DZ1405A1 - Dérivés de n-(3-hydroxy-4-piperidinyl)(dihydro-benzofuranne, dihydro-2h-benzopy-ranne ou dishydro-benzodioxin)carboxamide. - Google Patents
Dérivés de n-(3-hydroxy-4-piperidinyl)(dihydro-benzofuranne, dihydro-2h-benzopy-ranne ou dishydro-benzodioxin)carboxamide.Info
- Publication number
- DZ1405A1 DZ1405A1 DZ900052A DZ900052A DZ1405A1 DZ 1405 A1 DZ1405 A1 DZ 1405A1 DZ 900052 A DZ900052 A DZ 900052A DZ 900052 A DZ900052 A DZ 900052A DZ 1405 A1 DZ1405 A1 DZ 1405A1
- Authority
- DZ
- Algeria
- Prior art keywords
- dihydro
- alk
- piperidinyl
- hydroxy
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32694189A | 1989-03-22 | 1989-03-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ1405A1 true DZ1405A1 (fr) | 2004-09-13 |
Family
ID=23274437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ900052A DZ1405A1 (fr) | 1989-03-22 | 1990-03-20 | Dérivés de n-(3-hydroxy-4-piperidinyl)(dihydro-benzofuranne, dihydro-2h-benzopy-ranne ou dishydro-benzodioxin)carboxamide. |
Country Status (30)
Country | Link |
---|---|
US (12) | US5374637A (fr) |
EP (1) | EP0389037B1 (fr) |
JP (1) | JP2845341B2 (fr) |
KR (1) | KR0163587B1 (fr) |
CN (1) | CN1034502C (fr) |
AT (1) | ATE128132T1 (fr) |
AU (1) | AU616838B2 (fr) |
CA (1) | CA2012432C (fr) |
CY (1) | CY1921A (fr) |
DE (1) | DE69022453T2 (fr) |
DK (1) | DK0389037T3 (fr) |
DZ (1) | DZ1405A1 (fr) |
ES (1) | ES2081340T3 (fr) |
FI (1) | FI101624B1 (fr) |
GR (1) | GR3017992T3 (fr) |
HK (1) | HK131596A (fr) |
HU (2) | HU221621B1 (fr) |
IE (1) | IE67184B1 (fr) |
IL (1) | IL93817A (fr) |
JO (1) | JO1613B1 (fr) |
MA (1) | MA21778A1 (fr) |
MY (2) | MY106407A (fr) |
NO (1) | NO176101C (fr) |
NZ (1) | NZ232964A (fr) |
PT (1) | PT93531B (fr) |
RU (2) | RU2037492C1 (fr) |
TN (1) | TNSN90032A1 (fr) |
ZA (1) | ZA902188B (fr) |
ZM (1) | ZM1290A1 (fr) |
ZW (1) | ZW3390A1 (fr) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2009542C (fr) * | 1989-02-10 | 2000-03-14 | Albert A. Carr | Guanidines cycliques comme antagonistes du calcium |
GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
FR2674849B1 (fr) * | 1991-04-02 | 1994-12-23 | Logeais Labor Jacques | Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique. |
WO1993005038A1 (fr) * | 1991-09-12 | 1993-03-18 | Smithkline Beecham Plc | Antagonistes de recepteurs 5-hydroxytriptamine 4 |
US5240943A (en) * | 1991-12-19 | 1993-08-31 | G. D. Searle & Co. | Benzopyran class iii antiarrhythmic agents |
NZ246915A (en) * | 1992-02-06 | 1996-05-28 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives, preparation and pharmaceutical compositions thereof |
GB9219163D0 (en) * | 1992-09-10 | 1992-10-28 | Smithkline Beecham Plc | Pharmaceuticals |
TW294595B (fr) * | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv | |
GB9301660D0 (en) * | 1993-01-28 | 1993-03-17 | Smithkline Beecham Plc | Pharmaceuticals |
US6127379A (en) * | 1993-02-01 | 2000-10-03 | Smithkline Beecham P.L.C. | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
GB9312348D0 (en) * | 1993-06-16 | 1993-07-28 | Smithkline Beecham Plc | Pharmaceuticals |
JPH0820586A (ja) * | 1994-07-05 | 1996-01-23 | Sanwa Kagaku Kenkyusho Co Ltd | 1−アザビシクロ[3.3.0]オクタン誘導体、その塩及び製法並びに用途 |
JPH0873463A (ja) | 1994-07-05 | 1996-03-19 | Sanwa Kagaku Kenkyusho Co Ltd | ベンゾピランカルボキサミド誘導体、その塩及び製法並びに用途 |
HU218698B (hu) * | 1994-09-27 | 2000-11-28 | Janssen Pharmaceutica N.V. | Gyógyászati hatású N-szubsztituált piperidinil-(biciklusos benzoát)-származékok, intermedierjeik, előállításuk és alkalmazásuk |
EP0784619B1 (fr) * | 1994-09-27 | 1999-03-24 | Janssen Pharmaceutica N.V. | Derives benzoates bicycliques de phenyl-oxo-alkyl-(4-piperidinyle) |
TW490465B (en) * | 1994-11-24 | 2002-06-11 | Janssen Pharmaceutica Nv | Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof |
TW360653B (en) * | 1995-03-01 | 1999-06-11 | Janssen Pharmaceutica Nv | A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition |
US6586466B2 (en) | 1995-10-30 | 2003-07-01 | Smithkline Beecham Corporation | Carbohydrazide-protease inhibitors |
CZ132798A3 (cs) * | 1995-10-30 | 1999-02-17 | Smithkline Beecham Corporation | Inhibitory proteázy |
US6096761A (en) * | 1996-02-15 | 2000-08-01 | Janssen Pharmaceutica N.V. | Esters of 3-hydroxy-piperidinemethanol derivatives |
NZ330263A (en) * | 1996-02-15 | 1999-06-29 | Janssen Pharmaceutica Nv | Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying |
US20020128476A1 (en) * | 1996-08-08 | 2002-09-12 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
DZ2285A1 (fr) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
US6037354A (en) * | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
JP2002505684A (ja) * | 1997-06-18 | 2002-02-19 | メルク エンド カンパニー インコーポレーテッド | α1aアドレナリン受容体拮抗薬 |
TW402591B (en) * | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
AU758807B2 (en) | 1998-09-10 | 2003-03-27 | F. Hoffmann-La Roche Ag | Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists |
KR20010080025A (ko) * | 1998-11-23 | 2001-08-22 | 디르크 반테 | 소화불량 치료용 의약의 제조를 위한 프루칼로프라이드의용도 |
TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
US20030144175A1 (en) * | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
US20030044399A1 (en) * | 1998-12-23 | 2003-03-06 | Smithkline Beecham Corporation | Method of treatment |
TW592709B (en) * | 1999-04-29 | 2004-06-21 | Janssen Pharmaceutica Nv | Prucalopride oral solution |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (fr) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Inhibiteurs de protease |
CN1416346A (zh) * | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
US20040038965A1 (en) * | 2001-10-09 | 2004-02-26 | Marquis, Jr. Robert W. | Protease inhibitors |
KR100471499B1 (ko) * | 2002-01-08 | 2005-03-09 | 학교법인 이화학당 | 크로만 유도체 및 이를 활성성분으로 함유하는 약학적조성물 |
NZ533041A (en) * | 2002-01-16 | 2006-04-28 | Janssen Pharmaceutica Nv | Prucalopride-N-oxide |
US7169744B2 (en) * | 2002-06-06 | 2007-01-30 | Procter & Gamble Company | Organic catalyst with enhanced solubility |
US7557076B2 (en) | 2002-06-06 | 2009-07-07 | The Procter & Gamble Company | Organic catalyst with enhanced enzyme compatibility |
AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
DE10251394A1 (de) * | 2002-11-05 | 2004-05-13 | Clariant Gmbh | Blaues Farbmittel mit besonders hoher Reinheit und positiver triboelektrischer Steuerwirkung |
EP1593668A4 (fr) * | 2003-02-14 | 2007-07-11 | Wako Pure Chem Ind Ltd | Procede de production de compose hydroxylamine dans lequel un catalyseur au platine fixe sur une resine echangeuse d'ions est utilise |
DE602004009069T2 (de) * | 2003-06-19 | 2008-06-19 | Janssen Pharmaceutica N.V. | 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten |
ATE449093T1 (de) * | 2003-06-19 | 2009-12-15 | Janssen Pharmaceutica Nv | Heterocyclisch substituierte 4-(aminomethyl)- piperidinbenzamide als 5ht4-antagonisten |
JO2478B1 (en) * | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
US20050113246A1 (en) * | 2003-11-06 | 2005-05-26 | The Procter & Gamble Company | Process of producing an organic catalyst |
EP1709011B1 (fr) * | 2003-11-20 | 2015-07-29 | Janssen Pharmaceutica NV | 2-quinolinones et 2 quinoxalinones a substitution 7-phenylalkyl comme inhibiteurs de poly(adp-ribose) polymerase |
AU2004295058B9 (en) | 2003-11-20 | 2011-06-30 | Janssen Pharmaceutica N.V. | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors |
NZ547193A (en) * | 2003-12-05 | 2010-03-26 | Janssen Pharmaceutica Nv | 6-Substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
JP4969443B2 (ja) * | 2004-06-30 | 2012-07-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Parp阻害剤としてのキナゾリノン誘導体 |
WO2006003147A1 (fr) * | 2004-06-30 | 2006-01-12 | Janssen Pharmaceutica N.V. | Derives de phtalazine utilises comme inhibiteurs de parp |
ES2415771T3 (es) | 2004-06-30 | 2013-07-26 | Janssen Pharmaceutica N.V. | Derivados de quinazolina como inhibidores de PARP |
AR051659A1 (es) * | 2005-06-17 | 2007-01-31 | Procter & Gamble | Una composicion que comprende un catalizador organico con compatibilidada enzimatica mejorada |
GB0525661D0 (en) * | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Novel compounds |
ES2381446T3 (es) | 2007-03-08 | 2012-05-28 | Janssen Pharmaceutica, N.V. | Derivado de quinolinona como inhibidores de PARP y TANK |
PL2215075T3 (pl) * | 2007-10-26 | 2014-04-30 | Janssen Pharmaceutica Nv | Pochodne chinolinonu jako inhibitory PARP |
ES2367760T3 (es) * | 2008-03-27 | 2011-11-08 | Janssen Pharmaceutica, N.V. | Derivados de quinazolinona como inhibidores de la polimerización de la tubulina. |
US8889866B2 (en) | 2008-03-27 | 2014-11-18 | Janssen Pharmaceutica, Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors |
CN102295594B (zh) * | 2011-07-12 | 2016-01-20 | 上海医药工业研究院 | 4-n-取代-1-(3-甲氧基丙基)-4-哌啶胺类化合物及制备和应用 |
CN102942542B (zh) * | 2012-11-20 | 2015-08-05 | 南京华威医药科技开发有限公司 | 2,3-二氢苯并呋喃类化合物的制备方法 |
CN103755689B (zh) * | 2013-12-25 | 2016-06-29 | 连云港恒运医药科技有限公司 | 普卡必利降解杂质的制备方法 |
CN103664912B (zh) * | 2013-12-31 | 2015-11-25 | 南京正大天晴制药有限公司 | 一种普卡必利的合成工艺 |
US11053255B2 (en) * | 2015-06-22 | 2021-07-06 | Georgetown University | Synthesis of mahanine and related compounds |
WO2017137910A1 (fr) | 2016-02-11 | 2017-08-17 | Symed Labs Limited | Procédés pour la préparation de succinate de prucalopride très pur et de ses intermédiaires |
EP3858838A4 (fr) | 2018-09-28 | 2022-06-29 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique |
CN110938064B (zh) * | 2019-11-06 | 2022-12-27 | 广东东阳光药业有限公司 | N-取代哌啶酰胺衍生物及其用途 |
CN111620857A (zh) * | 2020-06-04 | 2020-09-04 | 南京恒通医药开发有限公司 | 一种琥珀酸普芦卡必利的连续合成方法 |
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US2652399A (en) * | 1950-10-24 | 1953-09-15 | Sterling Drug Inc | Tertiary-aminoalkyl derivatives of coumarilic acids and their preparation |
US4129655A (en) * | 1976-04-26 | 1978-12-12 | Ciba-Geigy Corporation | Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans |
US4186135A (en) * | 1976-08-04 | 1980-01-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation |
JPS5328181A (en) * | 1976-08-04 | 1978-03-16 | Ile De France | Production of nove substituted 2*33alkylenebis *oxy* benzoic acid |
FR2360305A1 (fr) * | 1976-08-04 | 1978-03-03 | Ile De France | Nouveaux 2,3-alkylene bis (oxy)benzamides substitues, leurs derives et leurs procedes de preparation |
FR2396757A2 (fr) * | 1977-07-08 | 1979-02-02 | Ile De France | Nouveaux 2,3-alkylene bis (oxy) benzamides substitues, leurs derives et leurs procedes de preparation |
US4281014A (en) * | 1980-06-04 | 1981-07-28 | Fmc Corporation | Stabilized compositions containing N-aminosulfenylated derivatives of carbofuran |
NL183618C (nl) * | 1980-10-08 | 1988-12-01 | Stago Bv | Koppelingssysteem voor in elkaars verlengde liggende kabelgoten. |
FR2493848B2 (fr) * | 1980-11-07 | 1986-05-16 | Delalande Sa | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
EP0069481A1 (fr) * | 1981-06-17 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylbenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
EP0069482A1 (fr) * | 1981-06-29 | 1983-01-12 | Beecham Group Plc | Azabicycloalkylenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
EP0068700A1 (fr) * | 1981-06-29 | 1983-01-05 | Beecham Group Plc | Azabicycloalkylbenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant |
CA1183847A (fr) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide; derives |
JPS59186969A (ja) * | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
CA1297877C (fr) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides utilises comme agents antiemetiques ou antipsychotiques |
US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
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SE8503055D0 (sv) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | Piperonylcarboxamido derivatives |
GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
FR2586018B1 (fr) * | 1985-08-12 | 1988-03-25 | Ile De France | Nouveau benzodioxepanne, son procede de synthese et ses applications en therapeutique |
JPS6299375A (ja) * | 1985-10-25 | 1987-05-08 | Kowa Co | ベンゾジオキソ−ル誘導体 |
GB8527052D0 (en) * | 1985-11-02 | 1985-12-04 | Beecham Group Plc | Compounds |
FR2593504B1 (fr) * | 1986-01-30 | 1988-12-09 | Ile De France | Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques |
JPS62234083A (ja) * | 1986-02-28 | 1987-10-14 | アーバモント インク ディビーエイ アドリヤ ラボラトリーズ | 鎮吐薬または精神病治療薬として有用なカルボキサミド類 |
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
ZA886585B (en) * | 1987-09-08 | 1990-05-30 | Lilly Co Eli | Specific 5-ht,antagonists |
CA1317940C (fr) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | N-(1-alkyl-3-hydroxy-4-piperidinyl) benzamides a substituant |
US4863921A (en) * | 1988-04-27 | 1989-09-05 | Rorer Pharmaceutical Corporation | Dibenzofurancarboxamides and their pharmaceutical compositions and methods |
TW294595B (fr) * | 1992-11-20 | 1997-01-01 | Janssen Pharmaceutica Nv |
-
1990
- 1990-03-06 US US07/489,419 patent/US5374637A/en not_active Expired - Lifetime
- 1990-03-13 EP EP90200589A patent/EP0389037B1/fr not_active Expired - Lifetime
- 1990-03-13 AT AT90200589T patent/ATE128132T1/de not_active IP Right Cessation
- 1990-03-13 DE DE69022453T patent/DE69022453T2/de not_active Expired - Fee Related
- 1990-03-13 DK DK90200589.1T patent/DK0389037T3/da active
- 1990-03-13 ES ES90200589T patent/ES2081340T3/es not_active Expired - Lifetime
- 1990-03-16 NZ NZ232964A patent/NZ232964A/en unknown
- 1990-03-16 CA CA002012432A patent/CA2012432C/fr not_active Expired - Fee Related
- 1990-03-19 JO JO19901613A patent/JO1613B1/en active
- 1990-03-20 ZW ZW33/90A patent/ZW3390A1/xx unknown
- 1990-03-20 IL IL9381790A patent/IL93817A/en unknown
- 1990-03-20 MY MYPI90000431A patent/MY106407A/en unknown
- 1990-03-20 DZ DZ900052A patent/DZ1405A1/fr active
- 1990-03-20 MY MYPI94003195A patent/MY131911A/en unknown
- 1990-03-20 JP JP2068541A patent/JP2845341B2/ja not_active Expired - Fee Related
- 1990-03-20 MA MA22042A patent/MA21778A1/fr unknown
- 1990-03-21 AU AU52091/90A patent/AU616838B2/en not_active Ceased
- 1990-03-21 RU SU904743491A patent/RU2037492C1/ru not_active IP Right Cessation
- 1990-03-21 IE IE104090A patent/IE67184B1/en not_active IP Right Cessation
- 1990-03-21 HU HU9001627A patent/HU221621B1/hu not_active IP Right Cessation
- 1990-03-21 NO NO901306A patent/NO176101C/no not_active IP Right Cessation
- 1990-03-21 CN CN90101524A patent/CN1034502C/zh not_active Expired - Fee Related
- 1990-03-21 KR KR1019900003782A patent/KR0163587B1/ko not_active IP Right Cessation
- 1990-03-21 FI FI901421A patent/FI101624B1/fi not_active IP Right Cessation
- 1990-03-21 ZA ZA902188A patent/ZA902188B/xx unknown
- 1990-03-21 ZM ZM12/90A patent/ZM1290A1/xx unknown
- 1990-03-21 PT PT93531A patent/PT93531B/pt not_active IP Right Cessation
- 1990-03-22 TN TNTNSN90032A patent/TNSN90032A1/fr unknown
-
1993
- 1993-11-02 RU RU93050009A patent/RU2108332C1/ru not_active IP Right Cessation
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1994
- 1994-09-07 US US08/301,825 patent/US5552553A/en not_active Expired - Fee Related
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1995
- 1995-03-31 US US08/414,676 patent/US5521314A/en not_active Expired - Fee Related
- 1995-03-31 US US08/414,673 patent/US5616738A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,885 patent/US5576448A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,953 patent/US5565582A/en not_active Expired - Fee Related
- 1995-04-03 US US08/415,888 patent/US5554772A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,826 patent/US5739134A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,658 patent/US5616583A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,728 patent/US5610157A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,659 patent/US5536733A/en not_active Expired - Fee Related
- 1995-04-13 US US08/421,727 patent/US5602129A/en not_active Expired - Fee Related
- 1995-06-21 HU HU95P/P00311P patent/HU211171A9/hu unknown
- 1995-11-08 GR GR950403101T patent/GR3017992T3/el unknown
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1996
- 1996-07-18 HK HK131596A patent/HK131596A/xx not_active IP Right Cessation
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1997
- 1997-03-07 CY CY192197A patent/CY1921A/xx unknown
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