HUE030619T2 - Kolonoszkópiás készítmény - Google Patents
Kolonoszkópiás készítmény Download PDFInfo
- Publication number
- HUE030619T2 HUE030619T2 HUE12710777A HUE12710777A HUE030619T2 HU E030619 T2 HUE030619 T2 HU E030619T2 HU E12710777 A HUE12710777 A HU E12710777A HU E12710777 A HUE12710777 A HU E12710777A HU E030619 T2 HUE030619 T2 HU E030619T2
- Authority
- HU
- Hungary
- Prior art keywords
- solution
- ascorbate
- ascorbic acid
- component
- colon
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 23
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 472
- 235000010323 ascorbic acid Nutrition 0.000 claims description 213
- 239000011668 ascorbic acid Substances 0.000 claims description 213
- 239000000203 mixture Substances 0.000 claims description 167
- 229960005070 ascorbic acid Drugs 0.000 claims description 133
- 210000001072 colon Anatomy 0.000 claims description 127
- 229920001223 polyethylene glycol Polymers 0.000 claims description 102
- 229940072107 ascorbate Drugs 0.000 claims description 80
- 150000003839 salts Chemical class 0.000 claims description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
- 235000003599 food sweetener Nutrition 0.000 claims description 44
- 239000003765 sweetening agent Substances 0.000 claims description 44
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 7
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 241000220479 Acacia Species 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 235000014676 Phragmites communis Nutrition 0.000 claims 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 235000014510 cooky Nutrition 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 229940109850 royal jelly Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 360
- 239000002202 Polyethylene glycol Substances 0.000 description 99
- 235000002639 sodium chloride Nutrition 0.000 description 85
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 72
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 68
- CIWBSHSKHKDKBQ-JLAZNSOCSA-M L-ascorbate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CIWBSHSKHKDKBQ-JLAZNSOCSA-M 0.000 description 45
- -1 bowel cleansers Substances 0.000 description 43
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 42
- 239000000796 flavoring agent Substances 0.000 description 34
- 239000001103 potassium chloride Substances 0.000 description 32
- 235000011164 potassium chloride Nutrition 0.000 description 32
- 239000011780 sodium chloride Substances 0.000 description 32
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 31
- 239000003792 electrolyte Substances 0.000 description 28
- 235000013355 food flavoring agent Nutrition 0.000 description 28
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 27
- 239000012530 fluid Substances 0.000 description 26
- 235000010378 sodium ascorbate Nutrition 0.000 description 25
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 25
- 229960005055 sodium ascorbate Drugs 0.000 description 25
- 238000000034 method Methods 0.000 description 22
- 238000011282 treatment Methods 0.000 description 22
- 210000003608 fece Anatomy 0.000 description 21
- 229910052938 sodium sulfate Inorganic materials 0.000 description 21
- 235000011152 sodium sulphate Nutrition 0.000 description 21
- 229910021653 sulphate ion Inorganic materials 0.000 description 21
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 18
- 229910052936 alkali metal sulfate Inorganic materials 0.000 description 18
- 210000002700 urine Anatomy 0.000 description 18
- 229940030786 moviprep Drugs 0.000 description 17
- 229940074358 magnesium ascorbate Drugs 0.000 description 16
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 16
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 16
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 14
- 229910052700 potassium Inorganic materials 0.000 description 14
- 239000011591 potassium Substances 0.000 description 14
- 239000000843 powder Substances 0.000 description 14
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- 150000001340 alkali metals Chemical class 0.000 description 12
- 239000002775 capsule Substances 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
- 239000004260 Potassium ascorbate Substances 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 238000002052 colonoscopy Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 235000019275 potassium ascorbate Nutrition 0.000 description 8
- 229940017794 potassium ascorbate Drugs 0.000 description 8
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 6
- 239000000619 acesulfame-K Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000001186 cumulative effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 230000037406 food intake Effects 0.000 description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 238000011835 investigation Methods 0.000 description 5
- 239000002207 metabolite Substances 0.000 description 5
- 235000020354 squash Nutrition 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 235000010376 calcium ascorbate Nutrition 0.000 description 4
- 239000011692 calcium ascorbate Substances 0.000 description 4
- 229940047036 calcium ascorbate Drugs 0.000 description 4
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 4
- 230000008014 freezing Effects 0.000 description 4
- 238000007710 freezing Methods 0.000 description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 4
- 235000019341 magnesium sulphate Nutrition 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 4
- 230000003204 osmotic effect Effects 0.000 description 4
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 4
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- 239000000523 sample Substances 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 3
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- 150000001342 alkaline earth metals Chemical class 0.000 description 3
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- SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Natural products OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Claims (6)
1 - Vastagbél tisztító oldal, mely uuiahna«;· . } UV- 0s\ s>, ïtn mos ko'O I, u Ml snD>ei j* \ΟχΟϊο^λ v^ ' ^s tohb jL<.*kov\H vs vagy cook keveréke szolgállak es b) V 2θ0 ^ 0Λ' } οΚηΛϊ y!?U\,
2. Az l. igénypont szeûmi vastagbél bsztitô okiak ahotM; aszkorhât asOcM Λΐ>'Φ)Ν«,νν>\ vags s 4k a » a sen- !- sosKss k»fior- ts karfott, magnézium-aszkorbttk ès k<ikUmua.srzkoi*sn vagy ezek kes erêke közül választón aszJtorbmsav~&i szolgáltatja. ' \' } \ vj.v ' xxO Λ}Ν\ΐί vX.sîO \nskn m2 u^zuto oknm nsd> neutone a) 301V20Ö0 mmol/luer nszkurbâr amont; s s \V :vv o hier h\sf' 40U'i Da otí sgos n-'k kutatóméin Pt Y>-ek o^ s 'km H \kn vk>t os \ mm k Kel
4. Az h vagy 2. ígényps-ni szerinti v&sîayK 1 ü«ztins öláaí; mekc Jényegébgtr vizet éy a kôs οκοζΎη tau Dnmva ai >00-2000 ses me 10 kér ssezkorhát am ms; bt K’-JOu ». fites ,Ό vu-uKXs Da aik.go.- nuik-kukoOivoga ΪΊΓΟ A nátrium kl'UsiOoi ν'- kahuet-klofD \ Vies K'Ok í/e-ukvavee, s..- Í) egy :-mg$ IÄ édeDtoszeu:
5. Az 1-4. igénypontok bármelyike szerinti vaDagbél tisztító oldat, mely 400-700 ο V/' 1 - ' mè!>\s-r 4 kaseeO D s. o.mu \ I soruk» ekük ahol ae okbî OMklMlkBÇô 120 g/i iter aexkorhät i^nnpooenfk tm vagy Al> aszkorbiiiíav se. vagy aszkorbiíiNuv és egy vagy tohb aszkorfemsav # keveréke., ] « Jgsmspo.í ok ivar ve sk „ ul sosUesI v *.n oldat uhui ,v oldat íasÉfefei»sa^4tsás.'«slm«tn-a^krsfbátc>t tartalmaz. ;1> Az :1>?; igenypnsnok btsmtdyike e/.ernns vastagbél Őszutó okiak ajiol az u|Ä i sais s mn-hsdr» - gén-karb>. mattol lens egében »nemes. 0 oom vt.no vei»'..' ' ad rare ohoka keszomem adm? cs.tbe^ ko* sam több rösalctiaen \ ;m, és tért ni asm: Äfefbtav só vagy aszkorbinsav és egy vagy több aszkorhinsav so keverék«?; <3« bt 5-1 CH)·g pofietiléngíikoH. 10. A 9, igénypont szerinti keszitmeny. mely tartalmaz; c> 25-220 g aezkorbái komponenst; hj 5-100 g 5000-4(H)0 Da átlagos inolokulatómegü HUJ komponenst; <, ' ne/atmo aVs-Jm er f-wjum kbrndot ? ;, \ '.' í^-vto pont ,- umlt km- sírnom, moh tonuveK u a k-^otkv/okbol ,nl if 25-221? g aszkorbát komponens: b) 5-100 g 3000-4000 Da átlagos rooiekmlatínnegii HÍG komponens; e ? nátíáppt#ö0ii^# |I|ionÄöpi o ? g\ up tm<b memto seen es f) egy vagy több édesítőszer. 12. Λ 9-1 ; igénypernek bármelyike szerinti készítmény, mely 25-75 g aszkorbât kompotamst tartalma«; 1 < Λ ° 12 y, nyp-TSA Kt nah ke - v n.o kesettne .p, almi a kotnpwmm >0 oog aszkorbát komp* menet tartalma«. 14. Λ 9-0 igénypontok bármelyike szerinti készítmeny, abO a kstnpozieió: aszkorbinsavat és nátriani-aszkorbátot tartalmaz.
15. Lgy kit. mely tanaimat - egy első vastagbél üszbto --Mátét, és - egy második vastagbél tisztító okiam!. a második vastagbél tisztim oldat egy. a/ 1-8, igénypontok bármelyike szeroHi óléit, ·' \ ^ ' mn ό m no ím .ed». -, s \ u.aek m ,íí' ,bí oaa smk: « 'sp N00 ~S! ' D ^ ^' . o\ v 10 t’ el m <ii) 2*0-20 g.O egy vagy több alkáliéneszidiaio?, alkáli-löldDmszuHínot vagy ezek keverékét.
7. Kit, mely várta!ma/ v> ee> első iaonp-'nenso ,nní >,es ke'-omiem, eg'. eső vastagbél e-Όηο old g v;e K'.-'/aaJas.A.-j vám doál'nasohoz li) egy második komponenst, ami eg> késxiuoény egy második vastagbél tisztító oldat víz ibdlzláíllstvii yáló: elMllitásaí mz,, c\ adón esetben bns/.n;üaU ntasiibak an^vbk tmüagbés na/me oki e onmoeh a/ 05 ,aen>r< na.<k hannd>=ke a/ennbeUn 1$. Λ i /, igön-vponi szedttü Inn «ο Sauna/.. A) «gy etrf. komponenst. mdy egy A* «»«WW WszMselK s«'>li«lô készítmény, ami tarialmazl tit 70-250 g/i 2500-4500 Da s.Ung<-4 mofek«ial#is«g§:;:Pf'X}-ct; ès o' V, st hb ...K.....ι^οίΛιμ,-^ϋ’«· 0} egy második komponenst, mely «S? második vastagbél tisxmo <4dat kèsziDaèm ^igaio Xkpenree î „Don .ooi-m? loi i *dbb 't -, l ibon lorgna/, ès -os x'.et o' ο nüo-2íS0ö κηηοΐ Otes a,. 1 »ahd ^nmu es i'} K?-20o g liter polkttkmglikol. a/ dso óidat különbözik a második oldásnál. i0. Λ 17. igénypont .szerinti kö> nsen tartalmaz: Λ) eevekvó kompoBenstvïSO^y éky4|sö vasukból uszuto óidat stta/sieséhez szolg<dw készítmény, ami ildáltpaz: ο) 72.:4187.5 g 2500-4500 D& átlagos mokkelatomogn PFG-tU; és tin D5D 7 y. eo> engy több alkàlifôm-szüliôlok a!kiii*t&idféaisxu!fátot vagy ezek keverékét: Iá 8? egy második kompönéttst, mély agy második szelgdtö aVü'M'- ,í,i i\v 'U V ,V' vs derv«' VUao> a ...n a-odós Komp«- ^ s>o.:ekvM' :al;2|s27t;| gmMörbát komponens, m asxkorbát komponens aszkorbinsav, egy vagy több eg> vagy több aszkorbinsav só keveréke; és b? 5-100 g poüetiléngllkok 20 A I b H ígtnyfnwnd. bannt hike szerint? kn, ?neh m?mhoo> X s. ^ eiv> ' \si, > a , e e s v t η>0\κ s* t *téo m v\ 1 ao-avi *'<.\nt lat+o lit 1 ? eg y ma sodi k z«o s km ; B2) egy h ars nádik zacskót; dvd a mnt-odd es harmadik zacskók eg'-nr bkno-otj tk om-hodik usztm-okkn Ivzszbescnez szükséges késziü??és?vh ahol ::¾. tp. bis#. zacskó ín.rtal?naz: u) 52.7.1845 g 250ii-aè0h ! ><« àuagoa öviekül ïtmnegn Pi u-t-n t;? ni; ! 7-15 g ev - a’.y *>-hh mienk mv/in-aon, aiknh-teldDnvzulvtet s ?g> e.-.l kés ereket. Bl):a második javaké tetelome: {;} a-;00 g 2$00'4500 Da adagos oudttuttöfnegú Fitt-et; (F) elektßd Fokal é#vag¥ cay vugy több i^/.ko-iansav sot; es E2) à; hankadlk kiesko m'%.0 vagy ®|è asekortttsav sé t második yttttttàft (ISI) is;MvÂkôrMiiàV:,4!!lkïî^adlk aattkttaa (Β2;) agwttsea 25-2211 g MlkôtMi kxmpömnäi hiMmll aa asakarbäí komponens áskkdtbiasav. sgy mgy kitt ssttotklssav sd, vagy saokorkmsgv és ag agg vagy tttb axeko rbótsav sé keveréke·
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PL3473248T3 (pl) | 2012-09-11 | 2022-07-25 | Norgine Bv | Kompozycje zawierające glikol polietylenowy i siarczany metali alkalicznych lub metali ziem alkalicznych do zastosowania jako kompozycje do oczyszczania jelita grubego |
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