DE69329383D1 - Halichondrine und verwandte Verbindungen - Google Patents

Halichondrine und verwandte Verbindungen

Info

Publication number
DE69329383D1
DE69329383D1 DE69329383T DE69329383T DE69329383D1 DE 69329383 D1 DE69329383 D1 DE 69329383D1 DE 69329383 T DE69329383 T DE 69329383T DE 69329383 T DE69329383 T DE 69329383T DE 69329383 D1 DE69329383 D1 DE 69329383D1
Authority
DE
Germany
Prior art keywords
halichondrine
related compounds
norhalichondrin
halichondrin
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69329383T
Other languages
English (en)
Inventor
Yoshito Kishi
Francis Fang
Craig J Forsyth
Paula M Scola
Suk Kyoon Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of DE69329383D1 publication Critical patent/DE69329383D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69329383T 1992-03-12 1993-03-12 Halichondrine und verwandte Verbindungen Expired - Lifetime DE69329383D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84976992A 1992-03-12 1992-03-12
PCT/US1993/002330 WO1993017690A1 (en) 1992-03-12 1993-03-12 Halichondrins and related compounds

Publications (1)

Publication Number Publication Date
DE69329383D1 true DE69329383D1 (de) 2000-10-12

Family

ID=25306481

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69329383T Expired - Lifetime DE69329383D1 (de) 1992-03-12 1993-03-12 Halichondrine und verwandte Verbindungen

Country Status (14)

Country Link
US (1) US5338865A (de)
EP (1) EP0642345B1 (de)
JP (1) JPH07504664A (de)
KR (1) KR950700308A (de)
AT (1) ATE196138T1 (de)
AU (1) AU674673B2 (de)
CA (1) CA2130905A1 (de)
DE (1) DE69329383D1 (de)
FI (1) FI944178A (de)
HU (1) HUT70956A (de)
NO (1) NO943347L (de)
NZ (1) NZ251177A (de)
RU (1) RU2112773C1 (de)
WO (1) WO1993017690A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399717A (en) * 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
EP1087960B1 (de) * 1998-06-17 2011-03-23 Eisai R&D Management Co., Ltd. Makrocyclische analoga und verfahren zu ihrer verwendung und herstellung
US8097648B2 (en) * 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
US6653341B1 (en) * 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
CN109180615A (zh) * 2004-06-03 2019-01-11 卫材R&D管理有限公司 用于制备软海绵素b的类似物的中间体
EP3587408A1 (de) 2004-06-03 2020-01-01 Eisai R&D Management Co., Ltd. Zwischenstoffe zur herstellung von halichondrin b
US20060045846A1 (en) * 2004-08-30 2006-03-02 Horstmann Thomas E Reagents and methods for labeling terminal olefins
CN104311571B (zh) 2007-10-03 2019-07-02 卫材R&D管理有限公司 用于合成软海绵素b类似物的中间体和方法
RU2517167C2 (ru) * 2008-04-04 2014-05-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Аналоги галихондрина в
CA2787919C (en) * 2010-01-26 2018-07-31 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
CN104053645A (zh) 2011-11-30 2014-09-17 阿方拉研究股份有限公司 用于制备(3r)-2,4-二-离去基团-3-甲基丁-1-烯的工艺
JP2015501818A (ja) 2011-12-16 2015-01-19 アルフォラ リサーチ インコーポレイテッドＡｌｐｈｏｒａ Ｒｅｓｅａｒｃｈ Ｉｎｃ． ３−（（２ｓ，５ｓ）−４−メチレン−５−（３−オキソプロピル）テトラヒドロフラン−２−イル）プロパノール誘導体およびそれらの有用な中間体を調製する方法
CN104080793B (zh) 2011-12-29 2017-09-19 阿方拉研究股份有限公司 2‑((2s,3s,4r,5r)‑5‑((s)‑3‑氨基‑2‑羟基丙‑1‑基)‑4‑甲氧基‑3‑(苯磺酰甲基)四氢呋喃‑2‑基)乙醛衍生物以及它们的制备方法
AU2013239290B2 (en) 2012-03-30 2017-08-03 Sandoz Ag Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein
EP2997017B1 (de) 2013-05-15 2017-08-09 Alphora Research Inc. 3-((2s,5s)-4-methylen-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol-derivate, deren herstellung und zwischenprodukte davon
JP6511613B2 (ja) 2013-07-03 2019-05-15 サンド・アクチエンゲゼルシヤフト ハリコンドリンＢの大環状Ｃ１−ケト類似体の製造のための合成方法及び該方法に有用な中間体、例えば−ＳＯ２−（ｐ−トリル）基を含有する中間体
JP6625533B2 (ja) 2013-11-04 2019-12-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 ハリコンドリンｂの類縁体の合成において有用な大環化反応および中間体
BR112016012237B1 (pt) 2013-12-06 2023-02-07 Eisai R&D Management Co., Ltd Métodos úteis na síntese de análogos de halicondrina b
US10556910B2 (en) 2014-06-30 2020-02-11 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
US10308661B2 (en) * 2015-05-07 2019-06-04 Eisai R&D Management Co., Ltd. Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
JP6786610B2 (ja) 2016-02-12 2020-11-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 エリブリンの合成における中間体および関連する合成方法
US11136335B2 (en) 2016-06-30 2021-10-05 Eisai R&D Management Co., Ltd. Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
TWI836643B (zh) 2017-04-05 2024-03-21 哈佛大學校長及研究員協會 巨環化合物及其用途
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
HUE061306T2 (hu) 2017-07-06 2023-06-28 Harvard College Halikondrinok szintézise
JP7266267B2 (ja) * 2017-07-06 2023-04-28 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｆｅ／ｃｕ媒介ケトン合成
EP4403560A3 (de) 2017-11-15 2024-10-23 President And Fellows Of Harvard College Makrozyklische verbindungen und verwendungen davon
US11542269B2 (en) 2018-01-03 2023-01-03 Eisai R&D Management Co., Ltd. Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
CN111285894B (zh) * 2018-12-10 2021-03-05 北京天一绿甫医药科技有限公司 用于制备软海绵素类化合物的中间体及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206244D0 (en) * 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge

Also Published As

Publication number Publication date
RU94042393A (ru) 1996-07-20
EP0642345A1 (de) 1995-03-15
ATE196138T1 (de) 2000-09-15
EP0642345B1 (de) 2000-09-06
FI944178A0 (fi) 1994-09-09
US5338865A (en) 1994-08-16
KR950700308A (ko) 1995-01-16
NO943347D0 (no) 1994-09-09
WO1993017690A1 (en) 1993-09-16
NZ251177A (en) 1996-10-28
JPH07504664A (ja) 1995-05-25
RU2112773C1 (ru) 1998-06-10
HUT70956A (en) 1995-11-28
EP0642345A4 (en) 1995-04-19
HU9402600D0 (en) 1994-12-28
CA2130905A1 (en) 1993-09-16
FI944178A (fi) 1994-09-09
AU3808293A (en) 1993-10-05
AU674673B2 (en) 1997-01-09
NO943347L (no) 1994-11-09

Similar Documents

Publication Publication Date Title
ATE196138T1 (de) Halichondrine und verwandte verbindungen
ATE67493T1 (de) Heterocyclische verbindungen.
ZA921804B (en) Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.
AU649421B2 (en) Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs
IL106517A0 (en) Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
ATE30591T1 (de) Totalsynthese von antitumorantibiotika.
DE69333062D1 (de) 4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
GR3023040T3 (en) Substituted indoles as anti-aids pharmaceuticals
CO4290432A1 (es) Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos.
DE3581566D1 (de) Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte.
YU40002A (sh) Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze
NO944946D0 (no) Forgrenet-amino-substituerte tiazoler, fremgangsmåter for fremstilling av dem og farmasöytiske blandinger inneholdende dem
GR1001597B (el) Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
ATE165357T1 (de) Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen
ES471809A1 (es) Procedimiento para preparar derivados de naftaleno
GR3023757T3 (en) Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents.
HUP9802518A2 (hu) Szulfonamidcsoporttal szubsztituált benzopiránszármazékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
FI870460A (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
DE3463143D1 (en) 1-0-alkyl-3-amino-propan-1.2-diol-2-0-phospholipids, process for producing the same and pharmaceutical preparations containing the same
RU94040727A (ru) Ангидриды кислот, способ их получения, таксаны, способ их получения и фармацевтическая композиция
SE9203824D0 (sv) Benzofuranylimidazole derivatives a process for the preparation and therapeutical compositions containing the same
NO305556B1 (no) Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer
ATE12393T1 (de) Synthese von 1rs,4sr,5rs-4-(4,8-dimethyl-5hydroxy-7-nonen-1-yl)-4-methyl-3,8dioxabicyclo(3.2.1)octan-1-essigs|ure und verwandte verbindungen.
DE3664044D1 (de) N,n-dialkylaminoalkyl-hexahydro-5-oxo-1h-pyrrolizine-3-carboxamides

Legal Events

Date Code Title Description
8332 No legal effect for de