IL75725A - Recombinant human gm-csf - Google Patents

Recombinant human gm-csf

Info

Publication number
IL75725A
IL75725A IL75725A IL7572585A IL75725A IL 75725 A IL75725 A IL 75725A IL 75725 A IL75725 A IL 75725A IL 7572585 A IL7572585 A IL 7572585A IL 75725 A IL75725 A IL 75725A
Authority
IL
Israel
Prior art keywords
csf
cdna
preparing
protein
rna
Prior art date
Application number
IL75725A
Other languages
English (en)
Other versions
IL75725A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27417446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL75725(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL75725A0 publication Critical patent/IL75725A0/xx
Priority to IL94754A priority Critical patent/IL94754A0/xx
Publication of IL75725A publication Critical patent/IL75725A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/44Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Debugging And Monitoring (AREA)
  • Fats And Perfumes (AREA)
IL75725A 1984-07-06 1985-07-04 Recombinant human gm-csf IL75725A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL94754A IL94754A0 (en) 1984-07-06 1990-06-17 Lymphokine production and purification

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62834284A 1984-07-06 1984-07-06
US65274284A 1984-09-19 1984-09-19
US65244784A 1984-09-19 1984-09-19

Publications (2)

Publication Number Publication Date
IL75725A0 IL75725A0 (en) 1985-11-29
IL75725A true IL75725A (en) 1993-02-21

Family

ID=27417446

Family Applications (2)

Application Number Title Priority Date Filing Date
IL75725A IL75725A (en) 1984-07-06 1985-07-04 Recombinant human gm-csf
IL94754A IL94754A0 (en) 1984-07-06 1990-06-17 Lymphokine production and purification

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL94754A IL94754A0 (en) 1984-07-06 1990-06-17 Lymphokine production and purification

Country Status (28)

Country Link
EP (2) EP0337359B1 (enExample)
JP (4) JP2540509B2 (enExample)
KR (1) KR910001809B1 (enExample)
AT (2) ATE172494T1 (enExample)
AU (3) AU599572B2 (enExample)
CA (2) CA1341618C (enExample)
CY (1) CY1629A (enExample)
DE (3) DE188479T1 (enExample)
DK (2) DK168709B1 (enExample)
ES (1) ES8701226A1 (enExample)
FI (1) FI108796B (enExample)
GR (1) GR851643B (enExample)
HK (1) HK111594A (enExample)
HU (1) HU208711B (enExample)
IE (2) IE60819B1 (enExample)
IL (2) IL75725A (enExample)
LU (1) LU88337I2 (enExample)
MY (1) MY102902A (enExample)
NL (1) NL930089I2 (enExample)
NO (4) NO179455C (enExample)
NZ (2) NZ228031A (enExample)
PL (1) PL153139B1 (enExample)
PT (1) PT80776B (enExample)
SA (1) SA94150015A (enExample)
SG (1) SG108991G (enExample)
SK (1) SK505985A3 (enExample)
UA (1) UA39161C2 (enExample)
WO (1) WO1986000639A1 (enExample)

Families Citing this family (66)

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AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
JPS61227526A (ja) * 1984-07-25 1986-10-09 Chugai Pharmaceut Co Ltd 新規なコロニー刺激因子
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
DE3586826T2 (de) * 1984-11-20 1993-03-25 Schering Biotech Corp Cdna-klone, kodierend fuer peptide mit der wirksamkeit eines menschlichen granulocyte-, makrophage- und eosinophilzellenwachstumsfaktors.
WO1986004587A1 (en) * 1985-02-05 1986-08-14 Cetus Corporation Purification of native colony stimulating factor-1
EP0220520B1 (en) * 1985-09-30 1991-09-18 Chugai Seiyaku Kabushiki Kaisha Human granulocyte colony stimulating factor
JPS63502795A (ja) * 1985-10-03 1988-10-20 バイオジェン インコーポレイテッド 顆粒球‐マクロファージコロニー刺激因子‐様ポリペプチド、dna配列、組換えdna分子並びに微生物細胞中でヒト顆粒球−マクロファ−ジコロニ−刺激因子−様ポリペプチドを高収量で生産する方法
CA1295567C (en) * 1988-07-25 1992-02-11 Lawrence T. Malek Expression system for the secretion of bioactive human granulocyte, macrophage-colony stimulating factor (gm-csf) and other heterologous proteins from streptomyces
US5298603A (en) * 1985-12-21 1994-03-29 Hoechst Aktiengesellschaft GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
GR871029B (en) 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US5162111A (en) * 1986-07-30 1992-11-10 Grabstein Kenneth H Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor
JPH01500483A (ja) * 1986-08-11 1989-02-23 シタス コーポレイション G‐csf及びそのミューテインの発現
GB8624899D0 (en) * 1986-10-17 1986-11-19 Sandoz Ltd Monoclonal antibodies
JPH0618781B2 (ja) * 1986-10-18 1994-03-16 中外製薬株式会社 感染症治療剤
EP0276846A3 (en) * 1987-01-29 1989-07-26 Zymogenetics, Inc. Colony-stimulating factor derivatives
JP2521094B2 (ja) * 1987-04-28 1996-07-31 アムジェン、インコーポレーテッド ヒト顆粒球マクロファ―ジコロニ―刺激因子をコ―ドする合成dna、そのdnaを含むプラスミド、およびそのdnaで形質転換された大腸菌
ATE121134T1 (de) * 1987-06-25 1995-04-15 Immunex Corp Rinder granulocyt-makrophagenkolonie stimulierender faktor.
US5391706A (en) * 1987-07-16 1995-02-21 Schering Plough Corporation Purification of GM-CSF
ES2034239T3 (es) * 1987-07-16 1993-04-01 Schering Corporation Purificacion de gm-csf.
CA1335717C (en) * 1987-07-17 1995-05-30 Takashi Yokota Human granulocyte-macrophage colony stimulating factor and muteins thereof
AU626530B2 (en) * 1987-07-17 1992-08-06 Schering Biotech Corporation Human granulocyte-macrophage colony stimulating factor and muteins thereof
WO1989001038A1 (en) * 1987-07-24 1989-02-09 Cetus Corporation PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM
EP0347057A1 (en) * 1988-05-31 1989-12-20 Schering Biotech Corporation Method of treating myeloid leukemias
AU618283B2 (en) * 1988-10-10 1991-12-19 Instituto Nazionale Per Lo Studio E La Cura Dei Tumori The use of GM-CSF in the treatment of a patient requiring high-dose chemo- or radiotherapy for cancer
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
JPH0322973A (ja) * 1989-01-19 1991-01-31 Wan Shen-Yuan ヒトヘパトーム細胞系によるコロニー形成促進因子(CSFs)の構成性産生
MY105946A (en) * 1989-07-14 1995-02-28 Schering Corp Antagonists of gm-csf derived from the carboxyl terminus.
DE69326829D1 (de) 1992-02-28 1999-11-25 Univ Texas Verwendung einer therapeutischen ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON VERBRENNUNGEN
US6004807A (en) * 1992-03-30 1999-12-21 Schering Corporation In vitro generation of human dendritic cells
US6361976B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US6413509B1 (en) 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US6361977B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Methods of using multivariant IL-3 hematopoiesis fusion protein
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US6403076B1 (en) 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
JP3681069B2 (ja) 1993-05-12 2005-08-10 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Bmp−11組成物
ATE210182T1 (de) * 1993-06-30 2001-12-15 Lucky Ltd Modifizierte-granulocyte-makrophage-kolonie- stimulierender-faktor-gen und seine expression in hefe
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
WO1995016035A2 (en) 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
US5599536A (en) * 1993-12-13 1997-02-04 Sandoz Ltd. Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5578301A (en) * 1993-12-14 1996-11-26 Sandoz Ltd. Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US6165748A (en) 1997-07-11 2000-12-26 Genetics Institute, Inc. Frazzled nucleotide sequences and expression products
US6676937B1 (en) 1998-03-09 2004-01-13 Caritas St. Elizabeth's Medical Center Of Boston Inc. Compositions and methods for modulating vascularization
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19905501B4 (de) 1999-02-10 2005-05-19 MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
EP1150666B1 (en) * 1999-02-12 2009-10-28 Washington University Gm-csf for the treatment of crohn's disease
CA2386408A1 (en) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations of hyaluronic acid for delivery of osteogenic proteins
WO2001042511A2 (en) * 1999-12-10 2001-06-14 Whitehead Institute For Biomedical Research Ibd-related polymorphisms
US6869762B1 (en) 1999-12-10 2005-03-22 Whitehead Institute For Biomedical Research Crohn's disease-related polymorphisms
US6689599B1 (en) 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2003012038A2 (en) 2001-07-27 2003-02-13 Wyeth Aggrecanase molecules
PL371525A1 (en) 2002-01-31 2005-06-27 Wyeth Aggrecanase molecules
CA2475329A1 (en) 2002-02-05 2003-08-14 Katy E. Georgiadis Truncated aggrecanase molecules
EP1525307A2 (en) 2002-07-29 2005-04-27 Wyeth Modified adamts4 molecules and method of use thereof
WO2025109150A1 (en) 2023-11-24 2025-05-30 Ludwig-Maximilians-Universität München, In Vertretung Des Freistaates Bayern The combination of gm-csf and inhibition of ccl22-ccr4 signaling in the treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428632A (en) * 1979-08-10 1984-01-31 Thomas & Betts Corporation Coaxial cable transition connector
JPS6030654B2 (ja) * 1980-12-31 1985-07-17 株式会社林原生物化学研究所 ヒトコロニ−刺激因子の製造方法
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
JPH0751511B2 (ja) * 1982-03-15 1995-06-05 味の素株式会社 インターロイキン2を含有してなる癌治療剤
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene

Also Published As

Publication number Publication date
DE3584089D1 (de) 1991-10-17
DK172679B1 (da) 1999-05-17
IE851695L (en) 1986-01-06
DE3588199D1 (de) 1998-11-26
SA94150015B1 (ar) 2004-09-04
PL254400A1 (en) 1986-06-17
FI860308A7 (fi) 1986-01-22
EP0188479B1 (en) 1991-09-11
LU88337I2 (fr) 1994-05-04
IL94754A0 (en) 1991-04-15
DK168709B1 (da) 1994-05-24
NO179455B (no) 1996-07-01
IL75725A0 (en) 1985-11-29
DK102886D0 (da) 1986-03-06
UA39161C2 (uk) 2001-06-15
CA1340852C (en) 1999-12-14
JPH07163351A (ja) 1995-06-27
MY102902A (en) 1993-03-31
DK59493D0 (da) 1993-05-21
ATE67244T1 (de) 1991-09-15
NO943300L (no) 1986-03-13
PT80776A (en) 1985-08-01
HU208711B (en) 1993-12-28
JP2594744B2 (ja) 1997-03-26
AU4545685A (en) 1986-02-10
SA94150015A (ar) 2005-12-03
JP2594743B2 (ja) 1997-03-26
KR860700264A (ko) 1986-08-01
DE3588199T2 (de) 1999-04-08
EP0337359A2 (en) 1989-10-18
WO1986000639A1 (en) 1986-01-30
DK59493A (da) 1993-05-21
JPH06319557A (ja) 1994-11-22
NZ212645A (en) 1990-02-26
IE930961L (en) 1986-01-06
PL153139B1 (en) 1991-03-29
NO961452D0 (no) 1996-04-12
JPS61502682A (ja) 1986-11-20
DK102886A (da) 1986-03-06
AU599572B2 (en) 1990-07-26
CY1629A (en) 1992-07-10
JP2594768B2 (ja) 1997-03-26
AU5497690A (en) 1990-09-13
AU644359B2 (en) 1993-12-09
FI860308A0 (fi) 1986-01-22
DE188479T1 (de) 1987-05-21
NO307348B1 (no) 2000-03-20
JPH06199897A (ja) 1994-07-19
NO179455C (no) 1996-10-09
HK111594A (en) 1994-10-21
IE60819B1 (en) 1994-08-10
NO1996016I1 (no) 1996-12-18
NO961452L (no) 1996-04-12
EP0337359A3 (en) 1990-02-07
NL930089I2 (nl) 1994-07-01
NO314941B1 (no) 2003-06-16
CA1341618C (en) 2011-07-19
HK1011709A1 (en) 1999-07-16
SK280265B6 (sk) 1999-10-08
AU628069B2 (en) 1992-09-10
HUT38675A (en) 1986-06-30
KR910001809B1 (ko) 1991-03-26
GR851643B (enExample) 1985-11-26
NL930089I1 (nl) 1993-10-01
AU4009089A (en) 1989-12-07
EP0188479A1 (en) 1986-07-30
PT80776B (pt) 1987-09-30
NO860775L (no) 1986-03-13
NO943300D0 (no) 1994-09-07
SK505985A3 (en) 1999-10-08
ES8701226A1 (es) 1986-11-16
ATE172494T1 (de) 1998-11-15
FI108796B (fi) 2002-03-28
SG108991G (en) 1992-03-20
JP2540509B2 (ja) 1996-10-02
ES544868A0 (es) 1986-11-16
NZ228031A (en) 1991-12-23
EP0337359B1 (en) 1998-10-21

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