IE59498B1 - Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form - Google Patents

Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form

Info

Publication number
IE59498B1
IE59498B1 IE285186A IE285186A IE59498B1 IE 59498 B1 IE59498 B1 IE 59498B1 IE 285186 A IE285186 A IE 285186A IE 285186 A IE285186 A IE 285186A IE 59498 B1 IE59498 B1 IE 59498B1
Authority
IE
Ireland
Prior art keywords
superoxide dismutase
analog
manganese superoxide
human manganese
human
Prior art date
Application number
IE285186A
Other languages
English (en)
Other versions
IE862851L (en
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of IE862851L publication Critical patent/IE862851L/xx
Priority to US07/912,213 priority Critical patent/US5270195A/en
Publication of IE59498B1 publication Critical patent/IE59498B1/en
Priority to US08/299,047 priority patent/US6610520B1/en
Priority to US08/370,461 priority patent/US5540911A/en
Priority to US08/686,466 priority patent/US6361772B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IE285186A 1985-11-22 1986-10-29 Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form IE59498B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US07/912,213 US5270195A (en) 1985-11-22 1992-07-10 Plasmids for expression and method of producing a human manganese superoxide dimutase analog
US08/299,047 US6610520B1 (en) 1985-11-22 1994-08-31 Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
US08/370,461 US5540911A (en) 1985-11-22 1995-01-09 Methods of use of human manganese superoxide dismutase
US08/686,466 US6361772B1 (en) 1985-11-22 1996-07-25 Human manganese superoxide dismutase DNA, its expression and method of recovering human manganese superoxide dismutase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80109085A 1985-11-22 1985-11-22
US90705186A 1986-09-12 1986-09-12

Publications (2)

Publication Number Publication Date
IE862851L IE862851L (en) 1987-05-22
IE59498B1 true IE59498B1 (en) 1994-03-09

Family

ID=27122291

Family Applications (1)

Application Number Title Priority Date Filing Date
IE285186A IE59498B1 (en) 1985-11-22 1986-10-29 Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form

Country Status (21)

Country Link
JP (2) JP2609449B2 (enrdf_load_stackoverflow)
AT (1) AT400443B (enrdf_load_stackoverflow)
AU (1) AU607897B2 (enrdf_load_stackoverflow)
BE (1) BE905796A (enrdf_load_stackoverflow)
CA (1) CA1341362C (enrdf_load_stackoverflow)
CH (1) CH676990A5 (enrdf_load_stackoverflow)
DE (1) DE3639725C2 (enrdf_load_stackoverflow)
DK (1) DK534686A (enrdf_load_stackoverflow)
ES (1) ES2003518A6 (enrdf_load_stackoverflow)
FI (1) FI90353C (enrdf_load_stackoverflow)
FR (1) FR2590591B1 (enrdf_load_stackoverflow)
GB (1) GB2183658B (enrdf_load_stackoverflow)
GR (1) GR862713B (enrdf_load_stackoverflow)
HK (1) HK75195A (enrdf_load_stackoverflow)
IE (1) IE59498B1 (enrdf_load_stackoverflow)
IL (2) IL106449A (enrdf_load_stackoverflow)
IT (1) IT1205418B (enrdf_load_stackoverflow)
LU (1) LU86676A1 (enrdf_load_stackoverflow)
NL (1) NL8602960A (enrdf_load_stackoverflow)
PT (1) PT83792B (enrdf_load_stackoverflow)
SE (1) SE8604884L (enrdf_load_stackoverflow)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS62215532A (ja) * 1986-03-18 1987-09-22 Ube Ind Ltd 抗炎症剤
JPH0643341B2 (ja) * 1986-03-27 1994-06-08 宇部興産株式会社 臓器機能改善剤
JPH0643340B2 (ja) * 1986-09-03 1994-06-08 宇部興産株式会社 虚血性心疾患治療薬
JPS6377822A (ja) * 1986-09-18 1988-04-08 Ube Ind Ltd 臓器機能改善剤
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
DE3854678T2 (de) * 1987-03-27 1996-06-13 Bio Technology General Corp Menschliches Mangansuperoxiddismutase und Behandlungsverfahren.
JPH01233228A (ja) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd 悪性腫瘍細胞転移防止剤
US5772996A (en) * 1990-08-03 1998-06-30 Public Health Laboratory Service Board Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DK0587055T3 (da) * 1992-09-09 2002-04-02 Bio Technology General Corp Anvendelse af mangan-superoxiddismutase (Mn-SOD) til fremstilling af lægemidler til behandling af sygdomme i lav dosering
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
WO2025178510A1 (ru) * 2024-02-21 2025-08-28 Евгений Владимирович ГРИГОРЬЕВ Способ применения супероксиддисмутазы 2 в качестве антиоксиданта в сверхмалых дозировках

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
BG49718A3 (bg) * 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
EP0138111B1 (en) * 1983-10-03 1991-11-21 Chiron Corporation Superoxide dismutase cloning and expression in microorganisms

Also Published As

Publication number Publication date
IE862851L (en) 1987-05-22
IT1205418B (it) 1989-03-15
CH676990A5 (enrdf_load_stackoverflow) 1991-03-28
DE3639725C2 (de) 1998-02-19
PT83792B (pt) 1989-01-17
DE3639725A1 (de) 1987-07-23
FI864756A7 (fi) 1987-05-23
IL106449A (en) 1997-02-18
GB8627294D0 (en) 1986-12-17
AT400443B (de) 1995-12-27
DK534686D0 (da) 1986-11-07
JPS62289187A (ja) 1987-12-16
FI90353B (fi) 1993-10-15
GR862713B (en) 1987-03-24
ES2003518A6 (es) 1988-11-01
SE8604884D0 (sv) 1986-11-14
ATA308986A (de) 1995-05-15
JPH08289792A (ja) 1996-11-05
IT8667865A0 (it) 1986-11-21
DK534686A (da) 1987-05-23
BE905796A (fr) 1987-03-16
CA1341362C (en) 2002-05-28
FI864756A0 (fi) 1986-11-21
HK75195A (en) 1995-05-26
IL106449A0 (en) 1993-11-15
PT83792A (en) 1986-12-01
JP2609449B2 (ja) 1997-05-14
AU607897B2 (en) 1991-03-21
AU6497586A (en) 1987-05-28
NL8602960A (nl) 1987-06-16
LU86676A1 (fr) 1987-05-04
FI90353C (fi) 1994-01-25
GB2183658A (en) 1987-06-10
IL80702A0 (en) 1987-02-27
GB2183658B (en) 1990-04-25
SE8604884L (sv) 1987-05-23
JP2967557B2 (ja) 1999-10-25
FR2590591A1 (fr) 1987-05-29
FR2590591B1 (fr) 1989-12-01

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