HUP0004916A2 - Eljárás 1,2,3,4-tetrahidroizokinolin-2,3-dikarbonsavanhidrid és felhasználásával (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására - Google Patents

Eljárás 1,2,3,4-tetrahidroizokinolin-2,3-dikarbonsavanhidrid és felhasználásával (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására

Info

Publication number
HUP0004916A2
HUP0004916A2 HU0004916A HUP0004916A HUP0004916A2 HU P0004916 A2 HUP0004916 A2 HU P0004916A2 HU 0004916 A HU0004916 A HU 0004916A HU P0004916 A HUP0004916 A HU P0004916A HU P0004916 A2 HUP0004916 A2 HU P0004916A2
Authority
HU
Hungary
Prior art keywords
tetrahydroisoquinoline
preparation
carboxamide
butyl
terc
Prior art date
Application number
HU0004916A
Other languages
English (en)
Inventor
Pietro Bellani
Marco Frigerio
Original Assignee
Clariant Life Science Molecules (Italia) S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clariant Life Science Molecules (Italia) S.P.A. filed Critical Clariant Life Science Molecules (Italia) S.P.A.
Publication of HUP0004916A2 publication Critical patent/HUP0004916A2/hu
Publication of HUP0004916A3 publication Critical patent/HUP0004916A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány szerinti eljárás során (VI) képletű N-karboxanhidridelőállítására (3S)-1,2,3,4-tetrahidroizokinolin-3-karbonsavattrifoszgénnel reagáltatnak oldószerként dioxánt alkalmazva, és kívántesetben az antivirális hatású gyógyszer hatóanyag, az (I) képletű (S)-N-terc-butil-1,2,3,4-tetrahidroizokinolin-3-karboxamid előállítására akapott reakcióelegyhez t-butil-amint adnak. Ó
HU0004916A 1998-06-26 1999-06-17 Process for the preparation of 1,2,3,4-tetrahydroisoquinoline-2,3-dicarboxylic acid anhydride and (s)-n-terc-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide by using thereof HUP0004916A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001478A IT1301825B1 (it) 1998-06-26 1998-06-26 Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
PCT/EP1999/004266 WO2000000494A1 (en) 1998-06-26 1999-06-17 Preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide

Publications (2)

Publication Number Publication Date
HUP0004916A2 true HUP0004916A2 (hu) 2001-05-28
HUP0004916A3 HUP0004916A3 (en) 2002-12-28

Family

ID=11380337

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004916A HUP0004916A3 (en) 1998-06-26 1999-06-17 Process for the preparation of 1,2,3,4-tetrahydroisoquinoline-2,3-dicarboxylic acid anhydride and (s)-n-terc-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide by using thereof

Country Status (13)

Country Link
US (1) US6340760B1 (hu)
EP (1) EP1009749B1 (hu)
JP (1) JP2002519351A (hu)
KR (1) KR100630787B1 (hu)
AT (1) ATE203994T1 (hu)
AU (1) AU4515299A (hu)
DE (1) DE69900214T2 (hu)
DK (1) DK1009749T3 (hu)
ES (1) ES2161567T3 (hu)
HU (1) HUP0004916A3 (hu)
IT (1) IT1301825B1 (hu)
PT (1) PT1009749E (hu)
WO (1) WO2000000494A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1313682B1 (it) * 1999-11-25 2002-09-09 Archimica Spa Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
IT1318986B1 (it) 2000-10-09 2003-09-19 Archimica S P A Ora Clariant L Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
ITMI20040452A1 (it) * 2004-03-09 2004-06-09 Clariant Lsm Italia Spa Processo per la preparazione di oxcarbazepina
CN1300115C (zh) * 2004-03-26 2007-02-14 厦门大学 一种合成1，2，3，4－四氢异喹啉衍生物的方法
US8772212B2 (en) 2008-08-07 2014-07-08 Conopco, Inc. Liquid personal cleansing composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256783A (en) * 1991-09-18 1993-10-26 Hoffmann-La Roche Inc. Method for producing 2-isoquinoline compounds
DE69603419T3 (de) * 1995-06-30 2006-06-29 Ajinomoto Co., Inc. Verfahren zur Herstellung von optisch aktiven Amiden
US5587481A (en) * 1996-02-20 1996-12-24 The Monsanto Company Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide
JPH10291979A (ja) * 1997-04-21 1998-11-04 Ichikawa Gosei Kagaku Kk １，２，３，４−テトラヒドロイソキノリン−３−カルボン酸ターシャリーブチルアミドの製造方法

Also Published As

Publication number Publication date
AU4515299A (en) 2000-01-17
WO2000000494A1 (en) 2000-01-06
JP2002519351A (ja) 2002-07-02
ES2161567T3 (es) 2001-12-01
DE69900214T2 (de) 2002-05-08
EP1009749B1 (en) 2001-08-08
ATE203994T1 (de) 2001-08-15
KR100630787B1 (ko) 2006-10-09
EP1009749A1 (en) 2000-06-21
ITMI981478A1 (it) 1999-12-26
IT1301825B1 (it) 2000-07-07
KR20010023266A (ko) 2001-03-26
HUP0004916A3 (en) 2002-12-28
US6340760B1 (en) 2002-01-22
PT1009749E (pt) 2002-01-30
DK1009749T3 (da) 2001-11-12
DE69900214D1 (de) 2001-09-13

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