IL143023A0 - Hiv replication inhibiting pyrimidines - Google Patents

Hiv replication inhibiting pyrimidines

Info

Publication number
IL143023A0
IL143023A0 IL14302399A IL14302399A IL143023A0 IL 143023 A0 IL143023 A0 IL 143023A0 IL 14302399 A IL14302399 A IL 14302399A IL 14302399 A IL14302399 A IL 14302399A IL 143023 A0 IL143023 A0 IL 143023A0
Authority
IL
Israel
Prior art keywords
hiv replication
replication inhibiting
inhibiting pyrimidines
pyrimidines
hiv
Prior art date
Application number
IL14302399A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26805159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL143023(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IL143023A0 publication Critical patent/IL143023A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL14302399A 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines IL143023A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10779298P 1998-11-10 1998-11-10
US14396299P 1999-07-15 1999-07-15
PCT/EP1999/007417 WO2000027825A1 (en) 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines

Publications (1)

Publication Number Publication Date
IL143023A0 true IL143023A0 (en) 2002-04-21

Family

ID=26805159

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14302399A IL143023A0 (en) 1998-11-10 1999-09-24 Hiv replication inhibiting pyrimidines
IL169949A IL169949A (en) 1998-11-10 2005-07-28 History of pyrimidines, their preparation, pharmaceutical preparations containing them and their use in HIV treatment drugs

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL169949A IL169949A (en) 1998-11-10 2005-07-28 History of pyrimidines, their preparation, pharmaceutical preparations containing them and their use in HIV treatment drugs

Country Status (41)

Country Link
US (5) US6878717B2 (de)
EP (2) EP1002795B1 (de)
JP (1) JP3635238B2 (de)
KR (1) KR100658489B1 (de)
CN (1) CN1214013C (de)
AP (1) AP1683A (de)
AR (1) AR024227A1 (de)
AT (2) ATE233740T1 (de)
AU (2) AU762523C (de)
BG (1) BG65103B1 (de)
BR (1) BRPI9915552B8 (de)
CA (1) CA2350801C (de)
CY (1) CY2008021I1 (de)
CZ (1) CZ301367B6 (de)
DE (3) DE69941934D1 (de)
DK (1) DK1002795T3 (de)
EA (1) EA004049B1 (de)
EE (1) EE05086B1 (de)
ES (2) ES2193664T3 (de)
FR (1) FR09C0004I2 (de)
HK (2) HK1025330A1 (de)
HR (2) HRP20010161B9 (de)
HU (2) HU230394B1 (de)
ID (1) ID28376A (de)
IL (2) IL143023A0 (de)
LT (1) LTC1002795I2 (de)
LU (1) LU91528I2 (de)
MY (1) MY121108A (de)
NL (1) NL300373I2 (de)
NO (3) NO318801B1 (de)
NZ (1) NZ511116A (de)
OA (1) OA11674A (de)
PL (1) PL204427B1 (de)
PT (1) PT1002795E (de)
SI (1) SI1002795T1 (de)
SK (2) SK287270B6 (de)
TR (1) TR200101306T2 (de)
TW (1) TWI238161B (de)
UA (1) UA70966C2 (de)
WO (1) WO2000027825A1 (de)
ZA (1) ZA200103769B (de)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA004049B1 (ru) * 1998-11-10 2003-12-25 Янссен Фармацевтика Н.В. Пиримидины, ингибирующие репликацию вич
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
PL207590B1 (pl) * 1999-09-24 2011-01-31 Janssen Pharmaceutica Nv Cząstka stanowiąca dyspersję stałą oraz postać dawkowania, sposób ich otrzymywania i zastosowanie
AU770600B2 (en) 1999-10-07 2004-02-26 Amgen, Inc. Triazine kinase inhibitors
WO2001060816A1 (en) 2000-02-17 2001-08-23 Amgen Inc. Kinase inhibitors
AU782948B2 (en) 2000-05-08 2005-09-15 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines
US7276510B2 (en) * 2000-05-08 2007-10-02 Janssen Pharmaceutica, Inc. HIV replication inhibitors
WO2002037338A1 (en) * 2000-11-01 2002-05-10 Snapnames.Com, Inc. Registry-integrated internet domain name acquisition system
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
EP1453516A2 (de) 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
EP2332924A1 (de) 2001-10-17 2011-06-15 Boehringer Ingelheim Pharma GmbH & Co. KG Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung
IL161662A0 (en) 2001-11-01 2004-09-27 Janssen Pharmaceutica Nv Heteroaryl amines as glycogen synthase kinase 3 beta inhibitors (gsk3 inhibitors)
HUP0402330A3 (en) 2001-11-01 2010-03-29 Janssen Pharmaceutica Nv Amide derivatives as glycogen synthase kinase 3-beta inhibitors, process for producing them, pharmaceutical compositions containing them and use thereof
SE0104140D0 (sv) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EP1485353B1 (de) 2002-03-13 2011-08-24 Janssen Pharmaceutica NV Histone-deacetylase-inhibitoren
MXPA04007776A (es) 2002-03-13 2004-10-15 Janssen Pharmaceutica Nv Derivados de sulfonilamino como nuevos inhibidores de histona deacetilasa.
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
WO2003093344A1 (en) * 2002-05-03 2003-11-13 Janssen Pharmaceutica N.V. Polymeric microemulsions
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
TW200409629A (en) 2002-06-27 2004-06-16 Bristol Myers Squibb Co 2,4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors
MXPA05001096A (es) 2002-07-29 2005-11-23 Rigel Pharmaceuticals Inc Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina.
AU2003266413B2 (en) * 2002-08-09 2009-04-02 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
EP2422775A3 (de) * 2002-09-20 2012-04-18 Alpharma, Inc. Sequestriermitteluntereinheit und zugehörige Zusammensetzungen und Verfahren
KR20050084027A (ko) * 2002-11-28 2005-08-26 쉐링 악티엔게젤샤프트 Ｃｈｋ-, ｐｄｋ- 및 ａｋｔ-억제성 피리미딘, 그의제조방법 및 약제로서의 그의 용도
EP1599468B1 (de) 2003-01-14 2007-10-03 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
MXPA05008364A (es) 2003-02-07 2005-11-04 Janssen Pharmaceutica Nv Derivados de pirimidina para la prevencion de una infeccion por vih.
PL232814B1 (pl) 2003-02-07 2019-07-31 Janssen Pharmaceutica Nv Pochodne 1,2,4-triazynowe, ich zastosowanie i zawierająca je kompozycja farmaceutyczna
JP4634367B2 (ja) 2003-02-20 2011-02-16 スミスクライン ビーチャム コーポレーション ピリミジン化合物
CL2004000306A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
BRPI0412734A (pt) 2003-07-17 2006-09-26 Tibotec Pharm Ltd processo para preparação de partìculas que contêm um antiviral
PL1656372T3 (pl) 2003-07-30 2013-08-30 Rigel Pharmaceuticals Inc Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym
AU2004274185B2 (en) * 2003-09-25 2009-12-10 Janssen Pharmaceutica N.V. HIV replication inhibiting purine derivatives
US8099262B2 (en) 2004-03-02 2012-01-17 Virco Bvba Estimation of clinical cut-offs
EP1598343A1 (de) * 2004-05-19 2005-11-23 Boehringer Ingelheim International GmbH 2-Arylaminopyrimidine als PLK Inhibitoren
AP2336A (en) 2004-07-28 2011-12-08 Janssen Pharmaceutica Nv Subsituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase.
WO2006015985A1 (en) 2004-08-10 2006-02-16 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
AU2005288866B2 (en) 2004-09-30 2012-07-26 Janssen Sciences Ireland Uc HIV inhibiting 5-substituted pyrimidines
ES2371923T3 (es) 2004-09-30 2012-01-11 Tibotec Pharmaceuticals 5-heterociclil-pirimidinas que inhiben el vih.
WO2006035068A2 (en) 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
EP1807430B1 (de) 2004-10-29 2014-07-23 Janssen R&D Ireland Hiv-hemmende bicyclische pyrimidinderivative
US20060106043A1 (en) * 2004-11-08 2006-05-18 Boehringer Ingelheim International Gmbh Method for treating HIV infection through co-administration of tipranavir and etravirine
US7557207B2 (en) 2004-11-24 2009-07-07 Rigel Pharmaceuticals, Inc. Spiro 2,4-pyrimidinediamine compounds and their uses
PT1856135E (pt) 2005-01-19 2010-02-26 Rigel Pharmaceuticals Inc Pró-fármacos de compostos 2,4-pirimidinodiamina e suas utilizações
AU2006208778B2 (en) * 2005-01-27 2012-08-09 Janssen Sciences Ireland Uc HIV inhibiting 2-( 4-cyanophenylamino) pyrimidine derivatives
DE602006001515D1 (de) 2005-02-16 2008-07-31 Astrazeneca Ab Chemische verbindungen
WO2006087387A1 (en) * 2005-02-18 2006-08-24 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives
RS51435B (en) * 2005-03-04 2011-04-30 Tibotec Pharmaceuticals 2- (4-CYANOPHENYL) -6-HYDROXYLAMINOPYRIMIDINE INHIBITING HIV
US20080287437A1 (en) 2005-05-16 2008-11-20 Astrazeneca Ab Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
ES2437202T3 (es) * 2005-05-26 2014-01-09 Janssen R&D Ireland Procedimiento para preparar 4-[(1,6-dihidro-6-oxo-2-pirimidinil)-amino]benzonitrilo
KR101312225B1 (ko) 2005-06-08 2013-09-26 리겔 파마슈티칼스, 인크. Ｊａｋ 경로의 억제를 위한 조성물 및 방법
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
AP2008004459A0 (en) * 2005-10-06 2008-06-30 Univ Massachusetts Composition and sythesis of new reagents for inhibition of HIV replication
TW200800963A (en) 2005-10-28 2008-01-01 Astrazeneca Ab Chemical compounds
CA2630717C (en) 2006-01-19 2015-02-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
DK1981874T3 (da) 2006-01-19 2009-09-28 Janssen Pharmactuica N V Aminophenylderivater som nye inhibitorer af histondeacetylase
EP1981875B1 (de) 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituierte indolyl-amino-alkyl-derivate als histon-deacetylase-inhibitoren
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
EP2004632B1 (de) 2006-03-30 2014-03-12 Janssen R&D Ireland Hiv-inhibierende 5-amido-substituierte pyrimidine
DE602007009508D1 (de) 2006-03-30 2010-11-11 Little Island Co Cork Hiv-inhibierende 5-(hydroxymethylen- und aminomethylen) substituierte pyrimidine
PE20120006A1 (es) 2006-05-15 2012-02-02 Boehringer Ingelheim Int Compuestos derivados de pirimidina como inhibidores de la quinasa aurora
BRPI0712346B8 (pt) 2006-06-06 2021-05-25 Janssen R & D Ireland processo para produzir pó farmacêutico sólido de tmc125, dispersão sólida e sua formulação farmacêutica
EP2526932B1 (de) 2006-06-19 2017-06-07 Alpharma Pharmaceuticals LLC Pharmazeutische Zusammensetzung
JP2010506833A (ja) * 2006-10-11 2010-03-04 アルファーマ，インコーポレイテッド 医薬組成物
JP5464584B2 (ja) * 2006-12-06 2014-04-09 ヤンセン・アールアンドデイ・アイルランド 抗ｈｉｖ化合物の臭化水素酸塩
KR20090094084A (ko) 2006-12-29 2009-09-03 티보텍 파마슈티칼즈 리미티드 Ｈｉｖ를 억제하는 5,6-치환된 피리미딘
ES2470570T3 (es) * 2006-12-29 2014-06-24 Janssen R&D Ireland Pirimidinas sustituidas en posición 6 inhibidoras del HIV
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
US8410124B2 (en) 2007-10-18 2013-04-02 Concert Pharmaceuticals Inc. Deuterated etravirine
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
AU2008338442A1 (en) * 2007-12-17 2009-06-25 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
NO2300013T3 (de) 2008-05-21 2018-02-03
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
KR20110025224A (ko) 2008-06-27 2011-03-09 아빌라 테라퓨틱스, 인크. 헤테로아릴 화합물 및 이의 용도
US20100137313A1 (en) * 2008-10-03 2010-06-03 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
BRPI1012666B8 (pt) 2009-03-30 2021-05-25 Janssen R&D Ireland cocristal de etravirina e nicotinamida, composição farmacêutica, combinação compreendendo o mesmo, seu processo para a preparação e uso
ES2659725T3 (es) 2009-05-05 2018-03-19 Dana-Farber Cancer Institute, Inc. Inhibidores de EGFR y procedimiento de tratamiento de trastornos
WO2010131118A2 (en) * 2009-05-12 2010-11-18 Pliva Hrvatska D.O.O. Polymorphs of etravirine and processes for preparation thereof
WO2010150279A2 (en) 2009-06-22 2010-12-29 Emcure Pharmaceuticals Limited Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor
WO2011017079A1 (en) 2009-07-27 2011-02-10 Teva Pharmaceutical Industries Ltd. Process for the preparation and purification of etravirine and intermediates thereof
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
SG185641A1 (en) 2010-06-04 2012-12-28 Hoffmann La Roche Aminopyrimidine derivatives as lrrk2 modulators
WO2012001695A1 (en) 2010-06-28 2012-01-05 Hetero Research Foundation A process for etra virine intermediate and polymorphs of etravirine
ES2617763T3 (es) 2010-08-10 2017-06-19 Celgene Avilomics Research, Inc. Sal de besilato de un inhibidor de BTK
EA201390421A1 (ru) 2010-09-22 2013-09-30 Арена Фармасьютикалз, Инк. Модуляторы рецептора gpr119 и лечение связанных с ним нарушений
WO2012061303A1 (en) 2010-11-01 2012-05-10 Avila Therapeutics, Inc. Heteroaryl compounds and uses thereof
WO2012061299A1 (en) 2010-11-01 2012-05-10 Avila Therapeutics, Inc. Heterocyclic compounds and uses thereof
JP5957003B2 (ja) 2010-11-10 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド 変異体選択的ｅｇｆｒ阻害剤およびその使用
EP2638031B9 (de) 2010-11-10 2020-01-08 Genentech, Inc. Pyrazolaminopyrimidinderivate als lrrk2-modulatoren
EP2702045B1 (de) 2011-04-26 2017-10-18 Mylan Laboratories Ltd. Neues verfahren zur herstellung von etravirin
CN103501612B (zh) 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
WO2012170647A1 (en) * 2011-06-09 2012-12-13 Assia Chemical Industriew Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
JP5993010B2 (ja) 2011-08-23 2016-09-14 エンドゥ ファーマシューティカルズ，インコーポレイティド ピリミド−ピリダジノン化合物及びその使用
US20130123498A1 (en) 2011-10-19 2013-05-16 Maja Sepelj MAJER Process for the preparation of etravirine and intermediates in the synthesis thereof
EP2770830A4 (de) 2011-10-28 2015-05-27 Celgene Avilomics Res Inc Verfahren zur behandlung einer bruton-tyrosinkinase-erkrankung oder -störung
US8703786B2 (en) * 2011-12-07 2014-04-22 Texas Southern University Etravirine formulations and uses thereof
DK2825042T3 (en) 2012-03-15 2018-11-26 Celgene Car Llc SALTS OF THE CHINASE INHIBITOR OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
BR112014022789B1 (pt) 2012-03-15 2022-04-19 Celgene Car Llc Formas sólidas de um inibidor de quinase de receptor do fator de crescimento epidérmico, composição farmacêutica e usos do mesmo
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
US20150336900A1 (en) * 2012-10-29 2015-11-26 Biophore India Pharmaceuticals Pvt. Ltd. Process for the Synthesis of Etravirine and Its Intermediates
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
WO2014100748A1 (en) 2012-12-21 2014-06-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
RU2015126505A (ru) 2012-12-21 2017-01-27 Верликс Фарма Инк. Применение и способы лечения заболеваний и патологических состояний печени
US9561228B2 (en) 2013-02-08 2017-02-07 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
DK3179858T3 (da) 2014-08-13 2019-07-22 Celgene Car Llc Forme og sammensætninger af en ERK-inhibitor
KR102595163B1 (ko) 2015-01-06 2023-10-30 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 상태의 치료 방법
CN104926829A (zh) * 2015-06-08 2015-09-23 山东大学 一种噻吩并嘧啶类衍生物及其制备方法和应用
WO2016209809A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(compound1) for use in sipi receptor-associated disorders
CN110066273A (zh) * 2019-06-05 2019-07-30 山东大学 一种含三氮唑环的单芳基嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
US11529350B2 (en) 2019-07-03 2022-12-20 Sumitomo Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof
CN111217833B (zh) * 2020-02-21 2021-03-16 山东大学 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用
CN111875548A (zh) * 2020-07-16 2020-11-03 山东大学 一种5位芳环取代的二芳基嘧啶类衍生物及其制备方法与应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
US4659363A (en) * 1983-07-25 1987-04-21 Ciba-Geigy Corporation N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
EP0172786B1 (de) * 1984-06-25 1991-01-30 Ciba-Geigy Ag Pyrimidinderivate wirksam als Schädlingsbekämpfungsmittel
ZA892407B (en) 1988-03-31 1989-11-29 Mitsubishi Chem Ind 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof
JPH02308248A (ja) 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
JP2895680B2 (ja) * 1992-07-08 1999-05-24 シャープ株式会社 磁気ヘッドおよびその製造方法
US5516775A (en) 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
GB9523675D0 (en) * 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
PL189122B1 (pl) 1995-11-23 2005-06-30 Janssen Pharmaceutica Nv Sposób wytwarzania mieszaniny stałej zawierającejjedną lub wiele cyklodekstryn, mieszanina stała ikompozycja farmaceutyczna
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
NO311614B1 (no) * 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituerte diamino-1,3,5-triazinderivater
GB9705361D0 (en) * 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
DE29704863U1 (de) * 1997-03-17 1997-05-22 Gesellschaft für Innenhochdruckverfahren mbH & Co. KG, 73441 Bopfingen Achsschwinge
NZ506417A (en) 1998-02-17 2003-05-30 Tularik Inc Anti-viral pyrimidine derivatives
BRPI9909191B8 (pt) * 1998-03-27 2021-07-06 Janssen Pharmaceutica Nv derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende
EP0945442A1 (de) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituierte Pyrimidine Derivate
TR200002760T2 (tr) 1998-03-27 2000-12-21 Janssen Pharmaceutica N.V. HIV engelleyici pirimidin türevleri
EA004049B1 (ru) * 1998-11-10 2003-12-25 Янссен Фармацевтика Н.В. Пиримидины, ингибирующие репликацию вич
AU782948B2 (en) * 2000-05-08 2005-09-15 Janssen Pharmaceutica N.V. Prodrugs of HIV replication inhibiting pyrimidines

Also Published As

Publication number Publication date
HRP20010161B9 (hr) 2014-10-24
BG65103B1 (bg) 2007-02-28
OA11674A (en) 2005-01-12
US20050288278A1 (en) 2005-12-29
HU227453B1 (en) 2011-06-28
KR100658489B1 (ko) 2006-12-18
ATE455107T1 (de) 2010-01-15
DE69905683D1 (de) 2003-04-10
DK1002795T3 (da) 2003-06-30
ID28376A (id) 2001-05-17
HK1048817B (zh) 2010-04-09
EA004049B1 (ru) 2003-12-25
US20080176880A1 (en) 2008-07-24
EP1270560B1 (de) 2010-01-13
EA200100536A1 (ru) 2002-02-28
CY2008021I2 (el) 2010-07-28
EP1002795B1 (de) 2003-03-05
WO2000027825A1 (en) 2000-05-18
HU230394B1 (hu) 2016-04-28
US20110263625A1 (en) 2011-10-27
FR09C0004I2 (fr) 2010-06-11
US7037917B2 (en) 2006-05-02
ZA200103769B (en) 2002-08-12
HK1025330A1 (en) 2000-11-10
HRP20080359A2 (en) 2008-12-31
EP1270560A1 (de) 2003-01-02
CZ301367B6 (cs) 2010-02-03
EP1002795A1 (de) 2000-05-24
CN1214013C (zh) 2005-08-10
IL169949A (en) 2011-02-28
US8530655B2 (en) 2013-09-10
CN1322198A (zh) 2001-11-14
HUP0104177A2 (hu) 2002-03-28
CA2350801A1 (en) 2000-05-18
JP2002529456A (ja) 2002-09-10
NO2009003I2 (no) 2010-06-07
NO20011696L (no) 2001-04-04
TWI238161B (en) 2005-08-21
EE05086B1 (et) 2008-10-15
DE122009000003I1 (de) 2009-05-20
KR20010075235A (ko) 2001-08-09
AU762523B2 (en) 2003-06-26
EE200100252A (et) 2002-10-15
BRPI9915552B8 (pt) 2021-05-25
MY121108A (en) 2005-12-30
ES2193664T3 (es) 2003-11-01
JP3635238B2 (ja) 2005-04-06
DE69905683T2 (de) 2004-03-18
TR200101306T2 (tr) 2001-10-22
NZ511116A (en) 2003-08-29
LU91528I9 (de) 2019-01-02
AU762523C (en) 2004-02-12
BR9915552A (pt) 2001-08-14
US8003789B2 (en) 2011-08-23
HK1048817A1 (en) 2003-04-17
PL204427B1 (pl) 2010-01-29
LTPA2008016I1 (lt) 2021-04-26
SK287269B6 (sk) 2010-05-07
LU91528I2 (fr) 2009-04-20
ES2338760T3 (es) 2010-05-12
ATE233740T1 (de) 2003-03-15
NO2009003I1 (no) 2009-03-09
LTC1002795I2 (lt) 2021-06-10
HUP0104177A3 (en) 2003-01-28
NO20011696D0 (no) 2001-04-04
AU2011200708A1 (en) 2011-03-10
DE69941934D1 (de) 2010-03-04
PT1002795E (pt) 2003-07-31
HRP20080359B1 (hr) 2016-01-01
US6878717B2 (en) 2005-04-12
NL300373I2 (nl) 2009-04-01
AU6200899A (en) 2000-05-29
BR9915552B1 (pt) 2013-11-19
NO2021015I1 (no) 2021-03-29
SK287270B6 (sk) 2010-05-07
US20030114472A1 (en) 2003-06-19
CY2008021I1 (el) 2010-07-28
UA70966C2 (uk) 2004-11-15
BG105418A (en) 2001-11-30
FR09C0004I1 (de) 2009-02-27
SK6032001A3 (en) 2002-01-07
HRP20010161A2 (en) 2002-02-28
US20040039005A1 (en) 2004-02-26
AP1683A (en) 2006-11-29
CA2350801C (en) 2008-05-20
NL300373I1 (nl) 2009-03-02
HRP20010161B1 (en) 2009-03-31
SI1002795T1 (en) 2003-10-31
CZ20011533A3 (cs) 2001-10-17
AR024227A1 (es) 2002-09-25
NO318801B1 (no) 2005-05-09
PL347586A1 (en) 2002-04-08

Similar Documents

Publication Publication Date Title
IL143023A0 (en) Hiv replication inhibiting pyrimidines
PL343196A1 (en) Hiv inhibiting pyrimidine derivatives
EG24684A (en) HIV replication inhibiting pyrimidines
DE59902573D1 (en) Dihydropyrimidine
HK1054940A1 (en) Pyrimidine derivatives
AU1041802A (en) Tetrahydro-heterocycloazepinyl pyrimidine derivatives
HK1078079A1 (en) Pyrimidine derivatives
ZA992322B (en) Phosphodiesterase iv-inhibiting diazepinoindoles.
MXPA03000504A (es) Derivados de pirimidina.
DE69940886D1 (en) Hiv impfstoff
IL166937A (en) Uracil compounds
ZA200007155B (en) Uracil compounds and use thereof.
ZA200100906B (en) Uracil compounds and use thereof.
EP0954316A4 (de) Pyrimidine derivaten
IL150715A0 (en) Substituted pyrimidines
GB9810027D0 (en) Incinerator
SI1303496T1 (sl) Pirimidinski derivati

Legal Events

Date Code Title Description
FF Patent granted
NE Application for restoration - patent lapsed through non-payment of renewal fees (section 60, patents law, 5727-1967)
KB Patent renewed
EXTJ Intention to grant a patent extension

Free format text: PRODUCT NAME: ETRAVIRINE

Extension date: 20201101

PEL Intention of commissioner to extend period of protection

Free format text: PRODUCT NAME: ETRAVIRINE

Extension date: 20201101

EXTG Extension of patent term granted

Extension date: 20201101

KB Patent renewed