ATE196138T1 - Halichondrine und verwandte verbindungen - Google Patents
Halichondrine und verwandte verbindungenInfo
- Publication number
- ATE196138T1 ATE196138T1 AT93907496T AT93907496T ATE196138T1 AT E196138 T1 ATE196138 T1 AT E196138T1 AT 93907496 T AT93907496 T AT 93907496T AT 93907496 T AT93907496 T AT 93907496T AT E196138 T1 ATE196138 T1 AT E196138T1
- Authority
- AT
- Austria
- Prior art keywords
- halichondrine
- related compounds
- norhalichondrin
- halichondrin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84976992A | 1992-03-12 | 1992-03-12 | |
PCT/US1993/002330 WO1993017690A1 (en) | 1992-03-12 | 1993-03-12 | Halichondrins and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE196138T1 true ATE196138T1 (de) | 2000-09-15 |
Family
ID=25306481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93907496T ATE196138T1 (de) | 1992-03-12 | 1993-03-12 | Halichondrine und verwandte verbindungen |
Country Status (14)
Country | Link |
---|---|
US (1) | US5338865A (de) |
EP (1) | EP0642345B1 (de) |
JP (1) | JPH07504664A (de) |
KR (1) | KR950700308A (de) |
AT (1) | ATE196138T1 (de) |
AU (1) | AU674673B2 (de) |
CA (1) | CA2130905A1 (de) |
DE (1) | DE69329383D1 (de) |
FI (1) | FI944178A0 (de) |
HU (1) | HUT70956A (de) |
NO (1) | NO943347L (de) |
NZ (1) | NZ251177A (de) |
RU (1) | RU2112773C1 (de) |
WO (1) | WO1993017690A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399717A (en) * | 1993-09-29 | 1995-03-21 | Merck & Co., Inc. | Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1 |
WO1999065894A1 (en) * | 1998-06-17 | 1999-12-23 | Eisai Co., Ltd. | Macrocyclic analogs and methods of their use and preparation |
US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
US6653341B1 (en) * | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
KR101434673B1 (ko) | 2004-06-03 | 2014-08-26 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 b 유사체의 제조를 위한 중간체 |
CN109180615A (zh) * | 2004-06-03 | 2019-01-11 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
US20060045846A1 (en) * | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
CN104311571B (zh) | 2007-10-03 | 2019-07-02 | 卫材R&D管理有限公司 | 用于合成软海绵素b类似物的中间体和方法 |
WO2009124237A1 (en) | 2008-04-04 | 2009-10-08 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
MX2012008510A (es) * | 2010-01-26 | 2012-11-21 | Eisai R&D Man Co Ltd | Derivados de furo [3, 2-b] pirano utiles en la sintesis de analogos de halicondrina b. |
JP2015500210A (ja) | 2011-11-30 | 2015-01-05 | アルフォラ リサーチ インコーポレイテッドAlphora Research Inc. | (3r)−2,4−ジ−脱離基−3−メチルブタ−1−エンの調製方法 |
CN104024237B (zh) | 2011-12-16 | 2016-02-24 | 阿方拉研究股份有限公司 | 用于制备3-((2s,5s)-4-亚甲基-5-(3-氧代丙基)四氢呋喃-2-基)丙醇衍生物的方法及其有用的中间体 |
US9062020B2 (en) | 2011-12-29 | 2015-06-23 | Alphora Research Inc. | 2-((2S,3S,4R,5R)-5-((S)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl)tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
US9278979B2 (en) | 2012-03-30 | 2016-03-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein |
WO2014183211A1 (en) | 2013-05-15 | 2014-11-20 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
WO2015000070A1 (en) | 2013-07-03 | 2015-01-08 | Alphora Research Inc. | Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein including intermediates containing -so2-(p-tolyl) groups |
WO2015066729A1 (en) | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
CN105916861B (zh) | 2013-12-06 | 2018-12-14 | 卫材R&D管理有限公司 | 可用于合成软海绵素b类似物的方法 |
WO2016003975A1 (en) * | 2014-06-30 | 2016-01-07 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
RU2739034C2 (ru) * | 2015-05-07 | 2020-12-21 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Реакции макроциклизации и промежуточное соединение и другие фрагменты, полезные в синтезе макролидов галихондринов |
US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
WO2018006031A1 (en) | 2016-06-30 | 2018-01-04 | Eisai R&D Management Co., Ltd. | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
JOP20190234B1 (ar) | 2017-04-05 | 2023-09-17 | Eisai Randd Man Co Ltd | مركب كبير الحلقات واستخداماته |
US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
KR20220124279A (ko) | 2017-07-06 | 2022-09-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 할리콘드린의 합성 |
JP7266267B2 (ja) * | 2017-07-06 | 2023-04-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Fe/cu媒介ケトン合成 |
US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
ES2974243T3 (es) | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
WO2019136145A1 (en) | 2018-01-03 | 2019-07-11 | Eisai R&D Management Co., Ltd. | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof |
CN111285894B (zh) * | 2018-12-10 | 2021-03-05 | 北京天一绿甫医药科技有限公司 | 用于制备软海绵素类化合物的中间体及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9206244D0 (en) * | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
-
1993
- 1993-01-29 US US08/011,104 patent/US5338865A/en not_active Expired - Lifetime
- 1993-03-12 NZ NZ251177A patent/NZ251177A/en unknown
- 1993-03-12 WO PCT/US1993/002330 patent/WO1993017690A1/en active IP Right Grant
- 1993-03-12 AU AU38082/93A patent/AU674673B2/en not_active Ceased
- 1993-03-12 CA CA002130905A patent/CA2130905A1/en not_active Abandoned
- 1993-03-12 JP JP5516045A patent/JPH07504664A/ja active Pending
- 1993-03-12 AT AT93907496T patent/ATE196138T1/de not_active IP Right Cessation
- 1993-03-12 DE DE69329383T patent/DE69329383D1/de not_active Expired - Lifetime
- 1993-03-12 HU HU9402600A patent/HUT70956A/hu active IP Right Revival
- 1993-03-12 RU RU94042393A patent/RU2112773C1/ru active
- 1993-03-12 EP EP93907496A patent/EP0642345B1/de not_active Expired - Lifetime
-
1994
- 1994-09-09 NO NO943347A patent/NO943347L/no unknown
- 1994-09-09 FI FI944178A patent/FI944178A0/fi unknown
- 1994-09-12 KR KR1019940703186A patent/KR950700308A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0642345A4 (en) | 1995-04-19 |
RU2112773C1 (ru) | 1998-06-10 |
DE69329383D1 (de) | 2000-10-12 |
WO1993017690A1 (en) | 1993-09-16 |
KR950700308A (ko) | 1995-01-16 |
HUT70956A (en) | 1995-11-28 |
AU674673B2 (en) | 1997-01-09 |
RU94042393A (ru) | 1996-07-20 |
NO943347D0 (no) | 1994-09-09 |
NO943347L (no) | 1994-11-09 |
AU3808293A (en) | 1993-10-05 |
CA2130905A1 (en) | 1993-09-16 |
FI944178A (fi) | 1994-09-09 |
HU9402600D0 (en) | 1994-12-28 |
US5338865A (en) | 1994-08-16 |
FI944178A0 (fi) | 1994-09-09 |
EP0642345B1 (de) | 2000-09-06 |
JPH07504664A (ja) | 1995-05-25 |
NZ251177A (en) | 1996-10-28 |
EP0642345A1 (de) | 1995-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE196138T1 (de) | Halichondrine und verwandte verbindungen | |
ATE67493T1 (de) | Heterocyclische verbindungen. | |
ZA921804B (en) | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them. | |
AU649421B2 (en) | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs | |
IL106517A0 (en) | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group | |
ATE243694T1 (de) | 4-mercaptoacetylamino-(2)benzazepinon(3)- derivate, und verwendung als enkephalinase- inhibitoren | |
GR3023040T3 (en) | Substituted indoles as anti-aids pharmaceuticals | |
DE3581566D1 (de) | Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte. | |
YU40002A (sh) | Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze | |
NO304598B1 (no) | Forgrenet-amino-substituerte tiazoler, anvendelse av dem og farmas°ytiske blandinger inneholdende dem | |
GR1001597B (el) | Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών. | |
ATE165357T1 (de) | Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen | |
ES471809A1 (es) | Procedimiento para preparar derivados de naftaleno | |
GR3023757T3 (en) | Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents. | |
HUP9802518A2 (hu) | Szulfonamidcsoporttal szubsztituált benzopiránszármazékok, eljárás előállításukra, gyógyszerként történő alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
FI870460A (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter. | |
DE3463143D1 (en) | 1-0-alkyl-3-amino-propan-1.2-diol-2-0-phospholipids, process for producing the same and pharmaceutical preparations containing the same | |
RU94040727A (ru) | Ангидриды кислот, способ их получения, таксаны, способ их получения и фармацевтическая композиция | |
SE9203824D0 (sv) | Benzofuranylimidazole derivatives a process for the preparation and therapeutical compositions containing the same | |
ATE12393T1 (de) | Synthese von 1rs,4sr,5rs-4-(4,8-dimethyl-5hydroxy-7-nonen-1-yl)-4-methyl-3,8dioxabicyclo(3.2.1)octan-1-essigs|ure und verwandte verbindungen. | |
ATE44149T1 (de) | N,n-dialkylaminoalkyl-hexahydro-5-oxo-1hpyrrolizin-3-carboxamide. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |