HUE033758T2 - Eljárás glikozilált immunglobulin elõállítására - Google Patents

Eljárás glikozilált immunglobulin elõállítására Download PDF

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Publication number
HUE033758T2
HUE033758T2 HUE10771093A HUE10771093A HUE033758T2 HU E033758 T2 HUE033758 T2 HU E033758T2 HU E10771093 A HUE10771093 A HU E10771093A HU E10771093 A HUE10771093 A HU E10771093A HU E033758 T2 HUE033758 T2 HU E033758T2
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HU
Hungary
Prior art keywords
cells
immunoglobulin
glucose
amount
cell
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HUE10771093A
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English (en)
Inventor
Reinhard Franze
Chikashi Hirashima
Thomas Link
Yoshinori Takagi
Shinya Takuma
Yuriko Tsuda
Original Assignee
Hoffmann La Roche
Chugai Pharmaceutical Co Ltd
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Application filed by Hoffmann La Roche, Chugai Pharmaceutical Co Ltd filed Critical Hoffmann La Roche
Publication of HUE033758T2 publication Critical patent/HUE033758T2/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Claims (6)

  1. KI JÁRÁS GUKOZILÁLTIMMUNGLOBULIN ELŐÁLLÍ TÁSÁRA Szabadalmi igénypontok
    1. Eljárás imrmmgiobntm előállítására, amely tartalmazza a) egy» az immunglobulint kódoló nakieínsavat tartalmazó eukarióta sejt tenyésztését tenyésztő tápoldatban, ahol a tenyésztő tápoldatban rendelkezésre álló glükóz, mennyiségét időegységenként adandó értéken ős egy olyáp: konstans értékre·korlátozva tartjvtk, amely kisebb* mint a tápoldatban lévő sejtek által legfeljebb felhasználható mennyiség <5ö%-a és -több, mint 20%»a, miáltal ez az állandó mennyiség -annak az eljárásnak minden.-időegysége alatt rendelkezésre áll. amelyben ezt a korlátozott giükőzbetáplálást végrehajtjuk, és b) az immunglobulin kinyerését a tenyészetből,
  2. 2. Az L igénypont szerinti eljárás azzal jellemezve, hogy a tenyésztés rálápiálááös SKdíászos tenyésztés. •3., A 2, igénypont szerinti eljárás azzal jellemezve, bogy a tenyésztés tátápiálásos szakaszos tenyésztés, amelynél a táplálást a tenyésztés -2, vagy 3. napján kezdjük. 4* Az előző igénypontok bármelyike1 szerinti eljárás azzal jellemesve. bogy a tenyésztést a pH o.S-íől 7.5-ig mnedo pH értéken végezzük. $. A 4. igénypont szerinti- eljárás azzal jellemezve» hogy ti tenyésztést pH 6,9-íő! 7.3-ig terjedő pH értéket) végezzük.
  3. 6. Az igénypont szerinti eljárás azzal jellemezve, hogy a tenyésztést pH 6.95-iől pH ?<ö5~ig vagy pH 7,lótól 7,25-ig terjedő pH értéken sége.zzílk.
  4. 7. Az előzó igénypontok bármelyike szerinti eljárás azzal jellemezve, hogy az intrmtnglobulin G vagy E osztályú imrmtnglobulin.
  5. 8. Az dózö igénypontok bármelyike szerinti eljárás azzal jellemezve, bogy az. eukarióta gazdagépét a CHO sejteket, NSO sejteket, BEK sejteket, BHK sejteket, hibridőma sejteket, PBR.C'ö® sejtekét, rovarsejtekét és $p2/Ö sejteket iartahnazó csoportúéi választjuk. 9. A 8. igénypont szedttîi eünás a/zd jellemen e. hogy az eukarióta sejt kínai hörcsög petefészek <€M.Ö) sejt
  6. 50, Az előző igénypontok bármelyike szerinti eljárás azzal jellemezve, hogy a gazdag téttyészt-^i#Íi^ÍÍÍ!ái5 napig végezzük. Η. Az előző tgenvpontok bármelyike szerinti eljárás azzal jellemezve, hogy az immunglobulin artú-IL-őR ellenanyag:,: ....
HUE10771093A 2009-10-26 2010-10-25 Eljárás glikozilált immunglobulin elõállítására HUE033758T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09013455 2009-10-26

Publications (1)

Publication Number Publication Date
HUE033758T2 true HUE033758T2 (hu) 2017-12-28

Family

ID=42060615

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HUE10771093A HUE033758T2 (hu) 2009-10-26 2010-10-25 Eljárás glikozilált immunglobulin elõállítására

Country Status (19)

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US (8) US20110117087A1 (hu)
EP (2) EP3202785A1 (hu)
JP (6) JP5711751B2 (hu)
KR (8) KR102071834B1 (hu)
CN (2) CN102596995B (hu)
AU (1) AU2010311567B2 (hu)
BR (2) BR112012009828B8 (hu)
CA (1) CA2773522C (hu)
DK (1) DK2493922T3 (hu)
ES (1) ES2622366T3 (hu)
HK (2) HK1171237A1 (hu)
HU (1) HUE033758T2 (hu)
IL (2) IL218997A0 (hu)
MX (2) MX2012004682A (hu)
PL (1) PL2493922T3 (hu)
SG (2) SG10201510640QA (hu)
SI (1) SI2493922T1 (hu)
TW (6) TW201540837A (hu)
WO (1) WO2011051231A1 (hu)

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