HUP0003731A2 - 4-Bróm- vagy 4-jód-fenil-amino-benzhidroxámsav-származékok és ilyen vegyületek MEK gátlóként való alkalmazása - Google Patents

4-Bróm- vagy 4-jód-fenil-amino-benzhidroxámsav-származékok és ilyen vegyületek MEK gátlóként való alkalmazása

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Publication number
HUP0003731A2
HUP0003731A2 HU0003731A HUP0003731A HUP0003731A2 HU P0003731 A2 HUP0003731 A2 HU P0003731A2 HU 0003731 A HU0003731 A HU 0003731A HU P0003731 A HUP0003731 A HU P0003731A HU P0003731 A2 HUP0003731 A2 HU P0003731A2
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HU
Hungary
Prior art keywords
alkyl
group
atom
hydrogen
hydroxyl
Prior art date
Application number
HU0003731A
Other languages
English (en)
Inventor
Stephen Douglas Barrett
Alexander James Bridges
Annette Marian Doherty
David Thomas Dudley
Alan Robert Saltiel
Haile Tecle
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Warner-Lambert Co.
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Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP0003731A2 publication Critical patent/HUP0003731A2/hu
Publication of HUP0003731A3 publication Critical patent/HUP0003731A3/hu

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • A61P35/00—Antineoplastic agents
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

A találmány (I) általános képletű vegyületekre, a vegyületekettartalmazó gyógyászati készítményekre és azok alkalmazásáravonatkozik, a képletben R1 jelentése hidrogén- vagy halogénatom, hidroxil-, alkil-, alkoxi-,trifluor-metil- vagy cianocsoport; R2 jelentése hidrogénatom; R3, R4 és R5 jelentése hidrogén- vagy halogénatom, hidroxil-,trifluor-metil-, alkil-, alkoxi-, nitro-, ciano- vagy (O vagy NH)m-(CH2)n-R9 általános képletű csoport, amelyben R9 jelentésehidrogénatom, hidroxil-, karboxil- vagy NR10R11 általános képletűcsoport; n értéke 0, 1, 2, 3 vagy 4; m értéke 0 vagy 1; R10 és R11 jelentése egymástól függetlenül hidrogénatom vagyalkilcsoport, vagy együtt a nitrogénatommal, amelyhez kapcsolódnak,gyűrűt alkot, amely adott esetben az oxigénatom, kénatom, az -NH- vagy-N(-alkil)- csoport közül választott egy vagy több továbbiheteroatomot tartalmaz; R6 jelentése hidrogénatom, alkil-, C(=O)-alkil-, aril-, aralkil- vagycikloalkilcsoport; R7 jelentése hidrogénatom, alkil-, alkenil-, alkinil-, cikloalkil-vagy olyan cikloalkilcsoport, amely adott esetben az oxigén- éskénatom és az NR9 általános képletű csoport közül választottheteroatomot tartalmaz; vagy R6 és R7 együtt az N-O-val, amelyhezkapcsolódnak, gyűrűt alkot, amely adott esetben az oxigén- vagykénatom, vagy az -NR10R11 általános képletű csoport közül választottegy vagy több további heteroatomot tartalmaz; és ahol a fenti alkil-,alkenil- és alkinilcsoportok adott esetben helyettesítettek. Ó
HU0003731A 1997-07-01 1998-06-24 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors HUP0003731A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5144097P 1997-07-01 1997-07-01
PCT/US1998/013106 WO1999001426A1 (en) 1997-07-01 1998-06-24 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors

Publications (2)

Publication Number Publication Date
HUP0003731A2 true HUP0003731A2 (hu) 2001-04-28
HUP0003731A3 HUP0003731A3 (en) 2002-11-28

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ID=21971339

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003731A HUP0003731A3 (en) 1997-07-01 1998-06-24 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors

Country Status (26)

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EP (1) EP0993439B1 (hu)
JP (1) JP2002511092A (hu)
KR (1) KR20010014362A (hu)
CN (1) CN1163475C (hu)
AR (1) AR016762A1 (hu)
AT (1) ATE277895T1 (hu)
AU (1) AU757046B2 (hu)
BR (1) BR9810366A (hu)
CA (1) CA2290506C (hu)
CO (1) CO4940442A1 (hu)
DE (1) DE69826662T2 (hu)
ES (1) ES2229515T3 (hu)
HR (1) HRP980368A2 (hu)
HU (1) HUP0003731A3 (hu)
IL (1) IL132840A (hu)
IS (1) IS5256A (hu)
MY (1) MY120994A (hu)
NO (1) NO315271B1 (hu)
NZ (1) NZ501276A (hu)
PE (1) PE97999A1 (hu)
PL (1) PL337698A1 (hu)
PT (1) PT993439E (hu)
TW (1) TW396149B (hu)
UY (1) UY25076A1 (hu)
WO (1) WO1999001426A1 (hu)
ZA (1) ZA985728B (hu)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068738A1 (en) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy

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US7354894B2 (en) 1998-08-18 2008-04-08 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
US6846799B1 (en) 1998-08-18 2005-01-25 The Regents Of The University Of California Preventing airway mucus production by administration of EGF-R antagonists
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US6686499B1 (en) 1999-04-21 2004-02-03 Warner-Lambert Company Method for making 2-(N-phenylamino)benzoic acids
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