisin analogs
US8801038 1988-03-28

Publications (3)

Publication Number Publication Date
DK686788A DK686788A (da) 1988-12-09
DK686788D0 DK686788D0 (da) 1988-12-09
DK175576B1 true DK175576B1 (da) 2004-12-13

Family

ID=21891131

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806867A DK175576B1 (da) 1987-04-10 1988-12-09 Subtilisinanaloger

Country Status (15)

Country Link
US (1) US4914031A (de)
EP (1) EP0309565B2 (de)
JP (1) JP2590247B2 (de)
KR (1) KR960006120B1 (de)
AT (1) ATE119941T1 (de)
AU (1) AU612653B2 (de)
CA (1) CA1316473C (de)
DE (1) DE3853328T3 (de)
DK (1) DK175576B1 (de)
FI (1) FI105695B (de)
HK (1) HK1007168A1 (de)
IL (1) IL85953A (de)
LV (1) LV11043B (de)
NO (1) NO179679C (de)
WO (1) WO1988008033A1 (de)

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US20210032639A1 (en) 2017-09-13 2021-02-04 Danisco Us Inc. Modified 5'-untranslated region (utr) sequences for increased protein production in bacillus
EP3703661A1 (de) 2017-11-02 2020-09-09 Danisco US Inc. Feste matrixzusammensetzungen mit gesenktem gefrierpunkt für die schmelzgranulation von enzymen
EP3735478B1 (de) 2018-01-03 2023-08-16 Danisco US Inc. Mutant und genetisch modifizierte bacillus-zellen und verfahren dafür für gesteigerte proteinproduktion
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CN116322625A (zh) 2020-08-24 2023-06-23 诺维信公司 包含果聚糖酶的口腔护理组合物
CN117881772A (zh) 2021-08-20 2024-04-12 丹尼斯科美国公司 编码新型核酸酶的多核苷酸、其组合物及其从蛋白质制剂中消除dna的方法

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EP0916732B1 (de) * 1987-04-06 2007-08-22 Novozymes A/S Regelung von elektrostatischen interaktionen an metallionen-Bindungsstellen zur Stabilisierung von Proteinen

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KR960006120B1 (ko) 1996-05-09
NO179679B (no) 1996-08-19
NO179679C (no) 1996-11-27
EP0309565B1 (de) 1995-03-15
LV11043B (en) 1996-06-20
NO885484L (no) 1989-02-09
JP2590247B2 (ja) 1997-03-12
EP0309565A4 (de) 1990-02-05
HK1007168A1 (en) 1999-04-01
FI885719A0 (fi) 1988-12-09
EP0309565A1 (de) 1989-04-05
ATE119941T1 (de) 1995-04-15
FI105695B (fi) 2000-09-29
US4914031A (en) 1990-04-03
EP0309565B2 (de) 2001-08-22
NO885484D0 (no) 1988-12-09
CA1316473C (en) 1993-04-20
DE3853328T2 (de) 1995-07-27
DE3853328T3 (de) 2002-06-06
IL85953A (en) 1993-01-31
DE3853328D1 (de) 1995-04-20
AU1701688A (en) 1988-11-04
AU612653B2 (en) 1991-07-18
JPH01502957A (ja) 1989-10-12
IL85953A0 (en) 1988-09-30
FI885719A (fi) 1988-12-09
WO1988008033A1 (en) 1988-10-20
DK686788A (da) 1988-12-09
DK686788D0 (da) 1988-12-09
KR890700668A (ko) 1989-04-26
LV11043A (lv) 1996-02-20

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