IL164147A0 - (+)-2-Ä1-(3-Ethoxy-4-methoxyphenyl)-2methylsulfonylethylÜ-4-acetylaminoisoindoline-1,3-dione:methodsof using and compositions thereof - Google Patents

(+)-2-Ä1-(3-Ethoxy-4-methoxyphenyl)-2methylsulfonylethylÜ-4-acetylaminoisoindoline-1,3-dione:methodsof using and compositions thereof

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Publication number
IL164147A0
IL164147A0 IL16414703A IL16414703A IL164147A0 IL 164147 A0 IL164147 A0 IL 164147A0 IL 16414703 A IL16414703 A IL 16414703A IL 16414703 A IL16414703 A IL 16414703A IL 164147 A0 IL164147 A0 IL 164147A0
Authority
IL
Israel
Prior art keywords
acetylaminoisoindoline
dione
methoxyphenyl
ethoxy
methodsof
Prior art date
Application number
IL16414703A
Other languages
English (en)
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28457137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL164147(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of IL164147A0 publication Critical patent/IL164147A0/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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IL16414703A 2002-03-20 2003-03-20 (+)-2-Ä1-(3-Ethoxy-4-methoxyphenyl)-2methylsulfonylethylÜ-4-acetylaminoisoindoline-1,3-dione:methodsof using and compositions thereof IL164147A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36651502P 2002-03-20 2002-03-20
US43845003P 2003-01-07 2003-01-07
PCT/US2003/008738 WO2003080049A1 (en) 2002-03-20 2003-03-20 (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof

Publications (1)

Publication Number Publication Date
IL164147A0 true IL164147A0 (en) 2005-12-18

Family

ID=28457137

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16414703A IL164147A0 (en) 2002-03-20 2003-03-20 (+)-2-Ä1-(3-Ethoxy-4-methoxyphenyl)-2methylsulfonylethylÜ-4-acetylaminoisoindoline-1,3-dione:methodsof using and compositions thereof
IL164147A IL164147A (en) 2002-03-20 2004-09-20 Stereomerically pure salt of (s) - 2 - (3 - ethoxy - 4 - methoxyphenyl) - 1- (methylsulfonylethy)] - eth - 2 - ylamine, process for its manufacture and pharmaceutical compositions comprising it for treating diseases
IL207149A IL207149A (he) 2002-03-20 2010-07-22 (+)–2–[1–(3–אתוקסי–4–מתוקסיפניל)–2–מתילסולפונילאתיל]–4–אצטילאמינו איזואינדולין–3,1–דיאון, פולימורף רוקחי מקובל, מלח, סולבאט או הידראט שלו לשימוש בטיפול במחלה אוטואימונית, באופן ברירתי יחד עם תרופה נוגדת דלקת

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL164147A IL164147A (en) 2002-03-20 2004-09-20 Stereomerically pure salt of (s) - 2 - (3 - ethoxy - 4 - methoxyphenyl) - 1- (methylsulfonylethy)] - eth - 2 - ylamine, process for its manufacture and pharmaceutical compositions comprising it for treating diseases
IL207149A IL207149A (he) 2002-03-20 2010-07-22 (+)–2–[1–(3–אתוקסי–4–מתוקסיפניל)–2–מתילסולפונילאתיל]–4–אצטילאמינו איזואינדולין–3,1–דיאון, פולימורף רוקחי מקובל, מלח, סולבאט או הידראט שלו לשימוש בטיפול במחלה אוטואימונית, באופן ברירתי יחד עם תרופה נוגדת דלקת

Country Status (23)

Country Link
US (14) US6962940B2 (he)
EP (9) EP2295055B1 (he)
JP (4) JP2005525386A (he)
KR (6) KR100997001B1 (he)
CN (2) CN101683334A (he)
AT (1) ATE440599T1 (he)
AU (1) AU2003224729C1 (he)
BE (1) BE2019C008I2 (he)
CA (2) CA2756798A1 (he)
CY (6) CY1109380T1 (he)
DE (1) DE60328974D1 (he)
DK (6) DK2962690T3 (he)
ES (8) ES2637509T3 (he)
FR (1) FR19C1046I2 (he)
HU (5) HUE045489T2 (he)
IL (3) IL164147A0 (he)
LU (1) LUC00125I2 (he)
MX (2) MX366328B (he)
NL (1) NL300994I2 (he)
NZ (1) NZ535798A (he)
PT (6) PT2420490T (he)
SI (5) SI2223687T1 (he)
WO (1) WO2003080049A1 (he)

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ES2315435T3 (es) * 1996-08-12 2009-04-01 Celgene Corporation Nuevos agentes inmunoterapeuticos y su uso para la reduccion de los niveles de citoquinas.
US8030343B2 (en) * 2000-06-08 2011-10-04 Celgene Corporation Pharmaceutically active isoindoline derivatives
US7276529B2 (en) * 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US7893101B2 (en) 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
CA2379887C (en) * 2002-04-09 2004-01-20 Bernard Charles Sherman Stable tablets comprising simvastatin
US20100129363A1 (en) * 2002-05-17 2010-05-27 Zeldis Jerome B Methods and compositions using pde4 inhibitors for the treatment and management of cancers
US8263637B2 (en) * 2002-05-17 2012-09-11 Celgene Corporation Methods for treatment of multiple myeloma using cyclopropane carboxylic acid {2-[(is)-1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1 h-isoindol-4-yl}-amide
US7842691B2 (en) * 2002-10-15 2010-11-30 Celgene Corporation Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
US20050203142A1 (en) * 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040087558A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
EP1567154A4 (en) 2002-11-06 2006-05-31 Celgene Corp METHODS AND COMPOSITIONS USING CYTOKINE SELECTIVE INHIBITION DRUGS FOR TREATING AND CONTROLLING CANCERS AND OTHER DISEASES
BR0316002A (pt) * 2002-11-06 2005-09-13 Celgene Corp Métodos de tratar ou prevenir e controlar uma doença mieloproliferativa, de reduzir ou evitar de um efeito adverso associado com a administração de um segundo agente ativo em um paciente sofrendo de uma doença mieloproliferativa e de aumentar a eficácia terapêutica de um tratamento de doença mieloproliferativa, composição farmacêutica e kit
WO2004045597A1 (en) * 2002-11-18 2004-06-03 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
KR100831545B1 (ko) * 2003-03-06 2008-05-21 셀진 코포레이션 중추 신경계 장애의 치료 또는 관리를 위한 선택적사이토카인 억제 약물의 사용 방법 및 그를 포함하는조성물
US20040175382A1 (en) * 2003-03-06 2004-09-09 Schafer Peter H. Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system
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