HUP0001547A2 - Az S-omeprazol új formája - Google Patents

Az S-omeprazol új formája

Info

Publication number
HUP0001547A2
HUP0001547A2 HU0001547A HUP0001547A HUP0001547A2 HU P0001547 A2 HUP0001547 A2 HU P0001547A2 HU 0001547 A HU0001547 A HU 0001547A HU P0001547 A HUP0001547 A HU P0001547A HU P0001547 A2 HUP0001547 A2 HU P0001547A2
Authority
HU
Hungary
Prior art keywords
omeprazole
neutral
organic solvents
solution
solid
Prior art date
Application number
HU0001547A
Other languages
English (en)
Inventor
Martin Bohlin
Karol Horvath
Sverker Von Unge
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20405146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0001547(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of HUP0001547A2 publication Critical patent/HUP0001547A2/hu
Publication of HU0001547D0 publication Critical patent/HU0001547D0/hu
Publication of HUP0001547A3 publication Critical patent/HUP0001547A3/hu
Publication of HU227589B1 publication Critical patent/HU227589B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Abstract

A találmány tárgyát az (S)-omeprazol neutrális alakjának új, szilárdhalmazállapotú, legalább részben kristályos formája, eljárás ennekelőállítására és ezt a formát tartalmazó gyógyszerkészítményekképezik. A találmány szerint úgy járnak el, hogy a) neutrális (S)-omeprazol egy vagy több szerves oldószerrel készített oldatát nagyontöményre bepárolják, további oldószert adva hozzá folytatják abepárlást mindaddig, amíg szilárd, amorf, neutrális (S)-omeprazolkeletkezik; vagy b) az (S)-omeprazolt egy vagy több szervesoldószerrel és adott esetben vízzel készített oldatábólkristályosítják; vagy c) az (S)-omeprazol alkalikus sójának vízzel ésadott esetben egy vagy több szerves oldószerrel készített oldatából az(S)-omeprazolt megfelelő savval kicsapják. Ó
HU0001547A 1996-12-20 1997-12-16 Crystal form of (s)-omeprazole HU227589B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604793A SE510666C2 (sv) 1996-12-20 1996-12-20 Nya Kristallmodifikationer
PCT/SE1997/002125 WO1998028294A1 (en) 1996-12-20 1997-12-16 A novel compound form

Publications (4)

Publication Number Publication Date
HUP0001547A2 true HUP0001547A2 (hu) 2002-05-29
HU0001547D0 HU0001547D0 (hu) 2002-05-29
HUP0001547A3 HUP0001547A3 (en) 2002-06-28
HU227589B1 HU227589B1 (en) 2011-09-28

Family

ID=20405146

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001547A HU227589B1 (en) 1996-12-20 1997-12-16 Crystal form of (s)-omeprazole

Country Status (37)

Country Link
US (1) US6162816A (hu)
EP (1) EP0946547B1 (hu)
JP (1) JP4402174B2 (hu)
KR (1) KR20000069595A (hu)
CN (1) CN1109684C (hu)
AR (1) AR010361A1 (hu)
AT (1) ATE236898T1 (hu)
AU (1) AU730129B2 (hu)
BR (1) BR9714059A (hu)
CA (1) CA2274076C (hu)
CZ (1) CZ294784B6 (hu)
DE (1) DE69720774T2 (hu)
DK (1) DK0946547T3 (hu)
EE (1) EE03923B1 (hu)
EG (1) EG24414A (hu)
ES (1) ES2194231T3 (hu)
HK (1) HK1022909A1 (hu)
HU (1) HU227589B1 (hu)
ID (1) ID21850A (hu)
IL (1) IL130450A0 (hu)
IS (1) IS1981B (hu)
MY (1) MY117032A (hu)
NO (1) NO317191B1 (hu)
NZ (1) NZ336024A (hu)
PL (1) PL190377B1 (hu)
PT (1) PT946547E (hu)
RS (1) RS49685B (hu)
RU (1) RU2184734C2 (hu)
SA (1) SA97180739B1 (hu)
SE (1) SE510666C2 (hu)
SI (1) SI0946547T1 (hu)
SK (1) SK285151B6 (hu)
TR (1) TR199901410T2 (hu)
TW (1) TW538039B (hu)
UA (1) UA55436C2 (hu)
WO (1) WO1998028294A1 (hu)
ZA (1) ZA9711046B (hu)

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US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
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SE9804003D0 (sv) 1998-11-23 1998-11-23 Astra Ab A method of producing drug particles
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TWI289557B (en) 1999-06-17 2007-11-11 Takeda Chemical Industries Ltd A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
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AU2003247729B2 (en) * 2002-06-27 2009-10-08 Dr. Reddy's Laboratories Limited A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
US7612098B2 (en) * 2002-08-30 2009-11-03 Dr. Reddy's Laboratories Limited Amorphous hydrous esomeprazole magnesium
EP2596792A1 (en) 2002-10-16 2013-05-29 Takeda Pharmaceutical Company Limited Stable solid preparations
US20040235903A1 (en) * 2002-10-22 2004-11-25 Khanna Mahavir Singh Amorphous form of esomeprazole salts
WO2004046134A2 (en) * 2002-11-18 2004-06-03 Dr. Reddy's Laboratories Limited Crystalline form ii of esomeprazole magnesium trihydrate and process for its preparation
CA2517714A1 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Polymorphs of s-omeprazole
CN100364987C (zh) * 2003-03-24 2008-01-30 卫材R&D管理有限公司 亚砜衍生物或其盐的非定形态的制备方法
US20070060556A1 (en) * 2003-05-05 2007-03-15 Yatendra Kumar Barium salt of benzimidazole derivative
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
SE0400410D0 (sv) 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
AU2005264864B2 (en) 2004-06-16 2011-08-11 Takeda Pharmaceutical Company Limited Multiple PPI dosage form
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ES2246149B1 (es) * 2004-07-02 2007-06-01 Esteve Quimica, S.A. Formas solidas de la sal magnesica de s-omeprazol y procedimientos para su preparacion.
WO2006120520A1 (en) * 2005-05-06 2006-11-16 Glenmark Pharmaceuticals Limited Esomeprazole strontium salt, process for its preparation and pharmaceutical compositions containing same
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US7563812B2 (en) 2005-06-15 2009-07-21 Hetero Drugs Limited Amorphous esomeprazole hydrate
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US7576219B2 (en) 2005-10-26 2009-08-18 Hanmi Pharm. Co., Ltd Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
EP1948637A4 (en) * 2005-11-14 2010-09-08 Hetero Drugs Ltd PROCESS FOR AMORPHES ESOMEPRAZOLE
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EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
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WO2009047775A2 (en) * 2007-10-08 2009-04-16 Hetero Drugs Limited Polymorphs of esomeprazole salts
NZ588379A (en) 2008-03-10 2012-07-27 Takeda Pharmaceutical Crystal of benzimidazole compound
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AU2009290712A1 (en) * 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
SG176724A1 (en) 2009-06-25 2012-01-30 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
SG181535A1 (en) 2009-12-08 2012-07-30 Codexis Inc Synthesis of prazole compounds
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
EA028049B1 (ru) 2011-12-28 2017-10-31 Поузен Инк. Улучшенные композиции и способы доставки омепразола и ацетилсалициловой кислоты
RU2501549C1 (ru) 2012-08-30 2013-12-20 Авва Девелопмент Лтд Фармацевтическая композиция для лечения гастроэзофагеальной рефлюксной болезни
CN107043367A (zh) * 2017-05-26 2017-08-15 重庆莱美隆宇药业有限公司 一种中性s‑奥美拉唑的干燥工艺
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Also Published As

Publication number Publication date
AU730129B2 (en) 2001-02-22
HK1022909A1 (en) 2000-08-25
BR9714059A (pt) 2000-05-09
ATE236898T1 (de) 2003-04-15
AU5502698A (en) 1998-07-17
RU2184734C2 (ru) 2002-07-10
HU227589B1 (en) 2011-09-28
SK76599A3 (en) 1999-12-10
WO1998028294A1 (en) 1998-07-02
KR20000069595A (ko) 2000-11-25
CZ220299A3 (cs) 2000-02-16
AR010361A1 (es) 2000-06-07
SE9604793D0 (sv) 1996-12-20
IS1981B (is) 2005-01-14
DK0946547T3 (da) 2003-06-30
HUP0001547A3 (en) 2002-06-28
CA2274076A1 (en) 1998-07-02
SA97180739B1 (ar) 2006-05-20
IS5070A (is) 1999-06-07
RS49685B (sr) 2007-11-15
TW538039B (en) 2003-06-21
CA2274076C (en) 2008-09-30
SE9604793L (sv) 1998-06-21
SK285151B6 (sk) 2006-07-07
EE03923B1 (et) 2002-12-16
NO317191B1 (no) 2004-09-13
EG24414A (en) 2009-05-25
NZ336024A (en) 2001-02-23
JP2001507025A (ja) 2001-05-29
IL130450A0 (en) 2000-06-01
UA55436C2 (uk) 2003-04-15
ES2194231T3 (es) 2003-11-16
ID21850A (id) 1999-08-05
ZA9711046B (en) 1998-06-22
NO993068L (no) 1999-06-21
JP4402174B2 (ja) 2010-01-20
CN1109684C (zh) 2003-05-28
NO993068D0 (no) 1999-06-21
CZ294784B6 (cs) 2005-03-16
SI0946547T1 (en) 2003-10-31
PL190377B1 (pl) 2005-12-30
CN1241183A (zh) 2000-01-12
EE9900259A (et) 2000-02-15
PT946547E (pt) 2003-07-31
DE69720774D1 (de) 2003-05-15
EP0946547B1 (en) 2003-04-09
HU0001547D0 (hu) 2002-05-29
SE510666C2 (sv) 1999-06-14
YU28199A (sh) 2002-03-18
TR199901410T2 (xx) 1999-08-23
DE69720774T2 (de) 2004-02-05
EP0946547A1 (en) 1999-10-06
MY117032A (en) 2004-04-30
PL334297A1 (en) 2000-02-14
US6162816A (en) 2000-12-19

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