BE903694A - Procede de preparation de silibinine depourvue d'isosilybine et medicaments renfermant de la silibinine. - Google Patents
Procede de preparation de silibinine depourvue d'isosilybine et medicaments renfermant de la silibinine.Info
- Publication number
- BE903694A BE903694A BE2/60851A BE2060851A BE903694A BE 903694 A BE903694 A BE 903694A BE 2/60851 A BE2/60851 A BE 2/60851A BE 2060851 A BE2060851 A BE 2060851A BE 903694 A BE903694 A BE 903694A
- Authority
- BE
- Belgium
- Prior art keywords
- silibinin
- preparation
- free
- isibilybine
- medicinal products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/04—Arrangements using dry fillers, e.g. using slag wool which is added to the object to be insulated by pouring, spreading, spraying or the like
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Préparation de la silibinine exempte d'isosilybine à partir de fruits séchés de Silybum marianum L. Gaertn. dont on extrait, de façon connue, une poudre brunatre, à la suite de quoi on sépare la silibinine en plusieurs étapes faisant intervenir des traitements par le méthanol et l'acétate d'éthyle, dans des conditions bien déterminées. Application à la préparation de médicaments pour le traitement et la prévention des troubles hépatiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3442641 | 1984-11-22 | ||
DE19853537656 DE3537656A1 (de) | 1984-11-22 | 1985-10-23 | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
Publications (1)
Publication Number | Publication Date |
---|---|
BE903694A true BE903694A (fr) | 1986-05-22 |
Family
ID=25826741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2/60851A BE903694A (fr) | 1984-11-22 | 1985-11-22 | Procede de preparation de silibinine depourvue d'isosilybine et medicaments renfermant de la silibinine. |
Country Status (26)
Country | Link |
---|---|
US (1) | US4871763A (fr) |
JP (1) | JPH0678228B2 (fr) |
AR (1) | AR241268A1 (fr) |
AT (1) | AT391315B (fr) |
BE (1) | BE903694A (fr) |
CA (1) | CA1337125C (fr) |
CH (1) | CH660008A5 (fr) |
CS (1) | CS271321B2 (fr) |
DE (1) | DE3537656A1 (fr) |
DK (3) | DK166541B1 (fr) |
EG (1) | EG17710A (fr) |
ES (2) | ES8609312A1 (fr) |
FI (1) | FI84065C (fr) |
FR (1) | FR2573426B1 (fr) |
GB (1) | GB2167746B (fr) |
HU (1) | HU195504B (fr) |
IE (1) | IE59209B1 (fr) |
IT (1) | IT1207508B (fr) |
LU (1) | LU86164A1 (fr) |
MX (1) | MX172175B (fr) |
NL (1) | NL192204C (fr) |
NO (1) | NO160206C (fr) |
PL (1) | PL146889B1 (fr) |
PT (1) | PT81531B (fr) |
SE (1) | SE457957B (fr) |
YU (1) | YU43690B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3357383B2 (ja) * | 1991-08-14 | 2002-12-16 | 昌宏 黒田 | 低分子化植物性組成物 |
DE4401902C2 (de) * | 1994-01-24 | 2000-02-03 | Madaus Ag | Verwendung von Flavolignanen als Adjuvans in der Tumortherapie |
FR2719451B1 (fr) * | 1994-05-04 | 1996-07-26 | Apcis Sa | Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité. |
DE19501266A1 (de) * | 1995-01-18 | 1996-07-25 | Madaus Ag | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
US6379714B1 (en) | 1995-04-14 | 2002-04-30 | Pharmaprint, Inc. | Pharmaceutical grade botanical drugs |
DE69824223T2 (de) | 1997-03-19 | 2004-09-30 | Unilever N.V. | Vorrichtung zum Handhaben von Gegenständen |
GB2327607B8 (en) * | 1997-07-31 | 2005-03-30 | Litton Internat Company Ltd | A process for producing a herbal extract composition |
DE10053384A1 (de) * | 2000-10-27 | 2002-05-08 | Bionorica Arzneimittel Gmbh | Pharmazeutische Zubereitung aus Mariendistel und Terpenen |
US6699900B2 (en) * | 2001-04-07 | 2004-03-02 | Jan E. Zielinski | Hydrophilic and lipophilic silibinin pro-forms |
DE10360954B3 (de) * | 2003-12-23 | 2005-08-18 | Esparma Gmbh | Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen |
BG65997B1 (bg) * | 2005-03-29 | 2010-09-30 | "Софарма" Ад | Метод за получаване на силибинин |
CN102300570B (zh) * | 2007-11-15 | 2015-01-14 | 马道斯有限责任公司 | 用于治疗肝炎的水飞蓟宾组分 |
AU2010247716B2 (en) * | 2009-05-14 | 2015-11-05 | Madaus Gmbh | Amorphous silibinin for the treatment of viral hepatitis |
WO2011051742A1 (fr) | 2009-10-28 | 2011-05-05 | Modutech S.A. | Préparation comprenant des acides aminés et des plantes et son activité dans la détoxification d'alcool |
CN103408539B (zh) * | 2013-08-28 | 2016-04-06 | 天津泰阳制药有限公司 | 高纯度水飞蓟宾的生产方法 |
CN109071482A (zh) * | 2016-01-15 | 2018-12-21 | 汉堡大学 | 携有o-鼠李糖基残基的类黄酮型化合物 |
WO2022070013A1 (fr) | 2020-09-29 | 2022-04-07 | Munisekhar Medasani | Extraction de composés bioactifs à partir de matières végétales de chardon marie et utilisation |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773932A (en) * | 1968-06-01 | 1973-11-20 | Madaus & Co Dr | Method for recovering silymarin comprising polyhydroxyphenyl chromanones |
DE1767666C3 (de) * | 1968-06-01 | 1986-07-31 | Dr. Madaus & Co, 5000 Koeln | Pharmazeutische Zubereitung gegen Lebererkrankungen |
DE1923082C3 (de) * | 1969-05-06 | 1985-08-22 | Dr. Madaus & Co, 5000 Koeln | Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch |
DE2416302B2 (de) * | 1974-04-04 | 1978-02-02 | Dr. Madaus & Co, 5000 Köln | Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
BE885558A (fr) * | 1980-10-07 | 1981-04-07 | Madaus & Co Dr | Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique |
DE3225688A1 (de) * | 1982-07-09 | 1984-01-12 | Suschnik Matthias Dr | Verfahren zur gewinnung von silymarin aus silybum marianum |
-
1985
- 1985-10-23 DE DE19853537656 patent/DE3537656A1/de active Granted
- 1985-11-11 GB GB08527809A patent/GB2167746B/en not_active Expired
- 1985-11-12 CH CH4854/85A patent/CH660008A5/de not_active IP Right Cessation
- 1985-11-13 LU LU86164A patent/LU86164A1/de unknown
- 1985-11-14 NL NL8503136A patent/NL192204C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854536A patent/FI84065C/fi not_active IP Right Cessation
- 1985-11-19 AT AT0337285A patent/AT391315B/de not_active IP Right Cessation
- 1985-11-20 CS CS858379A patent/CS271321B2/cs unknown
- 1985-11-20 CA CA000495805A patent/CA1337125C/fr not_active Expired - Fee Related
- 1985-11-20 YU YU1812/85A patent/YU43690B/xx unknown
- 1985-11-20 SE SE8505488A patent/SE457957B/sv not_active IP Right Cessation
- 1985-11-21 PT PT81531A patent/PT81531B/pt not_active IP Right Cessation
- 1985-11-21 IE IE292785A patent/IE59209B1/en not_active IP Right Cessation
- 1985-11-21 PL PL1985256373A patent/PL146889B1/pl unknown
- 1985-11-21 HU HU854449A patent/HU195504B/hu not_active IP Right Cessation
- 1985-11-21 IT IT8522933A patent/IT1207508B/it active
- 1985-11-21 DK DK537685A patent/DK166541B1/da not_active IP Right Cessation
- 1985-11-21 NO NO854657A patent/NO160206C/no unknown
- 1985-11-21 EG EG741/85A patent/EG17710A/xx active
- 1985-11-21 ES ES549119A patent/ES8609312A1/es not_active Expired
- 1985-11-22 BE BE2/60851A patent/BE903694A/fr not_active IP Right Cessation
- 1985-11-22 FR FR8517320A patent/FR2573426B1/fr not_active Expired
- 1985-11-22 MX MX009231A patent/MX172175B/es unknown
- 1985-11-22 AR AR85302358A patent/AR241268A1/es active
-
1986
- 1986-04-16 ES ES554022A patent/ES8704482A1/es not_active Expired
-
1988
- 1988-03-18 US US07/171,176 patent/US4871763A/en not_active Expired - Fee Related
-
1991
- 1991-01-29 JP JP3009169A patent/JPH0678228B2/ja not_active Expired - Lifetime
- 1991-11-20 DK DK189491A patent/DK164866C/da not_active IP Right Cessation
-
1992
- 1992-09-17 DK DK199201145A patent/DK172879B1/da active
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: DR. MADAUS G.M.B.H. & CO. Effective date: 20011130 |