ATE188996T1 - Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren - Google Patents

Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren

Info

Publication number
ATE188996T1
ATE188996T1 AT93903966T AT93903966T ATE188996T1 AT E188996 T1 ATE188996 T1 AT E188996T1 AT 93903966 T AT93903966 T AT 93903966T AT 93903966 T AT93903966 T AT 93903966T AT E188996 T1 ATE188996 T1 AT E188996T1
Authority
AT
Austria
Prior art keywords
dna sequences
proteins
factors
diferentation
sequences coding
Prior art date
Application number
AT93903966T
Other languages
English (en)
Inventor
Helge Neidhardt
Gertrud Hoetten
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Application granted granted Critical
Publication of ATE188996T1 publication Critical patent/ATE188996T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT93903966T 1992-02-12 1993-02-12 Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren ATE188996T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92102324 1992-02-12
PCT/EP1993/000350 WO1993016099A2 (en) 1992-02-12 1993-02-12 Dna sequences encoding novel growth/differentiation factors

Publications (1)

Publication Number Publication Date
ATE188996T1 true ATE188996T1 (de) 2000-02-15

Family

ID=8209321

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93903966T ATE188996T1 (de) 1992-02-12 1993-02-12 Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren

Country Status (16)

Country Link
EP (1) EP0625989B1 (de)
JP (2) JP3193050B2 (de)
KR (1) KR0172186B1 (de)
AT (1) ATE188996T1 (de)
CA (1) CA2129820C (de)
CZ (2) CZ287715B6 (de)
DE (1) DE69327645T2 (de)
DK (1) DK0625989T3 (de)
ES (1) ES2141761T3 (de)
GR (1) GR3032482T3 (de)
HU (1) HU218845B (de)
NZ (1) NZ249113A (de)
PT (1) PT625989E (de)
RU (1) RU2208638C2 (de)
UA (1) UA48105C2 (de)
WO (1) WO1993016099A2 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US7067637B1 (en) 1992-02-12 2006-06-27 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Antibody or antibody fragments specific for a protein of the TGF-β family
US6120760A (en) * 1992-02-12 2000-09-19 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Growth/differentiation factors of the TGF-β family
US5807713A (en) * 1992-02-12 1998-09-15 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung DNA encoding growth/differentiation factor
US6171584B1 (en) 1992-02-12 2001-01-09 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Method of treatment with growth/differentiation factors of the TGF-β family
DE19525416A1 (de) * 1995-07-12 1997-01-16 Bioph Biotech Entw Pharm Gmbh Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
US7025959B1 (en) 1992-02-12 2006-04-11 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh MP121, a growth/differentiation factor of the TGF-β family
EP1439190A1 (de) 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
EP0717633A4 (de) * 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-7
JPH09503903A (ja) * 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−6
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6764994B1 (en) 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
ES2255059T3 (es) * 1993-12-07 2006-06-16 Genetics Institute, Llc Bmp-12, bmp-13 y composiciones suyas inductoras de tendon.
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
IL114397A0 (en) * 1994-07-01 1995-10-31 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF-beta-family
PT770089E (pt) * 1994-07-13 2001-02-28 Univ Johns Hopkins Med Factor 12 de diferenciacao do crescimento
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
US5846770A (en) * 1994-11-22 1998-12-08 Genetics Institute, Inc. DNA molecules encoding human chordin
ATE325131T1 (de) 1995-04-19 2006-06-15 Bioph Biotech Entw Pharm Gmbh Neues protein und verfahren zu dessen herstellung
AP856A (en) * 1995-04-19 2000-07-12 Biopharm Gmbh A novel homodimer protein used in pharmaceutical preparation for treating cartlage and bone diseases.
US5635372A (en) * 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
PT831884E (pt) 1995-06-05 2003-11-28 New York Society Uso de proteinas morfogeneticas do caso para cicatrizacao e reparacao da ligacao do tecido conjuntivo
US5902785A (en) * 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
ZA966489B (en) * 1995-08-03 1997-02-26 Bioph Biotech Entw Pharm Gmbh New protein human MP52 Arg.
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
JPH1080273A (ja) 1996-05-13 1998-03-31 Hoechst Yakuhin Kogyo Kk Mp52に対するモノクローナル抗体
US5965403A (en) 1996-09-18 1999-10-12 Genetics Institute, Inc. Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
EA001579B1 (ru) * 1997-01-30 2001-06-25 Хехст Марион Рассел Лтд. Лиофилизированная композиция морфогенетического фактора роста кости мр52 человека и способ её получения
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP1988395A1 (de) 1997-05-30 2008-11-05 Curis, Inc. Verfahren zur Beurteilung von Gewebemorphogenese und- aktivität
US20020052026A1 (en) 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6027917A (en) * 1997-12-10 2000-02-22 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
BR0214275A (pt) 2001-11-19 2004-09-21 Scil Technology Gmbh Dispositivo tendo propriedades osteocondutora e osteoindutora
WO2004024199A1 (en) 2002-09-10 2004-03-25 Scil Technology Gmbh Metal implant coated under reduced oxygen concentration with osteoinductive protein
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
UA88275C2 (ru) 2003-09-12 2009-10-12 Уайет Композиция, которая включает остеогенный белок и фосфат кальция, которая имеет форму твердого штифта, пригодного для внутрикостной инъекции, способ ее получения и применения
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
EP1737734B1 (de) 2004-03-10 2010-08-18 Scil Technology GmbH Überzogene implantate, ihre herstellung und verwendung davon
AU2005247871A1 (en) 2004-04-27 2005-12-08 Research Development Foundation Antagonism of TGF-beta superfamily receptor signaling
AU2005247440B2 (en) 2004-05-25 2011-09-29 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US20060069008A1 (en) 2004-09-28 2006-03-30 Sanjay Mistry Treatment of neurological deficits in the striatum or substanta nigra pars compacta
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
WO2007092622A2 (en) 2006-02-09 2007-08-16 Biomimetic Therapeutics, Inc. Compositions and methods for treating bone
EP2035030A2 (de) 2006-05-17 2009-03-18 Stryker Corporation Verwendung löslicher morphogener proteinkomplexe zur behandlung von knorpeldefekten
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
CA2656278C (en) 2006-06-30 2016-02-09 Biomimetic Therapeutics, Inc. Compositions and methods for treating rotator cuff injuries
US8524265B2 (en) 2006-08-17 2013-09-03 Warsaw Orthopedic, Inc. Medical implant sheets useful for tissue regeneration
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CA2671925A1 (en) 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
PT2121142E (pt) * 2007-01-25 2013-04-30 Bioph Biotech Entw Pharm Gmbh Utilização de gdf-5 para a melhoria ou conservação do aspeto dérmico
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2187932B1 (de) 2007-08-07 2015-01-28 DePuy Synthes Products, LLC Proteinformulierungen mit gdf-5 in wässriger saurer lösung
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
ES2474194T3 (es) 2008-02-13 2014-07-08 Keith Hruska PMO-7 para su uso en el tratamiento de la hiperplasia de la neo�ntima
BRPI0911048A2 (pt) 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
AU2009291828C1 (en) 2008-09-09 2016-03-17 Biomimetic Therapeutics, Llc Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
CN102369017A (zh) 2009-02-12 2012-03-07 史赛克公司 用于微创系统性递送包含TGF-β超家族成员的蛋白质的组合物和方法
EP2396025A2 (de) 2009-02-12 2011-12-21 Stryker Corporation Periphere verabreichung von proteinen einschliesslich mitglieder der tgf-beta-superfamilie zur systemischen behandlung von störungen und erkrankungen
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US8609127B2 (en) 2009-04-03 2013-12-17 Warsaw Orthopedic, Inc. Medical implant with bioactive material and method of making the medical implant
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
CA2774024A1 (en) 2009-09-17 2011-03-24 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
AU2010341565A1 (en) 2009-12-22 2012-07-12 Stryker Corporation BMP-7 variants with reduced immunogenicity
CA2790403C (en) 2010-02-22 2019-08-27 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
US20130122066A1 (en) 2010-07-30 2013-05-16 Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
US10034945B2 (en) 2012-07-13 2018-07-31 Trustees Of Tufts College Silk powder compaction for production of constructs with high mechanical strength and stiffness
CN108430458B (zh) 2015-10-26 2022-05-10 哈佛学院院长等 还原和氧化的多糖及其使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
AU1539188A (en) * 1987-05-04 1988-11-10 Bristol-Myers Squibb Company TGF-B2 and novel compositions having anti-neoplastic activity
US5221620A (en) * 1987-10-06 1993-06-22 Oncogen Cloning and expression of transforming growth factor β2
AU668072B2 (en) * 1989-05-17 1996-04-26 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
FI95398C (fi) * 1989-06-24 1996-01-25 Boehringer Ingelheim Int Menetelmä ihmisen nuhaviruksen serotyypittämiseksi
EP0416578B1 (de) * 1989-09-06 1996-07-31 Takeda Chemical Industries, Ltd. Protein, DNA und ihre Verwendung
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
JPH03147787A (ja) * 1989-10-31 1991-06-24 Takara Shuzo Co Ltd 新しいdnaクローニング方法

Also Published As

Publication number Publication date
KR0172186B1 (ko) 1999-02-01
ES2141761T3 (es) 2000-04-01
PT625989E (pt) 2000-06-30
AU666170B2 (en) 1996-02-01
DE69327645T2 (de) 2000-09-07
DE69327645D1 (de) 2000-02-24
UA48105C2 (uk) 2002-08-15
CZ287715B6 (en) 2001-01-17
RU2208638C2 (ru) 2003-07-20
AU3497193A (en) 1993-09-03
WO1993016099A3 (en) 1993-09-30
HUT67683A (en) 1995-04-28
HU9402143D0 (en) 1994-09-28
EP0625989B1 (de) 2000-01-19
DK0625989T3 (da) 2000-06-26
JP3493105B2 (ja) 2004-02-03
GR3032482T3 (en) 2000-05-31
WO1993016099A2 (en) 1993-08-19
JPH07503847A (ja) 1995-04-27
JP3193050B2 (ja) 2001-07-30
JPH09182593A (ja) 1997-07-15
HU218845B (hu) 2000-12-28
CA2129820C (en) 2003-06-17
NZ249113A (en) 1996-07-26
CZ194294A3 (en) 1995-10-18
EP0625989A1 (de) 1994-11-30
CZ287810B6 (cs) 2001-02-14
KR950700331A (ko) 1995-01-16
CA2129820A1 (en) 1993-08-19
RU94046367A (ru) 1997-03-27

Similar Documents

Publication Publication Date Title
ATE188996T1 (de) Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren
DK0713529T3 (da) Vækst-/differentieringsfaktor af TGF-beta-familien
IL85878A (en) Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodies
DE69021263T2 (de) Fibronektinbindungsprotein und dessen Herstellung.
ATE114169T1 (de) Morphogenetisches knochenprotein.
DE69839444D1 (de) Smad 6 und dessen anwendungen
DE50112802D1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
DE69433690D1 (de) Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
ES2168361T3 (es) Secuencias de adn para metaloproteasas de la matriz, su preparacion y empleo.
DE69839702D1 (de) Neue antimikrobielle polypeptide und verfahren für ihre verwendung.
EP0232523A3 (en) Dna sequences which encode for proteins with the biological activity of husi-type i inhibitors, their production by gene technology and drugs containing these proteins
DE69120390D1 (de) Kollagen-bindendes protein sowie dessen herstellung
ES2059801T3 (es) Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.
DE69033553T2 (de) Rekombinante herstellung von laktoperoxidase