GB2183658B - Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form. - Google Patents

Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form.

Info

Publication number
GB2183658B
GB2183658B GB8627294A GB8627294A GB2183658B GB 2183658 B GB2183658 B GB 2183658B GB 8627294 A GB8627294 A GB 8627294A GB 8627294 A GB8627294 A GB 8627294A GB 2183658 B GB2183658 B GB 2183658B
Authority
GB
United Kingdom
Prior art keywords
plasmid
recovering
expression
active form
superoxide dismutase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8627294A
Other languages
English (en)
Other versions
GB2183658A (en
GB8627294D0 (en
Inventor
Jacob R Hartman
Yaffa Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Publication of GB8627294D0 publication Critical patent/GB8627294D0/en
Publication of GB2183658A publication Critical patent/GB2183658A/en
Application granted granted Critical
Publication of GB2183658B publication Critical patent/GB2183658B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GB8627294A 1985-11-22 1986-11-14 Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form. Expired - Fee Related GB2183658B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80109085A 1985-11-22 1985-11-22
US90705186A 1986-09-12 1986-09-12

Publications (3)

Publication Number Publication Date
GB8627294D0 GB8627294D0 (en) 1986-12-17
GB2183658A GB2183658A (en) 1987-06-10
GB2183658B true GB2183658B (en) 1990-04-25

Family

ID=27122291

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8627294A Expired - Fee Related GB2183658B (en) 1985-11-22 1986-11-14 Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form.

Country Status (21)

Country Link
JP (2) JP2609449B2 (enrdf_load_stackoverflow)
AT (1) AT400443B (enrdf_load_stackoverflow)
AU (1) AU607897B2 (enrdf_load_stackoverflow)
BE (1) BE905796A (enrdf_load_stackoverflow)
CA (1) CA1341362C (enrdf_load_stackoverflow)
CH (1) CH676990A5 (enrdf_load_stackoverflow)
DE (1) DE3639725C2 (enrdf_load_stackoverflow)
DK (1) DK534686A (enrdf_load_stackoverflow)
ES (1) ES2003518A6 (enrdf_load_stackoverflow)
FI (1) FI90353C (enrdf_load_stackoverflow)
FR (1) FR2590591B1 (enrdf_load_stackoverflow)
GB (1) GB2183658B (enrdf_load_stackoverflow)
GR (1) GR862713B (enrdf_load_stackoverflow)
HK (1) HK75195A (enrdf_load_stackoverflow)
IE (1) IE59498B1 (enrdf_load_stackoverflow)
IL (2) IL80702A0 (enrdf_load_stackoverflow)
IT (1) IT1205418B (enrdf_load_stackoverflow)
LU (1) LU86676A1 (enrdf_load_stackoverflow)
NL (1) NL8602960A (enrdf_load_stackoverflow)
PT (1) PT83792B (enrdf_load_stackoverflow)
SE (1) SE8604884L (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2821311C1 (ru) * 2024-02-21 2024-06-20 Евгений Владимирович Григорьев Способ применения супероксиддисмутазы 2 в качестве антиоксиданта в сверхмалых дозировках

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS62215532A (ja) * 1986-03-18 1987-09-22 Ube Ind Ltd 抗炎症剤
JPH0643341B2 (ja) * 1986-03-27 1994-06-08 宇部興産株式会社 臓器機能改善剤
JPH0643340B2 (ja) * 1986-09-03 1994-06-08 宇部興産株式会社 虚血性心疾患治療薬
JPS6377822A (ja) * 1986-09-18 1988-04-08 Ube Ind Ltd 臓器機能改善剤
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
ATE132902T1 (de) * 1987-03-14 1996-01-15 Boehringer Ingelheim Int Humane mangan-superoxiddismutase (hmn-sod)
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
JPH01233228A (ja) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd 悪性腫瘍細胞転移防止剤
US5772996A (en) * 1990-08-03 1998-06-30 Public Health Laboratory Service Board Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DE59310242D1 (de) * 1992-09-09 2002-01-17 Bio Technology General Corp Verwendung von Mangan-Superoxiddismutase (Mn-SOD) zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen in niedriger Dosierung
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0131843A1 (en) * 1983-07-15 1985-01-23 Bio-Technology General Corporation Expression vectors for enhanced production of polypeptides, plasmids containing the vectors, hosts containing the plasmids, products manufactured thereby and related methods
EP0138111B1 (en) * 1983-10-03 1991-11-21 Chiron Corporation Superoxide dismutase cloning and expression in microorganisms

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0131843A1 (en) * 1983-07-15 1985-01-23 Bio-Technology General Corporation Expression vectors for enhanced production of polypeptides, plasmids containing the vectors, hosts containing the plasmids, products manufactured thereby and related methods
EP0138111B1 (en) * 1983-10-03 1991-11-21 Chiron Corporation Superoxide dismutase cloning and expression in microorganisms

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Bacteriol. 1983, 155, *
J. Biol. Chem. 1984, 259 *
Proc. Third Int. Conf. o *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2821311C1 (ru) * 2024-02-21 2024-06-20 Евгений Владимирович Григорьев Способ применения супероксиддисмутазы 2 в качестве антиоксиданта в сверхмалых дозировках

Also Published As

Publication number Publication date
GB2183658A (en) 1987-06-10
DE3639725C2 (de) 1998-02-19
CH676990A5 (enrdf_load_stackoverflow) 1991-03-28
SE8604884L (sv) 1987-05-23
FI90353B (fi) 1993-10-15
IT1205418B (it) 1989-03-15
FR2590591B1 (fr) 1989-12-01
DK534686A (da) 1987-05-23
FI864756A7 (fi) 1987-05-23
JPH08289792A (ja) 1996-11-05
NL8602960A (nl) 1987-06-16
AT400443B (de) 1995-12-27
FI864756A0 (fi) 1986-11-21
PT83792A (en) 1986-12-01
IL80702A0 (en) 1987-02-27
LU86676A1 (fr) 1987-05-04
IT8667865A0 (it) 1986-11-21
AU607897B2 (en) 1991-03-21
HK75195A (en) 1995-05-26
ATA308986A (de) 1995-05-15
FI90353C (fi) 1994-01-25
BE905796A (fr) 1987-03-16
JP2967557B2 (ja) 1999-10-25
IL106449A0 (en) 1993-11-15
IL106449A (en) 1997-02-18
IE862851L (en) 1987-05-22
GR862713B (en) 1987-03-24
DE3639725A1 (de) 1987-07-23
AU6497586A (en) 1987-05-28
PT83792B (pt) 1989-01-17
JPS62289187A (ja) 1987-12-16
FR2590591A1 (fr) 1987-05-29
JP2609449B2 (ja) 1997-05-14
DK534686D0 (da) 1986-11-07
GB8627294D0 (en) 1986-12-17
CA1341362C (en) 2002-05-28
SE8604884D0 (sv) 1986-11-14
IE59498B1 (en) 1994-03-09
ES2003518A6 (es) 1988-11-01

Similar Documents

Publication Publication Date Title
GB2183658B (en) Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form.
EP0190736A3 (en) Chemical derivatives of ghl-cu
AU1061988A (en) Phosphinothricin-resistance gene active in plants, and its use
EP0199870A3 (en) Steerable and aimable catheter
IL74804A0 (en) Human physiologically active polypeptide,its production and pharmaceutical compositions containing it
EP0196334A4 (en) CELL DESTRUCTION METHOD AND CELL DESTRUCTING AGENT.
IL78739A0 (en) Ascorbic acid derivatives,production and use thereof
AU3754285A (en) Fibrinolytically active enzyme conjugated to one human protein
EP0350314A3 (en) Silicone type cinnamic acid derivative, preparation method thereof, uv-ray absorber, and external skin treatment agent.
AU6351186A (en) Pharmaceutical composition comprising 1-hydroxy-2-pyridone and method for the treatment of acne
EP0462836A3 (en) Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme
EP0288278A3 (en) Chemical derivatives of ghl-cu
AU6219186A (en) Expression of a polypeptide having the enzymatic activity of naturally-occurring human CU-ZN superoxide dismutase in mammalian cells
DE3661878D1 (en) Tobacco composition containing apocynum venetum or an extract thereof, and process to prepare it
IL85205A0 (en) Plasmid capable of high level expression in e. coli of soluble mature hil-1beta and derivatives with altered biological activity
EP0210333A3 (en) Active carbon and process for its manufacture
EP0507772A4 (en) NON-MELANOCYTIC EUKARYOTE CELL CONSTITUTIVELY EXPRESSING BIOLOGICALLY ACTIVE HUMAN TYROSINASE, AND ITS USE.
ZA868610B (en) Human manganese superoxide dismutase cdna,its expression in bacteria and method of recovering enzymatically active human manganese superoxide dismutase
ZA882272B (en) Immunogenic recombinant yeast expression product and method for purifying it
AU588262B2 (en) Diaminoalcohols, their preparation and their use as acid gas removal agents
ZA888701B (en) Expression of hiv proteins in e.coli and s. cerevisiae
DE3574249D1 (en) Û(1,3,-dioxo-1,3-propanediyl)diimino¨ bisbenzoic acid derivatives and their use
IL120245A0 (en) Enzymatically active analogs and mutants of human manganese superoxide dismutase
GB2177638B (en) Improvements in and relating to welding.
ZA863421B (en) Ascorbic acid derivatives,production and use thereof

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee