IL85609A - Pharmaceutical compositions containing phenyl carbamates for systemic transdermal applications,(s)-n-ethyl-3-((1-dimethylamino)ethyl)-n-methyl-phenyl-carbamate and salts thereof and their preparation - Google Patents
Pharmaceutical compositions containing phenyl carbamates for systemic transdermal applications,(s)-n-ethyl-3-((1-dimethylamino)ethyl)-n-methyl-phenyl-carbamate and salts thereof and their preparationInfo
- Publication number
- IL85609A IL85609A IL85609A IL8560988A IL85609A IL 85609 A IL85609 A IL 85609A IL 85609 A IL85609 A IL 85609A IL 8560988 A IL8560988 A IL 8560988A IL 85609 A IL85609 A IL 85609A
- Authority
- IL
- Israel
- Prior art keywords
- ethyl
- phenyl
- carbamate
- dimethylamino
- salts
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical class NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 230000009885 systemic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3706914 | 1987-03-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL85609A0 IL85609A0 (en) | 1988-08-31 |
| IL85609A true IL85609A (en) | 1992-07-15 |
Family
ID=6322236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL85609A IL85609A (en) | 1987-03-04 | 1988-03-02 | Pharmaceutical compositions containing phenyl carbamates for systemic transdermal applications,(s)-n-ethyl-3-((1-dimethylamino)ethyl)-n-methyl-phenyl-carbamate and salts thereof and their preparation |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5602176A (enExample) |
| JP (3) | JP2625478B2 (enExample) |
| KR (1) | KR0133686B1 (enExample) |
| AT (1) | AT394190B (enExample) |
| AU (1) | AU618949B2 (enExample) |
| BE (1) | BE1001467A3 (enExample) |
| CA (1) | CA1307003C (enExample) |
| CH (1) | CH675720A5 (enExample) |
| CS (1) | CS411091A3 (enExample) |
| CY (1) | CY1735A (enExample) |
| DK (1) | DK175762B1 (enExample) |
| ES (1) | ES2010527A6 (enExample) |
| FI (1) | FI89165C (enExample) |
| FR (1) | FR2611707B1 (enExample) |
| GB (1) | GB2203040C (enExample) |
| GR (1) | GR1000023B (enExample) |
| HK (1) | HK110093A (enExample) |
| HU (1) | HU201906B (enExample) |
| IE (1) | IE61714B1 (enExample) |
| IL (1) | IL85609A (enExample) |
| IT (1) | IT1219853B (enExample) |
| LU (2) | LU87150A1 (enExample) |
| MY (1) | MY103225A (enExample) |
| NL (1) | NL195004C (enExample) |
| NZ (1) | NZ223714A (enExample) |
| PT (1) | PT86875B (enExample) |
| SA (1) | SA93140384B1 (enExample) |
| SE (1) | SE8800731L (enExample) |
| ZA (1) | ZA881584B (enExample) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201906B (en) * | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| JP3598116B2 (ja) * | 1994-04-15 | 2004-12-08 | 雅臣 伊豫 | 遅発性ジスキネジアの治療用医薬組成物とその利用 |
| ES2241064T3 (es) | 1996-12-18 | 2005-10-16 | Teva Pharmaceutical Industries, Ltd. | Derivados de aminoindano. |
| WO1998026775A1 (en) * | 1996-12-18 | 1998-06-25 | Teva Pharmaceutical Industries, Ltd. | Phenylethylamine derivatives |
| US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
| GB9800526D0 (en) * | 1998-01-12 | 1998-03-11 | Ciba Geigy Ag | Organic compounds |
| US6316023B1 (en) * | 1998-01-12 | 2001-11-13 | Novartis Ag | TTS containing an antioxidant |
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| PL196945B1 (pl) | 1998-10-01 | 2008-02-29 | Novartis Ag | Doustna kompozycja farmaceutyczna o kontrolowanym uwalnianiu zawierająca rywastygminę oraz jej zastosowanie |
| US20040209849A1 (en) * | 1998-11-27 | 2004-10-21 | Sanochemia Pharmazeutika Aktiengesellschaft | Use of effectors of the central cholinergic nervous system for treatment of delirium |
| CA2354035A1 (en) * | 1998-12-11 | 2000-06-15 | Bonnie Davis | Use of acetylcholinesterase inhibitors on the modulation of the hypothalamic-pituitary-gonadal axis |
| GB9923045D0 (en) * | 1999-09-29 | 1999-12-01 | Novartis Ag | New oral formulations |
| US6534541B1 (en) | 1999-10-19 | 2003-03-18 | Novartis Ag | Treatment of ocular disorders |
| AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
| US20040010038A1 (en) * | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| GEP20094759B (en) * | 2002-10-24 | 2009-08-25 | Merz Pharma Gmbh & Co Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
| CZ293014B6 (cs) * | 2002-10-24 | 2004-01-14 | Léčiva, A.S. | Způsob výroby (-)-(S)-3-[1-(dimethylamino)ethyl]fenyl-N-ethyl-N-methylkarbamátu |
| EP1603548A4 (en) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | METHOD AND COMPOSITION FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US20050042284A1 (en) * | 2003-07-11 | 2005-02-24 | Myriad Genetics, Incorporated | Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease |
| AU2004285893B2 (en) * | 2003-10-21 | 2011-12-15 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| GB2409453A (en) | 2003-12-24 | 2005-06-29 | Generics | Process for the preparation of aminoalkyl phenylcarbamates |
| WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
| US20050252144A1 (en) * | 2004-04-29 | 2005-11-17 | Macdonald Robert A | Veneers for walls, retaining walls and the like |
| JPWO2006004201A1 (ja) * | 2004-07-01 | 2008-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 神経再生促進剤 |
| WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020853A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| JP4954886B2 (ja) * | 2004-11-08 | 2012-06-20 | エムキュア ファーマシューティカルズ リミテッド | (s)−3−[(1−ジメチルアミノ)エチル]−フェニル−n−エチル−n−メチル−カルバミン酸の効率的製造方法 |
| GB0507298D0 (en) | 2005-04-11 | 2005-05-18 | Novartis Ag | Organic compounds |
| EA200800360A1 (ru) * | 2005-07-22 | 2008-06-30 | Мириад Дженетикс, Инк. | Формуляции с высоким содержанием лекарства и дозированные формы |
| ES2267399B1 (es) | 2005-08-04 | 2008-02-01 | Ragactives, S.L. | Procedimiento para la obtencion de carbamatos de fenilo. |
| ATE543545T1 (de) | 2005-09-15 | 2012-02-15 | Sony Computer Entertainment Inc | Beschaffung einer eingabe zum kontrollieren der ausführung eines spielprogrammes |
| TWI389709B (zh) | 2005-12-01 | 2013-03-21 | Novartis Ag | 經皮治療系統 |
| CN103142570A (zh) * | 2005-12-09 | 2013-06-12 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 低剂量Ladostigil 用于神经保护的用途 |
| TW200744576A (en) * | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| US7767843B2 (en) * | 2006-03-02 | 2010-08-03 | Apotex Pharmachem Inc. | Process for the preparation of phenylcarbamates |
| WO2008006099A2 (en) * | 2006-07-07 | 2008-01-10 | Myriad Genetics, Inc. | Treatment of psychiatric disorders |
| CA2661009A1 (en) * | 2006-08-17 | 2008-02-21 | Alembic Limited | Improved process for the preparation of rivastigmine |
| WO2008037433A1 (en) | 2006-09-29 | 2008-04-03 | Synthon B.V. | Process for making aminoalkylphenyl carbamates and intermediates therefor |
| ATE549021T1 (de) | 2006-10-27 | 2012-03-15 | Medivation Neurology Inc | Kombinationstherapien zur behandlung von morbus alzheimer mit dimebon und donepezil |
| EP1942100A1 (en) * | 2007-01-04 | 2008-07-09 | Krka Tovarna Zdravil, D.D., Novo Mesto | Amorphous and crystalline forms of rivastigmine hydrogentartrate |
| CA2677241A1 (en) * | 2007-02-02 | 2008-08-14 | Colucid Pharmaceuticals, Inc. | Compounds that inhibit cholinesterase |
| US8013181B2 (en) * | 2007-04-10 | 2011-09-06 | Dr. Reddy's Laboratories Limited | Preparation of rivastigmine and its salts |
| WO2008124969A1 (en) * | 2007-04-16 | 2008-10-23 | Topharman Shanghai Co., Ltd. | Preparation method of rivastigmine and its intermediates |
| US7884121B2 (en) * | 2007-06-11 | 2011-02-08 | Apotex Pharmachem Inc. | Process for the preparation of phenylcarbamates |
| EP2182938A2 (en) * | 2007-07-18 | 2010-05-12 | Colucid Pharmaceuticals, Inc. | Methods for promoting wakefulness |
| US8593728B2 (en) * | 2009-02-19 | 2013-11-26 | Toyota Motor Engineering & Manufacturing North America, Inc. | Multilayer photonic structures |
| US20090082436A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched rivastigmine |
| EP2233465B1 (en) * | 2008-01-10 | 2017-06-28 | Shanghai Institute of Pharmaceutical Industry | Preparation method of rivastigmine, its intermediates and preparation method of the intermediates |
| US8420846B2 (en) | 2008-08-25 | 2013-04-16 | Jubilant Life Sciences Limited | Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates |
| US20100087768A1 (en) * | 2008-10-02 | 2010-04-08 | Forlano Paula | Transdermal drug delivery system for liquid active ingredient |
| GB0823554D0 (en) * | 2008-12-24 | 2009-01-28 | Novartis Ag | Process for the preparation of optically active compounds using transfer hydrogenation |
| CN101823970B (zh) * | 2009-03-03 | 2013-05-08 | 江苏恩华药业股份有限公司 | 卡巴拉汀及其中间体的合成方法 |
| CN102711744B (zh) | 2009-12-22 | 2014-06-25 | 阿西诺股份公司 | 用于施用利凡斯的明和其衍生物的透皮治疗系统 |
| US10076502B2 (en) | 2009-12-22 | 2018-09-18 | Luye Pharma Ag | Transdermal therapeutic system for administering rivastigmine or derivatives thereof |
| ES2363395B1 (es) * | 2010-01-20 | 2012-02-23 | Farmalider, S.A. | Composición farmacéutica l�?quida de rivastigmina o de una de sus sales de adición de �?cido para la administración por v�?a oral. |
| EP2533645B1 (en) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| TW201618806A (zh) | 2010-03-29 | 2016-06-01 | 諾華公司 | 有機化合物之組合物 |
| WO2011151669A1 (en) | 2010-06-02 | 2011-12-08 | Jubilant Life Sciences Limited | Process for producing enantiomerically enriched isomer of 3-(1-aminoethyl) phenyl derivative and employing the same to produce rivastigmine or its pharmaceutically acceptable salt |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| WO2011159910A2 (en) | 2010-06-17 | 2011-12-22 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol |
| NO3034079T3 (enExample) | 2010-11-15 | 2018-06-09 | ||
| RS54173B1 (sr) | 2010-12-14 | 2015-12-31 | Acino Ag | Transdermalni terapijski sistem za davanje aktivne supstance |
| CN102786441B (zh) | 2011-05-18 | 2013-11-13 | 浙江海正药业股份有限公司 | 利凡斯的明的制备方法、其中间体以及中间体的制备方法 |
| EP2711002A4 (en) | 2011-05-20 | 2014-10-29 | Sk Chemicals Co Ltd | PLASTER WITH RIVASTIGMIN |
| AR082640A1 (es) * | 2011-08-25 | 2012-12-19 | Amarin Technologies S A | Un dispositivo para la administracion transdermal de compuestos alcalinos susceptibles a la degradacion en su forma no salificada |
| WO2013031992A1 (ja) | 2011-08-31 | 2013-03-07 | 積水メディカル株式会社 | 貼付剤 |
| CN103073456B (zh) * | 2011-10-26 | 2014-03-19 | 连云港润众制药有限公司 | 重酒石酸卡巴拉汀中间体的制备方法 |
| EP2594261A1 (en) | 2011-11-18 | 2013-05-22 | Labtec GmbH | Composition for transdermal administration of rivastigmine |
| WO2013142339A1 (en) | 2012-03-23 | 2013-09-26 | Novartis Ag | Transdermal therapeutic system and method |
| ES2449215B1 (es) * | 2012-09-17 | 2014-07-14 | Galenicum Health S.L. | Solución oral de (S)-3-[1-(dimetilamino)etil]fenil N-etil-N-metilcarbamato |
| KR20140038237A (ko) | 2012-09-20 | 2014-03-28 | 에스케이케미칼주식회사 | 리바스티그민의 안정성이 개선된 의약품 |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN103896787A (zh) * | 2012-12-26 | 2014-07-02 | 江苏康倍得药业有限公司 | 一种卡巴拉汀前体[1-(3-甲氧基苯基)乙基]二甲胺的制备方法 |
| WO2014111790A2 (en) | 2013-01-15 | 2014-07-24 | Zydus Technologies Limited | Stable transdermal pharmaceutical drug delivery system comprising rivastigmine |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| CN103319374B (zh) * | 2013-06-09 | 2015-04-22 | 无锡佰翱得生物科学有限公司 | 一种(s)-卡巴拉汀的不对称合成方法 |
| EP3033082B1 (en) | 2013-08-16 | 2021-06-16 | Universiteit Maastricht | Treatment of cognitive impairment with pde4 inhibitor |
| US10329301B2 (en) | 2013-12-20 | 2019-06-25 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN107810002B (zh) | 2015-05-22 | 2021-01-05 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
| CA2990004C (en) | 2015-06-19 | 2024-04-23 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| BR112020026062B1 (pt) | 2018-06-19 | 2023-04-04 | Agenebio, Inc | Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson |
| KR20200035359A (ko) | 2018-09-26 | 2020-04-03 | 캐딜라 파마슈티클즈 리미티드 | 리바스티그민 제조용 중간체의 합성 |
| EP4572852A1 (en) | 2022-08-19 | 2025-06-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
| WO2025038382A1 (en) | 2023-08-11 | 2025-02-20 | Momentive Performance Materials Inc. | Pharmaceutical adhesive compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469700A (en) * | 1981-06-19 | 1984-09-04 | Lowell M. Somers | Benzoylecgonine or benzoylnorecgonine as active agents for the treatment of rheumatoid arthritis |
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| HU201906B (en) * | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
-
1988
- 1988-02-22 HU HU88827A patent/HU201906B/hu unknown
- 1988-02-22 NL NL8800436A patent/NL195004C/nl not_active IP Right Cessation
- 1988-02-29 FR FR888802597A patent/FR2611707B1/fr not_active Expired - Lifetime
- 1988-02-29 BE BE8800230A patent/BE1001467A3/fr not_active IP Right Cessation
- 1988-03-01 GB GB8804888A patent/GB2203040C/en not_active Expired - Lifetime
- 1988-03-01 CH CH774/88A patent/CH675720A5/de not_active IP Right Cessation
- 1988-03-02 AU AU12554/88A patent/AU618949B2/en not_active Expired
- 1988-03-02 FI FI880972A patent/FI89165C/fi active Protection Beyond IP Right Term
- 1988-03-02 SE SE8800731A patent/SE8800731L/xx not_active Application Discontinuation
- 1988-03-02 DK DK198801125A patent/DK175762B1/da not_active IP Right Cessation
- 1988-03-02 PT PT86875A patent/PT86875B/pt active IP Right Grant
- 1988-03-02 NZ NZ223714A patent/NZ223714A/en unknown
- 1988-03-02 IE IE58388A patent/IE61714B1/en not_active IP Right Cessation
- 1988-03-02 LU LU87150A patent/LU87150A1/fr active Protection Beyond IP Right Term
- 1988-03-02 IL IL85609A patent/IL85609A/xx not_active IP Right Cessation
- 1988-03-03 AT AT0055188A patent/AT394190B/de not_active IP Right Cessation
- 1988-03-03 MY MYPI88000215A patent/MY103225A/en unknown
- 1988-03-03 GR GR880100125A patent/GR1000023B/el not_active IP Right Cessation
- 1988-03-03 KR KR1019880002187A patent/KR0133686B1/ko not_active Expired - Lifetime
- 1988-03-03 CA CA000560457A patent/CA1307003C/en not_active Expired - Lifetime
- 1988-03-03 JP JP63052478A patent/JP2625478B2/ja not_active Expired - Lifetime
- 1988-03-04 ZA ZA881584A patent/ZA881584B/xx unknown
- 1988-03-04 IT IT47693/88A patent/IT1219853B/it active Protection Beyond IP Right Term
- 1988-03-04 ES ES8800651A patent/ES2010527A6/es not_active Expired
-
1991
- 1991-12-27 CS CS914110A patent/CS411091A3/cs unknown
-
1993
- 1993-10-21 HK HK1100/93A patent/HK110093A/xx not_active IP Right Cessation
- 1993-11-29 SA SA93140384A patent/SA93140384B1/ar unknown
-
1994
- 1994-06-03 CY CY173594A patent/CY1735A/en unknown
-
1995
- 1995-06-06 US US08/466,502 patent/US5602176A/en not_active Expired - Lifetime
-
1996
- 1996-09-12 JP JP8241702A patent/JPH09118617A/ja active Pending
- 1996-11-01 JP JP8291560A patent/JP2859225B2/ja not_active Expired - Lifetime
-
1998
- 1998-10-07 LU LU90297C patent/LU90297I2/fr unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of name of proprietor(s) | ||
| KB | Patent renewed | ||
| PEL | Intention of commissioner to extend period of protection | ||
| EXTG | Extension of patent term granted | ||
| EXTG | Extension of patent term granted | ||
| KB | Patent renewed | ||
| EXTN | Extension order renewed | ||
| EXTN | Extension order renewed | ||
| EXP | Patent expired |