IL75690A - 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile and its preparation - Google Patents

4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile and its preparation

Info

Publication number
IL75690A
IL75690A IL75690A IL7569085A IL75690A IL 75690 A IL75690 A IL 75690A IL 75690 A IL75690 A IL 75690A IL 7569085 A IL7569085 A IL 7569085A IL 75690 A IL75690 A IL 75690A
Authority
IL
Israel
Prior art keywords
preparation
fluorophenyl
benzonitrile
hydroxybutyl
hydroxymethyl
Prior art date
Application number
IL75690A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL75690(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IL75690A publication Critical patent/IL75690A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cosmetics (AREA)
  • Furan Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
IL75690A 1984-08-06 1985-07-01 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile and its preparation IL75690A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419963A GB8419963D0 (en) 1984-08-06 1984-08-06 Intermediate compound and method

Publications (1)

Publication Number Publication Date
IL75690A true IL75690A (en) 1988-10-31

Family

ID=10564974

Family Applications (1)

Application Number Title Priority Date Filing Date
IL75690A IL75690A (en) 1984-08-06 1985-07-01 4-(4-(dimethylamino)-1-(4'-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile and its preparation

Country Status (18)

Country Link
US (1) US4650884A (fr)
EP (1) EP0171943B1 (fr)
JP (1) JPH0625099B2 (fr)
AT (1) ATE38661T1 (fr)
AU (1) AU574819B2 (fr)
CA (1) CA1237147A (fr)
DE (1) DE3566251D1 (fr)
DK (2) DK172450B1 (fr)
ES (1) ES8606257A1 (fr)
FI (2) FI81338C (fr)
GB (1) GB8419963D0 (fr)
GR (1) GR851894B (fr)
IE (1) IE57817B1 (fr)
IL (1) IL75690A (fr)
NO (1) NO160364C (fr)
NZ (1) NZ212541A (fr)
PT (1) PT80913B (fr)
ZA (1) ZA855026B (fr)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JPH0675987U (ja) * 1993-04-09 1994-10-25 日立造船株式会社 貨物輸送船におけるバラストタンクへのアクセス用トランク構造
US5607939A (en) * 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO1998019513A2 (fr) 1997-07-08 1998-05-14 H. Lundbeck A/S Procede de preparation de citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (fr) 1997-11-11 2002-07-31 H. Lundbeck A/S Procédé de préparation de citaloprame
CA2291134C (fr) 1998-10-20 2006-05-23 H. Lundbeck A/S Methode de preparation de la citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
TR200401456T1 (tr) * 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
BR9917604A (pt) 1999-12-30 2002-12-31 Lundbeck & Co As H Método para preparação de citalopram
HUP0300343A2 (hu) * 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
AU2006201612B2 (en) * 2000-01-14 2008-03-13 H Lundbeck A/S Method for the preparation of 5-cyanophthalide
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
US6494503B1 (en) * 2000-03-25 2002-12-17 Non Metallic Resources, Inc. Pipe joint assembly and method for using same
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
BG64901B1 (bg) * 2000-05-29 2006-08-31 H. Lundbeck A/S Метод за получаване на циталопрам
IES20010693A2 (en) 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
CA2354877C (fr) * 2000-08-18 2006-05-02 H. Lundbeck A/S Methode de preparation de citalopram
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
ATE222899T1 (de) * 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram
EP1355897A1 (fr) 2001-01-30 2003-10-29 Orion Corporation Fermion Procede de preparation de 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US20050066373A1 (en) * 2001-02-02 2005-03-24 Matthew Rabinowitz Position location using broadcast digital television signals
EA200301195A1 (ru) * 2001-05-01 2004-04-29 Х. Лундбекк А/С Применение энантиомерно чистого эсциталопрама
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
BR0206164A (pt) 2001-07-31 2003-10-28 Lundbeck & Co As H Partìculas cristalinas de oxalato de escitalopram, método para a produção de partìculas cristalinas de oxalato de escitalopram, e, forma de dosagem unitária sólida
DE60108105T2 (de) * 2001-08-02 2005-12-08 Infosint Sa Verfahren zur Herstellung von 5-substituierten Isobenzofuranen
EP1288211A1 (fr) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Procédé amélioré pour la préparation d'hydrobromure de Citalopram à partir de 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
AU2003207774A1 (en) * 2002-01-30 2003-09-02 Montana State University Pestalotiopsis microsporia isolates and compounds derived therefrom
GB0204607D0 (en) 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (fr) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Methode de preparation et intermediaires connexes pour la synthese de l'escitalopram
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
BG65516B1 (bg) * 2002-07-31 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
AU2002330730A1 (en) * 2002-08-14 2004-03-03 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
UA80170C2 (en) * 2002-12-23 2007-08-27 Lundbeck & Co As H Escitalopram hydrobromide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
US7390913B2 (en) 2002-12-23 2008-06-24 H. Lundbeck A/S Process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
WO2004065375A1 (fr) * 2003-01-17 2004-08-05 Natco Pharma Limited Procede de preparation d'escitalopram et de son precurseur
US7687645B2 (en) * 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
NZ545494A (en) 2003-09-12 2009-10-30 Pfizer Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2005042473A1 (fr) * 2003-10-28 2005-05-12 Wockhardt Limited Procede ameliore de preparation d'hydrobromure de citalopram
ES2240931T3 (es) * 2003-10-28 2005-10-16 Adorkem Technology Spa Procedimiento para la preparacion de citalopram.
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2005070914A1 (fr) * 2004-01-23 2005-08-04 Jubilant Organosys Limited Procede de preparation de sels d'addition d'acide de citalopram
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2005077927A1 (fr) * 2004-02-16 2005-08-25 Jubilant Organosys Limited Synthese « one-pot » de citalopram a partir de 5-cyanophthalide
JP2005247710A (ja) * 2004-03-01 2005-09-15 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
JP2005263741A (ja) * 2004-03-19 2005-09-29 Sumitomo Chemical Co Ltd シタロプラムの製造方法ならびにその中間体およびその製造方法
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
US7790935B2 (en) 2004-08-23 2010-09-07 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
ITMI20041872A1 (it) * 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
WO2007012954A1 (fr) * 2005-07-27 2007-02-01 Aurobindo Pharma Limited Procédé amélioré pour la préparation d'escitalopram
EP1777221A1 (fr) * 2005-10-14 2007-04-25 Adorkem Technology SpA Verfahren zur Herstellung von 5-Cyanophthalid ausgehend von 5-Carboxyphthalid
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (fr) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Procédé de préparation d'escitalopram
US8022232B2 (en) 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
CN101265215B (zh) * 2008-04-18 2011-03-16 浙江奥托康制药集团股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2010004575A2 (fr) * 2008-06-16 2010-01-14 Shodhana Laboratories Limited Préparation de l’escitalopram, ses sels et ses intermédiaires
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
CN102190600B (zh) * 2010-03-13 2015-04-15 浙江华海药业股份有限公司 一种右旋西酞普兰中间体s-型二醇的制备方法
WO2016197320A1 (fr) 2015-06-09 2016-12-15 浙江华海药业股份有限公司 Procédé de préparation d'un intermédiaire glycolé de citalopram
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
KR102134179B1 (ko) * 2018-09-17 2020-07-16 (주)유케이케미팜 카보네이트를 이용한 시탈로프람 및 에스시탈로프람의 새로운 제조 방법
CN112409212B (zh) * 2020-11-30 2023-03-14 四川新迪医药化工有限公司 西酞普兰二醇中间体氢溴酸盐的制备方法及西酞普兰二醇中间体氢溴酸盐、西酞普兰

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (fr) * 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.

Also Published As

Publication number Publication date
PT80913B (pt) 1987-09-30
EP0171943B1 (fr) 1988-11-17
GB8419963D0 (en) 1984-09-12
ES545885A0 (es) 1986-04-01
ATE38661T1 (de) 1988-12-15
NO160364C (no) 1989-04-12
NO853091L (no) 1986-02-07
FI20031369A7 (fi) 2003-09-23
DK89595A (da) 1995-08-10
FI81338C (fi) 1990-10-10
CA1237147A (fr) 1988-05-24
DK172713B1 (da) 1999-06-14
JPH0625099B2 (ja) 1994-04-06
US4650884A (en) 1987-03-17
PT80913A (en) 1985-09-01
AU574819B2 (en) 1988-07-14
NZ212541A (en) 1988-05-30
ES8606257A1 (es) 1986-04-01
EP0171943A1 (fr) 1986-02-19
NO160364B (no) 1989-01-02
FI115300B (fi) 2005-04-15
FI852902L (fi) 1986-02-07
DE3566251D1 (en) 1988-12-22
FI852902A0 (fi) 1985-07-25
GR851894B (fr) 1985-12-03
FI81338B (fi) 1990-06-29
IE57817B1 (en) 1993-04-21
DK356285D0 (da) 1985-08-05
ZA855026B (en) 1986-06-25
DK172450B1 (da) 1998-08-10
IE851603L (en) 1986-02-06
JPS6187654A (ja) 1986-05-06
AU4577685A (en) 1986-02-13
DK356285A (da) 1986-02-07

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