NO176101C - Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(3-hydroksy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioksin)karboksamidderivater - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(3-hydroksy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioksin)karboksamidderivater

Info

Publication number
NO176101C
NO176101C NO901306A NO901306A NO176101C NO 176101 C NO176101 C NO 176101C NO 901306 A NO901306 A NO 901306A NO 901306 A NO901306 A NO 901306A NO 176101 C NO176101 C NO 176101C
Authority
NO
Norway
Prior art keywords
alk
dihydrobenzodioxin
dihydrobenzofuran
benzopyran
piperidinyl
Prior art date
Application number
NO901306A
Other languages
English (en)
Other versions
NO901306D0 (no
NO901306L (no
NO176101B (no
Inventor
Georges Henri Paul Van Daele
Frans Maria Alfons Van Keybus
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO901306D0 publication Critical patent/NO901306D0/no
Publication of NO901306L publication Critical patent/NO901306L/no
Publication of NO176101B publication Critical patent/NO176101B/no
Publication of NO176101C publication Critical patent/NO176101C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
NO901306A 1989-03-22 1990-03-21 Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(3-hydroksy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioksin)karboksamidderivater NO176101C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32694189A 1989-03-22 1989-03-22

Publications (4)

Publication Number Publication Date
NO901306D0 NO901306D0 (no) 1990-03-21
NO901306L NO901306L (no) 1990-09-24
NO176101B NO176101B (no) 1994-10-24
NO176101C true NO176101C (no) 1995-02-01

Family

ID=23274437

Family Applications (1)

Application Number Title Priority Date Filing Date
NO901306A NO176101C (no) 1989-03-22 1990-03-21 Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(3-hydroksy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioksin)karboksamidderivater

Country Status (30)

Country Link
US (12) US5374637A (no)
EP (1) EP0389037B1 (no)
JP (1) JP2845341B2 (no)
KR (1) KR0163587B1 (no)
CN (1) CN1034502C (no)
AT (1) ATE128132T1 (no)
AU (1) AU616838B2 (no)
CA (1) CA2012432C (no)
CY (1) CY1921A (no)
DE (1) DE69022453T2 (no)
DK (1) DK0389037T3 (no)
DZ (1) DZ1405A1 (no)
ES (1) ES2081340T3 (no)
FI (1) FI101624B1 (no)
GR (1) GR3017992T3 (no)
HK (1) HK131596A (no)
HU (2) HU221621B1 (no)
IE (1) IE67184B1 (no)
IL (1) IL93817A (no)
JO (1) JO1613B1 (no)
MA (1) MA21778A1 (no)
MY (2) MY106407A (no)
NO (1) NO176101C (no)
NZ (1) NZ232964A (no)
PT (1) PT93531B (no)
RU (2) RU2037492C1 (no)
TN (1) TNSN90032A1 (no)
ZA (1) ZA902188B (no)
ZM (1) ZM1290A1 (no)
ZW (1) ZW3390A1 (no)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232396A (en) * 1989-02-10 1991-07-26 Merrell Dow Pharma 2-(diphenylalkylamino) -1,3 nn heterocyclic compounds and pharmaceutical compositions
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
ES2135414T3 (es) * 1991-09-12 1999-11-01 Smithkline Beecham Plc Antagonistas del receptor 5-ht4.
US5240943A (en) * 1991-12-19 1993-08-31 G. D. Searle & Co. Benzopyran class iii antiarrhythmic agents
WO1993016072A1 (en) * 1992-02-06 1993-08-19 Smithkline Beecham Plc Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
TW294595B (no) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv
GB9301660D0 (en) * 1993-01-28 1993-03-17 Smithkline Beecham Plc Pharmaceuticals
US6127379A (en) * 1993-02-01 2000-10-03 Smithkline Beecham P.L.C. Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
JPH0820586A (ja) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
JPH0873463A (ja) 1994-07-05 1996-03-19 Sanwa Kagaku Kenkyusho Co Ltd ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途
RU2154064C2 (ru) * 1994-09-27 2000-08-10 Жансен Фармасетика Н.В. N-замещенные пиперидинилбензоаты, их n-оксидные формы, фармацевтически приемлемые соли присоединения кислот и стереохимически изомерные формы, способы их получения, фармацевтическая композиция на их основе и промежуточный продукт
BR9509035A (pt) * 1994-09-27 1997-10-14 Janssen Pharmaceutica Nv Derivados de benzoato de fenil-oxo-alquíl-(4-peperidinila)
TW490465B (en) 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
AP9801222A0 (en) * 1995-10-30 1998-06-30 Smithkline Beecham Corp Proatease inhibitors.
NZ330263A (en) * 1996-02-15 1999-06-29 Janssen Pharmaceutica Nv Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
US6096761A (en) * 1996-02-15 2000-08-01 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives
DZ2285A1 (fr) * 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
US20020128476A1 (en) * 1996-08-08 2002-09-12 Smithkline Beecham Corporation Inhibitors of cysteine protease
AU734892B2 (en) * 1997-06-18 2001-06-28 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
US6037354A (en) 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
AU758807B2 (en) 1998-09-10 2003-03-27 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
WO2000030640A1 (en) * 1998-11-23 2000-06-02 Janssen Pharmaceutica N.V. Use of prucalopride for the manufacture of a medicament for the treatment of dyspepsia
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20030144175A1 (en) * 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
US20030044399A1 (en) * 1998-12-23 2003-03-06 Smithkline Beecham Corporation Method of treatment
TW592709B (en) * 1999-04-29 2004-06-21 Janssen Pharmaceutica Nv Prucalopride oral solution
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1232154A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp PROTEASE INHIBITORS
EP1229914A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp PROTEASE INHIBITORS
AU4344101A (en) * 2000-03-21 2001-10-03 Smithkline Beecham Corp Protease inhibitors
US20040038965A1 (en) * 2001-10-09 2004-02-26 Marquis, Jr. Robert W. Protease inhibitors
KR100471499B1 (ko) * 2002-01-08 2005-03-09 학교법인 이화학당 크로만 유도체 및 이를 활성성분으로 함유하는 약학적조성물
DE60300683T2 (de) * 2002-01-16 2006-04-27 Janssen Pharmaceutica N.V. Prucaloprid-n-oxid
US7557076B2 (en) 2002-06-06 2009-07-07 The Procter & Gamble Company Organic catalyst with enhanced enzyme compatibility
US7169744B2 (en) * 2002-06-06 2007-01-30 Procter & Gamble Company Organic catalyst with enhanced solubility
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DE10251394A1 (de) * 2002-11-05 2004-05-13 Clariant Gmbh Blaues Farbmittel mit besonders hoher Reinheit und positiver triboelektrischer Steuerwirkung
JP4631702B2 (ja) * 2003-02-14 2011-02-16 和光純薬工業株式会社 イオン交換樹脂固定化白金触媒を用いたヒドロキシルアミン化合物の製造方法
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
PT1638959E (pt) * 2003-06-19 2007-12-12 Janssen Pharmaceutica Nv 4-(aminometil)piperidinobenzamidas antagonistas de 5ht4
CA2528642C (en) * 2003-06-19 2011-12-13 Janssen Pharmaceutica N.V. Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists
US20050113246A1 (en) * 2003-11-06 2005-05-26 The Procter & Gamble Company Process of producing an organic catalyst
WO2005054201A1 (en) 2003-11-20 2005-06-16 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
EP1709011B1 (en) * 2003-11-20 2015-07-29 Janssen Pharmaceutica NV 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors
AU2004295059B2 (en) * 2003-12-05 2010-12-16 Janssen Pharmaceutica N.V. 6-substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
EA012416B1 (ru) * 2004-06-30 2009-10-30 Янссен Фармацевтика Н.В. Производные замещенного 2-алкилхиназолинона как ингибиторы parp
EA014955B1 (ru) * 2004-06-30 2011-04-29 Янссен Фармацевтика Н. В. Производные фталазина в качестве ингибиторов parp
US8080557B2 (en) 2004-06-30 2011-12-20 Janssen Pharmaceutica, Nv Quinazolinedione derivatives as PARP inhibitors
AR051659A1 (es) * 2005-06-17 2007-01-31 Procter & Gamble Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
JP5545955B2 (ja) * 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
PL2215075T3 (pl) * 2007-10-26 2014-04-30 Janssen Pharmaceutica Nv Pochodne chinolinonu jako inhibitory PARP
RU2490260C2 (ru) 2008-03-27 2013-08-20 Янссен Фармацевтика Нв Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибиторов parp и ингибиторов полимеризации тубулина
WO2009118384A1 (en) * 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
CN102295594B (zh) * 2011-07-12 2016-01-20 上海医药工业研究院 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用
CN102942542B (zh) * 2012-11-20 2015-08-05 南京华威医药科技开发有限公司 2,3-二氢苯并呋喃类化合物的制备方法
CN103755689B (zh) * 2013-12-25 2016-06-29 连云港恒运医药科技有限公司 普卡必利降解杂质的制备方法
CN103664912B (zh) * 2013-12-31 2015-11-25 南京正大天晴制药有限公司 一种普卡必利的合成工艺
US11053255B2 (en) * 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
WO2017137910A1 (en) 2016-02-11 2017-08-17 Symed Labs Limited Processes for the preparation of highly pure prucalopride succinate and its intermediates
CN110938064B (zh) * 2019-11-06 2022-12-27 广东东阳光药业有限公司 N-取代哌啶酰胺衍生物及其用途
CN111620857A (zh) * 2020-06-04 2020-09-04 南京恒通医药开发有限公司 一种琥珀酸普芦卡必利的连续合成方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652399A (en) * 1950-10-24 1953-09-15 Sterling Drug Inc Tertiary-aminoalkyl derivatives of coumarilic acids and their preparation
US4129655A (en) * 1976-04-26 1978-12-12 Ciba-Geigy Corporation Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans
JPS5328181A (en) * 1976-08-04 1978-03-16 Ile De France Production of nove substituted 2*33alkylenebis *oxy* benzoic acid
US4186135A (en) * 1976-08-04 1980-01-29 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation
FR2360305A1 (fr) * 1976-08-04 1978-03-03 Ile De France Nouveaux 2,3-alkylene bis (oxy)benzamides substitues, leurs derives et leurs procedes de preparation
FR2396757A2 (fr) * 1977-07-08 1979-02-02 Ile De France Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation
US4281014A (en) * 1980-06-04 1981-07-28 Fmc Corporation Stabilized compositions containing N-aminosulfenylated derivatives of carbofuran
NL183618C (nl) * 1980-10-08 1988-12-01 Stago Bv Koppelingssysteem voor in elkaars verlengde liggende kabelgoten.
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
EP0069481A1 (en) * 1981-06-17 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
EP0068700A1 (en) * 1981-06-29 1983-01-05 Beecham Group Plc Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them
EP0069482A1 (en) * 1981-06-29 1983-01-12 Beecham Group Plc Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
CA1297877C (en) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides useful as antiemetic or antipsychotic agents
US4808624A (en) * 1984-06-28 1989-02-28 Bristol-Myers Company Pharmacologically active substituted benzamides
US4722935A (en) * 1985-04-03 1988-02-02 Ciba-Geigy Corporation Pesticidal compositions
SE8503055D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Piperonylcarboxamido derivatives
GB8519707D0 (en) * 1985-08-06 1985-09-11 Fordonal Sa Chemical compounds
FR2586018B1 (fr) * 1985-08-12 1988-03-25 Ile De France Nouveau benzodioxepanne, son procede de synthese et ses applications en therapeutique
JPS6299375A (ja) * 1985-10-25 1987-05-08 Kowa Co ベンゾジオキソ−ル誘導体
GB8527052D0 (en) * 1985-11-02 1985-12-04 Beecham Group Plc Compounds
FR2593504B1 (fr) * 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
JPS62234083A (ja) * 1986-02-28 1987-10-14 アーバモント　インク　ディビーエイ　アドリヤ　ラボラトリーズ 鎮吐薬または精神病治療薬として有用なカルボキサミド類
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
IL87674A (en) * 1987-09-08 1993-08-18 Lilly Co Eli Azabicycloalkyl esters and amides of heterocyclic acids, their preparation and pharmaceutical compositions containing them
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US4863921A (en) * 1988-04-27 1989-09-05 Rorer Pharmaceutical Corporation Dibenzofurancarboxamides and their pharmaceutical compositions and methods
TW294595B (no) * 1992-11-20 1997-01-01 Janssen Pharmaceutica Nv

Also Published As

Publication number Publication date
JO1613B1 (en) 1990-07-01
NO901306D0 (no) 1990-03-21
US5616583A (en) 1997-04-01
ES2081340T3 (es) 1996-03-01
DE69022453D1 (de) 1995-10-26
DK0389037T3 (da) 1995-10-16
AU616838B2 (en) 1991-11-07
US5602129A (en) 1997-02-11
PT93531B (pt) 1998-01-30
DZ1405A1 (fr) 2004-09-13
CA2012432C (en) 2000-11-14
HU211171A9 (en) 1995-11-28
JP2845341B2 (ja) 1999-01-13
CA2012432A1 (en) 1990-09-22
HUT58322A (en) 1992-02-28
AU5209190A (en) 1990-09-27
US5552553A (en) 1996-09-03
US5565582A (en) 1996-10-15
US5739134A (en) 1998-04-14
MA21778A1 (fr) 1990-10-01
KR0163587B1 (ko) 1998-12-01
FI901421A0 (fi) 1990-03-21
US5536733A (en) 1996-07-16
ZW3390A1 (en) 1991-10-23
FI101624B (fi) 1998-07-31
US5554772A (en) 1996-09-10
RU2108332C1 (ru) 1998-04-10
US5521314A (en) 1996-05-28
US5616738A (en) 1997-04-01
DE69022453T2 (de) 1996-03-28
HU221621B1 (hu) 2002-12-28
EP0389037B1 (en) 1995-09-20
MY106407A (en) 1995-05-30
HK131596A (en) 1996-07-26
GR3017992T3 (en) 1996-02-29
NO901306L (no) 1990-09-24
CN1045781A (zh) 1990-10-03
NO176101B (no) 1994-10-24
US5610157A (en) 1997-03-11
KR900014371A (ko) 1990-10-23
IL93817A0 (en) 1990-12-23
MY131911A (en) 2007-09-28
RU2037492C1 (ru) 1995-06-19
CN1034502C (zh) 1997-04-09
NZ232964A (en) 1991-07-26
CY1921A (en) 1997-03-07
EP0389037A1 (en) 1990-09-26
ATE128132T1 (de) 1995-10-15
US5374637A (en) 1994-12-20
ZM1290A1 (en) 1992-07-31
TNSN90032A1 (fr) 1991-03-05
ZA902188B (en) 1991-11-27
HU901627D0 (en) 1990-06-28
JPH02289566A (ja) 1990-11-29
IE67184B1 (en) 1996-03-06
IL93817A (en) 1995-03-30
FI101624B1 (fi) 1998-07-31
US5576448A (en) 1996-11-19
IE901040L (en) 1990-09-22
PT93531A (pt) 1990-11-07

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