FI925422A0 - Indolopyrrolokarbazolderivat - Google Patents

Indolopyrrolokarbazolderivat

Info

Publication number
FI925422A0
FI925422A0 FI925422A FI925422A FI925422A0 FI 925422 A0 FI925422 A0 FI 925422A0 FI 925422 A FI925422 A FI 925422A FI 925422 A FI925422 A FI 925422A FI 925422 A0 FI925422 A0 FI 925422A0
Authority
FI
Finland
Prior art keywords
substd
opt
carboxyl
alkyl
carbamoyl
Prior art date
Application number
FI925422A
Other languages
English (en)
Other versions
FI106864B (fi
FI925422A (fi
Inventor
Katsuhisa Kojiri
Hisao Kondo
Hiroharu Arakawa
Mitsuru Ohkubo
Hiroyuki Suda
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of FI925422A0 publication Critical patent/FI925422A0/fi
Publication of FI925422A publication Critical patent/FI925422A/fi
Application granted granted Critical
Publication of FI106864B publication Critical patent/FI106864B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FI925422A 1991-11-29 1992-11-27 Menetelmä terapeuttisesti käyttökelpoisten indolopyrrolokarbatsolijohdannaisten valmistamiseksi FI106864B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP34191691 1991-11-29
JP34191691 1991-11-29
JP6926992 1992-02-18
JP6926992 1992-02-18
JP25730692 1992-09-01
JP25730692 1992-09-01

Publications (3)

Publication Number Publication Date
FI925422A0 true FI925422A0 (fi) 1992-11-27
FI925422A FI925422A (fi) 1993-05-30
FI106864B FI106864B (fi) 2001-04-30

Family

ID=27300000

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925422A FI106864B (fi) 1991-11-29 1992-11-27 Menetelmä terapeuttisesti käyttökelpoisten indolopyrrolokarbatsolijohdannaisten valmistamiseksi

Country Status (27)

Country Link
EP (1) EP0545195B1 (fi)
JP (1) JP2629542B2 (fi)
KR (1) KR100275976B1 (fi)
AT (1) ATE130617T1 (fi)
AU (1) AU650376B2 (fi)
BG (1) BG61036B1 (fi)
CA (1) CA2083534C (fi)
CZ (1) CZ287304B6 (fi)
DE (1) DE69206242T2 (fi)
DK (1) DK0545195T3 (fi)
DZ (1) DZ1634A1 (fi)
ES (1) ES2079774T3 (fi)
FI (1) FI106864B (fi)
GR (1) GR3018527T3 (fi)
HU (3) HU217611B (fi)
IL (1) IL103844A (fi)
MX (1) MX9206847A (fi)
MY (1) MY114655A (fi)
NO (1) NO178929C (fi)
NZ (1) NZ245203A (fi)
PL (1) PL171468B1 (fi)
RO (1) RO113469B1 (fi)
RU (1) RU2117671C1 (fi)
SA (1) SA93130351B1 (fi)
TW (1) TW224469B (fi)
WO (1) WO1993011145A1 (fi)
YU (1) YU48963B (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU683749B2 (en) * 1994-05-09 1997-11-20 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1995030682A1 (fr) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
JP3707075B2 (ja) * 1994-06-13 2005-10-19 萬有製薬株式会社 グリコシルトランスフェラーゼをコードする遺伝子及びその用途
WO1996004293A1 (fr) * 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazoles antitumoraux
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
US5475110A (en) * 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5594009A (en) * 1994-10-14 1997-01-14 Cephalon, Inc. Fused pyrrolocarbazoles
US5591855A (en) * 1994-10-14 1997-01-07 Cephalon, Inc. Fused pyrrolocarbazoles
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
US5616724A (en) * 1996-02-21 1997-04-01 Cephalon, Inc. Fused pyrrolo[2,3-c]carbazole-6-ones
BR9711306A (pt) * 1996-08-22 1999-08-17 Bristol Myers Squibb Co Amino a-Úcar citotÄxico e derivados de a-Úcar correlatos de indolopirrolocarbazÄis
GB9811624D0 (en) * 1998-05-29 1998-07-29 Merck Sharp & Dohme Therapeutic use
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6703373B1 (en) 1999-09-10 2004-03-09 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives and antitumor agents
FR2801054B1 (fr) * 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1258490T3 (da) 2000-02-24 2004-04-05 Banyu Pharma Co Ltd Fremgangsmåde til fremstilling af indolopyrrolocarbazol, mellemprodukter dertil og fremgangsmåde til fremstillingen af mellemprodukterne
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6555677B2 (en) 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
US6559299B2 (en) 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
US20050171036A1 (en) * 2002-03-26 2005-08-04 Banyu Pharmaceutical Co., Ltd. Use of antitumor indolopyrrolocarbazole derivative and other anticancer agent in combination
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
AU2003248103A1 (en) * 2003-07-24 2005-02-14 Banyu Pharmaceutical Co., Ltd Indolopyrrolocarbazole derivative and antitumor agent
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
US7241779B2 (en) * 2003-12-23 2007-07-10 Cephalon, Inc. Fused pyrrolocarbazoles
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
EP2367829B1 (en) 2008-11-19 2013-01-02 Cephalon, Inc. Novel forms of an indazolo [5,4-a] pyrrolo [3,4-c] carbazole compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2037596C (en) * 1990-03-06 1995-07-18 Kin Sing Lam Rebeccamycin analog by bromide precursor feeding
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
AU2963792A (en) 1993-06-03
ATE130617T1 (de) 1995-12-15
EP0545195A1 (en) 1993-06-09
NO924593L (no) 1993-06-01
ES2079774T3 (es) 1996-01-16
DK0545195T3 (da) 1995-12-18
GR3018527T3 (en) 1996-03-31
CA2083534A1 (en) 1993-05-30
RU2117671C1 (ru) 1998-08-20
DZ1634A1 (fr) 2002-02-17
FI106864B (fi) 2001-04-30
YU102692A (sh) 1996-02-19
JP2629542B2 (ja) 1997-07-09
IL103844A (en) 1997-09-30
HU9203754D0 (en) 1993-03-29
HU217611B (hu) 2000-03-28
AU650376B2 (en) 1994-06-16
BG61036B1 (bg) 1996-09-30
EP0545195B1 (en) 1995-11-22
WO1993011145A1 (en) 1993-06-10
YU48963B (sh) 2003-01-31
CZ287304B6 (cs) 2000-10-11
HUT65699A (en) 1994-07-28
KR930010039A (ko) 1993-06-21
NO924593D0 (no) 1992-11-27
IL103844A0 (en) 1993-04-04
SA93130351B1 (ar) 2005-10-16
FI925422A (fi) 1993-05-30
TW224469B (fi) 1994-06-01
MY114655A (en) 2002-12-31
NZ245203A (en) 1997-07-27
PL304729A1 (en) 1995-01-09
KR100275976B1 (ko) 2001-02-01
CZ350892A3 (en) 1993-10-13
NO178929B (no) 1996-03-25
DE69206242T2 (de) 1996-03-28
MX9206847A (es) 1993-06-30
CA2083534C (en) 2003-01-28
DE69206242D1 (de) 1996-01-04
NO178929C (no) 1996-07-03
RO113469B1 (ro) 1998-07-30
JPH06128283A (ja) 1994-05-10
PL171468B1 (pl) 1997-05-30
HU211254A9 (en) 1995-11-28
BG97970A (bg) 1994-04-29

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