HUE025283T2 - LOX és LOX2 inhibitorok és azok felhasználása - Google Patents
LOX és LOX2 inhibitorok és azok felhasználása Download PDFInfo
- Publication number
- HUE025283T2 HUE025283T2 HUE08830207A HUE08830207A HUE025283T2 HU E025283 T2 HUE025283 T2 HU E025283T2 HU E08830207 A HUE08830207 A HU E08830207A HU E08830207 A HUE08830207 A HU E08830207A HU E025283 T2 HUE025283 T2 HU E025283T2
- Authority
- HU
- Hungary
- Prior art keywords
- antibody
- loxl2
- antibodies
- amino acid
- lox
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
- G01N2333/90605—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4)
- G01N2333/90633—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3) in general
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
Claims (7)
- Szsbrsdalnri igényperek1. Izolált antitest vagy annak axmgénkntS ftagmengö, .amely kőt egy Üril oxkláz sasfő 2 (LDX1.2} proteinhez, ahol az antitest vagy antigenköté b-agment speeifikgssn kőt' a. SBQ ΙΟ Μι: ö srafeossy szekvenciához: és gáíoha az 1:0X0; proteis soztmaiamtást, ská a gátlás nem fempeMv.
- 2. Az 1. igénypont szériát* antitest vagy ásnák astigéskoíö akoi az antitest vagy t&gmeat tartatom egy variábilis aéhéz láncot, .amelynek legalább 75Mos mámmy szekvencia azonossága vas a SH-.Q ID NO: I -bee lein atntsosöv szekvenciához.képest
- 3. Az: L vagy 2. igénypont szériáit antitest vagy annak anbgénfeM) tMgjsentie, ahol az antitest vagy thagreeat. tartalmaz egy variábilis könnyít láncot, amelynek legalább ?S%-os anrincsav szekvencia azonessága van a SEQ- ID NO: 2-hes leírt aminosav szekvenciáitok képest.
- 4. Az N3. i^aypöntok bármelyike. szerinti antitest vagy annak antsgéakdtö itagmeniie, ahol az antitest vagy aatjgénfeötő .iragment. bstmánizált vagy rnsn-ázs, 5. A 4. 'tgőöypöet xmrintl mri&est vagy annak antigénkőtö fragmeotje, akti az antitest vagy Iragment hsnréaizáit és tartalmaz variábilis nehéz: láncot CDRs, amelynek -van CDRI-3 aminosav szekvenciája GAAFTYYOü t$gQ W NO;41), VlNPÖbÖöéWNSvFRÖ tSíEQ W NÖ:42) és N'WMNFDY. és ISfeíiMeg wíábíüs: Manyit láncé C.'I):Rs-t, amelynek van CP&i-S aminosav .szekvenciába RSSKSLOBMGNTYLY (SEQ 10 ΝΟ:57), RMSN1..AS (SEQ iD MOí5S> és MQÍEJEYFYT pbQ 10 N0:5$). é. .A 4. vagy 5. igénypont szerinti antitest vagy annak aniígénköfo íragmeoíre, sW az antitest vagy ffagmeat bamánízált és van egy variábilis neltéz: láaea, amelynek legalább 75%-os anánosav szekvencia azonossága van a SJEQ ID NÖ; 23,. 26,27 vagy 2S-ben. leírt aminossv szekvenciához képest. 7. A 6. igénypont szériáit antitest vagy annak amlgénkotő JAsgrnernje, ahol a: variábilis nehéz Mnc tartalmazza S&Q 1D NO: 27-t 3. A 4~1. igénypontok bfeaelyike :szerítP:i antitest vagy attrssk atiigénkoto Pigmentje, aboi az amitesí vagy pigment: Inmiánizált és van egy variábilis könnyű Sánca, amelynek legalább-legalább 7554-os smtnosav szekvencia azonossága van -a SHQ JD NO: 30, 31 vagy 324bm.kirt amfeow szekvenciához képest. 9, A 8. igénypont szerlsb antitest vagy annak antigérrkötö Pigmentje , ölről a variábilis könnye tánc tartalmazza SBQID NÖ: 31-t. lö. .Az 1. igénypont: szerinti Immanizáis antitest vagy annak atiíigéskolő feögmentje, amelyik versenyez egy antitest vagy annak antigén kStíá fragmenijévd, amely tartalmaz egy variábilis nehéz láncot, mdymk· vas egy SEQ ID NÖ:: l-bstr leirt m&mmv szekvenciája és egy variábilis köirnyü lánca, ansslynek van. SEQ ÍD NÖ: 2-hea leirt: smmmv szckvvrnelája LÖ2íl.2 -bez kötéshez:
- 11. Az 1 -10. igenypnotok bársnelyike szerinti snittest vagy rámák sttrigenkotö fíagrnenfie. ahol az antitest vagy íhtgmest meg vas jelelve egy íkertmiás labdlel vagy egy csagJieazílkas: labelld, 12. A 1-11.. igénypont szerinti antitest vagy simák anhgérikoto frzgtneíitie, akii sz isríritesl, vagy íragnrejg labelezve: van egy áetektálbr-aó tebeilel.
- 53. Az 1~Ι;2. igénypontok bsnnelyike sa&ritó antitest vagy -msek atkígénklké &apnsní|e, aM! áz ata&sfct vagy íriigmersi: egy Pv, egy seFv, egy Fák egy Fíyk}2, egy géntedmilafciíag megválteialoii aníisesí, vagy egy rnnintkiön antitest,
- 14. Az 1-1.3, *gé«y|KM«ík. bármelyike sxeriwi antitest vagy simák sibigenköto Sngmeniye, Mlsasználásra -eljtóstet tamornövekeáes csökkentésére, metasztazls csökkentésére, angsügenesis gátlására, Sbrözis keaelésere, vagy esrraeelieiáris mátrix kép«xkA csökkentésére. 15. A 14. igényporri szerinti antitest vagy annak axusgéíxk&ö fragsaentjje MfeasisnáMsta·, ahd mérést \>agy mmak anrigeriköto bngmeaiie kembtsáeiébaa van használva egy második terápiás szméL 16. A 55. igénypont szerinti antitest vagy sasiak, a»%étásS$· fsagstesíje felhasználásra, alsó! a második terápiás szer aggni egy antitest vagy egy kemoterápiás szer. 17. A 14. igénypont szerinti antitest vagy annak aotigénköiö fragtnentje felhasználásra, ebei az feozis egy n;%Sbcózis, egytádö ribrezis, egy veseliferozis, egy szíviibrozis vagy sklecedermis. IS, A 57. igenypcrni szerinti antitest vagy araiak anrigénkőtő feagmentje felhasználásra, ahol a indőtibrozis idiopstíkns pilmonáris hbrozis (IPF), kriptogén ribrozílálő alvenbris, loönikns ilnmláí<5 intemíidális pnemtöái&s: mtmticMlk tüdő betegség díribz garencMmáiis tinin betegség ílkPLIk), emphisenta, k-'onikas ribsirnktiv pitrnonáris betegség (CO:F:D), vagy krónika» asztma, ib. A 17. igénypont szerinti antitest: vagy annak soogértketö itaginentje, alól a rnájifíbrozis clrrhosts. krónikus vitális hepatitis, sem sikoltok);? zsírmáj betegség (NAFLCf), alkoholos smttáep&tkis (ÁSB). nem alkoholos síeaiofeepaaiis (MASH), primer bib&ris cinriosis biliarrs rirtbosts, vagy asleúmmm hepatitis.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96324807P | 2007-08-02 | 2007-08-02 | |
US96324607P | 2007-08-02 | 2007-08-02 | |
US96321407P | 2007-08-02 | 2007-08-02 | |
US96328207P | 2007-08-02 | 2007-08-02 | |
US96324907P | 2007-08-02 | 2007-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE025283T2 true HUE025283T2 (hu) | 2016-03-29 |
Family
ID=40094743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE08830207A HUE025283T2 (hu) | 2007-08-02 | 2008-08-01 | LOX és LOX2 inhibitorok és azok felhasználása |
Country Status (16)
Country | Link |
---|---|
US (10) | US8461303B2 (hu) |
EP (4) | EP2182981B1 (hu) |
JP (8) | JP5659014B2 (hu) |
CN (6) | CN105330743B (hu) |
AU (4) | AU2008282739B2 (hu) |
CA (2) | CA2693310C (hu) |
CY (2) | CY1113897T1 (hu) |
DK (2) | DK2185198T3 (hu) |
ES (3) | ES2402334T3 (hu) |
HK (2) | HK1143543A1 (hu) |
HR (2) | HRP20130287T1 (hu) |
HU (1) | HUE025283T2 (hu) |
PL (2) | PL2182981T3 (hu) |
PT (3) | PT2185198E (hu) |
SI (2) | SI2185198T1 (hu) |
WO (2) | WO2009017833A2 (hu) |
Families Citing this family (132)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
GB0604647D0 (en) | 2006-03-08 | 2006-04-19 | Shchepinov Mikhail | Stabilized food supplements and their derivatives |
CN105330743B (zh) | 2007-08-02 | 2019-05-28 | 吉利德生物制剂公司 | Lox和loxl2抑制剂及其应用 |
US10029956B2 (en) | 2008-03-14 | 2018-07-24 | Retrotope, Inc. | Therapies for cancer using isotopically substituted lysine |
WO2010080769A2 (en) * | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
WO2010091279A1 (en) * | 2009-02-06 | 2010-08-12 | Arresto Biosciences, Inc. | Methods and compositions for treatment of neovascularization |
JP2012519282A (ja) * | 2009-02-27 | 2012-08-23 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法 |
BRPI1013201A2 (pt) * | 2009-05-05 | 2019-02-26 | Yeda res & development co ltd | meios e métodos para reconhecer o desenvolvimento de doenças cardiovascular em um indivíduo |
US20110076272A1 (en) * | 2009-08-21 | 2011-03-31 | Victoria Smith | Therapeutic methods and compositions |
US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
AU2010284000A1 (en) * | 2009-08-21 | 2012-03-22 | Gilead Biologics, Inc. | In vitro screening assays |
RU2015124151A (ru) * | 2009-08-21 | 2015-12-27 | Джилид Байолоджикс, Инк. | Способы и композиции для лечения фиброзных заболеваний легких |
SG178845A1 (en) * | 2009-08-21 | 2012-04-27 | Gilead Biologics Inc | Catalytic domains from lysyl oxidase and loxl2 |
JP5885664B2 (ja) | 2009-09-25 | 2016-03-15 | ゾーマ テクノロジー リミテッド | スクリーニング法 |
KR20120091146A (ko) * | 2009-09-29 | 2012-08-17 | 길리아드 바이오로직스, 인크. | 안구 섬유증의 치료를 위한 조성물 및 방법 |
EP3536317A1 (en) | 2009-10-30 | 2019-09-11 | Retrotope, Inc. | Alleviating oxidative stress disorders with pufa derivatives |
WO2011092181A1 (en) | 2010-01-26 | 2011-08-04 | Centre Leon Berard | Screening method for identifying compounds which block tumour growth by inducing irreversible senescence in tumour cells |
AU2014215963B2 (en) * | 2010-02-04 | 2016-04-14 | Gilead Biologics, Inc | Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor |
WO2011097513A1 (en) * | 2010-02-04 | 2011-08-11 | Gilead Biologics, Inc | Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor |
US20120329061A1 (en) * | 2010-03-11 | 2012-12-27 | Board Of Regents, The University Of Texas System | Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of cancer patients |
WO2011132085A2 (en) * | 2010-04-21 | 2011-10-27 | Kalluri, Raghu | Methods and compositions for treating fibrosis |
AU2012219582A1 (en) | 2011-02-21 | 2013-08-22 | Fibrostatin S.L. | Methods for treating and diagnosing disease |
WO2012139045A1 (en) * | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
JP6106157B2 (ja) | 2011-04-26 | 2017-03-29 | レトロトップ、 インコーポレイテッドRetrotope, Inc. | 神経変性障害および筋疾患に関与するpufa |
EP3730135A1 (en) | 2011-04-26 | 2020-10-28 | Retrotope, Inc. | Impaired energy processing disorders and mitochondrial deficiency |
EP3689342A1 (en) | 2011-04-26 | 2020-08-05 | Retrotope, Inc. | Oxidative retinal diseases |
KR102110175B1 (ko) | 2011-04-26 | 2020-05-13 | 레트로토프 인코포레이티드 | Pufa 산화와 관련된 장애 |
WO2012155071A1 (en) * | 2011-05-12 | 2012-11-15 | Gilead Biologics, Inc. | Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners |
WO2012167181A1 (en) * | 2011-06-01 | 2012-12-06 | Gilead Biologics, Inc. | Lysyl oxidase-like 2 assay and methods of use thereof |
FR2976587B1 (fr) | 2011-06-20 | 2015-04-03 | Basf Beauty Care Solutions F | Methode de dosage in vitro par technique immunologique |
EP2761289B1 (en) * | 2011-09-30 | 2020-02-12 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
CN102397544A (zh) * | 2011-11-25 | 2012-04-04 | 百泰生物药业有限公司 | 一种单克隆抗体用于治疗非小细胞肺癌的用途 |
NZ629178A (en) | 2012-02-29 | 2016-09-30 | Gilead Biologics Inc | Antibodies to matrix metalloproteinase 9 |
WO2014052962A1 (en) | 2012-09-28 | 2014-04-03 | Case Western Reserve University | System and method for detecting lysyl oxidase-like 2 protein (loxl2) and breast cancer |
SG10201703240RA (en) | 2012-10-30 | 2017-06-29 | Gilead Sciences Inc | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
US10293023B2 (en) * | 2013-03-15 | 2019-05-21 | Children's Medical Center Corporation | Method of altering vascular permeability and uses thereof |
WO2014190316A1 (en) * | 2013-05-23 | 2014-11-27 | Shire Human Genetic Therapies, Inc. | Anti-ccl2 and anti-loxl2 combination therapy for treatment of scleroderma |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
WO2015081127A2 (en) | 2013-11-26 | 2015-06-04 | Gilead Sciences, Inc. | Therapies for treating myeloproliferative disorders |
WO2015109286A1 (en) | 2014-01-20 | 2015-07-23 | Gilead Sciences, Inc. | Therapies for treating cancers |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US20150342943A1 (en) * | 2014-06-03 | 2015-12-03 | Gilead Sciences, Inc. | Methods of treating liver disease |
BR112016028750A2 (pt) * | 2014-06-11 | 2017-11-14 | Gilead Sciences Inc | ?métodos para tratar, prevenir, ou melhorar pelo menos um sintoma associado e para diagnosticar e monitorar insuficiência cardíaca ou fibrilação atrial, inibidor da lisil oxidase ativa ou proteína lisil tipo oxidase, e, composição? |
WO2016012993A1 (en) * | 2014-07-24 | 2016-01-28 | Yeda Research And Development Co. Ltd. | Antibodies targeted against loxl-2 for the treatment of collagen-associated pathologies |
EP2990480A1 (en) * | 2014-08-29 | 2016-03-02 | Christian-Albrechts-Universität zu Kiel | Anti-LOXL4 antibodies and derivatives there |
US11220545B2 (en) | 2014-12-08 | 2022-01-11 | Dana-Farber Cancer Institute, Inc. | Methods for upregulating immune responses using combinations of anti-RGMb and anti-PD-1 agents |
MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
TW201639573A (zh) | 2015-02-03 | 2016-11-16 | 吉李德科學股份有限公司 | 有關治療癌症之合併治療 |
EP3263599A4 (en) * | 2015-02-16 | 2018-12-19 | Pharma Foods International Co., Ltd. | Anti-cancer agent and antimetastatic agent using fstl1, and concomitant drug for same |
HUE050029T2 (hu) | 2015-03-04 | 2020-11-30 | Gilead Sciences Inc | 4,6-Diamino-pirido[3,2-d]pirimidin-származékok és alkalmazásuk toll-szerû receptorok modulátoraként |
CN107624110B (zh) | 2015-03-06 | 2021-01-26 | 法玛克亚公司 | 赖氨酰氧化酶样2抑制剂及其用途 |
SG11201707246YA (en) | 2015-03-06 | 2017-10-30 | Pharmakea Inc | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
CN106442956A (zh) * | 2015-08-11 | 2017-02-22 | 钱朝南 | 一种筛选抗肿瘤转移的化合物的方法 |
CA2998875C (en) | 2015-09-17 | 2023-08-29 | Ohio State Innovation Foundation | Carborane compounds and methods of use thereof |
JP2018530550A (ja) | 2015-10-01 | 2018-10-18 | ギリアド サイエンシズ, インコーポレイテッド | 癌を治療するためのbtk阻害剤とチェックポイント阻害剤との組合せ |
US11207393B2 (en) | 2015-10-16 | 2021-12-28 | President And Fellows Of Harvard College | Regulatory T cell PD-1 modulation for regulating T cell effector immune responses |
EP3950649A1 (en) | 2015-11-23 | 2022-02-09 | Retrotope, Inc. | Site-specific isotopic labeling of 1, 4-diene systems |
US10316049B2 (en) | 2015-12-17 | 2019-06-11 | Gilead Sciences, Inc. | Tank-binding kinase inhibitor compounds |
JP7094219B2 (ja) * | 2016-02-03 | 2022-07-01 | ノルディック バイオサイエンス エイ/エス | 線維症の組み合わせたバイオマーカー測定 |
SG11201806700RA (en) | 2016-02-12 | 2018-09-27 | Pharmaxis Ltd | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof |
GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
CA3016081A1 (en) | 2016-03-04 | 2017-09-08 | Gilead Sciences, Inc. | Compositions and combinations of autotaxin inhibitors |
KR20190080825A (ko) | 2016-03-21 | 2019-07-08 | 다나-파버 캔서 인스티튜트 인크. | T-세포 기능소실 상태-특이적 유전자 발현 조절인자 및 그 용도 |
WO2017177179A1 (en) | 2016-04-08 | 2017-10-12 | Gilead Sciences, Inc. | Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases |
JP6754846B2 (ja) * | 2016-04-19 | 2020-09-16 | 南京中硼▲聯▼康医▲療▼科技有限公司Neuboron Medtech Ltd. | βアミロイド沈着プラークを除去するための中性子捕捉治療システム |
WO2017197088A1 (en) * | 2016-05-12 | 2017-11-16 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors for the treatment of inflammatory conditions |
CA3027209C (en) | 2016-06-13 | 2022-08-16 | I-Mab | Anti-pd-l1 antibodies and uses thereof |
AU2017305303B2 (en) | 2016-08-04 | 2020-05-28 | Gilead Sciences, Inc. | Cobicistat for use in cancer treatments |
JP6746776B2 (ja) | 2016-09-02 | 2020-08-26 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体調節剤化合物 |
WO2018045150A1 (en) | 2016-09-02 | 2018-03-08 | Gilead Sciences, Inc. | 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators |
EP3509594A4 (en) | 2016-09-07 | 2020-05-06 | Pharmakea, Inc. | USE OF A LYSYLOXIDASE-LIKE 2 INHIBITOR |
SG11201901999XA (en) | 2016-09-07 | 2019-04-29 | Pharmakea Inc | Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making |
WO2018048930A1 (en) * | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Lysyl oxidase-like 2 inhibitors and uses thereof |
US20180133212A1 (en) | 2016-11-03 | 2018-05-17 | Gilead Sciences, Inc. | Combination of a bcl-2 inhibitor and a bromodomain inhibitor for treating cancer |
CN106492218A (zh) * | 2016-11-08 | 2017-03-15 | 清华大学 | 氨基丙腈在制备药物中的用途 |
US20180141939A1 (en) | 2016-11-22 | 2018-05-24 | Gilead Sciences, Inc. | Solid forms of a bet inhibitor |
UA126571C2 (uk) | 2017-01-24 | 2022-11-02 | Ай-Маб Байофарма Юес Лімітед | Антитіло до cd73 та його застосування |
DE102017000896A1 (de) * | 2017-02-01 | 2018-08-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Selektives Freisetzungssystem für Tumortherapeutika und Tumordiagnostika sowie Biosensor für Tumorgewebe |
AR110998A1 (es) | 2017-02-24 | 2019-05-22 | Gilead Sciences Inc | Inhibidores de la tirosina cinasa de bruton |
JP2020508326A (ja) | 2017-02-24 | 2020-03-19 | ギリアド サイエンシズ, インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤 |
WO2018170488A1 (en) * | 2017-03-17 | 2018-09-20 | Gilead Sciences, Inc. | Method of purifying an antibody |
KR20240033102A (ko) | 2017-04-06 | 2024-03-12 | 서스테인 홀딩스, 엘엘씨 | 콜라겐 펩티드-계 의약 조성물 및 이의 생산 장비 및 방법 및 사용 |
JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
AU2018392212B9 (en) | 2017-12-20 | 2021-03-18 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
US20210060060A1 (en) * | 2018-01-11 | 2021-03-04 | Emphysema Solutions Bv | Compositions and methods for the treatment of lung emphysema and other forms of copd |
TWI796596B (zh) | 2018-02-13 | 2023-03-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | 2,2,─環二核苷酸 |
CA3093888A1 (en) | 2018-04-06 | 2019-10-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
KR102591947B1 (ko) | 2018-04-19 | 2023-10-25 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
WO2019217780A1 (en) | 2018-05-11 | 2019-11-14 | Phosphorex, Inc. | Microparticles and nanoparticles having negative surface charges |
WO2019222112A1 (en) | 2018-05-14 | 2019-11-21 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
CN112399874B (zh) | 2018-07-13 | 2024-03-22 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
KR20210045984A (ko) | 2018-08-03 | 2021-04-27 | 파맥시스 엘티디 | 라이실 옥시다제의 할로알릴아민 설폰 유도체 저해제 및 이의 용도 |
EP3860717A1 (en) | 2018-10-03 | 2021-08-11 | Gilead Sciences, Inc. | Imidozopyrimidine derivatives |
CN112955435A (zh) | 2018-10-24 | 2021-06-11 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
CA3116347A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
IL282535B2 (en) | 2018-10-31 | 2024-05-01 | Gilead Sciences Inc | Transformed 6-azabanzimidazole compounds as HPK1 inhibitors |
JP2022513024A (ja) * | 2018-11-12 | 2022-02-07 | エージェンシー フォー サイエンス,テクノロジー アンド リサーチ | がんの細胞状態移行を操作するための方法 |
WO2020117799A1 (en) * | 2018-12-03 | 2020-06-11 | Ohio State Innovation Foundation | Carborane compounds, carborane analogs, and methods of use thereof |
KR20210137517A (ko) | 2019-03-07 | 2021-11-17 | 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. | 2'3'-사이클릭 다이뉴클레오티드 및 이의 프로드럭 |
CN113574063A (zh) | 2019-03-07 | 2021-10-29 | 捷克共和国有机化学与生物化学研究所 | 3’3’-环二核苷酸及其前药 |
EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
MX2021012579A (es) | 2019-04-22 | 2021-11-12 | Sustain Holdings Llc | Composiciones farmaceuticas a base de peptidos de colageno y dispositivos y metodos de produccion y uso de los mismos. |
US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
US20220305115A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
PE20220231A1 (es) | 2019-06-25 | 2022-02-07 | Gilead Sciences Inc | Proteinas de fusion flt3l-fc y metodos de uso |
US11697807B2 (en) | 2019-09-30 | 2023-07-11 | Case Western Reserve University | Electrochemical biosensor |
KR20210044589A (ko) * | 2019-10-15 | 2021-04-23 | 재단법인 한국파스퇴르연구소 | 2-메톡시에스트라디올 유도체 및 이들의 의약 용도 |
CN111118142A (zh) * | 2020-01-17 | 2020-05-08 | 上海市同济医院 | 血清赖氨酸氧化酶作为肾间质纤维化的分层诊断性生物标志物 |
CA3169451A1 (en) | 2020-02-14 | 2021-08-19 | Jounce Therapeutics, Inc. | Antibodies and fusion proteins that bind to ccr8 and uses thereof |
EP4107163A1 (en) | 2020-02-21 | 2022-12-28 | Retrotope, Inc. | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
JP7327855B2 (ja) | 2020-06-26 | 2023-08-16 | ラクオリア創薬株式会社 | レチノイドとがん治療薬との併用療法が有効ながん患者の選択方法およびレチノイドとがん治療薬との併用医薬 |
TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用FLT3L—Fc融合蛋白之方法 |
CN113321743B (zh) * | 2021-07-02 | 2022-10-21 | 海南精准医疗科技有限公司 | 一种靶向赖氨酰氧化酶1的嵌合抗原受体及其用途 |
TW202330504A (zh) | 2021-10-28 | 2023-08-01 | 美商基利科學股份有限公司 | 嗒𠯤—3(2h)—酮衍生物 |
AU2022376954A1 (en) | 2021-10-29 | 2024-05-02 | Gilead Sciences, Inc. | Cd73 compounds |
US20230242508A1 (en) | 2021-12-22 | 2023-08-03 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
WO2023122581A2 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Parp7抑制劑 |
EP4245756A1 (en) | 2022-03-17 | 2023-09-20 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
TW202400138A (zh) | 2022-04-21 | 2024-01-01 | 美商基利科學股份有限公司 | Kras g12d調節化合物 |
WO2023239764A1 (en) * | 2022-06-08 | 2023-12-14 | Ohio State Innovation Foundation | Methods and compositions for treating lupus |
WO2024006929A1 (en) | 2022-07-01 | 2024-01-04 | Gilead Sciences, Inc. | Cd73 compounds |
CN116064765B (zh) * | 2022-08-02 | 2023-09-05 | 首都医科大学附属北京友谊医院 | 检测loxl1基因突变的物质在制备肝纤维化患者分子分型的产品中的应用 |
WO2024075844A1 (ja) * | 2022-10-07 | 2024-04-11 | 株式会社ナノエッグ | 炎症性皮膚疾患の検出及び重症度の判定方法 |
Family Cites Families (244)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7002A (en) * | 1850-01-08 | Obe-washek | ||
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) * | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) * | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) * | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) * | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) * | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
JPS5913521B2 (ja) | 1975-06-19 | 1984-03-30 | メイトウサンギヨウ カブシキガイシヤ | 磁性酸化鉄・デキストラン複合体の製造法 |
US3984533A (en) * | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4036945A (en) | 1976-05-03 | 1977-07-19 | The Massachusetts General Hospital | Composition and method for determining the size and location of myocardial infarcts |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
DE3164437D1 (en) | 1980-08-25 | 1984-08-02 | Kabivitrum Ab | Peptide substrates for determination of protease activity |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
DE3278334D1 (en) | 1981-10-23 | 1988-05-19 | Genetics Int Inc | Sensor for components of a liquid mixture |
US4485088A (en) | 1982-03-26 | 1984-11-27 | Bio-Products, Inc. | Method of treatment of fibrotic lesions by topical administration of lathyrogenic drugs |
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5011771A (en) * | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
PT81498B (pt) | 1984-11-23 | 1987-12-30 | Schering Ag | Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas |
ATE45735T1 (de) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4627445A (en) | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
US4801531A (en) * | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
US4916193A (en) | 1987-12-17 | 1990-04-10 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
US5021404A (en) * | 1988-04-20 | 1991-06-04 | The Children's Medical Center Corporation | Angiostatic collagen modulators |
US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
US5092877A (en) | 1988-09-01 | 1992-03-03 | Corvita Corporation | Radially expandable endoprosthesis |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5120764A (en) | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
CA2006008C (en) | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US6352862B1 (en) | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
US4994071A (en) | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
ATE144793T1 (de) | 1989-06-29 | 1996-11-15 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
US5262035A (en) | 1989-08-02 | 1993-11-16 | E. Heller And Company | Enzyme electrodes |
US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US4997854A (en) | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5163952A (en) | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
GB9022788D0 (en) | 1990-10-19 | 1990-12-05 | Cortecs Ltd | Pharmaceutical formulations |
US5641484A (en) | 1990-12-04 | 1997-06-24 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
EP0562025B1 (en) | 1990-12-06 | 2001-02-07 | Affymetrix, Inc. (a Delaware Corporation) | Compounds and their use in a binary synthesis strategy |
AT397134B (de) * | 1991-02-19 | 1994-02-25 | Hoerbiger Ventilwerke Ag | Ventil |
US20020123476A1 (en) | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
US6933286B2 (en) * | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
EP0586505A1 (en) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
US5661133B1 (en) * | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
CA2122732C (en) | 1991-11-25 | 2008-04-08 | Marc D. Whitlow | Multivalent antigen-binding proteins |
US6235887B1 (en) * | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
CA2087413A1 (en) | 1992-01-17 | 1993-07-18 | Joseph R. Lakowicz | Fluorescent energy transfer immunoassay |
US5281521A (en) * | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
US6015562A (en) * | 1992-09-22 | 2000-01-18 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
US5721138A (en) | 1992-12-15 | 1998-02-24 | Sandford University | Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use |
FI92882C (fi) | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5646185A (en) | 1993-10-14 | 1997-07-08 | The Board Of Trustees Of The Leland Stanford Junior University | Tumor treatment method |
US5674693A (en) | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
US5700695A (en) | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
US5908635A (en) | 1994-08-05 | 1999-06-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for the liposomal delivery of nucleic acids |
US5807718A (en) | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
US6096716A (en) | 1994-12-12 | 2000-08-01 | The Board Of Regents, The University Of Texas System | Liposome-mediated transfection of central nervous system cells |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5935860A (en) | 1995-03-07 | 1999-08-10 | The George Washington University | Use of uteroglobin expression as a molecular marker for prostatic intraepithelial neoplasia |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
WO1996040746A1 (en) | 1995-06-07 | 1996-12-19 | Trustees Of Boston University | Lysyloxidase inhibitors |
AUPN363995A0 (en) | 1995-06-19 | 1995-07-13 | Memtec Limited | Electrochemical cell |
US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
AU724579B2 (en) | 1996-04-01 | 2000-09-28 | Sankyo Company Limited | Anti-Fas recombinant antibodies and DNA therefor |
AUPO156596A0 (en) | 1996-08-09 | 1996-09-05 | University Of Sydney, The | Synthetic polynucleotides |
WO1998012156A1 (en) | 1996-09-20 | 1998-03-26 | President And Fellows Of Harvard College | Combinatorial approach for generating novel coordination complexes |
US5958703A (en) | 1996-12-03 | 1999-09-28 | Glaxo Group Limited | Use of modified tethers in screening compound libraries |
JP3394262B2 (ja) | 1997-02-06 | 2003-04-07 | セラセンス、インク. | 小体積インビトロ被検体センサー |
AU6468998A (en) * | 1997-03-19 | 1998-10-12 | Board Of Trustees Of The University Of Arkansas, The | Compositions and method for the early diagnosis of ovarian cancer |
US20020004482A1 (en) | 1997-08-08 | 2002-01-10 | Xiaozhu Huang | Treatment of acute lung injury and fibrosis with antagonists of avbeta6 |
US6277622B1 (en) | 1997-08-11 | 2001-08-21 | The University Of Sydney | Synthetic polynucleotides |
US6225118B1 (en) | 1997-10-01 | 2001-05-01 | Biocure Limited | Multicellular in vitro assay of angiogenesis |
CA2308565A1 (en) * | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
US6140056A (en) | 1999-01-27 | 2000-10-31 | Millennium Pharmaceuticals, Inc. | MSP-18 protein and nucleic acid molecules and uses therefor |
US6300092B1 (en) | 1999-01-27 | 2001-10-09 | Millennium Pharmaceuticals Inc. | Methods of use of a novel lysyl oxidase-related protein |
US20020072089A1 (en) * | 1999-11-23 | 2002-06-13 | Holtzman Douglas A. | Novel ITALY, Lor-2, STRIFE, TRASH, BDSF, LRSG, and STMST protein and nucleic acid molecules and uses therefor |
WO1999046385A2 (en) * | 1998-03-13 | 1999-09-16 | Baylor College Of Medicine | Compositions and methods for the treatment and prevention of metastatic disorders |
WO1999065928A2 (en) | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
US6228538B1 (en) * | 1998-08-28 | 2001-05-08 | Micron Technology, Inc. | Mask forming methods and field emission display emitter mask forming methods |
US20040058355A1 (en) | 1998-09-30 | 2004-03-25 | Millennium Pharmaceuticals, Inc. | Novel 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, H1983, M1983, 38555 or 593 molecules and uses therefor |
US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
US20030149997A1 (en) * | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
US7108982B1 (en) | 1999-02-19 | 2006-09-19 | University Of Iowa Research Foundation | Diagnostics and the therapeutics for macular degeneration |
PL198975B1 (pl) * | 1999-04-22 | 2008-08-29 | Biogen Idec Inc | Zastosowanie kompozycji zawierającej homolog przeciwciała, który jest antagonistą interakcji między integryną niosącą podjednostkę alfa 4 a jej ligandem |
US20030152926A1 (en) | 1999-08-11 | 2003-08-14 | Eos Biotechnology, Inc. | Novel methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
GB0001309D0 (en) | 2000-01-20 | 2000-03-08 | Nestle Sa | Valve arrangement |
US6808707B2 (en) | 2000-02-04 | 2004-10-26 | Matrix Design | Wound healing compositions and methods using tropoelastin and lysyl oxidase |
CA2405781A1 (en) | 2000-04-14 | 2001-10-25 | Incyte Genomics, Inc. | Secreted proteins |
WO2001083702A2 (en) * | 2000-05-03 | 2001-11-08 | University Of Hawaii | Novel members of the lysyl oxidases family of amine oxidases related applications |
AU2001265162A1 (en) | 2000-05-26 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | 47765, a novel human lysyl oxidase and uses thereof |
US7700359B2 (en) | 2000-06-02 | 2010-04-20 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells |
GB0014185D0 (en) * | 2000-06-09 | 2000-08-02 | Novartis Res Found | Compound and method |
US20090233270A9 (en) | 2000-08-02 | 2009-09-17 | St Croix Brad | Secreted and cytoplasmic tumor endothelial markers |
MXPA03001196A (es) | 2000-08-08 | 2004-04-05 | Wyeth Corp | Un nuevo miembro de la familia del gen de oxidasa de lisilo. |
US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
EP2359853B1 (en) | 2000-08-08 | 2013-11-06 | Technion Research and Development Foundation, Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis |
US20020156263A1 (en) * | 2000-10-05 | 2002-10-24 | Huei-Mei Chen | Genes expressed in breast cancer |
US20030104393A1 (en) * | 2000-11-28 | 2003-06-05 | Sharp Frank R. | Blood assessment of injury |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7112668B2 (en) * | 2001-01-23 | 2006-09-26 | Curagen Corporation | Polypeptides and nucleic acids encoded thereby |
US20040029114A1 (en) * | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
WO2002061092A2 (en) | 2001-01-29 | 2002-08-08 | Bayer Aktiengesellschaft | Regulation of human lysyl oxidase |
AU2002257004A1 (en) | 2001-02-14 | 2002-10-15 | Protein Design Labs, Inc. | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
AU2002237124B2 (en) | 2001-02-28 | 2008-03-06 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
US20020182274A1 (en) | 2001-03-21 | 2002-12-05 | Kung-Ming Lu | Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract |
CA2444691A1 (en) | 2001-04-18 | 2002-10-31 | Protein Design Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
US20030211076A1 (en) | 2001-05-10 | 2003-11-13 | Wande Li | Compositions and methods for treatment of proliferative disorders |
US20030092037A1 (en) | 2001-07-18 | 2003-05-15 | Osamu Matsuzaki | Elk1 phosphorylation related gene |
FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
US20030129672A1 (en) | 2001-08-29 | 2003-07-10 | Dyer Richard Dennis | Method for identifying metalloenzyme inhibitors |
WO2003031939A2 (en) | 2001-10-12 | 2003-04-17 | Incyte Genomics, Inc. | Protein modification and maintenance molecules |
JP2005506087A (ja) * | 2001-10-26 | 2005-03-03 | リボファーマ アーゲー | プラス鎖rnaウイルスによる感染症を処置するための2本鎖リボ核酸の使用 |
KR100450950B1 (ko) * | 2001-11-29 | 2004-10-02 | 삼성전자주식회사 | 구내/공중망 무선 패킷데이터 서비스를 받는 이동단말기의 인증 방법 및 그 사설망 시스템 |
WO2003051388A2 (en) | 2001-12-18 | 2003-06-26 | Mondobiotech Laboratories Anstalt | Pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases |
US7186540B2 (en) | 2001-12-27 | 2007-03-06 | National Institute of Advanced Indusrtial Science and Technology | Thermostable glutaminase and thermostable glutaminase gene |
AU2003217966A1 (en) | 2002-03-07 | 2003-10-08 | Licentia, Ltd. | Lymphatic and blood endothelial cell genes |
US7655397B2 (en) | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
WO2003100016A2 (en) | 2002-05-22 | 2003-12-04 | Incyte Corporation | Protein modification and maintenance molecules |
CA2488441C (en) * | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
WO2004002427A2 (en) * | 2002-06-27 | 2004-01-08 | The General Hospital Corporation | Methods for the treatment or prevention of obesity |
AU2003262717A1 (en) * | 2002-08-15 | 2004-03-03 | Genzyme Corporation | Brain endothelial cell expression patterns |
WO2004023973A2 (en) | 2002-09-12 | 2004-03-25 | Incyte Corporation | Molecules for diagnostics and therapeutics |
EP1556402B1 (en) | 2002-09-25 | 2011-06-22 | University of Massachusetts | In vivo gene silencing by chemically modified and stable sirna |
US20050260639A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
US20050259483A1 (en) | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Genes and polypeptides relating to prostate cancers |
AU2003298786A1 (en) | 2002-11-26 | 2004-06-18 | Protein Design Labs, Inc. | Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators |
AU2003298873B2 (en) | 2002-12-06 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy |
US20060188889A1 (en) | 2003-11-04 | 2006-08-24 | Christopher Burgess | Use of differentially expressed nucleic acid sequences as biomarkers for cancer |
EP1581812B1 (en) | 2003-01-06 | 2008-07-16 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
WO2004063355A2 (en) | 2003-01-10 | 2004-07-29 | Protein Design Labs, Inc. | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of matastatic cancer |
US7393531B2 (en) | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US20060134801A1 (en) * | 2003-03-03 | 2006-06-22 | Board Of Regents, The University Of Texas System | Methods and compositions involving MDA-7 |
US7641643B2 (en) * | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
AT500650B1 (de) * | 2003-04-17 | 2009-11-15 | Altropus Gmbh | Immunogener rekombinanter antikörper |
NZ543751A (en) | 2003-05-23 | 2008-05-30 | Genentech Inc | Compositions and methods for the diagnosis and treatment of tumors of glial origin |
US20060019256A1 (en) | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
FR2855968B1 (fr) * | 2003-06-13 | 2012-11-30 | Coletica | Stimulation de la synthese et de l'activite d'une isoforme de la lysyl oxydase-like loxl pour stimuler la formation de fibres elastiques |
FR2855969B1 (fr) | 2003-06-13 | 2012-11-30 | Coletica | Stimulation de l'activite d'une isoforme de lysyl oxydase pour lutter contre certaines pathologies dues a une elastogenese incomplete, absente ou desorganisee |
CN105316405A (zh) * | 2003-07-17 | 2016-02-10 | 环太平洋生物技术有限公司 | 用于胃癌检测的标记物 |
EP1670494A1 (en) | 2003-09-16 | 2006-06-21 | Hadasit Medical Research Services & Development Ltd. | Glatiramer acetate for use as an immuno-modulatory agent |
EP1693448A4 (en) * | 2003-10-14 | 2008-03-05 | Chugai Pharmaceutical Co Ltd | DOUBLE SPECIFICITY ANTIBODY FOR FUNCTIONAL PROTEIN SUBSTITUTION |
US20070028314A1 (en) | 2003-10-20 | 2007-02-01 | Toshihisa Komori | Bone and/or joint disease-associated genes |
US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
TW200530269A (en) * | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
US20080261870A1 (en) | 2004-01-13 | 2008-10-23 | Trackman Philip C | Use of the Pro-Peptide Domain of Lysyl Oxidase as a Therapeutic Agent |
EP1706139A4 (en) | 2004-01-23 | 2009-06-17 | Massachusetts Eye & Ear Infirm | LYSYL OXIDASE-LIKE 1 (LOXL1) AND ELASTOGENESIS |
JP4980878B2 (ja) | 2004-02-23 | 2012-07-18 | エラスムス ユニバーシティ メディカル センター ロッテルダム | 遺伝子発現プロファイリングによる急性骨髄性白血病の分類、診断、および予後 |
AU2005217623A1 (en) * | 2004-02-24 | 2005-09-09 | Attenuon Llp | Inhibition of superoxide dismutase by tetrathiomolybdate: identification of new anti-angiogenic and antitumor agents |
CA2561742A1 (en) | 2004-04-01 | 2005-10-27 | Sequenom, Inc. | Methods for identifying risk of osteoarthritis and treatments thereof |
AU2005295595C1 (en) * | 2004-10-15 | 2012-06-21 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
US20060134172A1 (en) | 2004-12-21 | 2006-06-22 | Alcon, Inc. | Agents which regulate, inhibit, or modulate the activity and/or expression of lysyl oxidase (LOX) and LOX-like proteases as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies |
NZ560225A (en) | 2005-02-09 | 2010-10-29 | Arqule Inc | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
WO2006094106A2 (en) * | 2005-02-28 | 2006-09-08 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
US20060216722A1 (en) | 2005-03-25 | 2006-09-28 | Christer Betsholtz | Glomerular expression profiling |
EP1870455A4 (en) | 2005-03-31 | 2010-01-20 | Two Cells Co Ltd | METHOD FOR DISTINCTION OF MESENCHYMAL STEM CELL USING MOLECULAR MARKER AND USE THEREOF |
WO2006108048A1 (en) * | 2005-04-05 | 2006-10-12 | The General Hospital Corporation | Method for predicting responsiveness to drugs |
WO2006128740A2 (en) | 2005-06-02 | 2006-12-07 | Centelion | Anti-vascular methods and therapies employing lysyl oxidase inhibitors |
US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
CA2623125A1 (en) | 2005-09-20 | 2007-03-29 | Osi Pharmaceuticals, Inc. | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
US8158107B2 (en) * | 2005-09-30 | 2012-04-17 | National Jewish Health | Genes and proteins associated with angiogenesis and uses thereof |
GB0521139D0 (en) | 2005-10-18 | 2005-11-23 | Univ Sheffield | Therapeutic agent |
US20090035348A1 (en) | 2005-11-22 | 2009-02-05 | Z & Z Medical Holdings, Inc. | Dissolution of arterial plaque |
US8445198B2 (en) | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
GB0524991D0 (en) | 2005-12-08 | 2006-01-18 | Ge Healthcare Ltd | Novel imaging agents for fibrosis |
BRPI0619595B8 (pt) | 2005-12-09 | 2022-12-13 | Ucb Pharma Sa | anticorpo neutralizante, sequência de dna isolada, vetor de clonagem ou expressão, célula hospedeira, processo para a produção de um anticorpo, composição farmacêutica, e, uso de um anticorpo neutralizante humanizado |
US20090275633A1 (en) | 2006-04-13 | 2009-11-05 | Oncomethylome Sciences Sa | Novel Tumour Suppressor |
JP5313886B2 (ja) | 2006-06-07 | 2013-10-09 | バイオアライアンス セー.フェー. | 癌細胞で発現するcd−43およびceaの炭水化物含有エピトープを認識する抗体およびそれを使用する方法 |
US20100092476A1 (en) | 2006-11-17 | 2010-04-15 | Hanash Samir M | Pancreatic cancer biomarkers |
US20100074897A1 (en) | 2006-12-01 | 2010-03-25 | University Of Utah Research Foundation | Methods and Compositions related to HIF-1 alpha |
US8077896B2 (en) | 2006-12-12 | 2011-12-13 | Sound Services, Llc | Laser inclinometer audio direction |
KR101443214B1 (ko) | 2007-01-09 | 2014-09-24 | 삼성전자주식회사 | 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이 |
GB0708002D0 (en) | 2007-04-25 | 2007-06-06 | Univ Sheffield | Antibodies |
WO2008138578A2 (en) | 2007-05-11 | 2008-11-20 | Medical Prognosis Institute | Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
US8178091B2 (en) | 2007-05-21 | 2012-05-15 | University Of Washington | Compositions and methods for the treatment of respiratory disorders |
CA2692171C (en) * | 2007-06-22 | 2019-10-22 | Randolph Watnick | Methods and uses thereof of prosaposin |
IL184627A0 (en) | 2007-07-15 | 2008-12-29 | Technion Res & Dev Foundation | Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue |
CN105330743B (zh) | 2007-08-02 | 2019-05-28 | 吉利德生物制剂公司 | Lox和loxl2抑制剂及其应用 |
US8815946B2 (en) | 2008-01-25 | 2014-08-26 | University of Pittsburgh—of the Commonwealth System of Higher Education | Inhibition of proliferation and fibrotic response of activated corneal stromal cells |
JP2010038735A (ja) | 2008-08-05 | 2010-02-18 | Terumo Corp | 腹膜機能の評価方法および腹膜機能評価用イムノクロマト試験紙 |
WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
WO2010091279A1 (en) | 2009-02-06 | 2010-08-12 | Arresto Biosciences, Inc. | Methods and compositions for treatment of neovascularization |
US20110076272A1 (en) * | 2009-08-21 | 2011-03-31 | Victoria Smith | Therapeutic methods and compositions |
RU2015124151A (ru) | 2009-08-21 | 2015-12-27 | Джилид Байолоджикс, Инк. | Способы и композиции для лечения фиброзных заболеваний легких |
US20110044907A1 (en) * | 2009-08-21 | 2011-02-24 | Derek Marshall | In vivo screening assays |
SG178845A1 (en) | 2009-08-21 | 2012-04-27 | Gilead Biologics Inc | Catalytic domains from lysyl oxidase and loxl2 |
AU2010284000A1 (en) * | 2009-08-21 | 2012-03-22 | Gilead Biologics, Inc. | In vitro screening assays |
KR20120091146A (ko) | 2009-09-29 | 2012-08-17 | 길리아드 바이오로직스, 인크. | 안구 섬유증의 치료를 위한 조성물 및 방법 |
WO2011097513A1 (en) | 2010-02-04 | 2011-08-11 | Gilead Biologics, Inc | Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor |
WO2012139045A1 (en) | 2011-04-08 | 2012-10-11 | Gilead Biologics, Inc. | Methods and compositions for normalization of tumor vasculature by inhibition of loxl2 |
WO2012167181A1 (en) | 2011-06-01 | 2012-12-06 | Gilead Biologics, Inc. | Lysyl oxidase-like 2 assay and methods of use thereof |
SG10201703240RA (en) | 2012-10-30 | 2017-06-29 | Gilead Sciences Inc | Therapeutic and diagnostic methods related to lysyl oxidase-like 2 (loxl2) |
CN105188749B (zh) * | 2012-12-21 | 2017-12-19 | 西雅图基因公司 | 抗ntb‑a抗体及相关组合物和方法 |
-
2008
- 2008-08-01 CN CN201510390365.4A patent/CN105330743B/zh not_active Expired - Fee Related
- 2008-08-01 DK DK08830207.0T patent/DK2185198T3/en active
- 2008-08-01 HU HUE08830207A patent/HUE025283T2/hu unknown
- 2008-08-01 EP EP08795003A patent/EP2182981B1/en active Active
- 2008-08-01 CN CN201610065872.5A patent/CN105622756B/zh active Active
- 2008-08-01 SI SI200831396T patent/SI2185198T1/sl unknown
- 2008-08-01 CN CN200880101321A patent/CN101835490A/zh active Pending
- 2008-08-01 ES ES08795003T patent/ES2402334T3/es active Active
- 2008-08-01 JP JP2010519951A patent/JP5659014B2/ja active Active
- 2008-08-01 ES ES12172222T patent/ES2700141T3/es active Active
- 2008-08-01 PT PT8830207T patent/PT2185198E/pt unknown
- 2008-08-01 EP EP12172222.7A patent/EP2537529B1/en not_active Not-in-force
- 2008-08-01 EP EP08830207.0A patent/EP2185198B1/en active Active
- 2008-08-01 CA CA2693310A patent/CA2693310C/en not_active Expired - Fee Related
- 2008-08-01 CN CN201510392364.3A patent/CN105214085A/zh active Pending
- 2008-08-01 EP EP12172214.4A patent/EP2543389A3/en not_active Withdrawn
- 2008-08-01 DK DK08795003.6T patent/DK2182981T3/da active
- 2008-08-01 US US12/185,050 patent/US8461303B2/en active Active
- 2008-08-01 WO PCT/US2008/009354 patent/WO2009017833A2/en active Application Filing
- 2008-08-01 AU AU2008282739A patent/AU2008282739B2/en active Active
- 2008-08-01 CA CA2693208A patent/CA2693208A1/en not_active Abandoned
- 2008-08-01 CN CN201910353780.0A patent/CN110372795A/zh active Pending
- 2008-08-01 PL PL08795003T patent/PL2182981T3/pl unknown
- 2008-08-01 JP JP2010519263A patent/JP5312459B2/ja not_active Expired - Fee Related
- 2008-08-01 PL PL08830207T patent/PL2185198T3/pl unknown
- 2008-08-01 AU AU2008299784A patent/AU2008299784B9/en not_active Ceased
- 2008-08-01 CN CN200880110519A patent/CN101842114A/zh active Pending
- 2008-08-01 ES ES08830207.0T patent/ES2534490T3/es active Active
- 2008-08-01 PT PT87950036T patent/PT2182981E/pt unknown
- 2008-08-01 WO PCT/US2008/072039 patent/WO2009035791A1/en active Application Filing
- 2008-08-01 SI SI200830930T patent/SI2182981T1/sl unknown
- 2008-08-01 US US12/185,054 patent/US8679485B2/en active Active
- 2008-08-01 PT PT12172222T patent/PT2537529T/pt unknown
-
2010
- 2010-10-27 HK HK10110112.0A patent/HK1143543A1/xx not_active IP Right Cessation
- 2010-10-29 HK HK10110176.3A patent/HK1143736A1/xx unknown
-
2011
- 2011-08-05 US US13/204,336 patent/US20120087917A1/en not_active Abandoned
-
2012
- 2012-12-06 US US13/707,495 patent/US8658167B2/en active Active
-
2013
- 2013-03-28 HR HRP20130287AT patent/HRP20130287T1/hr unknown
- 2013-04-03 CY CY20131100280T patent/CY1113897T1/el unknown
- 2013-05-06 US US13/888,293 patent/US9176139B2/en not_active Expired - Fee Related
- 2013-05-06 US US13/888,289 patent/US20140079707A1/en not_active Abandoned
- 2013-05-31 JP JP2013116416A patent/JP5770219B2/ja not_active Expired - Fee Related
- 2013-12-19 US US14/135,178 patent/US20140128284A1/en not_active Abandoned
-
2014
- 2014-02-04 US US14/172,865 patent/US20140349309A1/en not_active Abandoned
- 2014-06-06 JP JP2014117893A patent/JP5851555B2/ja active Active
- 2014-07-21 AU AU2014204536A patent/AU2014204536B2/en not_active Ceased
-
2015
- 2015-02-23 HR HRP20150208TT patent/HRP20150208T1/hr unknown
- 2015-03-30 CY CY20151100310T patent/CY1116178T1/el unknown
- 2015-06-23 JP JP2015125989A patent/JP2015212281A/ja active Pending
- 2015-10-07 US US14/877,655 patent/US20160185877A1/en not_active Abandoned
- 2015-12-02 JP JP2015235400A patent/JP2016094428A/ja active Pending
-
2016
- 2016-11-02 US US15/341,729 patent/US10494443B2/en not_active Expired - Fee Related
-
2017
- 2017-01-31 AU AU2017200635A patent/AU2017200635B9/en not_active Ceased
- 2017-05-11 JP JP2017095079A patent/JP6357264B2/ja not_active Expired - Fee Related
-
2018
- 2018-06-15 JP JP2018114560A patent/JP2018172398A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2017200635B2 (en) | LOX and LOXL2 inhibitors and uses thereof | |
JP6134142B2 (ja) | リシルオキシダーゼ様2(loxl2)に結合する抗体及びその使用方法 |