ES2141761T3 - Secuencias de dna codificantes de nuevos factores de crecimiento/diferenciacion. - Google Patents
Secuencias de dna codificantes de nuevos factores de crecimiento/diferenciacion.Info
- Publication number
- ES2141761T3 ES2141761T3 ES93903966T ES93903966T ES2141761T3 ES 2141761 T3 ES2141761 T3 ES 2141761T3 ES 93903966 T ES93903966 T ES 93903966T ES 93903966 T ES93903966 T ES 93903966T ES 2141761 T3 ES2141761 T3 ES 2141761T3
- Authority
- ES
- Spain
- Prior art keywords
- proteins
- differentiation factors
- coding sequences
- dna coding
- new growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA INVENCION PROPORCIONA SECUENCIAS DEL DNA CODIFICANDO NUEVOS MIEMBROS DE LA FAMILIA TGB-(BETA) DE PROTEINAS. LA FAMILIA TGF-(BETA) COMPRENDE PROTEINAS QUE FUNCIONAN COMO FACTORES DE CRECIMIENTO Y/O DIFERENCIACION, Y QUE SON UTILES EN APLICACIONES MEDICAS. DE CONFORMIDAD CON ESTO, LA INVENCION DESCRIBE TAMBIEN EL AISLAMIENTO DE LAS SECUENCIA DEL DNA ANTERIORMENTE MENCIONADAS, LA EXPRESION DE LAS PROTEINAS CODIFICADAS, LA PRODUCCION DE LAS CITADAS PROTEINAS Y LAS COMPOSICIONES FARMACEUTICAS QUE CONTIENEN LAS CITADAS PROTEINAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92102324 | 1992-02-12 | ||
PCT/EP1993/000350 WO1993016099A2 (en) | 1992-02-12 | 1993-02-12 | Dna sequences encoding novel growth/differentiation factors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2141761T3 true ES2141761T3 (es) | 2000-04-01 |
Family
ID=8209321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93903966T Expired - Lifetime ES2141761T3 (es) | 1992-02-12 | 1993-02-12 | Secuencias de dna codificantes de nuevos factores de crecimiento/diferenciacion. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0625989B1 (es) |
JP (2) | JP3193050B2 (es) |
KR (1) | KR0172186B1 (es) |
AT (1) | ATE188996T1 (es) |
CA (1) | CA2129820C (es) |
CZ (2) | CZ287715B6 (es) |
DE (1) | DE69327645T2 (es) |
DK (1) | DK0625989T3 (es) |
ES (1) | ES2141761T3 (es) |
GR (1) | GR3032482T3 (es) |
HU (1) | HU218845B (es) |
NZ (1) | NZ249113A (es) |
PT (1) | PT625989E (es) |
RU (1) | RU2208638C2 (es) |
UA (1) | UA48105C2 (es) |
WO (1) | WO1993016099A2 (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US5807713A (en) * | 1992-02-12 | 1998-09-15 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung | DNA encoding growth/differentiation factor |
US7025959B1 (en) | 1992-02-12 | 2006-04-11 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | MP121, a growth/differentiation factor of the TGF-β family |
DE19525416A1 (de) | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
US7067637B1 (en) | 1992-02-12 | 2006-06-27 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Antibody or antibody fragments specific for a protein of the TGF-β family |
US6120760A (en) | 1992-02-12 | 2000-09-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung | Growth/differentiation factors of the TGF-β family |
US6171584B1 (en) | 1992-02-12 | 2001-01-09 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Method of treatment with growth/differentiation factors of the TGF-β family |
CA2153654A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
WO1995001801A1 (en) * | 1993-07-09 | 1995-01-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-6 |
AU688779B2 (en) | 1993-07-09 | 1998-03-19 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-7 |
IL110589A0 (en) * | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
US6764994B1 (en) | 1993-08-10 | 2004-07-20 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Growth/differential factor of the TGF-B family |
US6027919A (en) | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
ATE319823T1 (de) * | 1993-12-07 | 2006-03-15 | Inst Genetics Llc | Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen |
IL114397A0 (en) * | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
WO1996002559A1 (en) * | 1994-07-13 | 1996-02-01 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-12 |
WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
US5846770A (en) * | 1994-11-22 | 1998-12-08 | Genetics Institute, Inc. | DNA molecules encoding human chordin |
AP856A (en) * | 1995-04-19 | 2000-07-12 | Biopharm Gmbh | A novel homodimer protein used in pharmaceutical preparation for treating cartlage and bone diseases. |
DK0955313T3 (da) | 1995-04-19 | 2006-08-21 | Bioph Biotech Entw Pharm Gmbh | Nyt protein og fremgangsmåde til fremstilling af samme |
US5635372A (en) * | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
EP1364656B1 (en) | 1995-06-05 | 2013-11-20 | Genetics Institute, LLC | Use of bone morphogenetic proteins for healing and repair of connective tissue attachment |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
ZA966489B (en) * | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
US5700774A (en) * | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
JPH1080273A (ja) | 1996-05-13 | 1998-03-31 | Hoechst Yakuhin Kogyo Kk | Mp52に対するモノクローナル抗体 |
US5965403A (en) * | 1996-09-18 | 1999-10-12 | Genetics Institute, Inc. | Nucleic acids encoding bone morphogenic protein-16 (BMP-16) |
HU226554B1 (en) * | 1997-01-30 | 2009-03-30 | Bioph Biotech Entw Pharm Gmbh | Freeze-dried composition of bone morphogenetic protein human mp52 |
US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
EP1988395A1 (en) | 1997-05-30 | 2008-11-05 | Curis, Inc. | Methods for evaluating tissue morphogenesis and morphogenic activity |
US20020052026A1 (en) | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
US6027917A (en) | 1997-12-10 | 2000-02-22 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-17 and BMP-18 compositions |
US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
EP1448246B2 (en) | 2001-11-19 | 2015-09-09 | Scil Technology GmbH | Method for producing a homogeneously coated device having osteoinductive and osteoconductive properties |
PL207552B1 (pl) | 2002-09-10 | 2010-12-31 | Scil Technology Gmbh | Sposób wytwarzania urządzenia, urządzenie, kompozycja farmaceutyczna, zastosowanie urządzenia i zestaw |
US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
US8361467B2 (en) | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
ES2282904T3 (es) | 2003-09-12 | 2007-10-16 | Wyeth | Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas. |
US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
US8372419B2 (en) | 2004-03-10 | 2013-02-12 | Scil Technology Gmbh | Coated implants, their manufacturing and use thereof |
EP1740609A2 (en) | 2004-04-27 | 2007-01-10 | Research Development Foundation | Antagonism of tgf-beta superfamily receptor signaling |
EP1763362B1 (en) | 2004-05-25 | 2011-07-06 | Stryker Corporation | Use of op-1 for treating cartilage defects |
US20060069008A1 (en) | 2004-09-28 | 2006-03-30 | Sanjay Mistry | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US8147860B2 (en) | 2005-12-06 | 2012-04-03 | Etex Corporation | Porous calcium phosphate bone material |
CA2641860C (en) | 2006-02-09 | 2015-07-14 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
JP5362554B2 (ja) | 2006-05-17 | 2013-12-11 | ストライカー コーポレイション | 軟骨の欠損を処置するための可溶性形態形成タンパク質の使用 |
ES2664229T3 (es) | 2006-06-30 | 2018-04-18 | Biomimetic Therapeutics, Llc | Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US8524265B2 (en) | 2006-08-17 | 2013-09-03 | Warsaw Orthopedic, Inc. | Medical implant sheets useful for tissue regeneration |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
EP2120859B1 (en) | 2006-12-21 | 2013-11-20 | Stryker Corporation | Sustained-release formulations comprising bmp-7 crystals |
SI2121142T1 (sl) * | 2007-01-25 | 2012-12-31 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Uporaba GDF-5 za izboljšanje ali vzdrževanje videza kože |
US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
EP2187932B1 (en) | 2007-08-07 | 2015-01-28 | DePuy Synthes Products, LLC | Protein formulations comprising gdf-5 in aqueous acidic solution |
US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
US8741840B2 (en) | 2008-02-13 | 2014-06-03 | Washington University | BMP-7 for use in treating neointimal hyperplasia |
WO2009129101A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
AU2009291828C1 (en) | 2008-09-09 | 2016-03-17 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
SG173634A1 (en) | 2009-02-12 | 2011-09-29 | Stryker Corp | COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS |
JP5819733B2 (ja) | 2009-02-12 | 2015-11-24 | ストライカー コーポレイションStryker Corporation | 障害および疾患に対する全身治療のためのTGF−βスーパーファミリーメンバー含有タンパク質の末梢投与 |
US20120148539A1 (en) | 2009-03-24 | 2012-06-14 | Moulay Hicham Alaoui-Ismaili | Methods and Compositions for Tissue Engineering |
US8609127B2 (en) | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
WO2011031856A1 (en) | 2009-09-09 | 2011-03-17 | Stryker Corporation | Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint |
EP2352750B1 (en) | 2009-09-17 | 2012-06-13 | Stryker Corporation | Buffers for controlling the ph of bone morphogenetic proteins |
CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
US8492335B2 (en) | 2010-02-22 | 2013-07-23 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
CA2806143A1 (en) | 2010-07-30 | 2012-02-02 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mb H | Drug delivery devices and growth factor formulations for accelerated wound healing |
EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
ES2846848T3 (es) | 2015-10-26 | 2021-07-29 | Harvard College | Polisacáridos reducidos y oxidados y métodos de uso de los mismos |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
AU1539188A (en) * | 1987-05-04 | 1988-11-10 | Bristol-Myers Squibb Company | TGF-B2 and novel compositions having anti-neoplastic activity |
US5221620A (en) * | 1987-10-06 | 1993-06-22 | Oncogen | Cloning and expression of transforming growth factor β2 |
WO1990014360A1 (en) * | 1989-05-17 | 1990-11-29 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
FI95398C (fi) * | 1989-06-24 | 1996-01-25 | Boehringer Ingelheim Int | Menetelmä ihmisen nuhaviruksen serotyypittämiseksi |
ATE140965T1 (de) * | 1989-09-06 | 1996-08-15 | Takeda Chemical Industries Ltd | Protein, dna und ihre verwendung |
DK0448704T3 (da) * | 1989-10-17 | 1999-04-06 | Stryker Corp | Osteogene anordninger |
JPH03147787A (ja) * | 1989-10-31 | 1991-06-24 | Takara Shuzo Co Ltd | 新しいdnaクローニング方法 |
-
1993
- 1993-02-12 NZ NZ249113A patent/NZ249113A/en not_active IP Right Cessation
- 1993-02-12 UA UA94085688A patent/UA48105C2/uk unknown
- 1993-02-12 JP JP51379393A patent/JP3193050B2/ja not_active Expired - Lifetime
- 1993-02-12 EP EP93903966A patent/EP0625989B1/en not_active Expired - Lifetime
- 1993-02-12 PT PT93903966T patent/PT625989E/pt unknown
- 1993-02-12 DE DE69327645T patent/DE69327645T2/de not_active Expired - Lifetime
- 1993-02-12 DK DK93903966T patent/DK0625989T3/da active
- 1993-02-12 CZ CZ19941942A patent/CZ287715B6/cs not_active IP Right Cessation
- 1993-02-12 CA CA002129820A patent/CA2129820C/en not_active Expired - Lifetime
- 1993-02-12 AT AT93903966T patent/ATE188996T1/de active
- 1993-02-12 ES ES93903966T patent/ES2141761T3/es not_active Expired - Lifetime
- 1993-02-12 KR KR1019940702756A patent/KR0172186B1/ko not_active IP Right Cessation
- 1993-02-12 RU RU94046367/13A patent/RU2208638C2/ru active
- 1993-02-12 HU HU9402143A patent/HU218845B/hu unknown
- 1993-02-12 WO PCT/EP1993/000350 patent/WO1993016099A2/en active IP Right Grant
-
1996
- 1996-10-30 JP JP28876696A patent/JP3493105B2/ja not_active Expired - Fee Related
-
1997
- 1997-04-08 CZ CZ19971069A patent/CZ287810B6/cs not_active IP Right Cessation
-
2000
- 2000-01-26 GR GR20000400177T patent/GR3032482T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ249113A (en) | 1996-07-26 |
KR0172186B1 (ko) | 1999-02-01 |
WO1993016099A2 (en) | 1993-08-19 |
PT625989E (pt) | 2000-06-30 |
RU94046367A (ru) | 1997-03-27 |
JP3493105B2 (ja) | 2004-02-03 |
GR3032482T3 (en) | 2000-05-31 |
UA48105C2 (uk) | 2002-08-15 |
DK0625989T3 (da) | 2000-06-26 |
JPH07503847A (ja) | 1995-04-27 |
ATE188996T1 (de) | 2000-02-15 |
EP0625989A1 (en) | 1994-11-30 |
RU2208638C2 (ru) | 2003-07-20 |
CA2129820C (en) | 2003-06-17 |
CA2129820A1 (en) | 1993-08-19 |
DE69327645T2 (de) | 2000-09-07 |
CZ287810B6 (cs) | 2001-02-14 |
HUT67683A (en) | 1995-04-28 |
CZ194294A3 (en) | 1995-10-18 |
HU218845B (hu) | 2000-12-28 |
JPH09182593A (ja) | 1997-07-15 |
JP3193050B2 (ja) | 2001-07-30 |
HU9402143D0 (en) | 1994-09-28 |
CZ287715B6 (en) | 2001-01-17 |
KR950700331A (ko) | 1995-01-16 |
EP0625989B1 (en) | 2000-01-19 |
AU666170B2 (en) | 1996-02-01 |
AU3497193A (en) | 1993-09-03 |
WO1993016099A3 (en) | 1993-09-30 |
DE69327645D1 (de) | 2000-02-24 |
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