HUP0301764A2 - Fungicid hatású heterociklusos aromás amidovegyületek, továbbá e vegyületeket tartalmazó készítmények, valamint kezelési eljárás - Google Patents
Fungicid hatású heterociklusos aromás amidovegyületek, továbbá e vegyületeket tartalmazó készítmények, valamint kezelési eljárásInfo
- Publication number
- HUP0301764A2 HUP0301764A2 HU0301764A HUP0301764A HUP0301764A2 HU P0301764 A2 HUP0301764 A2 HU P0301764A2 HU 0301764 A HU0301764 A HU 0301764A HU P0301764 A HUP0301764 A HU P0301764A HU P0301764 A2 HUP0301764 A2 HU P0301764A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- group
- alkenyl
- general formula
- alkynyl
- Prior art date
Links
- 125000006615 aromatic heterocyclic group Chemical group 0.000 title abstract 2
- 230000000855 fungicidal effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- -1 hydroxyl- Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgyát olyan heterociklusos aromás amidvegyületekképezik, ahol az amidcsoporttal szomszédos helyzetben hidroxilcsoportvan jelen; a találmány szerinti (I) általános képletű vegyületekeredményesen alkalmazhatók gombaellenes szerként különösen növényekkezelésére. Az (I) általános képletben a szubsztituensek jelentéseigen sokféle lehet, így például a) a vegyület részét képező (a)általános képletű csoport jelentése 5- vagy 6-tagú heterociklusosaromás gyűrű, amelyben például i) X1, X2, X3 és X4 jelentése egymástólfüggetlenül O, S, NR', N, CR< vagy vegyérrtékkötés; ii) ahol X1, X2,X3 és X4 közül legfeljebb egyik jelenthet O, S vagy NR' csoportot; R'jelentése H, alkil-, alkenil-, alkinil-, hidroxil-, acil-oxi-,alkoximetil-, CHF2, ciklopropil- vagy alkoxicsoport, továbbá R<jelentése egymástól függetlenül például alkil-, halogénalkil-,ciklopropil-, alkoxi-, halogénalkoxi-, alkiltio-, aril-, ahol aszomszédos R< szubsztituensek vagy a szomszédos R' és R<szubsztituensek gyűrűt képezhetnek; b) Z jelentése O, S vagy NORz,ahol Rz jelentése H vagy alkilcsoport és c) A jelentése például i)alkil-, alkenil- vagy alkinilcsoport, ahol ezen csoportok mindegyikeegyenes vagy elágazó láncú és adott esetben különféle csoportokkallehet szubsztituálva, ii) cikloalkilcsoport, amely 0-3 heteroatomot és0-2 telítetlen kötést tartalmazhat és amely adott esetben különfélecsoportokkal szubsztituálva lehet, iii) 6-14 szénatomos di- vagytriciklusos gyűrűs rendszer, amely 0-3 heteroatomot és 0-2 telítetlenkötést tartalmaz, és amely adott esetben különféle csoportokkalszubsztituálva lehet, iv) aril- vagy heteroarilcsoport, amelyek adottesetben különféle csoportokkal szubsztituálva lehetnek és v) (b)általános képletű csoport, ahol a * a kapcsolódási pontot jelöli, Q1és Q2 jelentése O vagy S; W jelentése O, CH2, CHR6 vagy egyvegyértékkötés; R1 jelentése például alkil-, alkenil-, alkinil-,cikloalkil-, aril-vagy heteroarilcsoport; R2 jelentése H, alkil-,alkenil- vagy alkinilcsoport; R3 jelentése H, R1, OR1, OC(O)R1,OC(O)OR1 vagy OC(O)NR1R6; R4 és R5 jelentése egymástól függetlenül H,alkil- vagy alkenilcsoport, azzal a feltétellel, hogy az R4 és R5helyén állócsoportokban a szénatomok száma összesen 6 vagy ennélkevesebb, továbbá azzal a feltétellel, hogy R4 és R5 együttesen 3-6szénatomos gyűrűt képezhet; R6 és R7 jelentése egymástól függetlenülpéldául alkil-, cikloalkil- vagy alkinilcsoport, azzal a feltétellel,hogy R5 és R6 közül legalább az egyik jelentése hidrogénatom; azzal afeltétellel, hogy amennyiben az (I) általános képletű vegyület (I-1)általános képletű vegyületet képez, ahol R< jelentése H vagy OCH3, úgyR1 jelentése alkil- vagy alkenilcsoporttól eltérő. A találmánytárgyához tartoznak az (I) általános képletű vegyületeket tartalmazófungicid készítmények is, amelyek a hatóanyag mellett
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14467699P | 1999-07-20 | 1999-07-20 | |
PCT/US2000/019794 WO2001005769A2 (en) | 1999-07-20 | 2000-07-20 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301764A2 true HUP0301764A2 (hu) | 2003-09-29 |
HUP0301764A3 HUP0301764A3 (en) | 2004-06-28 |
Family
ID=22509639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301764A HUP0301764A3 (en) | 1999-07-20 | 2000-07-20 | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
Country Status (18)
Country | Link |
---|---|
US (3) | US6521622B1 (hu) |
EP (1) | EP1196388A2 (hu) |
JP (1) | JP2003528806A (hu) |
KR (1) | KR100743262B1 (hu) |
CN (1) | CN1208321C (hu) |
AU (1) | AU780698B2 (hu) |
BR (1) | BR0012615A (hu) |
CA (1) | CA2374995C (hu) |
CR (1) | CR6557A (hu) |
CZ (1) | CZ2002219A3 (hu) |
DK (1) | DK1516874T3 (hu) |
ES (1) | ES2546386T3 (hu) |
HU (1) | HUP0301764A3 (hu) |
PL (1) | PL206415B1 (hu) |
TR (1) | TR200200587T2 (hu) |
UA (1) | UA73519C2 (hu) |
WO (1) | WO2001005769A2 (hu) |
ZA (1) | ZA200200436B (hu) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
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US20030018052A1 (en) | 1999-07-20 | 2003-01-23 | Ricks Michael J. | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
US6355660B1 (en) | 1999-07-20 | 2002-03-12 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
ATE362925T1 (de) * | 1999-08-20 | 2007-06-15 | Hutchinson Fred Cancer Res | Zusammensetungen und verfahren zur modulation von apoptose in cellen, die proteine der bc1-2- familie exprimieren |
PT1204643E (pt) * | 1999-08-20 | 2008-09-15 | Dow Agrosciences Llc | Amidas aromáticas heterocíclicas fungicidas e suas composições, métodos de utilização e preparação |
EP1234824A1 (en) * | 1999-08-20 | 2002-08-28 | Dow AgroSciences LLC | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
US7241804B1 (en) | 2000-08-18 | 2007-07-10 | Fred Hutchinson Cancer Research Center | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins |
MXPA03002338A (es) * | 2000-09-18 | 2003-09-10 | Du Pont | Piridinilamidas y piridinilimidas para uso como fungicidas. |
WO2002080928A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
FR2827286A1 (fr) * | 2001-07-11 | 2003-01-17 | Aventis Cropscience Sa | Nouveaux composes fongicides |
US6987123B2 (en) | 2001-07-26 | 2006-01-17 | Cadila Healthcare Limited | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine |
WO2003011857A1 (en) * | 2001-07-31 | 2003-02-13 | Dow Agrosciences Llc | Reductive cleavage of the exocyclic ester of uk-2a or its derivatives and products formed therefrom |
DE10161765A1 (de) | 2001-12-15 | 2003-07-03 | Bayer Cropscience Gmbh | Substituierte Phenylderivate |
EP1503986B1 (en) * | 2001-12-21 | 2015-09-30 | Cytokinetics, Inc. | Compositions and methods for treating heart failure |
JPWO2003070277A1 (ja) * | 2002-02-19 | 2005-06-09 | 塩野義製薬株式会社 | 抗掻痒剤 |
BRPI0406810A (pt) * | 2003-01-31 | 2005-12-27 | Astrazeneca Ab | Compostos, processos de preparação e uso respectivos, composição farmacêutica e métodos de inibição da ativação dos receptores de mglur do grupo i e de tratamento de desordens mediadas pelos mesmos |
SG145745A1 (en) | 2003-08-06 | 2008-09-29 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
US20050176767A1 (en) * | 2003-10-30 | 2005-08-11 | Laval Chan Chun Kong | Pyridine carboxamide and methods for inhibiting HIV integrase |
EP1548007A1 (en) | 2003-12-19 | 2005-06-29 | Bayer CropScience S.A. | 2-Pyridinylethylcarboxamide derivatives and their use as fungicides |
KR100857312B1 (ko) | 2004-01-28 | 2008-09-05 | 미쓰이 가가쿠 가부시키가이샤 | 아미드 유도체 및 그 제조 방법 및 그의 살충제로서의 사용 방법 |
EP1574511A1 (en) * | 2004-03-03 | 2005-09-14 | Bayer CropScience S.A. | 2-Pyridinylethylcarboxamide derivatives and their use as fungicides |
US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
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CN1450993A (zh) | 2003-10-22 |
PL363114A1 (en) | 2004-11-15 |
US7034035B2 (en) | 2006-04-25 |
BR0012615A (pt) | 2004-03-30 |
US6927225B2 (en) | 2005-08-09 |
KR20020040753A (ko) | 2002-05-30 |
CA2374995C (en) | 2010-12-07 |
CR6557A (es) | 2008-09-22 |
CN1208321C (zh) | 2005-06-29 |
CA2374995A1 (en) | 2001-01-25 |
WO2001005769A2 (en) | 2001-01-25 |
HUP0301764A3 (en) | 2004-06-28 |
CZ2002219A3 (cs) | 2002-10-16 |
AU6357200A (en) | 2001-02-05 |
JP2003528806A (ja) | 2003-09-30 |
US20040048864A1 (en) | 2004-03-11 |
PL206415B1 (pl) | 2010-08-31 |
EP1196388A2 (en) | 2002-04-17 |
ZA200200436B (en) | 2004-05-26 |
US20040034025A1 (en) | 2004-02-19 |
DK1516874T3 (en) | 2015-11-23 |
US6521622B1 (en) | 2003-02-18 |
ES2546386T3 (es) | 2015-09-23 |
TR200200587T2 (tr) | 2004-12-21 |
KR100743262B1 (ko) | 2007-07-27 |
UA73519C2 (en) | 2005-08-15 |
AU780698B2 (en) | 2005-04-14 |
WO2001005769A3 (en) | 2001-11-22 |
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