ATE551336T1 - Substituierte hydantoine - Google Patents

Substituierte hydantoine

Info

Publication number
ATE551336T1
ATE551336T1 AT08786933T AT08786933T ATE551336T1 AT E551336 T1 ATE551336 T1 AT E551336T1 AT 08786933 T AT08786933 T AT 08786933T AT 08786933 T AT08786933 T AT 08786933T AT E551336 T1 ATE551336 T1 AT E551336T1
Authority
AT
Austria
Prior art keywords
compounds
substituted hydantoins
mek2
mek
enzymes
Prior art date
Application number
AT08786933T
Other languages
English (en)
Inventor
Shaoqing Chen
Nicholas Huby
Norman Kong
John Moliterni
Omar Morales
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE551336T1 publication Critical patent/ATE551336T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08786933T 2007-08-16 2008-08-06 Substituierte hydantoine ATE551336T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95614507P 2007-08-16 2007-08-16
PCT/EP2008/060326 WO2009021887A1 (en) 2007-08-16 2008-08-06 Substituted hydantoins

Publications (1)

Publication Number Publication Date
ATE551336T1 true ATE551336T1 (de) 2012-04-15

Family

ID=39830023

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08786933T ATE551336T1 (de) 2007-08-16 2008-08-06 Substituierte hydantoine

Country Status (12)

Country Link
US (1) US7557221B2 (de)
EP (1) EP2188276B1 (de)
JP (1) JP2010536723A (de)
KR (1) KR101147583B1 (de)
CN (1) CN101778839A (de)
AT (1) ATE551336T1 (de)
AU (1) AU2008288556A1 (de)
BR (1) BRPI0815180A2 (de)
CA (1) CA2695956A1 (de)
ES (1) ES2383927T3 (de)
MX (1) MX2010001581A (de)
WO (1) WO2009021887A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102020651B (zh) 2010-11-02 2012-07-18 北京赛林泰医药技术有限公司 6-芳基氨基吡啶酮甲酰胺mek抑制剂
CA2843595C (en) 2011-08-01 2022-10-18 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
US20150265679A1 (en) 2012-11-02 2015-09-24 The United States Of America, As Represented By Secretary, Department Of Health And Human Services Method of reducing adverse effects in a cancer patient undregoing treatment with a mek inhibitor
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
EP3055287B1 (de) * 2013-10-08 2019-11-06 Lu, Qing-Bin Nicht-platin-basierte antikrebsverbindungen zur verwendung in einer gezielten chemotherapie
SG11201700074YA (en) 2014-07-15 2017-02-27 Genentech Inc Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE277895T1 (de) 1997-07-01 2004-10-15 Warner Lambert Co 4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
KR19990012061A (ko) 1997-07-26 1999-02-25 성재갑 파네실 전이효소 저해제로 유용한 하이덴토인 유도체
ATE304011T1 (de) 2000-05-03 2005-09-15 Hoffmann La Roche Hydantoin-enthaltende glucokinase aktivatoren
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
DE602004023207D1 (de) * 2003-07-24 2009-10-29 Warner Lambert Co Benzimidazol-derivate als mek-hemmer
CA2557398A1 (en) * 2004-02-26 2005-09-09 Hans-Peter Buchstaller Benzimidazolyl derivatives as kinase inhibitors
ATE404556T1 (de) * 2004-08-17 2008-08-15 Hoffmann La Roche Substituierte hydantoine
TW200621766A (en) 2004-09-17 2006-07-01 Hoffmann La Roche Substituted hydantoins
WO2006124780A2 (en) 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
US7612212B2 (en) * 2006-02-22 2009-11-03 Hoffmann-La Roche Inc. Substituted hydantoins

Also Published As

Publication number Publication date
BRPI0815180A2 (pt) 2019-09-24
WO2009021887A1 (en) 2009-02-19
ES2383927T3 (es) 2012-06-27
JP2010536723A (ja) 2010-12-02
KR20100031777A (ko) 2010-03-24
EP2188276A1 (de) 2010-05-26
MX2010001581A (es) 2010-03-15
KR101147583B1 (ko) 2012-05-21
US20090048452A1 (en) 2009-02-19
US7557221B2 (en) 2009-07-07
EP2188276B1 (de) 2012-03-28
CN101778839A (zh) 2010-07-14
CA2695956A1 (en) 2009-02-19
AU2008288556A1 (en) 2009-02-19

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