IL262366B2 - Immunomodulatory proteins and CD80 variants and their uses - Google Patents

Immunomodulatory proteins and CD80 variants and their uses

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Publication number
IL262366B2
IL262366B2 IL262366A IL26236618A IL262366B2 IL 262366 B2 IL262366 B2 IL 262366B2 IL 262366 A IL262366 A IL 262366A IL 26236618 A IL26236618 A IL 26236618A IL 262366 B2 IL262366 B2 IL 262366B2
Authority
IL
Israel
Prior art keywords
variant
polypeptide
domain
seq
amino acid
Prior art date
Application number
IL262366A
Other languages
English (en)
Hebrew (he)
Other versions
IL262366A (en
IL262366B1 (en
Original Assignee
Alpine Immune Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpine Immune Sciences Inc filed Critical Alpine Immune Sciences Inc
Publication of IL262366A publication Critical patent/IL262366A/en
Publication of IL262366B1 publication Critical patent/IL262366B1/en
Publication of IL262366B2 publication Critical patent/IL262366B2/en

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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/7051T-cell receptor (TcR)-CD3 complex
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70532B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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IL262366A 2016-04-15 2017-04-14 Immunomodulatory proteins and CD80 variants and their uses IL262366B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662323595P 2016-04-15 2016-04-15
US201662394743P 2016-09-14 2016-09-14
US201662410844P 2016-10-20 2016-10-20
US201762472570P 2017-03-16 2017-03-16
US201762475201P 2017-03-22 2017-03-22
PCT/US2017/027817 WO2017181152A2 (en) 2016-04-15 2017-04-14 Cd80 variant immunomodulatory proteins and uses thereof

Publications (3)

Publication Number Publication Date
IL262366A IL262366A (en) 2018-11-29
IL262366B1 IL262366B1 (en) 2024-03-01
IL262366B2 true IL262366B2 (en) 2024-07-01

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IL262366A IL262366B2 (en) 2016-04-15 2017-04-14 Immunomodulatory proteins and CD80 variants and their uses
IL310729A IL310729A (en) 2016-04-15 2017-04-14 Cd80 variant immunomodulatory proteins and uses thereof

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IL310729A IL310729A (en) 2016-04-15 2017-04-14 Cd80 variant immunomodulatory proteins and uses thereof

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US (5) US11078282B2 (enExample)
EP (1) EP3443000B1 (enExample)
JP (3) JP7527758B2 (enExample)
KR (3) KR20190006495A (enExample)
CN (1) CN109715657A (enExample)
AU (2) AU2017248830B2 (enExample)
CA (1) CA3019202A1 (enExample)
IL (2) IL262366B2 (enExample)
MA (1) MA43552A (enExample)
NZ (2) NZ787233A (enExample)
SG (1) SG11201808783XA (enExample)
WO (1) WO2017181152A2 (enExample)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
EP3283508B1 (en) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
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