IE59209B1 - A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it - Google Patents

A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it

Info

Publication number
IE59209B1
IE59209B1 IE292785A IE292785A IE59209B1 IE 59209 B1 IE59209 B1 IE 59209B1 IE 292785 A IE292785 A IE 292785A IE 292785 A IE292785 A IE 292785A IE 59209 B1 IE59209 B1 IE 59209B1
Authority
IE
Ireland
Prior art keywords
weight
parts
ethyl acetate
vacuum
silibinin
Prior art date
Application number
IE292785A
Other languages
English (en)
Other versions
IE852927L (en
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of IE852927L publication Critical patent/IE852927L/xx
Publication of IE59209B1 publication Critical patent/IE59209B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L59/00—Thermal insulation in general
    • F16L59/04—Arrangements using dry fillers, e.g. using slag wool

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IE292785A 1984-11-22 1985-11-21 A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it IE59209B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442641 1984-11-22
DE19853537656 DE3537656A1 (de) 1984-11-22 1985-10-23 Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin

Publications (2)

Publication Number Publication Date
IE852927L IE852927L (en) 1986-05-22
IE59209B1 true IE59209B1 (en) 1994-01-26

Family

ID=25826741

Family Applications (1)

Application Number Title Priority Date Filing Date
IE292785A IE59209B1 (en) 1984-11-22 1985-11-21 A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it

Country Status (26)

Country Link
US (1) US4871763A (en:Method)
JP (1) JPH0678228B2 (en:Method)
AR (1) AR241268A1 (en:Method)
AT (1) AT391315B (en:Method)
BE (1) BE903694A (en:Method)
CA (1) CA1337125C (en:Method)
CH (1) CH660008A5 (en:Method)
CS (1) CS271321B2 (en:Method)
DE (1) DE3537656A1 (en:Method)
DK (3) DK166541B1 (en:Method)
EG (1) EG17710A (en:Method)
ES (2) ES8609312A1 (en:Method)
FI (1) FI84065C (en:Method)
FR (1) FR2573426B1 (en:Method)
GB (1) GB2167746B (en:Method)
HU (1) HU195504B (en:Method)
IE (1) IE59209B1 (en:Method)
IT (1) IT1207508B (en:Method)
LU (1) LU86164A1 (en:Method)
MX (1) MX172175B (en:Method)
NL (1) NL192204C (en:Method)
NO (1) NO160206C (en:Method)
PL (1) PL146889B1 (en:Method)
PT (1) PT81531B (en:Method)
SE (1) SE457957B (en:Method)
YU (1) YU43690B (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3357383B2 (ja) * 1991-08-14 2002-12-16 昌宏 黒田 低分子化植物性組成物
DE4401902C2 (de) * 1994-01-24 2000-02-03 Madaus Ag Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
FR2719451B1 (fr) * 1994-05-04 1996-07-26 Apcis Sa Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité.
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
DE69824223T2 (de) 1997-03-19 2004-09-30 Unilever N.V. Vorrichtung zum Handhaben von Gegenständen
GB2327607B8 (en) * 1997-07-31 2005-03-30 Litton Internat Company Ltd A process for producing a herbal extract composition
DE10053384A1 (de) * 2000-10-27 2002-05-08 Bionorica Arzneimittel Gmbh Pharmazeutische Zubereitung aus Mariendistel und Terpenen
US6699900B2 (en) * 2001-04-07 2004-03-02 Jan E. Zielinski Hydrophilic and lipophilic silibinin pro-forms
DE10360954B3 (de) * 2003-12-23 2005-08-18 Esparma Gmbh Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen
BG65997B1 (bg) * 2005-03-29 2010-09-30 "Софарма" Ад Метод за получаване на силибинин
ES2662700T3 (es) * 2007-11-15 2018-04-09 Madaus Gmbh Componente de silibinina para el tratamiento de la hepatitis
DK2430017T3 (en) * 2009-05-14 2016-10-03 Madaus Gmbh PROCESS FOR THE PREPARATION OF AMORPHOUS silibinin.
WO2011051742A1 (en) * 2009-10-28 2011-05-05 Modutech S.A. Preparation comprising amino acids and plants and its activity in the alcohol detoxification
CN103408539B (zh) * 2013-08-28 2016-04-06 天津泰阳制药有限公司 高纯度水飞蓟宾的生产方法
JP2019508383A (ja) * 2016-01-15 2019-03-28 ウニベルジテート ハンブルグＵｎｉｖｅｒｓｉｔａｅｔ Ｈａｍｂｕｒｇ Ｏ−ラムノシル残基を有するフラボノイド型化合物
KR20230058156A (ko) 2020-09-29 2023-05-02 무니색하 매다사니 실리범 마리아넘 식물 물질로부터 생리활성 화합물의 추출 및 이의 이용

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923082C3 (de) * 1969-05-06 1985-08-22 Dr. Madaus & Co, 5000 Koeln Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch
DE1767666C3 (de) * 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
US3773932A (en) * 1968-06-01 1973-11-20 Madaus & Co Dr Method for recovering silymarin comprising polyhydroxyphenyl chromanones
DE2416302B2 (de) * 1974-04-04 1978-02-02 Dr. Madaus & Co, 5000 Köln Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
BE885558A (fr) * 1980-10-07 1981-04-07 Madaus & Co Dr Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique
DE3225688A1 (de) * 1982-07-09 1984-01-12 Suschnik Matthias Dr Verfahren zur gewinnung von silymarin aus silybum marianum

Also Published As

Publication number Publication date
JPH05271071A (ja) 1993-10-19
AR241268A1 (es) 1992-04-30
SE8505488L (sv) 1986-05-23
CS837985A2 (en) 1990-02-12
CH660008A5 (de) 1987-03-13
DK537685D0 (da) 1985-11-21
PL256373A1 (en) 1986-12-02
DK164866B (da) 1992-08-31
ATA337285A (de) 1990-03-15
PT81531B (pt) 1987-11-11
DK189491A (da) 1991-11-20
NL8503136A (nl) 1986-06-16
PT81531A (de) 1985-12-01
IT8522933A0 (it) 1985-11-21
YU43690B (en) 1989-10-31
AT391315B (de) 1990-09-25
NO160206C (no) 1989-03-22
ES549119A0 (es) 1986-09-01
GB2167746B (en) 1989-01-11
DK164866C (da) 1993-01-18
ES554022A0 (es) 1987-04-01
FI854536L (fi) 1986-05-23
FR2573426B1 (fr) 1988-06-10
ES8609312A1 (es) 1986-09-01
CS271321B2 (en) 1990-09-12
IT1207508B (it) 1989-05-25
DE3537656C2 (en:Method) 1989-03-16
EG17710A (en) 1990-10-30
MX172175B (es) 1993-12-07
CA1337125C (en) 1995-09-26
NL192204B (nl) 1996-11-01
HU195504B (en) 1988-05-30
DK189491D0 (da) 1991-11-20
PL146889B1 (en) 1989-03-31
SE457957B (sv) 1989-02-13
DK114592A (da) 1992-09-17
HUT40115A (en) 1986-11-28
BE903694A (fr) 1986-05-22
DK114592D0 (da) 1992-09-17
SE8505488D0 (sv) 1985-11-20
DK172879B1 (da) 1999-09-06
YU181285A (en) 1987-12-31
GB2167746A (en) 1986-06-04
FI854536A0 (fi) 1985-11-18
DK537685A (da) 1986-05-23
DK166541B1 (da) 1993-06-07
FI84065C (fi) 1991-10-10
NO854657L (no) 1986-05-23
US4871763A (en) 1989-10-03
ES8704482A1 (es) 1987-04-01
GB8527809D0 (en) 1985-12-18
LU86164A1 (de) 1986-03-24
FI84065B (fi) 1991-06-28
IE852927L (en) 1986-05-22
NL192204C (nl) 1997-03-04
FR2573426A1 (fr) 1986-05-23
NO160206B (no) 1988-12-12
JPH0678228B2 (ja) 1994-10-05
DE3537656A1 (de) 1986-05-22

Similar Documents

Publication Publication Date Title
IE59209B1 (en) A process for the preparation of isosilybin-free silibinin and pharmaceutical compositions containing it
KR100263680B1 (ko) 율무 알맹이로부터 추출된 중성지질 및 이것을 함유한 제약조성물
NO318694B1 (no) Blandinger avledet fra korn av Eug±nia Jambolana Lamarck, fremstilling og anvendelse av blandingene og noen av deres bestanddeler som medikamenter.
JPH06507601A (ja) セスキテルペンラクトンの抽出方法
JPH10218769A (ja) 抗潰瘍剤
US6475520B1 (en) Pharmaceutical composition with low toxicity for anti-inflammation and anti-exudation
KR0183448B1 (ko) 진세노사이드 Rg5를 함유하는 항암제 조성물
KR930003073B1 (ko) 이소실리빈이 없는 실리비닌의 제조방법
US3864484A (en) Therapeutic compositions and methods using silymarin comprising poly-hydroxyphenyl chromanones
FI85855B (fi) Foerfarande foer framstaellning av isosilybinfri silibin och silibin innehaollande laekemedel.
JP4643936B2 (ja) 血栓症改善剤
KR100625222B1 (ko) 신규 짐넴산 유도체, 그 제조 방법, 및 그의 약학적 용도
US12397032B2 (en) Methods for preparation of Plectranthus amboinicus extracts
JPH0535131B2 (en:Method)
JPH0212932B2 (en:Method)
NO160207B (no) Fremgangsmaate ved fremstilling av isosilybininfritt silibinin.
RU1811849C (ru) Противоопухолевое средство
JPH0339506B2 (en:Method)
IE53980B1 (en) Pharmaceutical compositions containing a fraction extracted from mandassi (cyperus articulatus l.)
KR100242283B1 (ko) 당뇨병 치료제 조성물과 그의 제조방법
JPH0859482A (ja) アルコール吸収抑制剤
SI8511812A8 (sl) Postopek za pripravo silibinina brez izosilibina
KR980008236A (ko) 지모추출물을 유효성분으로 함유하는 면역억제제
BE664894A (en:Method)
JPH09315990A (ja) 糖尿病予防剤

Legal Events

Date Code Title Description
MM4A Patent lapsed