ID16158A - Garam kalsium asam [r-(r*,r*)]-2-(4-fluorofenil)-.beta,teta-dihidroksi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1h-pirol-1-heptanoat bentuk iii kristal (2:1) - Google Patents

Garam kalsium asam [r-(r*,r*)]-2-(4-fluorofenil)-.beta,teta-dihidroksi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1h-pirol-1-heptanoat bentuk iii kristal (2:1)

Info

Publication number
ID16158A
ID16158A IDP962021A ID962021A ID16158A ID 16158 A ID16158 A ID 16158A ID P962021 A IDP962021 A ID P962021A ID 962021 A ID962021 A ID 962021A ID 16158 A ID16158 A ID 16158A
Authority
ID
Indonesia
Prior art keywords
dihydroxy
carbonyl
beta
form iii
metiletyl
Prior art date
Application number
IDP962021A
Other languages
English (en)
Indonesian (id)
Inventor
Ann I Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID16158(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ID16158A publication Critical patent/ID16158A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IDP962021A 1995-07-17 1996-07-15 Garam kalsium asam [r-(r*,r*)]-2-(4-fluorofenil)-.beta,teta-dihidroksi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1h-pirol-1-heptanoat bentuk iii kristal (2:1) ID16158A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
ID16158A true ID16158A (id) 1997-09-11

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP962021A ID16158A (id) 1995-07-17 1996-07-15 Garam kalsium asam [r-(r*,r*)]-2-(4-fluorofenil)-.beta,teta-dihidroksi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1h-pirol-1-heptanoat bentuk iii kristal (2:1)

Country Status (33)

Country Link
US (1) US6121461A (uk)
JP (1) JP3296563B2 (uk)
KR (1) KR100431039B1 (uk)
CN (1) CN1081632C (uk)
AT (1) ATE207465T1 (uk)
AU (1) AU725368B2 (uk)
BG (1) BG63629B1 (uk)
BR (1) BR9610567A (uk)
CA (1) CA2220458C (uk)
CO (1) CO4700442A1 (uk)
CZ (1) CZ294109B6 (uk)
DK (1) DK0848704T3 (uk)
EA (1) EA000505B1 (uk)
EE (1) EE03607B1 (uk)
ES (1) ES2166456T3 (uk)
GE (1) GEP20002028B (uk)
HK (1) HK1018053A1 (uk)
HR (1) HRP960313B1 (uk)
HU (1) HU223598B1 (uk)
ID (1) ID16158A (uk)
IL (3) IL122162A (uk)
MX (1) MX9708857A (uk)
MY (1) MY118398A (uk)
NO (1) NO309899B1 (uk)
NZ (1) NZ312906A (uk)
PE (1) PE1798A1 (uk)
PL (1) PL192244B1 (uk)
RO (1) RO120068B1 (uk)
SK (1) SK284201B6 (uk)
TW (1) TW401399B (uk)
UA (1) UA44796C2 (uk)
WO (1) WO1997003958A1 (uk)
ZA (1) ZA966045B (uk)

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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
IL128862A (en) 1995-07-17 2007-12-03 Warner Lambert Co [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
IN191236B (uk) * 1999-05-25 2003-10-11 Ranbaxy Lab Ltd
US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
PT1235799E (pt) * 1999-11-17 2005-05-31 Teva Pharma Forma polimorfica de atorvastatina-calcio
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
WO2001044181A1 (en) * 1999-12-17 2001-06-21 Warner Lambert Research And Development Ireland Limited A process for producing crystalline atorvastatin calcium
DE60024133T2 (de) * 1999-12-17 2006-08-03 Pfizer Science And Technology Ireland Ltd., Dun Laoghaire Herstellungsverfahren auf industrieller basis von atorvastatin trihydrat hemi-kalziumsalz in kristalliner form
IL155734A0 (en) * 2000-11-03 2003-11-23 Teve Pharmaceutical Ind Ltd Atorvastatin hemi-calcium form vii
US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
LT5196B (lt) 2000-11-30 2005-02-25 Teva Pharmaceutical Industries Ltd. Naujos atorvastatino pusiau kalcio kristalinės formos ir jų gavimo būdai, taip pat ir nauji kitų formų gavimo būdai
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
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EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
EA005317B1 (ru) 2001-06-29 2004-12-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1h-пиррол-1-гептановой кислоты кальциевой соли (2:1) (аторвастатин)
EP1414796A1 (en) * 2001-07-30 2004-05-06 Dr. Reddy's Laboratories Ltd. Crystalline forms vi and vii of atorvastatin calcium
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
PE20030324A1 (es) * 2001-07-31 2003-04-03 Warner Lambert Co Composiciones farmaceuticas de amlodipina y atorvastatina
CN102516150A (zh) 2001-08-03 2012-06-27 西巴特殊化学品控股有限公司 氟伐他汀钠的晶形
US20060020137A1 (en) * 2001-11-29 2006-01-26 Limor Tessler Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
PL372303A1 (en) * 2002-02-15 2005-07-11 Teva Pharmaceutical Industries Ltd. Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix
MXPA04007995A (es) * 2002-02-19 2004-11-26 Teva Pharma Desolvatacion de solvatos de hemicalcio de atorvastatina.
ATE452871T1 (de) * 2002-03-18 2010-01-15 Biocon Ltd Amorphe hmg-coa-reduktase-inhibitoren mit gewünschter teilchengrösse
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
PL375415A1 (en) * 2002-08-06 2005-11-28 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
CA2491051A1 (en) * 2002-09-03 2004-03-18 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
SI21302A (sl) 2002-10-11 2004-04-30 LEK farmacevtska dru�ba d.d. Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
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US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
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JP5000502B2 (ja) * 2004-07-16 2012-08-15 レツク・フアーマシユーテイカルズ・デー・デー アトルバスタチンカルシウムの酸化分解生成物
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CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
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BRPI0610344A2 (pt) 2005-12-13 2016-11-29 Teva Pharma forma cristalizada do atorvastatin hemi-calcium, processo para sua preparação, produto famacêutico derivado e seu uso medicinal
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
EP1877375A1 (en) * 2006-03-01 2008-01-16 Teva Pharmaceutical Industries Ltd Process for preparing a crystalline form of atorvastatin hemi-calcium
US20070265456A1 (en) * 2006-05-09 2007-11-15 Judith Aronhime Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
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US20110142883A1 (en) * 2007-07-20 2011-06-16 Actavis Group Ptc Ehf Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
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US20090124817A1 (en) * 2007-11-09 2009-05-14 The Industry & Academic Cooperation In Chungnam National University Process for Preparing Amorphous Atorvastatin Calcium Nanoparticles
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
CZ201039A3 (cs) 2010-01-19 2011-07-27 Zentiva, K. S Zpusob prumyslové výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu) s vysokým specifickým povrchem a jeho použití v lékové forme
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN102424663B (zh) * 2010-12-03 2013-08-14 天津滨江药物研发有限公司 一种阿托伐他汀氨基酸盐及其制备方法
US9050342B2 (en) 2011-03-29 2015-06-09 Pfizer Inc. Beneficial effects of combination therapy on cholesterol
US20140335179A1 (en) 2011-07-01 2014-11-13 Dsm Sinochem Pharmaceuticals Netherlands B.V. Micronized crystals of atorvastatin hemicalcium
CN103483238B (zh) * 2013-08-20 2014-12-31 蚌埠丰原医药科技发展有限公司 阿托伐他汀钙三水合物的制备方法
CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
KR101723783B1 (ko) 2017-02-24 2017-04-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법

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Also Published As

Publication number Publication date
CN1190957A (zh) 1998-08-19
CZ12398A3 (cs) 1998-06-17
JP3296563B2 (ja) 2002-07-02
IL128863A0 (en) 2000-01-31
IL177378A0 (en) 2006-12-10
MX9708857A (es) 1998-03-31
NZ312906A (en) 2000-12-22
RO120068B1 (ro) 2005-08-30
PL192244B1 (pl) 2006-09-29
CA2220458A1 (en) 1997-02-06
CN1081632C (zh) 2002-03-27
KR19990029044A (ko) 1999-04-15
BG102186A (en) 1998-10-30
HRP960313A2 (en) 1998-04-30
HK1018053A1 (en) 1999-12-10
ES2166456T3 (es) 2002-04-16
HUP9901687A3 (en) 2000-04-28
PE1798A1 (es) 1998-03-04
NO980208L (no) 1998-01-16
HRP960313B1 (en) 2002-08-31
SK284201B6 (sk) 2004-10-05
IL122162A (en) 1999-07-14
KR100431039B1 (ko) 2004-08-25
AU725368B2 (en) 2000-10-12
JPH11509229A (ja) 1999-08-17
ATE207465T1 (de) 2001-11-15
WO1997003958A1 (en) 1997-02-06
BR9610567A (pt) 1999-07-06
CO4700442A1 (es) 1998-12-29
BG63629B1 (bg) 2002-07-31
DK0848704T3 (da) 2002-02-04
SK5998A3 (en) 1998-05-06
CA2220458C (en) 2002-09-24
ZA966045B (en) 1997-02-04
TW401399B (en) 2000-08-11
CZ294109B6 (cs) 2004-10-13
AU6484196A (en) 1997-02-18
HUP9901687A2 (hu) 1999-10-28
GEP20002028B (en) 2000-04-10
UA44796C2 (uk) 2002-03-15
EE03607B1 (et) 2002-02-15
MY118398A (en) 2004-10-30
NO309899B1 (no) 2001-04-17
HU223598B1 (hu) 2004-10-28
EE9800016A (et) 1998-08-17
NO980208D0 (no) 1998-01-16
EA199800129A1 (ru) 1998-08-27
IL122162A0 (en) 1998-04-05
US6121461A (en) 2000-09-19
IL128863A (en) 2006-09-05
PL324532A1 (en) 1998-06-08
EA000505B1 (ru) 1999-10-28

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