RU94031126A - Циклические мочевины и их аналоги, пригодные в качестве ингибиторов протеазы ретровирусов, способ лечения вирусных инфекций, фармацевтическая композиция - Google Patents
Циклические мочевины и их аналоги, пригодные в качестве ингибиторов протеазы ретровирусов, способ лечения вирусных инфекций, фармацевтическая композицияInfo
- Publication number
- RU94031126A RU94031126A RU94031126/04A RU94031126A RU94031126A RU 94031126 A RU94031126 A RU 94031126A RU 94031126/04 A RU94031126/04 A RU 94031126/04A RU 94031126 A RU94031126 A RU 94031126A RU 94031126 A RU94031126 A RU 94031126A
- Authority
- RU
- Russia
- Prior art keywords
- protease inhibitors
- viral infections
- pharmaceutical composition
- cyclic urea
- treating viral
- Prior art date
Links
- 206010047461 Viral infection Diseases 0.000 title claims 2
- 208000001756 Virus Disease Diseases 0.000 title claims 2
- 229940042399 direct acting antivirals Protease inhibitors Drugs 0.000 title claims 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 2
- 239000004202 carbamide Substances 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000001177 retroviral Effects 0.000 claims 1
- 230000017613 viral reproduction Effects 0.000 claims 1
Claims (1)
- Настоящее изобретение относится к замещенным циклическим карбонилам и их производным, пригодным в качестве ингибиторов протеаз ретровирусов, к содержащим такие соединения фармацевтическим композициям и к способам использования этих соединений для лечения вирусных инфекций.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77649191A | 1991-10-11 | 1991-10-11 | |
US07/776,491 | 1991-10-11 | ||
US88394492A | 1992-05-15 | 1992-05-15 | |
US07/883,944 | 1992-05-15 | ||
US95327292A | 1992-09-29 | 1992-09-29 | |
US07/953,272 | 1992-09-30 | ||
PCT/US1992/008749 WO1993007128A1 (en) | 1991-10-11 | 1992-10-13 | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94031126A true RU94031126A (ru) | 1996-03-10 |
RU2131420C1 RU2131420C1 (ru) | 1999-06-10 |
Family
ID=27419722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94031126/04A RU2131420C1 (ru) | 1991-10-11 | 1992-10-13 | Циклические мочевины, способ ингибирования роста ретровирусов и фармацевтическая композиция |
Country Status (19)
Country | Link |
---|---|
EP (3) | EP0607334B1 (ru) |
JP (1) | JP3208140B2 (ru) |
KR (1) | KR100268694B1 (ru) |
AT (2) | ATE216371T1 (ru) |
AU (2) | AU2871592A (ru) |
BR (1) | BR9206623A (ru) |
CA (1) | CA2120925A1 (ru) |
CZ (1) | CZ284872B6 (ru) |
DE (2) | DE69232568T2 (ru) |
DK (1) | DK0607334T3 (ru) |
ES (1) | ES2104946T3 (ru) |
FI (1) | FI941649A (ru) |
GR (1) | GR3025005T3 (ru) |
HK (1) | HK1002257A1 (ru) |
HU (1) | HU221816B1 (ru) |
NO (1) | NO306720B1 (ru) |
RU (1) | RU2131420C1 (ru) |
SK (1) | SK280882B6 (ru) |
WO (1) | WO1993007128A1 (ru) |
Families Citing this family (70)
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EP0815108A1 (en) * | 1995-03-17 | 1998-01-07 | The Du Pont Merck Pharmaceutical Company | Cyclic urea hiv protease inhibitors |
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AU1592697A (en) * | 1995-08-22 | 1997-03-19 | Du Pont Merck Pharmaceutical Company, The | Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
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US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
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US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
KR19990016003A (ko) * | 1997-08-12 | 1999-03-05 | 성재갑 | 치토크롬 저해제 조성물 |
KR100348561B1 (ko) * | 1997-08-12 | 2002-09-18 | 주식회사 엘지씨아이 | Lb71350과 dmp450을 함유하는 조성물 |
US6313110B1 (en) | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
DE19962923A1 (de) * | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Benzoylcyclohexandione |
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FR2810039B1 (fr) | 2000-06-13 | 2007-05-25 | Centre Nat Rech Scient | Composes urees cycliques et leur procede de preparation |
UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
WO2004011429A1 (ja) * | 2002-07-26 | 2004-02-05 | Nihon Nohyaku Co., Ltd. | 新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法 |
JP2004107323A (ja) * | 2002-07-26 | 2004-04-08 | Nippon Nohyaku Co Ltd | 新規なハロアルキルスルホンアニリド誘導体及び除草剤並びにその使用方法 |
US7834043B2 (en) | 2003-12-11 | 2010-11-16 | Abbott Laboratories | HIV protease inhibiting compounds |
US20080033167A1 (en) | 2005-12-29 | 2008-02-07 | Gilles Guichard | Compositions and methods for synthesizing heterocyclic therapeutic compounds |
JP5486928B2 (ja) | 2007-02-26 | 2014-05-07 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1のサイクリックウレアおよびカルバメートインヒビター |
JP5448854B2 (ja) | 2007-03-12 | 2014-03-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−プロテアーゼ阻害剤複合体 |
AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
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US9095620B2 (en) | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
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JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
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JP5860042B2 (ja) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用 |
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HUE026832T2 (en) * | 2010-10-13 | 2016-07-28 | Abbvie Bahamas Ltd | Antiviral 1-phenyl-2,5-dibenzimidazol-5-ylpyrrolidine derivative |
CN103179960A (zh) | 2010-11-02 | 2013-06-26 | 贝林格尔.英格海姆国际有限公司 | 治疗代谢疾病的药物组合 |
GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
US4652552A (en) | 1984-09-10 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Tetrapeptide methyl ketone inhibitors of viral proteases |
US4644055A (en) | 1984-12-17 | 1987-02-17 | E. I. Du Pont De Nemours And Company | Method for preparing specific inhibitors of virus-specified proteases |
US4837204A (en) | 1985-01-23 | 1989-06-06 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols |
FR2600252A1 (fr) | 1986-06-19 | 1987-12-24 | Inst Nat Sante Rech Med | Medicament et composition medicamenteuse pour le traitement de maladies infectieuses dues aux virus, ainsi que pour le traitement des tumeurs |
IL90218A0 (en) | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
EP0374097A3 (de) | 1988-12-15 | 1991-06-12 | Ciba-Geigy Ag | Verwendung von Peptidisosteren als retrovirale Proteasehemmer |
US5049548A (en) | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
CA2010531A1 (en) | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
CA2032259A1 (en) | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
CA2026832A1 (fr) | 1990-10-03 | 1992-04-04 | Nouredine Haouas | Systeme demontable d'attache rapide pour objets tridimensionnels entre eux |
-
1992
- 1992-10-13 SK SK407-94A patent/SK280882B6/sk unknown
- 1992-10-13 AT AT96118182T patent/ATE216371T1/de not_active IP Right Cessation
- 1992-10-13 ES ES92922262T patent/ES2104946T3/es not_active Expired - Lifetime
- 1992-10-13 BR BR9206623A patent/BR9206623A/pt not_active Application Discontinuation
- 1992-10-13 JP JP50724493A patent/JP3208140B2/ja not_active Expired - Fee Related
- 1992-10-13 AU AU28715/92A patent/AU2871592A/en not_active Abandoned
- 1992-10-13 WO PCT/US1992/008749 patent/WO1993007128A1/en active IP Right Grant
- 1992-10-13 EP EP92922262A patent/EP0607334B1/en not_active Expired - Lifetime
- 1992-10-13 DE DE69232568T patent/DE69232568T2/de not_active Expired - Fee Related
- 1992-10-13 CZ CZ94814A patent/CZ284872B6/cs not_active IP Right Cessation
- 1992-10-13 CA CA002120925A patent/CA2120925A1/en not_active Abandoned
- 1992-10-13 HU HU9401020A patent/HU221816B1/hu not_active IP Right Cessation
- 1992-10-13 RU RU94031126/04A patent/RU2131420C1/ru not_active IP Right Cessation
- 1992-10-13 EP EP96118182A patent/EP0765873B1/en not_active Expired - Lifetime
- 1992-10-13 EP EP01119426A patent/EP1153921A3/en not_active Withdrawn
- 1992-10-13 KR KR1019940701169A patent/KR100268694B1/ko not_active IP Right Cessation
- 1992-10-13 AT AT92922262T patent/ATE156123T1/de not_active IP Right Cessation
- 1992-10-13 DE DE69221309T patent/DE69221309T2/de not_active Expired - Fee Related
- 1992-10-13 DK DK92922262.8T patent/DK0607334T3/da active
-
1994
- 1994-04-08 NO NO941278A patent/NO306720B1/no not_active IP Right Cessation
- 1994-04-08 FI FI941649A patent/FI941649A/fi unknown
- 1994-05-02 AU AU61808/94A patent/AU694417B2/en not_active Ceased
-
1997
- 1997-10-09 GR GR970402648T patent/GR3025005T3/el unknown
-
1998
- 1998-01-23 HK HK98100641A patent/HK1002257A1/xx not_active IP Right Cessation
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