HUE034492T2 - Oxazolidin-2-one pyrimidine derivative - Google Patents

Info

Publication number

HUE034492T2

HUE034492T2 HUE13795867A HUE13795867A HUE034492T2 HU E034492 T2 HUE034492 T2 HU E034492T2 HU E13795867 A HUE13795867 A HU E13795867A HU E13795867 A HUE13795867 A HU E13795867A HU E034492 T2 HUE034492 T2 HU E034492T2

Authority

HU

Hungary

Prior art keywords

compound

amino

alkoxy

oxazolidin

pharmaceutically acceptable

Prior art date

2012-11-12

Links

• Espacenet
• Global Dossier
• Discuss

• VDOLEZNCZWNTEU-UHFFFAOYSA-N 1,3-oxazolidin-2-one;pyrimidine Chemical class C1=CN=CN=C1.O=C1NCCO1 VDOLEZNCZWNTEU-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 262
• 150000003839 salts Chemical class 0.000 claims description 96
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• 125000001424 substituent group Chemical group 0.000 claims description 42
• -1 cyclic styrenes Chemical class 0.000 claims description 39
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 37
• 239000003814 drug Substances 0.000 claims description 30
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
• 125000003545 alkoxy group Chemical group 0.000 claims description 20
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 17
• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 17
• 239000008194 pharmaceutical composition Substances 0.000 claims description 16
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• 125000004076 pyridyl group Chemical group 0.000 claims description 12
• 125000004432 carbon atom Chemical group C* 0.000 claims description 11
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• 239000000126 substance Substances 0.000 claims description 8
• 229910052717 sulfur Inorganic materials 0.000 claims description 8
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims description 5
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 5
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• 206010020649 Hyperkeratosis Diseases 0.000 claims 1
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• WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical compound C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 claims 1
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