KR960041167A - 임의의 2-치환 5-클로로이미다졸-4-카르보알데히드의 제조방법 - Google Patents

임의의 2-치환 5-클로로이미다졸-4-카르보알데히드의 제조방법 Download PDF

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Publication number
KR960041167A
KR960041167A KR1019960016181A KR19960016181A KR960041167A KR 960041167 A KR960041167 A KR 960041167A KR 1019960016181 A KR1019960016181 A KR 1019960016181A KR 19960016181 A KR19960016181 A KR 19960016181A KR 960041167 A KR960041167 A KR 960041167A
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KR
South Korea
Prior art keywords
chloroimidazol
substituted
general formula
ylidenemethyl
dimethylamine
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KR1019960016181A
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English (en)
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KR100412248B1 (ko
Inventor
그리피츠 가레트
슈투키 게르하르트
Original Assignee
비트 라우어. 베르너 데겐
론자 리미티드
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Publication of KR960041167A publication Critical patent/KR960041167A/ko
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Publication of KR100412248B1 publication Critical patent/KR100412248B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

Abstract

하기 일반식 Ⅰ의 2-치환 5-클로로이미다졸-4-카르보알데히드의 신규 제조방법이 기재되어 있다.
상기 화합물은 혈압 강하제, 또는 제초제 제조 매우 중요한 출발물질이다.

Description

임의의 2-치환 5-클로로이미다졸-4-카르보알데히드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식 Ⅱ의 임의의 2-치환 5-클로로이미다졸과 하기 일반식 Ⅲ의 아민과 반응시켜, 하기 일반식Ⅳ의 임의의 2-치환 5-클로로 이미다졸-4-일리덴메틸아민을 수득하고, 최종적으로 이 화합물을 가수분해하여, 목적 생성물을 수득하는 것을 특징으로 하는 하기 일반식 Ⅰ의 임의의 2-치환 5-클로로이미다졸-4-카르보알데히드의 제조방법.
    〔식중, R은 수소, 알킬기, 알케닐기, 시클로알킬기, 벤질기, 또는 페닐기를 나타내며, R1및 R2는 동일하거나 상이하며, (C1-C6)-알킬기를 나타내거나, 또는 R1및 R2가 함께 (C2-C3)-알킬렌 브리지를 형성하고, R3및 R4가 동일하거나 상이하며, (C1-C6)-알킬기를 나타내거나, 또는 R2및 R4는 아민 질소와 함께, 부가된 이종원자로 산소나 질소를 함유할 수 있는 5원, 또는 6원의 포화 복소환을 형성한다〕.
  2. 제1항에 있어서, 염기로서 3차 아민이 존재할 때에 반응이 수행됨을 특징으로 하는 제조방법.
  3. 제1항 또는 제2항에 있어서, 일반식 Ⅳ의 2-치환 5-클로로이미다졸-4-일리덴메틸아민이 단리되지 않음을 특징으로 하는 제조방법.
  4. 제1항 또는 제2항에 있어서, 일반식 Ⅲ의 아민과의 반응이, 불용성 용매의 존재하에, 온도가 20℃ 내지 200℃이 온도에서 수행되는 것을 특징으로 하는 제조방법.
  5. 하기 일반식 Ⅳ의 2-치환 5-클로로이미다졸-4-일리덴메틸아민
    〔식중, R, R3및 R4는 제1항에서 정의한 것과 동일하다〕.
  6. (2-n-부틸-5-클로로이미다졸-4-일리덴메틸)-디메틸아민.
  7. (2-n-부틸-5-클로로이미다졸-4-일리덴메틸)-디메틸아민.
  8. (2-n-프로필-5-클로로이미다졸-4-일리덴메틸)-디메틸아민.
  9. (2-n-프로필-5-클로로이미다졸-4-일리덴메틸)-디메틸아민.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960016181A 1995-05-17 1996-05-15 선택적으로2-치환된5-클로로이미다졸-4-카르브알데히드의제조방법 KR100412248B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01451/95-3 1995-05-17
CH145195 1995-05-17

Publications (2)

Publication Number Publication Date
KR960041167A true KR960041167A (ko) 1996-12-19
KR100412248B1 KR100412248B1 (ko) 2004-05-22

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KR1019960016181A KR100412248B1 (ko) 1995-05-17 1996-05-15 선택적으로2-치환된5-클로로이미다졸-4-카르브알데히드의제조방법

Country Status (10)

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US (2) US5698707A (ko)
EP (1) EP0743306B1 (ko)
JP (1) JP4140066B2 (ko)
KR (1) KR100412248B1 (ko)
AT (1) ATE198742T1 (ko)
CA (1) CA2175420C (ko)
DE (1) DE59606328D1 (ko)
DK (1) DK0743306T3 (ko)
ES (1) ES2155547T3 (ko)
HU (1) HU216154B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes
US6590106B2 (en) * 1997-05-09 2003-07-08 Pharm-Eco Laboratories, Inc. Amino acid derivatives and methods of making the same
WO2003006435A1 (en) * 2001-07-09 2003-01-23 Merck & Co., Inc. Process for oxidation of alcohols
US20040147787A1 (en) * 2001-10-16 2004-07-29 Miller Ross A Process for oxidation of alcohols

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL53783A (en) * 1977-02-03 1982-08-31 American Cyanamid Co Imidazo(1,5-d)-as-triazine-4 (3h)-(thi)one derivatives,their preparation and pharmaceutical compositions containing them
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4345935A (en) * 1981-10-05 1982-08-24 Eli Lilly And Company 2,4-Imidazolidinediones, compositions and herbicidal method
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
US5565577A (en) * 1992-09-23 1996-10-15 Smithkline Beecham Corporation Process for preparing 1-alkyaryl-2-alkyl-5-formylimidazole
US5484939A (en) * 1993-03-12 1996-01-16 Lonza Ltd. 2-substituted 5-chlorimidazoles
ES2108894T3 (es) * 1993-03-12 1998-01-01 Lonza Ag Procedimiento para la preparacion de 5-cloroimidazoles eventualmente sustituidos en posicion 2.
EP0614889A1 (de) * 1993-03-12 1994-09-14 Lonza Ag Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
JP2517836B2 (ja) * 1993-07-23 1996-07-24 株式会社コニカケミカル ４−クロロイミダゾ―ル−５−カルバルデヒド誘導体の製造法
JPH08816B2 (ja) * 1993-07-23 1996-01-10 株式会社コニカケミカル ２−ブチル−４−クロロイミダゾール−５−カルバルデヒドの製造法
CA2135541C (en) * 1993-11-15 2006-01-10 Gareth Griffiths Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
US5395943A (en) * 1994-02-16 1995-03-07 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Method for purification of 2-alkyl-4-halo-5-formylimidazoles
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes

Also Published As

Publication number Publication date
US5698707A (en) 1997-12-16
JP4140066B2 (ja) 2008-08-27
DE59606328D1 (de) 2001-02-22
HU9601325D0 (en) 1996-07-29
HU216154B (hu) 1999-04-28
KR100412248B1 (ko) 2004-05-22
CA2175420A1 (en) 1996-11-18
HUP9601325A2 (en) 1997-04-28
EP0743306A1 (de) 1996-11-20
CA2175420C (en) 2007-04-10
JPH08311037A (ja) 1996-11-26
EP0743306B1 (de) 2001-01-17
ATE198742T1 (de) 2001-02-15
ES2155547T3 (es) 2001-05-16
US5684157A (en) 1997-11-04
HUP9601325A3 (en) 1997-09-29
DK0743306T3 (da) 2001-02-05

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