IL150986A0 - 1,2,3,4,- tetrahydroisoquinoline derivatives - Google Patents
1,2,3,4,- tetrahydroisoquinoline derivativesInfo
- Publication number
- IL150986A0 IL150986A0 IL15098601A IL15098601A IL150986A0 IL 150986 A0 IL150986 A0 IL 150986A0 IL 15098601 A IL15098601 A IL 15098601A IL 15098601 A IL15098601 A IL 15098601A IL 150986 A0 IL150986 A0 IL 150986A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- tetrahydroisoquinoline derivatives
- derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0002245 | 2000-03-14 | ||
| PCT/EP2001/002733 WO2001068609A1 (en) | 2000-03-14 | 2001-03-12 | 1,2,3,4-tetrahydroisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL150986A0 true IL150986A0 (en) | 2003-02-12 |
Family
ID=8163870
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15098601A IL150986A0 (en) | 2000-03-14 | 2001-03-12 | 1,2,3,4,- tetrahydroisoquinoline derivatives |
| IL150986A IL150986A (en) | 2000-03-14 | 2002-07-30 | History 4,3,2,1 - Tetrahydroisoquinoline |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL150986A IL150986A (en) | 2000-03-14 | 2002-07-30 | History 4,3,2,1 - Tetrahydroisoquinoline |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6703392B2 (ja) |
| JP (1) | JP4009460B2 (ja) |
| KR (2) | KR100842698B1 (ja) |
| CN (1) | CN100393703C (ja) |
| AT (1) | ATE286500T1 (ja) |
| AU (2) | AU2001260113B2 (ja) |
| BR (1) | BRPI0109200B8 (ja) |
| CA (1) | CA2402431C (ja) |
| DE (1) | DE60108236T2 (ja) |
| ES (1) | ES2234840T3 (ja) |
| HU (1) | HU227811B1 (ja) |
| IL (2) | IL150986A0 (ja) |
| MX (1) | MXPA02008797A (ja) |
| NO (1) | NO324932B1 (ja) |
| NZ (1) | NZ520624A (ja) |
| PT (1) | PT1274687E (ja) |
| WO (1) | WO2001068609A1 (ja) |
| ZA (1) | ZA200206467B (ja) |
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| GB0126292D0 (en) | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
| GB0130388D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| EP1554239B1 (en) | 2002-10-11 | 2011-01-26 | Actelion Pharmaceuticals Ltd. | Sulfonylamino-acetic acid derivatives and their use as orexin receptor antagonists |
| GB0225884D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7557120B2 (en) * | 2003-02-24 | 2009-07-07 | Merck & Co., Inc. | Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity |
| US20060178515A1 (en) * | 2003-03-26 | 2006-08-10 | Hamed Aissaoui | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| WO2004096780A1 (en) * | 2003-04-28 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Quinoxalinone-3- one derivatives as orexin receptor antagonists |
| JP4765627B2 (ja) | 2003-09-22 | 2011-09-07 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| US20100048513A1 (en) | 2008-08-20 | 2010-02-25 | Hawkins Michael J | Novel inhibitors of chymase |
| MXPA06008375A (es) * | 2004-01-23 | 2007-03-21 | Johnson & Johnson | Novedosos inhibidores de quimasa. |
| EP1751111B1 (en) * | 2004-03-01 | 2014-12-31 | Actelion Pharmaceuticals Ltd. | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| EP2127676A3 (en) | 2004-11-01 | 2013-09-04 | Amylin Pharmaceuticals, LLC | Treatment of obesity and related disorders |
| WO2006081522A2 (en) * | 2005-01-26 | 2006-08-03 | The Regents Of The Unversity Of California | Modulation of nmda receptor currents via orexin receptor and/or crf receptor |
| US7501395B2 (en) | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| RU2417985C2 (ru) | 2005-05-30 | 2011-05-10 | Баниу Фармасьютикал Ко., Лтд. | Новые производные пиперидина |
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|---|---|---|---|---|
| DE258817C (ja) | ||||
| DE204917C (ja) | ||||
| DE261158C (ja) | ||||
| CA205079A (en) * | 1920-10-26 | Nelson Lionel | Gas producer | |
| CA110459A (en) * | 1907-12-09 | 1908-02-25 | Charles Albert Keller | Electric furnace |
| CA173523A (en) * | 1916-04-01 | 1916-11-28 | Raymond B. Price | Textile material |
| CA170679A (en) * | 1916-05-26 | 1916-07-11 | Edwin W. Webb | Car brake |
| US3480714A (en) * | 1966-02-07 | 1969-11-25 | Ciba Geigy Corp | N-substituted isoquinolines as antiprotozoal agents |
| DD204917A1 (de) * | 1981-12-31 | 1983-12-14 | Gerhard Kempter | Verfahren zur herstellung phenylsubstituierter und benzkondensierter cycloalkylaminoacetanilide |
| JPS6153268A (ja) * | 1984-08-24 | 1986-03-17 | Hokuriku Seiyaku Co Ltd | アントラニルアミド誘導体 |
| DD261158A1 (de) * | 1987-01-08 | 1988-10-19 | Univ Halle Wittenberg | Verfahren zur herstellung von 2-aminoalkyl-3,4-dihydro-4-oxo-7h-pyrrolo 2.3-d pyrimidinen |
| DD258817A1 (de) * | 1987-01-19 | 1988-08-03 | Univ Halle Wittenberg | Verfahren zur herstellung von 2-(aminoalkyl) -pyrimido-4,5'-5,4 pyrrolo 3,2-f 1,4 thiazepinderivaten |
| WO1992012132A1 (en) * | 1991-01-11 | 1992-07-23 | Laboratoires Glaxo S.A. | Acridine derivatives |
| ES2116601T3 (es) * | 1993-06-22 | 1998-07-16 | Knoll Ag | Derivados de isoquinolina como agentes terapeuticos. |
| JPH07267961A (ja) * | 1994-03-30 | 1995-10-17 | Taisho Pharmaceut Co Ltd | ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体 |
| JPH1095766A (ja) * | 1996-09-19 | 1998-04-14 | Sanwa Kagaku Kenkyusho Co Ltd | アセトアミド誘導体、及びその用途 |
| WO1998023593A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
| AR016817A1 (es) | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| DE69906960T2 (de) | 1998-05-08 | 2004-01-29 | Smithkline Beecham Plc | Phenylurea und phenylthio urea derivate |
| WO2000029399A1 (en) | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
| GB9827467D0 (en) * | 1998-12-15 | 1999-02-10 | Zeneca Ltd | Chemical compounds |
| GB9914015D0 (en) * | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| GB9914025D0 (en) * | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| WO2001002368A1 (en) * | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
-
2001
- 2001-03-12 CN CNB018063268A patent/CN100393703C/zh not_active Expired - Lifetime
- 2001-03-12 NZ NZ520624A patent/NZ520624A/xx not_active IP Right Cessation
- 2001-03-12 IL IL15098601A patent/IL150986A0/xx active IP Right Grant
- 2001-03-12 JP JP2001567703A patent/JP4009460B2/ja not_active Expired - Lifetime
- 2001-03-12 KR KR1020027011533A patent/KR100842698B1/ko active IP Right Grant
- 2001-03-12 CA CA002402431A patent/CA2402431C/en not_active Expired - Lifetime
- 2001-03-12 AT AT01933685T patent/ATE286500T1/de active
- 2001-03-12 PT PT01933685T patent/PT1274687E/pt unknown
- 2001-03-12 ES ES01933685T patent/ES2234840T3/es not_active Expired - Lifetime
- 2001-03-12 US US10/239,693 patent/US6703392B2/en not_active Expired - Lifetime
- 2001-03-12 KR KR1020077016214A patent/KR20070087103A/ko active Search and Examination
- 2001-03-12 AU AU2001260113A patent/AU2001260113B2/en not_active Expired
- 2001-03-12 AU AU6011301A patent/AU6011301A/xx active Pending
- 2001-03-12 BR BRPI0109200A patent/BRPI0109200B8/pt not_active IP Right Cessation
- 2001-03-12 MX MXPA02008797A patent/MXPA02008797A/es active IP Right Grant
- 2001-03-12 HU HU0300207A patent/HU227811B1/hu unknown
- 2001-03-12 DE DE60108236T patent/DE60108236T2/de not_active Expired - Lifetime
- 2001-03-12 WO PCT/EP2001/002733 patent/WO2001068609A1/en active IP Right Grant
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2002
- 2002-07-30 IL IL150986A patent/IL150986A/en unknown
- 2002-08-13 ZA ZA200206467A patent/ZA200206467B/en unknown
- 2002-09-11 NO NO20024339A patent/NO324932B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20024339L (no) | 2002-09-11 |
| DE60108236D1 (de) | 2005-02-10 |
| KR100842698B1 (ko) | 2008-07-01 |
| HUP0300207A3 (en) | 2005-07-28 |
| MXPA02008797A (es) | 2005-09-08 |
| US20030176415A1 (en) | 2003-09-18 |
| HU227811B1 (en) | 2012-03-28 |
| JP4009460B2 (ja) | 2007-11-14 |
| AU6011301A (en) | 2001-09-24 |
| BRPI0109200B8 (pt) | 2021-05-25 |
| WO2001068609B1 (en) | 2002-02-21 |
| JP2003527374A (ja) | 2003-09-16 |
| KR20020080465A (ko) | 2002-10-23 |
| NZ520624A (en) | 2004-02-27 |
| AU2001260113B2 (en) | 2006-04-06 |
| ES2234840T3 (es) | 2005-07-01 |
| NO324932B1 (no) | 2008-01-07 |
| ATE286500T1 (de) | 2005-01-15 |
| PT1274687E (pt) | 2005-04-29 |
| CA2402431A1 (en) | 2001-09-20 |
| WO2001068609A1 (en) | 2001-09-20 |
| CN1416420A (zh) | 2003-05-07 |
| NO20024339D0 (no) | 2002-09-11 |
| HUP0300207A2 (en) | 2003-05-28 |
| BR0109200A (pt) | 2003-06-03 |
| CN100393703C (zh) | 2008-06-11 |
| CA2402431C (en) | 2009-10-06 |
| ZA200206467B (en) | 2003-11-13 |
| US6703392B2 (en) | 2004-03-09 |
| DE60108236T2 (de) | 2005-12-22 |
| IL150986A (en) | 2007-07-04 |
| KR20070087103A (ko) | 2007-08-27 |
| BRPI0109200B1 (pt) | 2015-08-11 |
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