HUP9802702A2 - A Her-2 receptort szelektíven gátló aril- és heteroaril-kinazolinok alkalmazása gyógyszerkészítmények előállítására, az új vegyületek és az azokat tartalmazó gyógyszerkészítmények - Google Patents
A Her-2 receptort szelektíven gátló aril- és heteroaril-kinazolinok alkalmazása gyógyszerkészítmények előállítására, az új vegyületek és az azokat tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9802702A2 HUP9802702A2 HU9802702A HUP9802702A HUP9802702A2 HU P9802702 A2 HUP9802702 A2 HU P9802702A2 HU 9802702 A HU9802702 A HU 9802702A HU P9802702 A HUP9802702 A HU P9802702A HU P9802702 A2 HUP9802702 A2 HU P9802702A2
- Authority
- HU
- Hungary
- Prior art keywords
- pharmaceutical compositions
- aryl
- autophosphorylation
- properties
- new compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 230000035578 autophosphorylation Effects 0.000 title 1
- -1 heteroaryl quinazoline compounds Chemical class 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 abstract 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
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- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
- C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
A találmány a hűmán epidermális növekedési faktőr 2 típűsúreceptőrának (HER2) aktivitásával jellemezhető sejtnövekedés ésdifferenciálódás szelektív kezelési eljárására alkalmasgyógyszerkészítmények előállítására vőnatkőzik. Az alkalmazőtt vegyületek (I) általánős képletében A jelentése 5-12szénatőmős mőnő- vagy biciklűsős aril, heterőaril, ciklőalkil vagyheterőciklőalkil gyűrűrendszer; X jelentése kötés, őxigén- vagykénatőm, -SO-, -SO2-, -OCH2- -CR4=CR4-, -CC-, -NR4- vagy -NR4CH2-csőpőrt; R5, R6, R7, R8 hidrőgénatőm, alkőxi- vagy aralkőxi-csőpőrt; Rhidrőgénatőmőt vagy különböző helyettesítőket jelent. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/469,147 US5721237A (en) | 1991-05-10 | 1995-06-06 | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
Publications (2)
Publication Number | Publication Date |
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HUP9802702A2 true HUP9802702A2 (hu) | 1999-03-29 |
HUP9802702A3 HUP9802702A3 (en) | 2001-11-28 |
Family
ID=23862606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802702A HUP9802702A3 (en) | 1995-06-06 | 1996-06-06 | Use of aryl and heteroaryl quinazoline compounds having selective inhibition of her-2 autophosphorylation properties for producing pharmaceutical compositions, the new compound and pharmaceutical compositions containing them |
Country Status (14)
Country | Link |
---|---|
US (1) | US5721237A (hu) |
EP (1) | EP0831831A4 (hu) |
JP (1) | JPH11507355A (hu) |
KR (1) | KR19990022533A (hu) |
CN (1) | CN1100540C (hu) |
AU (1) | AU696456B2 (hu) |
BR (1) | BR9608638A (hu) |
CA (1) | CA2223016C (hu) |
CZ (1) | CZ289338B6 (hu) |
EA (1) | EA000840B1 (hu) |
HU (1) | HUP9802702A3 (hu) |
SI (1) | SI9620092A (hu) |
SK (1) | SK284475B6 (hu) |
WO (1) | WO1996039145A1 (hu) |
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1995
- 1995-06-06 US US08/469,147 patent/US5721237A/en not_active Expired - Lifetime
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1996
- 1996-06-06 JP JP9501889A patent/JPH11507355A/ja not_active Ceased
- 1996-06-06 HU HU9802702A patent/HUP9802702A3/hu unknown
- 1996-06-06 CZ CZ19973503A patent/CZ289338B6/cs not_active IP Right Cessation
- 1996-06-06 CA CA002223016A patent/CA2223016C/en not_active Expired - Fee Related
- 1996-06-06 AU AU61044/96A patent/AU696456B2/en not_active Ceased
- 1996-06-06 CN CN96194512A patent/CN1100540C/zh not_active Expired - Fee Related
- 1996-06-06 KR KR1019970709014A patent/KR19990022533A/ko not_active Application Discontinuation
- 1996-06-06 EP EP96918362A patent/EP0831831A4/en not_active Ceased
- 1996-06-06 WO PCT/US1996/009606 patent/WO1996039145A1/en not_active Application Discontinuation
- 1996-06-06 SK SK1663-97A patent/SK284475B6/sk not_active IP Right Cessation
- 1996-06-06 EA EA199800020A patent/EA000840B1/ru not_active IP Right Cessation
- 1996-06-06 SI SI9620092A patent/SI9620092A/sl not_active IP Right Cessation
- 1996-06-06 BR BR9608638A patent/BR9608638A/pt not_active Application Discontinuation
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CN1100540C (zh) | 2003-02-05 |
AU696456B2 (en) | 1998-09-10 |
SK166397A3 (en) | 1998-06-03 |
EP0831831A1 (en) | 1998-04-01 |
EP0831831A4 (en) | 1998-05-27 |
EA199800020A1 (ru) | 1998-06-25 |
SI9620092A (sl) | 1998-08-31 |
JPH11507355A (ja) | 1999-06-29 |
AU6104496A (en) | 1996-12-24 |
CZ350397A3 (cs) | 1998-03-18 |
BR9608638A (pt) | 1999-06-29 |
CA2223016A1 (en) | 1996-12-12 |
MX9709430A (es) | 1998-10-31 |
CZ289338B6 (cs) | 2002-01-16 |
HUP9802702A3 (en) | 2001-11-28 |
CN1187129A (zh) | 1998-07-08 |
WO1996039145A1 (en) | 1996-12-12 |
SK284475B6 (sk) | 2005-04-01 |
KR19990022533A (ko) | 1999-03-25 |
US5721237A (en) | 1998-02-24 |
EA000840B1 (ru) | 2000-04-24 |
CA2223016C (en) | 2003-05-20 |
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