HUP0400610A2 - Javított eljárás benzimidazoltípusú vegyületek előállítására - Google Patents

Javított eljárás benzimidazoltípusú vegyületek előállítására

Info

Publication number
HUP0400610A2
HUP0400610A2 HU0400610A HUP0400610A HUP0400610A2 HU P0400610 A2 HUP0400610 A2 HU P0400610A2 HU 0400610 A HU0400610 A HU 0400610A HU P0400610 A HUP0400610 A HU P0400610A HU P0400610 A2 HUP0400610 A2 HU P0400610A2
Authority
HU
Hungary
Prior art keywords
improved process
type compounds
general formula
methoxy
extracted
Prior art date
Application number
HU0400610A
Other languages
English (en)
Inventor
Rudy Laurent Maria Broeckx
Stefan Marcel Herman Leurs
Dirk De Smaele
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of HUP0400610A2 publication Critical patent/HUP0400610A2/hu
Publication of HUP0400610A3 publication Critical patent/HUP0400610A3/hu
Publication of HU230155B1 publication Critical patent/HU230155B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

A találmány tárgya javított eljárás (I) általános képletűbenzimidazol-típusú vegyületek előállítására - a képletben R1 és R2jelentése azonos vagy különböző, hidrogénatom, metoxi- vagydifluormetoxicsoport, R3, R4 és R5 jelentése azonos vagy különböző,hidrogénatom, metil-, metoxi-, metoxipropoxi- vagytrifluormetoxicsoport -, oly módon, hogy a) egy (II) általános képletűvegyületet egy alkalmas oldószerben egy oxidálószerrel reagáltatnak,b) a reakcióelegyet egy 9, 50 és 12, 00 közötti pH-értékű vizesalkálikus oldattal extrahálják, és a vizes fázist eltávolítják, c) azelőző lépésben kapott szerves fázist egy 13,00 vagy ennél magasabb pH-értékű vizes alkálikus oldattal extrahálják, és a szerves fázisteltávolítják, d) az előző lépésben kapott vizes fázisból elkülönítikaz (I) általános képletű vegyületet. Ó
HU0400610A 2001-07-16 2002-07-09 Javított eljárás benzimidazol típusú vegyületek előállítására HU230155B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01202696.9 2001-07-16
EP01202696 2001-07-16
PCT/EP2002/007693 WO2003008406A1 (en) 2001-07-16 2002-07-09 Improved process for preparing benzimidazole-type compounds

Publications (3)

Publication Number Publication Date
HUP0400610A2 true HUP0400610A2 (hu) 2004-08-30
HUP0400610A3 HUP0400610A3 (en) 2012-09-28
HU230155B1 HU230155B1 (hu) 2015-09-28

Family

ID=8180641

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400610A HU230155B1 (hu) 2001-07-16 2002-07-09 Javított eljárás benzimidazol típusú vegyületek előállítására

Country Status (23)

Country Link
US (1) US6919459B2 (hu)
EP (1) EP1409478B1 (hu)
JP (1) JP4320250B2 (hu)
KR (1) KR100914175B1 (hu)
CN (1) CN1235899C (hu)
AT (1) ATE321758T1 (hu)
AU (1) AU2002321204B2 (hu)
BR (1) BRPI0211101B8 (hu)
CA (1) CA2450433C (hu)
CZ (1) CZ304526B6 (hu)
DE (1) DE60210292T2 (hu)
EA (1) EA005773B1 (hu)
EE (1) EE05402B1 (hu)
ES (1) ES2261703T3 (hu)
HK (1) HK1069168A1 (hu)
HU (1) HU230155B1 (hu)
IL (2) IL159854A0 (hu)
MX (1) MXPA04000433A (hu)
NO (1) NO324257B1 (hu)
NZ (1) NZ530168A (hu)
PL (1) PL208291B1 (hu)
SK (1) SK287245B6 (hu)
WO (1) WO2003008406A1 (hu)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003278406A1 (en) * 2002-10-22 2004-05-13 Ranbaxy Laboratories Limited Amorphous form of esomeprazole salts
CA2528993A1 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
JP4987477B2 (ja) * 2004-08-20 2012-07-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンズイミダゾール誘導体の製造方法
WO2006049486A1 (en) * 2004-11-08 2006-05-11 Dishman Pharmaceuticals And Chemicals Ltd. A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES
EP1681056A1 (en) 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Process for preparing lansoprazole
GB0525710D0 (en) * 2005-12-17 2006-01-25 Pliva Hrvatska D O O An improved process for preparing of substituted 2-benzimidazolesulfoxide compounds
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
EP1818331A1 (en) 2006-02-14 2007-08-15 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the preparation of 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole substantially free of sulfone impurity
WO2007129328A2 (en) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles
WO2007138468A2 (en) * 2006-06-01 2007-12-06 Wockhardt Ltd Processes for the preparation of lansoprazole
WO2008017020A2 (en) * 2006-08-03 2008-02-07 Dr. Reddy's Laboratories Limited Process for preparing proton pump inhibitors
EP2069329A4 (en) * 2006-10-06 2010-04-07 Reddys Lab Ltd Dr PROCESS FOR THE PREPARATION OF BENZIMIDAZOLE DERIVATIVES AND THEIR SALTS
EP1947099A1 (en) 2007-01-18 2008-07-23 LEK Pharmaceuticals D.D. Process for solvent removal from omeprazole salts
WO2008152462A1 (en) * 2007-06-15 2008-12-18 Emcure Pharmaceuticals Limited A process of sulfoxidation of biologically active compounds
US8247568B2 (en) * 2007-06-21 2012-08-21 Matrix Laboratories Ltd Process for the preparation of pure rabeprazole
EP2022789A1 (en) * 2007-08-06 2009-02-11 Farmaprojects, S.A. Process for the preparation of a gastric acid secretion inhibitor
WO2009066317A2 (en) * 2007-08-20 2009-05-28 Macleods Pharmaceuticals Limited Process for the preparation of pantoprazole sodium
EP2030973A1 (en) * 2007-08-31 2009-03-04 KRKA, tovarna zdravil, d.d., Novo mesto Process for preparing 2-sulfinyl-1H-benzimidazoles
US8071781B2 (en) * 2008-11-11 2011-12-06 Syn-Tech Chem. & Pharm. Co., Ltd. Process for preparing rabeprazole sodium
WO2011109308A1 (en) * 2010-03-02 2011-09-09 Seattle Genetics, Inc. Methods for screening antibodies
CN104418837A (zh) * 2013-08-19 2015-03-18 长沙市如虹医药科技有限公司 一种氧化硫醚成亚砜的方法
CN104402867A (zh) * 2014-11-07 2015-03-11 烟台万润精细化工股份有限公司 一种制备埃索美拉唑杂质h和b的方法
CN104402866A (zh) * 2014-11-07 2015-03-11 烟台万润精细化工股份有限公司 一种制备埃索美拉唑杂质j和k的方法
CN104530006B (zh) * 2015-01-06 2018-05-11 江苏奥赛康药业股份有限公司 兰索拉唑的制备方法
CN104744440B (zh) * 2015-03-12 2016-09-07 常州康丽制药有限公司 雷贝拉唑硫醚的回收方法
CN110487918B (zh) * 2018-05-14 2022-02-08 中国医学科学院药物研究所 泮托拉唑钠及其起始原料中基因毒性杂质的分析方法
CN109354587B (zh) * 2018-10-18 2020-09-18 成都天台山制药有限公司 泮托拉唑钠的制备方法和泮托拉唑钠

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
KR960002912B1 (ko) * 1993-02-19 1996-02-28 영진약품공업주식회사 신규한 벤즈이미다졸 유도체
ES2094694B1 (es) 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
CN1053444C (zh) * 1996-03-20 2000-06-14 常州市第四制药厂 奥美拉唑的一种精制方法
SK283805B6 (sk) * 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola

Also Published As

Publication number Publication date
HUP0400610A3 (en) 2012-09-28
DE60210292D1 (de) 2006-05-18
PL367006A1 (en) 2005-02-07
IL159854A0 (en) 2004-06-20
AU2002321204B2 (en) 2008-05-08
US6919459B2 (en) 2005-07-19
SK287245B6 (sk) 2010-04-07
EE05402B1 (et) 2011-04-15
CZ2004208A3 (cs) 2005-03-16
ES2261703T3 (es) 2006-11-16
CN1235899C (zh) 2006-01-11
KR20040016877A (ko) 2004-02-25
EA005773B1 (ru) 2005-06-30
EP1409478B1 (en) 2006-03-29
IL159854A (en) 2008-11-03
CZ304526B6 (cs) 2014-06-18
BR0211101B1 (pt) 2013-12-17
BR0211101A (pt) 2004-06-22
CA2450433C (en) 2010-05-25
WO2003008406A1 (en) 2003-01-30
EP1409478A1 (en) 2004-04-21
ATE321758T1 (de) 2006-04-15
BRPI0211101B8 (pt) 2021-05-25
EA200400185A1 (ru) 2004-06-24
MXPA04000433A (es) 2004-03-18
CN1525970A (zh) 2004-09-01
US20040209918A1 (en) 2004-10-21
HK1069168A1 (en) 2005-05-13
SK922004A3 (en) 2004-08-03
EE200400052A (et) 2004-04-15
NO20040074L (no) 2004-01-08
HU230155B1 (hu) 2015-09-28
DE60210292T2 (de) 2006-12-07
JP4320250B2 (ja) 2009-08-26
NZ530168A (en) 2004-08-27
KR100914175B1 (ko) 2009-08-27
NO324257B1 (no) 2007-09-17
CA2450433A1 (en) 2003-01-30
JP2005500333A (ja) 2005-01-06
PL208291B1 (pl) 2011-04-29

Similar Documents

Publication Publication Date Title
HUP0400610A2 (hu) Javított eljárás benzimidazoltípusú vegyületek előállítására
HUP0302755A2 (hu) Eljárás kamptotecin-analóg vegyületek előállítására
BG106622A (en) Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
CA2192824A1 (en) Pyridone-carboxylic acid derivatives, processes for the preparation thereof and anti-tumor agents containing the pyridone-carboxylic acid derivatives
CA2238163A1 (en) Triazinylaminostilbene compounds
HUP0204347A2 (en) Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them and their use
MY149146A (en) Processes and intermediates useful in the preparation of pharmaceutical compounds such as fulvestrant
WO2002044194A1 (fr) Derives d'acide l-nucleique et procedes de synthese correspondants
HUP0101230A2 (hu) Eljárás 2-[(2-piridil)-metilszulfinil]-1H-benzimidazol-származékok előállítására
CA2334821A1 (en) Chemical synthesis of morpholine derivatives
HUP9702399A2 (hu) Eljárás taxol és származékai előállítására
DK1250335T3 (da) Fremgangsmåde og mellemprodukter til fremstilling af imidazopyridiner
HUP0300816A2 (hu) Folyamatos eljárás peszticid hatású klór-tiazol-származékok elżállítására
DE50209490D1 (de) Verfahren zur herstellung von zolpidem
DE59611302D1 (de) Verfahren zur herstellung von 3,5-diarylpyrazolen
HUP0001596A2 (hu) Eljárás 5-(amino-metil)-2-klór-piridin-származékok előállítására
JPS62283980A (ja) １，３ジヒドロジシラザン官能基
HUP9603178A2 (hu) Eljárás benzil-éterek előállítására fázistranszferrel
DE50203881D1 (de) Markierungsfähige verbindungen zur einfachen synthese von 3'-[18f]fluor-3'-deoxythymidin und verfahren zu deren herstellung
ATE528358T1 (de) Verfahren zur herstellung einer azoverbindung
HUP0300179A2 (en) Process for the preparation of 6-(perfluoroalkyl)uracil compounds
HUP0301672A2 (hu) Eljárás peszticid hatású vegyületek előállítására
HUP0004916A2 (hu) Eljárás 1,2,3,4-tetrahidroizokinolin-2,3-dikarbonsavanhidrid és felhasználásával (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására
HUP0202858A2 (hu) Eljárás betainok előállítására
DE50102050D1 (de) Verfahren zur herstellung von heterocyclischen verbindungen