MX9709430A - Compuesto de proteina tirosina quinasa, aril y heteroaril quinazolina que tienen inhibicion de las propiedades de autofosforilacion de her-2, composiciones que los contienen y uso de los mismos. - Google Patents

Compuesto de proteina tirosina quinasa, aril y heteroaril quinazolina que tienen inhibicion de las propiedades de autofosforilacion de her-2, composiciones que los contienen y uso de los mismos.

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Publication number
MX9709430A
MX9709430A MX9709430A MX9709430A MX9709430A MX 9709430 A MX9709430 A MX 9709430A MX 9709430 A MX9709430 A MX 9709430A MX 9709430 A MX9709430 A MX 9709430A MX 9709430 A MX9709430 A MX 9709430A
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MX
Mexico
Prior art keywords
aryl
autophosphorylation
properties
tyrosine kinase
protein tyrosine
Prior art date
Application number
MX9709430A
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English (en)
Other versions
MXPA97009430A (es
Inventor
Michael R Myers
Alfred P Spada
Martin P Maguire
Paul E Persons
Original Assignee
Rhone Poulenc Rorer Pharma
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Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Publication of MX9709430A publication Critical patent/MX9709430A/es
Publication of MXPA97009430A publication Critical patent/MXPA97009430A/es

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    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
    • C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

Esta invencion se refiere a un método poara el tratamiento selectivo del crecimiento y la diferencicion celular caracterizados por la actividad del receptor del factor de crecimiento epidérmico humano tipo 2 (HER2); más específicamente, esta envencion se refiere al uso de compuestos mono o bicíclicos de arilo, heteroarilo, cicloalquilo o heterocicloalquilo substituidos o no substituidos para regular el selectivamente el crecimeito celular; también se describen las composiciones farmacéuticas utiles para el tratamiento selectivo del crecimiento y la diferenciacion celular.
MXPA/A/1997/009430A 1995-06-06 1997-12-02 Compuesto de proteina tirosina quinasa, aril y heteroaril quinazolina que tienen inhibicion de laspropiedades de autofosforilacion de her-2, composiciones que los contienen y uso de los mismos MXPA97009430A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/469,147 US5721237A (en) 1991-05-10 1995-06-06 Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
US08469147 1995-06-06

Publications (2)

Publication Number Publication Date
MX9709430A true MX9709430A (es) 1998-10-31
MXPA97009430A MXPA97009430A (es) 1999-01-11

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Also Published As

Publication number Publication date
CN1100540C (zh) 2003-02-05
EA000840B1 (ru) 2000-04-24
SK166397A3 (en) 1998-06-03
CZ350397A3 (cs) 1998-03-18
EP0831831A4 (en) 1998-05-27
BR9608638A (pt) 1999-06-29
KR19990022533A (ko) 1999-03-25
AU696456B2 (en) 1998-09-10
AU6104496A (en) 1996-12-24
US5721237A (en) 1998-02-24
CZ289338B6 (cs) 2002-01-16
EA199800020A1 (ru) 1998-06-25
HUP9802702A3 (en) 2001-11-28
JPH11507355A (ja) 1999-06-29
CN1187129A (zh) 1998-07-08
CA2223016A1 (en) 1996-12-12
HUP9802702A2 (hu) 1999-03-29
WO1996039145A1 (en) 1996-12-12
SI9620092A (sl) 1998-08-31
EP0831831A1 (en) 1998-04-01
CA2223016C (en) 2003-05-20
SK284475B6 (sk) 2005-04-01

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