IL103844A - Rebeccamycin analogs, their preparation and pharmaceutical compositions containing them - Google Patents

Rebeccamycin analogs, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL103844A
IL103844A IL103844A IL10384492A IL103844A IL 103844 A IL103844 A IL 103844A IL 103844 A IL103844 A IL 103844A IL 10384492 A IL10384492 A IL 10384492A IL 103844 A IL103844 A IL 103844A
Authority
IL
Israel
Prior art keywords
substd
opt
carboxyl
alkyl
carbamoyl
Prior art date
Application number
IL103844A
Other languages
English (en)
Other versions
IL103844A0 (en
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of IL103844A0 publication Critical patent/IL103844A0/xx
Publication of IL103844A publication Critical patent/IL103844A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL103844A 1991-11-29 1992-11-23 Rebeccamycin analogs, their preparation and pharmaceutical compositions containing them IL103844A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP6926992 1992-02-18
JP25730692 1992-09-01

Publications (2)

Publication Number Publication Date
IL103844A0 IL103844A0 (en) 1993-04-04
IL103844A true IL103844A (en) 1997-09-30

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
IL103844A IL103844A (en) 1991-11-29 1992-11-23 Rebeccamycin analogs, their preparation and pharmaceutical compositions containing them

Country Status (27)

Country Link
EP (1) EP0545195B1 (cs)
JP (1) JP2629542B2 (cs)
KR (1) KR100275976B1 (cs)
AT (1) ATE130617T1 (cs)
AU (1) AU650376B2 (cs)
BG (1) BG61036B1 (cs)
CA (1) CA2083534C (cs)
CZ (1) CZ287304B6 (cs)
DE (1) DE69206242T2 (cs)
DK (1) DK0545195T3 (cs)
DZ (1) DZ1634A1 (cs)
ES (1) ES2079774T3 (cs)
FI (1) FI106864B (cs)
GR (1) GR3018527T3 (cs)
HU (3) HU9203754D0 (cs)
IL (1) IL103844A (cs)
MX (1) MX9206847A (cs)
MY (1) MY114655A (cs)
NO (1) NO178929C (cs)
NZ (1) NZ245203A (cs)
PL (1) PL171468B1 (cs)
RO (1) RO113469B1 (cs)
RU (1) RU2117671C1 (cs)
SA (1) SA93130351B1 (cs)
TW (1) TW224469B (cs)
WO (1) WO1993011145A1 (cs)
YU (1) YU48963B (cs)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
PT760375E (pt) * 1994-05-09 2004-04-30 Banyu Pharma Co Ltd Derivado de indolopiprolocarbazole anti-tumoral
ES2206506T3 (es) * 1994-06-13 2004-05-16 Banyu Pharmaceutical Co., Ltd. Gen que codifica glicosil-transferasa, y su utilizacion.
WO1996004293A1 (en) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
CN1097460C (zh) * 1996-08-22 2003-01-01 布里斯托尔-迈尔斯斯奎布公司 吲哚并吡咯并咔唑的细胞毒的氨基糖及相关的糖衍生物
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
WO2004083228A1 (ja) 1999-09-10 2004-09-30 Katsuhisa Kojiri インドロピロロカルバゾール誘導体及び抗腫瘍剤
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE255122T1 (de) 2000-02-24 2003-12-15 Banyu Pharma Co Ltd Verfahren zur herstellung von indolopyrrolocarbazol-derivaten, deren zwischenprodukte sowie verfahren zur herstellung der zwischenprodukte
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
CZ20032876A3 (en) 2001-03-22 2004-03-17 Bristol-Myers Squibb Company Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
JPWO2003080077A1 (ja) * 2002-03-26 2005-07-21 萬有製薬株式会社 抗腫瘍性インドロピロロカルバゾール誘導体と他の抗がん剤との併用
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
EP1541582A1 (en) * 2002-08-23 2005-06-15 Banyu Pharmaceutical Co., Ltd. Process for producing indolopyrrolocarbazole derivative
AU2003248103A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd Indolopyrrolocarbazole derivative and antitumor agent
JPWO2005026185A1 (ja) * 2003-09-16 2006-11-16 萬有製薬株式会社 抗腫瘍性新規インドロピロロカルバゾール誘導体
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
RU2255089C1 (ru) * 2003-12-26 2005-06-27 Закрытое акционерное общество "АСГЛ-Исследовательские Лаборатории" Производные гликозидов индоло[2,3-а]пирроло[3,4-с]карбазол-5,7-дионов, обладающие цитотоксической и противоопухолевой активностью
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2742790C (en) 2008-11-19 2018-02-13 Cephalon, Inc. Novel forms of an indazolo[5,4-a]pyrrolo [3,4-c] carbazole compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2037596C (en) * 1990-03-06 1995-07-18 Kin Sing Lam Rebeccamycin analog by bromide precursor feeding
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
WO1992018507A1 (en) * 1991-04-11 1992-10-29 Schering Corporation Anti-tumor and anti-psoriatic agents

Also Published As

Publication number Publication date
DE69206242T2 (de) 1996-03-28
DE69206242D1 (de) 1996-01-04
EP0545195A1 (en) 1993-06-09
NO178929C (no) 1996-07-03
FI106864B (fi) 2001-04-30
RU2117671C1 (ru) 1998-08-20
JP2629542B2 (ja) 1997-07-09
FI925422L (fi) 1993-05-30
DK0545195T3 (da) 1995-12-18
YU102692A (sh) 1996-02-19
MY114655A (en) 2002-12-31
DZ1634A1 (fr) 2002-02-17
GR3018527T3 (en) 1996-03-31
AU2963792A (en) 1993-06-03
KR100275976B1 (ko) 2001-02-01
NO178929B (no) 1996-03-25
TW224469B (cs) 1994-06-01
EP0545195B1 (en) 1995-11-22
SA93130351B1 (ar) 2005-10-16
YU48963B (sh) 2003-01-31
CZ350892A3 (en) 1993-10-13
NO924593L (no) 1993-06-01
ES2079774T3 (es) 1996-01-16
HU217611B (hu) 2000-03-28
JPH06128283A (ja) 1994-05-10
WO1993011145A1 (en) 1993-06-10
BG61036B1 (bg) 1996-09-30
KR930010039A (ko) 1993-06-21
HU9203754D0 (en) 1993-03-29
NO924593D0 (no) 1992-11-27
PL171468B1 (pl) 1997-05-30
FI925422A0 (fi) 1992-11-27
CZ287304B6 (cs) 2000-10-11
RO113469B1 (ro) 1998-07-30
MX9206847A (es) 1993-06-30
NZ245203A (en) 1997-07-27
PL304729A1 (en) 1995-01-09
HUT65699A (en) 1994-07-28
AU650376B2 (en) 1994-06-16
CA2083534C (en) 2003-01-28
HU211254A9 (en) 1995-11-28
ATE130617T1 (de) 1995-12-15
IL103844A0 (en) 1993-04-04
CA2083534A1 (en) 1993-05-30
BG97970A (bg) 1994-04-29

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