NO943347L - Halichondriner og beslektede forbindelser - Google Patents

Halichondriner og beslektede forbindelser

Info

Publication number
NO943347L
NO943347L NO943347A NO943347A NO943347L NO 943347 L NO943347 L NO 943347L NO 943347 A NO943347 A NO 943347A NO 943347 A NO943347 A NO 943347A NO 943347 L NO943347 L NO 943347L
Authority
NO
Norway
Prior art keywords
halichondrins
related compounds
norhalichondrin
halichondrin
compounds
Prior art date
Application number
NO943347A
Other languages
English (en)
Other versions
NO943347D0 (no
Inventor
Yoshito Kishi
Francis Fang
Craig J Forsyth
Paula M Scola
Suk Kyoon Yoon
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of NO943347D0 publication Critical patent/NO943347D0/no
Publication of NO943347L publication Critical patent/NO943347L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nye kjemiske forbindelser som kan anvendes til syntese av halikondrin B og norhalikondrin B, og beslektede derivater. Den totale syntese av halikondrin B og norhalikondrin B er også beskrevet.
NO943347A 1992-03-12 1994-09-09 Halichondriner og beslektede forbindelser NO943347L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84976992A 1992-03-12 1992-03-12
PCT/US1993/002330 WO1993017690A1 (en) 1992-03-12 1993-03-12 Halichondrins and related compounds

Publications (2)

Publication Number Publication Date
NO943347D0 NO943347D0 (no) 1994-09-09
NO943347L true NO943347L (no) 1994-11-09

Family

ID=25306481

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943347A NO943347L (no) 1992-03-12 1994-09-09 Halichondriner og beslektede forbindelser

Country Status (14)

Country Link
US (1) US5338865A (no)
EP (1) EP0642345B1 (no)
JP (1) JPH07504664A (no)
KR (1) KR950700308A (no)
AT (1) ATE196138T1 (no)
AU (1) AU674673B2 (no)
CA (1) CA2130905A1 (no)
DE (1) DE69329383D1 (no)
FI (1) FI944178A0 (no)
HU (1) HUT70956A (no)
NO (1) NO943347L (no)
NZ (1) NZ251177A (no)
RU (1) RU2112773C1 (no)
WO (1) WO1993017690A1 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399717A (en) * 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
US6653341B1 (en) * 1998-06-17 2003-11-25 Eisai Co., Ltd. Methods and compositions for use in treating cancer
IL139960A0 (en) * 1998-06-17 2002-02-10 Eisai Co Ltd Macrocylic analogs and methods of their use and preparation
US8097648B2 (en) * 1998-06-17 2012-01-17 Eisai R&D Management Co., Ltd. Methods and compositions for use in treating cancer
CN108997267A (zh) * 2004-06-03 2018-12-14 卫材R&D管理有限公司 用于制备软海绵素b的类似物的中间体
SI2522663T1 (sl) 2004-06-03 2015-08-31 Eisai R&D Management Co., Ltd. Vmesne spojine za pripravo halihondrina B
US20060045846A1 (en) * 2004-08-30 2006-03-02 Horstmann Thomas E Reagents and methods for labeling terminal olefins
US8093410B2 (en) 2007-10-03 2012-01-10 Eisai R&D Management Co., Ltd. Intermediates and methods for the synthesis of halichondrin B analogs
CN105801599A (zh) * 2008-04-04 2016-07-27 卫材R&D管理有限公司 软海绵素b类似物
WO2011094339A1 (en) * 2010-01-26 2011-08-04 Eisai R&D Management Co., Ltd. Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs
AU2012344697A1 (en) 2011-11-30 2014-07-10 Alphora Research Inc. Process for preparation of (3R)-2,4-di-leaving group-3-methylbut-1-ene
WO2013086634A1 (en) 2011-12-16 2013-06-20 Alphora Research Inc. Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof
JP6300030B2 (ja) 2011-12-29 2018-03-28 サンド アクツィエンゲゼルシャフト ２−（（２ｓ，３ｓ，４ｒ，５ｒ）−５−（（ｓ）−３−アミノ−２−ヒドロキシプロプ−１−イル）−４−メトキシ−３−（フェニルスルホニルメチル）テトラヒドロフラン−２−イル）アセトアルデヒド誘導体およびこれらを調製するためのプロセス
IN2014MN02106A (no) 2012-03-30 2015-09-11 Alphora Res Inc
AU2014268086A1 (en) 2013-05-15 2015-11-05 Alphora Research Inc. 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof
US9850254B2 (en) 2013-07-03 2017-12-26 Sandoz Ag Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing-SO2-(p-tolyl) groups
ES2787603T3 (es) 2013-11-04 2020-10-16 Eisai R&D Man Co Ltd Reacciones de macrociclación y productos intermedios útiles en la síntesis de análogos de halicondrina B
CN105916861B (zh) 2013-12-06 2018-12-14 卫材R&D管理有限公司 可用于合成软海绵素b类似物的方法
WO2016003975A1 (en) 2014-06-30 2016-01-07 President And Fellows Of Harvard College Synthesis of halichondrin analogs and uses thereof
WO2016176560A1 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Chromium-mediated coupling and application to the synthesis of halichondrins
MX2017014237A (es) 2015-05-07 2018-09-17 Eisai R&D Man Co Ltd Reacciones de macro-ciclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
EP3413887B1 (en) 2016-02-12 2021-04-07 Eisai R&D Management Co., Ltd. Intermediates in the synthesis of eribulin and related methods of synthesis
MX2018016329A (es) 2016-06-30 2019-09-18 Eisai R&D Man Co Ltd Reaccion de prins e intermediarios utiles en la sintesis de macrolidos de halicondrina y analogos de los mismos.
JP6978758B2 (ja) 2016-11-11 2021-12-08 プレジデント アンド フェローズ オブ ハーバード カレッジ パラジウム媒介ケトール化
WO2018187331A1 (en) 2017-04-05 2018-10-11 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
US9938288B1 (en) 2017-04-05 2018-04-10 President And Fellows Of Harvard College Macrocyclic compound and uses thereof
JP7266267B2 (ja) * 2017-07-06 2023-04-28 プレジデント アンド フェローズ オブ ハーバード カレッジ Ｆｅ／ｃｕ媒介ケトン合成
US11498892B2 (en) 2017-07-06 2022-11-15 President And Fellows Of Harvard College Fe/Cu-mediated ketone synthesis
SG11201912342QA (en) 2017-07-06 2020-01-30 Harvard College Synthesis of halichondrins
CN111566113B (zh) * 2017-11-15 2024-01-09 哈佛大学的校长及成员们 大环化合物及其用途
CN111868044A (zh) 2018-01-03 2020-10-30 卫材R&D管理有限公司 可用于合成软海绵素大环内酯及其类似物的普林斯反应和化合物
CN111285894B (zh) * 2018-12-10 2021-03-05 北京天一绿甫医药科技有限公司 用于制备软海绵素类化合物的中间体及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9206244D0 (en) * 1992-03-23 1992-05-06 Pharma Mar Sa Cytotoxic compound from a marine sponge

Also Published As

Publication number Publication date
EP0642345A1 (en) 1995-03-15
RU94042393A (ru) 1996-07-20
NZ251177A (en) 1996-10-28
AU674673B2 (en) 1997-01-09
ATE196138T1 (de) 2000-09-15
EP0642345A4 (en) 1995-04-19
KR950700308A (ko) 1995-01-16
CA2130905A1 (en) 1993-09-16
AU3808293A (en) 1993-10-05
HU9402600D0 (en) 1994-12-28
FI944178A (fi) 1994-09-09
WO1993017690A1 (en) 1993-09-16
JPH07504664A (ja) 1995-05-25
NO943347D0 (no) 1994-09-09
DE69329383D1 (de) 2000-10-12
US5338865A (en) 1994-08-16
HUT70956A (en) 1995-11-28
FI944178A0 (fi) 1994-09-09
EP0642345B1 (en) 2000-09-06
RU2112773C1 (ru) 1998-06-10

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