DK164866C - Fremgangsmaade til isolering af isosilybinfrit silibinin - Google Patents
Fremgangsmaade til isolering af isosilybinfrit silibininInfo
- Publication number
- DK164866C DK164866C DK189491A DK189491A DK164866C DK 164866 C DK164866 C DK 164866C DK 189491 A DK189491 A DK 189491A DK 189491 A DK189491 A DK 189491A DK 164866 C DK164866 C DK 164866C
- Authority
- DK
- Denmark
- Prior art keywords
- silibinine
- isosilybin
- insulating
- procedure
- free
- Prior art date
Links
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
- F16L59/00—Thermal insulation in general
- F16L59/04—Arrangements using dry fillers, e.g. using slag wool
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3442641 | 1984-11-22 | ||
| DE3442641 | 1984-11-22 | ||
| DE3537656 | 1985-10-23 | ||
| DE19853537656 DE3537656A1 (de) | 1984-11-22 | 1985-10-23 | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK189491A DK189491A (da) | 1991-11-20 |
| DK189491D0 DK189491D0 (da) | 1991-11-20 |
| DK164866B DK164866B (da) | 1992-08-31 |
| DK164866C true DK164866C (da) | 1993-01-18 |
Family
ID=25826741
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK537685A DK166541B1 (da) | 1984-11-22 | 1985-11-21 | Fremgangsmaade til isolering af isosilybinfrit silibinin |
| DK189491A DK164866C (da) | 1984-11-22 | 1991-11-20 | Fremgangsmaade til isolering af isosilybinfrit silibinin |
| DK199201145A DK172879B1 (da) | 1984-11-22 | 1992-09-17 | Silibininholdigt farmaceutisk præparat |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK537685A DK166541B1 (da) | 1984-11-22 | 1985-11-21 | Fremgangsmaade til isolering af isosilybinfrit silibinin |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199201145A DK172879B1 (da) | 1984-11-22 | 1992-09-17 | Silibininholdigt farmaceutisk præparat |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4871763A (da) |
| JP (1) | JPH0678228B2 (da) |
| AR (1) | AR241268A1 (da) |
| AT (1) | AT391315B (da) |
| BE (1) | BE903694A (da) |
| CA (1) | CA1337125C (da) |
| CH (1) | CH660008A5 (da) |
| CS (1) | CS271321B2 (da) |
| DE (1) | DE3537656A1 (da) |
| DK (3) | DK166541B1 (da) |
| EG (1) | EG17710A (da) |
| ES (2) | ES8609312A1 (da) |
| FI (1) | FI84065C (da) |
| FR (1) | FR2573426B1 (da) |
| GB (1) | GB2167746B (da) |
| HU (1) | HU195504B (da) |
| IE (1) | IE59209B1 (da) |
| IT (1) | IT1207508B (da) |
| LU (1) | LU86164A1 (da) |
| MX (1) | MX172175B (da) |
| NL (1) | NL192204C (da) |
| NO (1) | NO160206C (da) |
| PL (1) | PL146889B1 (da) |
| PT (1) | PT81531B (da) |
| SE (1) | SE457957B (da) |
| YU (1) | YU43690B (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3357383B2 (ja) * | 1991-08-14 | 2002-12-16 | 昌宏 黒田 | 低分子化植物性組成物 |
| DE4401902C2 (de) * | 1994-01-24 | 2000-02-03 | Madaus Ag | Verwendung von Flavolignanen als Adjuvans in der Tumortherapie |
| FR2719451B1 (fr) * | 1994-05-04 | 1996-07-26 | Apcis Sa | Utilisation de la silybinine dans le gavage des palmipèdes, en vue de l'obtention d'un foie gras de meilleure qualité. |
| DE19501266A1 (de) * | 1995-01-18 | 1996-07-25 | Madaus Ag | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US6379714B1 (en) | 1995-04-14 | 2002-04-30 | Pharmaprint, Inc. | Pharmaceutical grade botanical drugs |
| DE69824223T2 (de) | 1997-03-19 | 2004-09-30 | Unilever N.V. | Vorrichtung zum Handhaben von Gegenständen |
| GB2327607B8 (en) * | 1997-07-31 | 2005-03-30 | Litton Internat Company Ltd | A process for producing a herbal extract composition |
| DE10053384A1 (de) * | 2000-10-27 | 2002-05-08 | Bionorica Arzneimittel Gmbh | Pharmazeutische Zubereitung aus Mariendistel und Terpenen |
| US6699900B2 (en) * | 2001-04-07 | 2004-03-02 | Jan E. Zielinski | Hydrophilic and lipophilic silibinin pro-forms |
| DE10360954B3 (de) * | 2003-12-23 | 2005-08-18 | Esparma Gmbh | Verwendung von Silibinin, dessen Salzen und/oder dessen Prodrugs zusammen mit α-Liponsäure zur Behandlung chronisch obstruktiver Lungenerkrankungen |
| BG65997B1 (bg) * | 2005-03-29 | 2010-09-30 | "Софарма" Ад | Метод за получаване на силибинин |
| CA2703834C (en) * | 2007-11-15 | 2014-05-20 | Madaus Gmbh | Silibinin component for the treatment of hepatitis |
| TWI529167B (zh) | 2009-05-14 | 2016-04-11 | 歐羅梅德股份有限公司 | 用於治療病毒性肝炎之非晶型水飛薊賓 |
| WO2011051742A1 (en) * | 2009-10-28 | 2011-05-05 | Modutech S.A. | Preparation comprising amino acids and plants and its activity in the alcohol detoxification |
| CN103408539B (zh) * | 2013-08-28 | 2016-04-06 | 天津泰阳制药有限公司 | 高纯度水飞蓟宾的生产方法 |
| JP2019508383A (ja) * | 2016-01-15 | 2019-03-28 | ウニベルジテート ハンブルグＵｎｉｖｅｒｓｉｔａｅｔ Ｈａｍｂｕｒｇ | Ｏ−ラムノシル残基を有するフラボノイド型化合物 |
| JP2024510862A (ja) | 2020-09-29 | 2024-03-12 | ムニセクハー メダサニ， | オオアザミの植物体からの生物活性化合物抽出物及び使用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1767666C3 (de) * | 1968-06-01 | 1986-07-31 | Dr. Madaus & Co, 5000 Koeln | Pharmazeutische Zubereitung gegen Lebererkrankungen |
| DE1923082C3 (de) * | 1969-05-06 | 1985-08-22 | Dr. Madaus & Co, 5000 Koeln | Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch |
| US3773932A (en) * | 1968-06-01 | 1973-11-20 | Madaus & Co Dr | Method for recovering silymarin comprising polyhydroxyphenyl chromanones |
| DE2416302B2 (de) * | 1974-04-04 | 1978-02-02 | Dr. Madaus & Co, 5000 Köln | Dimeres sowie trimeres silybin und deren n-methylglucaminsalz und verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| BE885558A (fr) * | 1980-10-07 | 1981-04-07 | Madaus & Co Dr | Procede pour l'extraction de silymarine a partir des plantes silymarine ainsi obtenue et son utilisation en therapeutique |
| DE3225688A1 (de) * | 1982-07-09 | 1984-01-12 | Suschnik Matthias Dr | Verfahren zur gewinnung von silymarin aus silybum marianum |
-
1985
- 1985-10-23 DE DE19853537656 patent/DE3537656A1/de active Granted
- 1985-11-11 GB GB08527809A patent/GB2167746B/en not_active Expired
- 1985-11-12 CH CH4854/85A patent/CH660008A5/de not_active IP Right Cessation
- 1985-11-13 LU LU86164A patent/LU86164A1/de unknown
- 1985-11-14 NL NL8503136A patent/NL192204C/nl not_active IP Right Cessation
- 1985-11-18 FI FI854536A patent/FI84065C/fi not_active IP Right Cessation
- 1985-11-19 AT AT0337285A patent/AT391315B/de not_active IP Right Cessation
- 1985-11-20 YU YU1812/85A patent/YU43690B/xx unknown
- 1985-11-20 SE SE8505488A patent/SE457957B/sv not_active IP Right Cessation
- 1985-11-20 CS CS858379A patent/CS271321B2/cs unknown
- 1985-11-20 CA CA000495805A patent/CA1337125C/en not_active Expired - Fee Related
- 1985-11-21 HU HU854449A patent/HU195504B/hu not_active IP Right Cessation
- 1985-11-21 NO NO854657A patent/NO160206C/no unknown
- 1985-11-21 ES ES549119A patent/ES8609312A1/es not_active Expired
- 1985-11-21 PT PT81531A patent/PT81531B/pt not_active IP Right Cessation
- 1985-11-21 IE IE292785A patent/IE59209B1/en not_active IP Right Cessation
- 1985-11-21 DK DK537685A patent/DK166541B1/da not_active IP Right Cessation
- 1985-11-21 EG EG741/85A patent/EG17710A/xx active
- 1985-11-21 PL PL1985256373A patent/PL146889B1/pl unknown
- 1985-11-21 IT IT8522933A patent/IT1207508B/it active
- 1985-11-22 MX MX009231A patent/MX172175B/es unknown
- 1985-11-22 FR FR8517320A patent/FR2573426B1/fr not_active Expired
- 1985-11-22 BE BE2/60851A patent/BE903694A/fr not_active IP Right Cessation
- 1985-11-22 AR AR85302358A patent/AR241268A1/es active
-
1986
- 1986-04-16 ES ES554022A patent/ES8704482A1/es not_active Expired
-
1988
- 1988-03-18 US US07/171,176 patent/US4871763A/en not_active Expired - Fee Related
-
1991
- 1991-01-29 JP JP3009169A patent/JPH0678228B2/ja not_active Expired - Lifetime
- 1991-11-20 DK DK189491A patent/DK164866C/da not_active IP Right Cessation
-
1992
- 1992-09-17 DK DK199201145A patent/DK172879B1/da active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |