ATE196138T1 - Halichondrine und verwandte verbindungen - Google Patents
Halichondrine und verwandte verbindungenInfo
- Publication number
- ATE196138T1 ATE196138T1 AT93907496T AT93907496T ATE196138T1 AT E196138 T1 ATE196138 T1 AT E196138T1 AT 93907496 T AT93907496 T AT 93907496T AT 93907496 T AT93907496 T AT 93907496T AT E196138 T1 ATE196138 T1 AT E196138T1
- Authority
- AT
- Austria
- Prior art keywords
- halichondrine
- related compounds
- norhalichondrin
- halichondrin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dental Preparations (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84976992A | 1992-03-12 | 1992-03-12 | |
| PCT/US1993/002330 WO1993017690A1 (en) | 1992-03-12 | 1993-03-12 | Halichondrins and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE196138T1 true ATE196138T1 (de) | 2000-09-15 |
Family
ID=25306481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93907496T ATE196138T1 (de) | 1992-03-12 | 1993-03-12 | Halichondrine und verwandte verbindungen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5338865A (de) |
| EP (1) | EP0642345B1 (de) |
| JP (1) | JPH07504664A (de) |
| KR (1) | KR950700308A (de) |
| AT (1) | ATE196138T1 (de) |
| AU (1) | AU674673B2 (de) |
| CA (1) | CA2130905A1 (de) |
| DE (1) | DE69329383D1 (de) |
| FI (1) | FI944178A0 (de) |
| HU (1) | HUT70956A (de) |
| NO (1) | NO943347L (de) |
| NZ (1) | NZ251177A (de) |
| RU (1) | RU2112773C1 (de) |
| WO (1) | WO1993017690A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399717A (en) * | 1993-09-29 | 1995-03-21 | Merck & Co., Inc. | Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1 |
| IL139960A0 (en) * | 1998-06-17 | 2002-02-10 | Eisai Co Ltd | Macrocylic analogs and methods of their use and preparation |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| CN101899026B (zh) | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| CN109180615A (zh) * | 2004-06-03 | 2019-01-11 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| US20060045846A1 (en) * | 2004-08-30 | 2006-03-02 | Horstmann Thomas E | Reagents and methods for labeling terminal olefins |
| BRPI0817909B1 (pt) * | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| JP6001857B2 (ja) * | 2008-04-04 | 2016-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体 |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| EP2785687B1 (de) | 2011-11-30 | 2019-02-20 | Sandoz AG | Verfahren zur herstellung von (3r-)2,4-di-abganbgsgruppen-3-methylbut-1-en |
| EP2791123B1 (de) | 2011-12-16 | 2018-07-18 | Sandoz AG | Verfahren zur herstellung von 3-((2s, 5s)-4-methylen-5-(3-oxopropyl) tetrahydrofuran-2-yl)-propanolderivaten und zwischenprodukte davon |
| AU2012363334B2 (en) | 2011-12-29 | 2017-02-02 | Alphora Research Inc. | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl) tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| WO2014183211A1 (en) | 2013-05-15 | 2014-11-20 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| AU2014286880B2 (en) | 2013-07-03 | 2017-12-14 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing -SO2-(p-TOLYL) groups |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX380284B (es) * | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| SG11201811671XA (en) | 2016-06-30 | 2019-01-30 | Eisai R&D Man Co Ltd | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| JP7168580B2 (ja) | 2017-04-05 | 2022-11-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびその使用 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| JP7266267B2 (ja) * | 2017-07-06 | 2023-04-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｆｅ／ｃｕ媒介ケトン合成 |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| IL295588B2 (en) | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of halichondrins |
| ES2974243T3 (es) * | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
| KR20250057138A (ko) | 2018-01-03 | 2025-04-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 화합물 |
| CN111285894B (zh) | 2018-12-10 | 2021-03-05 | 北京天一绿甫医药科技有限公司 | 用于制备软海绵素类化合物的中间体及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9206244D0 (en) * | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
-
1993
- 1993-01-29 US US08/011,104 patent/US5338865A/en not_active Expired - Lifetime
- 1993-03-12 AU AU38082/93A patent/AU674673B2/en not_active Ceased
- 1993-03-12 RU RU94042393A patent/RU2112773C1/ru active
- 1993-03-12 WO PCT/US1993/002330 patent/WO1993017690A1/en not_active Ceased
- 1993-03-12 FI FI944178A patent/FI944178A0/fi unknown
- 1993-03-12 AT AT93907496T patent/ATE196138T1/de not_active IP Right Cessation
- 1993-03-12 CA CA002130905A patent/CA2130905A1/en not_active Abandoned
- 1993-03-12 EP EP93907496A patent/EP0642345B1/de not_active Expired - Lifetime
- 1993-03-12 JP JP5516045A patent/JPH07504664A/ja active Pending
- 1993-03-12 NZ NZ251177A patent/NZ251177A/en unknown
- 1993-03-12 DE DE69329383T patent/DE69329383D1/de not_active Expired - Lifetime
- 1993-03-12 HU HU9402600A patent/HUT70956A/hu active IP Right Revival
-
1994
- 1994-09-09 NO NO943347A patent/NO943347L/no unknown
- 1994-09-12 KR KR1019940703186A patent/KR950700308A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| NZ251177A (en) | 1996-10-28 |
| HUT70956A (en) | 1995-11-28 |
| FI944178L (fi) | 1994-09-09 |
| DE69329383D1 (de) | 2000-10-12 |
| RU94042393A (ru) | 1996-07-20 |
| KR950700308A (ko) | 1995-01-16 |
| EP0642345A1 (de) | 1995-03-15 |
| EP0642345A4 (en) | 1995-04-19 |
| RU2112773C1 (ru) | 1998-06-10 |
| CA2130905A1 (en) | 1993-09-16 |
| WO1993017690A1 (en) | 1993-09-16 |
| AU3808293A (en) | 1993-10-05 |
| FI944178A7 (fi) | 1994-09-09 |
| HU9402600D0 (en) | 1994-12-28 |
| EP0642345B1 (de) | 2000-09-06 |
| AU674673B2 (en) | 1997-01-09 |
| JPH07504664A (ja) | 1995-05-25 |
| FI944178A0 (fi) | 1994-09-09 |
| NO943347D0 (no) | 1994-09-09 |
| US5338865A (en) | 1994-08-16 |
| NO943347L (no) | 1994-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE196138T1 (de) | Halichondrine und verwandte verbindungen | |
| ATE67493T1 (de) | Heterocyclische verbindungen. | |
| ZA921804B (en) | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them. | |
| AU649421B2 (en) | Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs | |
| IL106517A0 (en) | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group | |
| ES2149883T3 (es) | Sintesis quimica de taxol y de derivados de taxol. | |
| ATE243694T1 (de) | 4-mercaptoacetylamino-(2)benzazepinon(3)- derivate, und verwendung als enkephalinase- inhibitoren | |
| ATE30591T1 (de) | Totalsynthese von antitumorantibiotika. | |
| ATE251141T1 (de) | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien | |
| GR3023040T3 (en) | Substituted indoles as anti-aids pharmaceuticals | |
| CO4290432A1 (es) | Nuevos derivados de pirazinacarboxamida, su preparacion y su utilizacion en medicamentos. | |
| DE3581566D1 (de) | Oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte. | |
| NO304598B1 (no) | Forgrenet-amino-substituerte tiazoler, anvendelse av dem og farmas°ytiske blandinger inneholdende dem | |
| NO951747L (no) | Fremgangsmåte ved fremstilling av xylitol | |
| YU40002A (sh) | Antipikornavirusna jedinjenja i kompozicije, njihove farmaceutske upotrebe, i materijali za njihove sinteze | |
| HUP9701660A2 (hu) | 10,13,15-trioxa-triciklo[9.2.1.1. 9.6]pentadekanon-származékok, eljárás ezek előállítására, és az e vegyületeket tartalmazó gyógyászati készítmények | |
| EP0660822A1 (de) | Cyclische benzylamino-, benzylamido- und benzylimido derivate als antipsychotische wirkstoffe. | |
| TR199701298T1 (xx) | Tetralinler. | |
| FI870460A0 (fi) | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter. | |
| RU94040727A (ru) | Ангидриды кислот, способ их получения, таксаны, способ их получения и фармацевтическая композиция | |
| NO305556B1 (no) | Tiokarbamoylforbindelser og anvendelse derav samt middel for beskyttelse av tekniske materialer | |
| ATE87314T1 (de) | Platin-arzneimittel. | |
| NO984227L (no) | Cycloalkylderivater og syntese i fast fase av slike derivater | |
| ATE12393T1 (de) | Synthese von 1rs,4sr,5rs-4-(4,8-dimethyl-5hydroxy-7-nonen-1-yl)-4-methyl-3,8dioxabicyclo(3.2.1)octan-1-essigs|ure und verwandte verbindungen. | |
| DE3664044D1 (de) | N,n-dialkylaminoalkyl-hexahydro-5-oxo-1h-pyrrolizine-3-carboxamides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |