IL150565A0 - Benzimidazole derivatives and pharmaceutical compositions containing the same - Google Patents

Benzimidazole derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL150565A0
IL150565A0 IL15056501A IL15056501A IL150565A0 IL 150565 A0 IL150565 A0 IL 150565A0 IL 15056501 A IL15056501 A IL 15056501A IL 15056501 A IL15056501 A IL 15056501A IL 150565 A0 IL150565 A0 IL 150565A0
Authority
IL
Israel
Prior art keywords
halo
optionally substituted
oxo
trihalomethyl
alk
Prior art date
Application number
IL15056501A
Other languages
English (en)
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of IL150565A0 publication Critical patent/IL150565A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL15056501A 2000-01-17 2001-01-17 Benzimidazole derivatives and pharmaceutical compositions containing the same IL150565A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000007533 2000-01-17
JP2000392303 2000-12-25
PCT/JP2001/000271 WO2001053291A1 (fr) 2000-01-17 2001-01-17 Derives benzimidazoles

Publications (1)

Publication Number Publication Date
IL150565A0 true IL150565A0 (en) 2003-02-12

Family

ID=26583615

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15056501A IL150565A0 (en) 2000-01-17 2001-01-17 Benzimidazole derivatives and pharmaceutical compositions containing the same

Country Status (19)

Country Link
EP (1) EP1249450B1 (fr)
JP (1) JP4059671B2 (fr)
KR (2) KR100763779B1 (fr)
CN (2) CN1198819C (fr)
AT (1) ATE375156T1 (fr)
AU (2) AU777813B2 (fr)
CA (1) CA2396908A1 (fr)
CZ (1) CZ301504B6 (fr)
DE (1) DE60130865T2 (fr)
DK (1) DK1249450T3 (fr)
ES (1) ES2295128T3 (fr)
HK (1) HK1050009A1 (fr)
IL (1) IL150565A0 (fr)
NO (1) NO324049B1 (fr)
NZ (1) NZ520028A (fr)
PT (1) PT1249450E (fr)
RU (1) RU2263674C2 (fr)
SI (1) SI1249450T1 (fr)
WO (1) WO2001053291A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066457A1 (fr) * 2001-02-22 2002-08-29 Teijin Limited Derive benzo[b]thiophene et procede de production correspondant
US6774245B2 (en) 2001-05-07 2004-08-10 Teijin Limited 3-Hydroxymethylbenzo[b]thiophene derivatives and process for their preparation
KR100902799B1 (ko) * 2001-08-24 2009-06-12 데이진 가부시키가이샤 키마제 저해제 및 ａｃｅ 저해제를 유효성분으로 함유하는약제
CL2004001034A1 (es) 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
KR20060120601A (ko) * 2003-08-22 2006-11-27 데이진 화-마 가부시키가이샤 키마제 저해제를 유효 성분으로서 함유하는 약제
WO2006052026A1 (fr) * 2004-11-12 2006-05-18 Teijin Pharma Limited Sel acide de derive de benzimidazole et cristal dudit sel
CA2619744C (fr) 2005-08-18 2014-09-02 Teijin Pharma Limited Formulation avec fonction de division en doses precises
CA2619745A1 (fr) 2005-08-18 2007-02-22 Teijin Pharma Limited Comprime avec des sections contenant de multiples medicaments
EP1947097A1 (fr) 2005-10-27 2008-07-23 Teijin Pharma Limited Derive de benzoýb¨thiophene et procede permettant de produire ce derive
KR20080058430A (ko) 2005-10-27 2008-06-25 데이진 화-마 가부시키가이샤 3-히드록시메틸벤조〔ｂ〕티오펜 유도체 및 그 제조 방법
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
EP2152674B1 (fr) * 2007-05-22 2011-08-03 Boehringer Ingelheim International GmbH Inhibiteurs de benzimidazolone chymase
MX2009012749A (es) 2007-05-25 2010-03-10 Abbott Gmbh & Co Kg Compuestos heterociclicos como moduladores positivos del receptor de glutamato metabotropico 2 (receptor mglu2).
TW200916098A (en) * 2007-06-14 2009-04-16 Teijin Pharma Ltd Agent for lowering uric acid level
WO2009133964A1 (fr) * 2008-04-28 2009-11-05 国立大学法人九州大学 Agent pour la prévention du stress oxydatif
EP2364313B1 (fr) 2008-09-09 2014-01-08 Boehringer Ingelheim International GmbH Inhibiteurs d'aza-benzimidazolone chymase
MX2011003239A (es) 2008-09-26 2011-04-28 Merck Sharp & Dohme Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos.
AU2009307884B2 (en) 2008-10-22 2014-07-31 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
MX2011004505A (es) 2008-10-29 2011-05-31 Merck Sharp & Dohme Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos.
US8329914B2 (en) 2008-10-31 2012-12-11 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
RU2542582C2 (ru) * 2009-11-18 2015-02-20 Астразенека Аб Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3
WO2011106273A1 (fr) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Nouveaux dérivés benzimidazole cycliques utiles comme agents antidiabétiques
US8796258B2 (en) 2011-02-25 2014-08-05 Merck Sharp & Dohme Corp. Cyclic azabenzimidazole derivatives useful as anti-diabetic agents
AP2014008040A0 (en) * 2012-05-04 2014-10-31 Novartis Ag Complement pathway modulators and uses thereof
US20140045746A1 (en) 2012-08-02 2014-02-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2888007B1 (fr) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Dérivés de benzimidazole tétrahydrofurane en tant qu'activateurs de la protéine kinase activée par l'amp
ES2755087T3 (es) 2012-08-22 2020-04-21 Merck Sharp & Dohme Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP
WO2014031465A1 (fr) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Nouveaux dérivés d'azabenzimidazole tétrahydropyrane
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
BR112015003109A2 (pt) 2012-08-22 2017-08-15 Merck Sharp & Dohme Composto, composição, uso de um composto, e, métodos para tratar ou prevenir um distúrbio, condição ou doença e para tratar diabetes mellitus tipo 2.
EP2906040B1 (fr) 2012-08-22 2021-02-17 Merck Sharp & Dohme Corp. Nouveaux dérivés de benzimidazole tétrahydropyrane
EP2970119B1 (fr) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
US10519115B2 (en) 2013-11-15 2019-12-31 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015089809A1 (fr) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Composés hétéroaryles substitués antidiabétiques
CN111004125B (zh) * 2019-12-24 2022-11-22 东华理工大学 一种缩醛或缩酮化合物的制备方法
CN116903541B (zh) * 2023-08-14 2023-12-08 中国环境科学研究院 用于酚类污染物检测的酰基咪唑类化合物、制备方法及应用

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FR2430950A1 (fr) * 1978-07-10 1980-02-08 Delalande Sa Nouveaux derives heterocycliques de la benzimidazole, leur procede de preparation et leur application en therapeutique
DE2928055A1 (de) * 1978-07-12 1980-01-31 Eastman Kodak Co Verfahren zur verbesserung der widerstandsfaehigkeit von polyesterformkoerpern gegenueber einem abbau durch u.v.- licht
JPS62212386A (ja) * 1986-03-14 1987-09-18 Suntory Ltd ２−ピリジルメチルベンズイミダゾ−ル誘導体
JPH01265089A (ja) * 1988-04-15 1989-10-23 Zeria Pharmaceut Co Ltd 新規１−（イミダゾール−４−イル）メチルベンズイミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤
GB9225141D0 (en) * 1992-12-01 1993-01-20 Smithkline Beecham Corp Chemical compounds
US5527597A (en) * 1995-03-01 1996-06-18 Southern Mills, Inc. Stretchable flame resistant fabric
WO1999026932A1 (fr) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. Derives heterocycliques substitues par un groupe amidino et leur utilisation en tant qu'anticoagulants
AU758789B2 (en) * 1998-07-15 2003-03-27 Teijin Limited Thiobenzimidazole derivatives
TR200103805T2 (tr) * 1999-06-28 2002-06-21 Janssen Pharmaceutica N.V. Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler
CZ2001153A3 (cs) * 1999-07-14 2001-06-13 Teijin Ltd Thiobenzimidazolové deriváty

Also Published As

Publication number Publication date
KR20070057276A (ko) 2007-06-04
JP4059671B2 (ja) 2008-03-12
AU2704901A (en) 2001-07-31
RU2002122105A (ru) 2004-01-10
KR20020065929A (ko) 2002-08-14
KR100763779B1 (ko) 2007-10-05
NO20023415L (no) 2002-07-16
CN100415723C (zh) 2008-09-03
CN1198819C (zh) 2005-04-27
HK1050009A1 (en) 2003-06-06
CN1680339A (zh) 2005-10-12
EP1249450B1 (fr) 2007-10-10
AU2005200172B2 (en) 2007-08-23
CA2396908A1 (fr) 2001-07-26
NO20023415D0 (no) 2002-07-16
DE60130865D1 (de) 2007-11-22
CZ301504B6 (cs) 2010-03-24
AU2005200172A1 (en) 2005-02-10
ATE375156T1 (de) 2007-10-15
DK1249450T3 (da) 2008-02-11
EP1249450A1 (fr) 2002-10-16
AU777813B2 (en) 2004-11-04
EP1249450A4 (fr) 2003-04-09
DE60130865T2 (de) 2008-07-17
PT1249450E (pt) 2008-01-02
NO324049B1 (no) 2007-08-06
RU2263674C2 (ru) 2005-11-10
SI1249450T1 (sl) 2008-04-30
ES2295128T3 (es) 2008-04-16
NZ520028A (en) 2004-07-30
WO2001053291A1 (fr) 2001-07-26
CN1418211A (zh) 2003-05-14

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