ES2079774T3 - Derivados de indolopirrolocarbazol. - Google Patents

Derivados de indolopirrolocarbazol.

Info

Publication number
ES2079774T3
ES2079774T3 ES92119904T ES92119904T ES2079774T3 ES 2079774 T3 ES2079774 T3 ES 2079774T3 ES 92119904 T ES92119904 T ES 92119904T ES 92119904 T ES92119904 T ES 92119904T ES 2079774 T3 ES2079774 T3 ES 2079774T3
Authority
ES
Spain
Prior art keywords
substd
opt
carboxyl
alkyl
carbamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119904T
Other languages
English (en)
Inventor
Kojiri Katsuhisa
Kondo Hisao
Arakawa Hiroharu
Mitsuru Ohkubo
Suda Hiroyuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Application granted granted Critical
Publication of ES2079774T3 publication Critical patent/ES2079774T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL SIGUIENTE Y UNA SAL ACEPTABLE FARMACEUTICAMENTE CONSIGUIENTE DONDE R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, GRUPO ALQUILO INFERIOR, GRUPO ALQUENILO INFERIOR, GRUPO ALQUINILO INFERIOR, GRUPO ARILO, GRUPO ARALQUILO O GRUPO HETEROCICLICO (EL GRUPO ALQUILO INFERIOR, GRUPO ALQUENILO INFERIOR, GRUPO ALQUINILO INFERIOR, GRUPO ARILO, GRUPO ARALQUILO O GRUPO HETEROCICLICO PUEDEN TENER CADA UNO DE 1 A 5 SUSTITUYENTES SELECCIONADOS DEL GRUPO CONSISTENTE DE GRUPO CARBOXILO, GRUPO CARBAMOILO, GRUPO SULFI, GRUPO AMINO, GRUPO CIANO, GRUPO MONO-ALQUILAMINO INFERIOR, GRUPO DI-ALQUILAMINO INFERIOR, GRUPO HIDROXILO O ATOMOS HALOGENOS) O UN GRUPO DE LA FORMULA SENTA UN GRUPO CARBONILO, GRUPO TIOCARBONILO O GRUPO SULFONILO, Y R3 REPRESENTA UN ATOMO DE HIDROGENO, GRUPO ALQUILO INFERIOR, GRUPO CICLOALQUILO, GRUPO CICLOALQUILALQUILO, GRUPO ARILO, GRUPO ARALQUILO, GRUPO ALCOXI INFERIOR, GRUPO HIDRAZINO, GRUPO AMINO, GRUPO ARILAMINO, GRUPO CARBAMOILO O GRUPO HETEROCICLICO (EL GRUPO ALQUILO INFERIOR, GRUPO CICLOALQUILO, GRUPO CICLOALQUILALQUILO, GRUPO ARILO, GRUPO ARALQUILO, O GRUPO HETEROCICLICO PUEDE TENER CADA UNO DE 1 A 4 SUSTITUYENTES SELECCIONADOS DEL GRUPO CONSISTENTE DE ATOMOS HALOGENOS, GRUPO HIDROXILO OPCIONALMENTE PROTEGIDO, GRUPO AMINO, GRUPO CARBOXILO, GRUPO CARBAMOILO, GRUPO CIANO, GRUPO ALILO Y GRUPO ALCOXICARBONILO INFERIOR, Y EL GRUPO AMINO Y GRUPO CARBAMOILO PUEDE ESTAR CADA UNO MONO O DI SUSTITUIDOS POR GRUPOS ALQUILO INFERIORES OPCIONALMENTE SUSTITUIDOS POR SUSTITUYENTES SELECCIONADOS DEL GRUPO CONSISTENTE DE ATOMOS HALOGENOS, GRUPO HIDROXILO, GRUPO AMINO, GRUPO CARBOXILO, GRUPO CARBAMOILO, Y GRUPO ALCOXICARBONILO INFERIOR); O R1 Y R2 SE COMBINAN PARA REPRESENTAR UN GRUPO ALQUILIDENO INFERIOR (EL GRUPO ALQUILIDENO INFERIOR PUEDE TENER 1 A 4 SUSTITUYENTES SELECCIONADOS DEL GRUPO CONSISTENTE DE GRUPO AMINO, GRUPO MONO-ALQUILAMINO INFERIOR, GRUPO DI-ALQUILAMINO INFERIOR, GRUPO HIDROXILO, GRUPO CARBOXILO O GRUPO SULFONILO); O R1 Y R2 SE COMBINAN CON EL ATOMO DE NITROGENO AL QUE ESTAN ENLAZADOS PARA FORMAR UN GRUPO HETEROCICLICO ( EL GRUPO HETEROCICLICO PUEDE TENER EN EL ANILLO GRUPO ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO POR GRUPO SELECCIONADO DEL GRUPO CONSISTENTE DE GRUPO AMINO, GRUPO HIDROXILO, GRUPO CARBOXILO Y GRUPO SULFO), G REPRESENTA UN GRUPO PENTOSA, Y X1 Y X2 REPRESENTAN INDEPENDIENTEMENTE CADA UNO UN ATOMO DE HIDROGENO, ATOMO HALOGENO, GRUPO AMINO, GRUPO MONO-ALQUILAMINO INFERIOR, GRUPO DI-ALQUILAMINO INFERIOR, GRUPO HIDROXILO, GRUPO ALCOXI INFERIOR, GRUPO ARALCOXI, GRUPO CARBOXILO, GRUPO ALCOXICARBONILO INFERIOR O GRUPO ALQUILO INFERIOR. ESTE COMPUESTO POSEE UN EXCELENTE EFECTO ANTITUMORAL.
ES92119904T 1991-11-29 1992-11-23 Derivados de indolopirrolocarbazol. Expired - Lifetime ES2079774T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP6926992 1992-02-18
JP25730692 1992-09-01

Publications (1)

Publication Number Publication Date
ES2079774T3 true ES2079774T3 (es) 1996-01-16

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119904T Expired - Lifetime ES2079774T3 (es) 1991-11-29 1992-11-23 Derivados de indolopirrolocarbazol.

Country Status (27)

Country Link
EP (1) EP0545195B1 (es)
JP (1) JP2629542B2 (es)
KR (1) KR100275976B1 (es)
AT (1) ATE130617T1 (es)
AU (1) AU650376B2 (es)
BG (1) BG61036B1 (es)
CA (1) CA2083534C (es)
CZ (1) CZ287304B6 (es)
DE (1) DE69206242T2 (es)
DK (1) DK0545195T3 (es)
DZ (1) DZ1634A1 (es)
ES (1) ES2079774T3 (es)
FI (1) FI106864B (es)
GR (1) GR3018527T3 (es)
HU (3) HU217611B (es)
IL (1) IL103844A (es)
MX (1) MX9206847A (es)
MY (1) MY114655A (es)
NO (1) NO178929C (es)
NZ (1) NZ245203A (es)
PL (1) PL171468B1 (es)
RO (1) RO113469B1 (es)
RU (1) RU2117671C1 (es)
SA (1) SA93130351B1 (es)
TW (1) TW224469B (es)
WO (1) WO1993011145A1 (es)
YU (1) YU48963B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0760375T3 (da) * 1994-05-09 2003-12-29 Banyu Pharma Co Ltd Antitumor-indolopyrrolocarbazolderivater
WO1995030682A1 (fr) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
USRE37206E1 (en) * 1994-06-13 2001-06-05 Banyu Pharmaceutical Co, Ltd Gene encoding glycosyltransferase and its uses
WO1996004293A1 (fr) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazoles antitumoraux
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
ES2169414T3 (es) * 1996-08-22 2002-07-01 Bristol Myers Squibb Co Amino-azucar citotoxico y derivados de azucares relacionados de indolopirrolocarbazoles.
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en) 1999-09-10 2004-03-09 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2001234119A1 (en) 2000-02-24 2001-09-03 Banyu Pharmaceutical Co. Ltd. Process for preparing indolopyrrolocarbazole derivatives, intermediates therefor, and preparation process of the intermediates
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
CZ20032876A3 (en) 2001-03-22 2004-03-17 Bristol-Myers Squibb Company Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
WO2003080077A1 (fr) * 2002-03-26 2003-10-02 Banyu Pharmaceutical Co., Ltd. Utilisation combinee de derives anticancereux de l'indolopyrrolocarbazole et d'un autre agent anticancereux
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
WO2005010017A1 (ja) * 2003-07-24 2005-02-03 Banyu Pharmaceutical Co., Ltd インドロピロロカルバゾール誘導体及び抗腫瘍剤
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
MX2011005055A (es) 2008-11-19 2011-05-31 Cephalon Inc Nuevas formas de un compuesto de indazolo [5,4-a]pirrolo[3,4-c]car bazol.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2037596C (en) * 1990-03-06 1995-07-18 Kin Sing Lam Rebeccamycin analog by bromide precursor feeding
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
CA2083534A1 (en) 1993-05-30
EP0545195B1 (en) 1995-11-22
PL304729A1 (en) 1995-01-09
KR100275976B1 (ko) 2001-02-01
RU2117671C1 (ru) 1998-08-20
JP2629542B2 (ja) 1997-07-09
YU48963B (sh) 2003-01-31
CZ287304B6 (cs) 2000-10-11
CZ350892A3 (en) 1993-10-13
WO1993011145A1 (en) 1993-06-10
FI106864B (fi) 2001-04-30
IL103844A0 (en) 1993-04-04
AU2963792A (en) 1993-06-03
PL171468B1 (pl) 1997-05-30
IL103844A (en) 1997-09-30
HU217611B (hu) 2000-03-28
EP0545195A1 (en) 1993-06-09
NO178929C (no) 1996-07-03
TW224469B (es) 1994-06-01
FI925422A0 (fi) 1992-11-27
DE69206242D1 (de) 1996-01-04
DZ1634A1 (fr) 2002-02-17
HU211254A9 (en) 1995-11-28
DE69206242T2 (de) 1996-03-28
NZ245203A (en) 1997-07-27
YU102692A (sh) 1996-02-19
RO113469B1 (ro) 1998-07-30
KR930010039A (ko) 1993-06-21
HU9203754D0 (en) 1993-03-29
BG97970A (bg) 1994-04-29
CA2083534C (en) 2003-01-28
NO178929B (no) 1996-03-25
BG61036B1 (bg) 1996-09-30
SA93130351B1 (ar) 2005-10-16
JPH06128283A (ja) 1994-05-10
NO924593L (no) 1993-06-01
HUT65699A (en) 1994-07-28
NO924593D0 (no) 1992-11-27
FI925422A (fi) 1993-05-30
MY114655A (en) 2002-12-31
MX9206847A (es) 1993-06-30
ATE130617T1 (de) 1995-12-15
AU650376B2 (en) 1994-06-16
DK0545195T3 (da) 1995-12-18
GR3018527T3 (en) 1996-03-31

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