HU227807B1 - Oxacarbazepine film-coated tablets, process for producing them - Google Patents
Oxacarbazepine film-coated tablets, process for producing them Download PDFInfo
- Publication number
- HU227807B1 HU227807B1 HU0000886A HUP0000886A HU227807B1 HU 227807 B1 HU227807 B1 HU 227807B1 HU 0000886 A HU0000886 A HU 0000886A HU P0000886 A HUP0000886 A HU P0000886A HU 227807 B1 HU227807 B1 HU 227807B1
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- HU
- Hungary
- Prior art keywords
- oxcarbazepine
- microns
- particle size
- film
- excipients
- Prior art date
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- AWLUSOLTCFEHNE-UHFFFAOYSA-N sodium;urea Chemical compound [Na].NC(N)=O AWLUSOLTCFEHNE-UHFFFAOYSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007103 stamina Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 208000005809 status epilepticus Diseases 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940090016 tegretol Drugs 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH33197 | 1997-02-14 | ||
| PCT/EP1998/000794 WO1998035681A1 (en) | 1997-02-14 | 1998-02-12 | Oxacarbazepine film-coated tablets |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0000886A2 HUP0000886A2 (hu) | 2000-09-28 |
| HUP0000886A3 HUP0000886A3 (en) | 2002-10-28 |
| HU227807B1 true HU227807B1 (en) | 2012-03-28 |
Family
ID=4184588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000886A HU227807B1 (en) | 1997-02-14 | 1998-02-12 | Oxacarbazepine film-coated tablets, process for producing them |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20070036863A1 (enExample) |
| EP (1) | EP0966287B1 (enExample) |
| JP (3) | JP2000511935A (enExample) |
| KR (3) | KR19980071337A (enExample) |
| CN (2) | CN1626093A (enExample) |
| AR (1) | AR011142A1 (enExample) |
| AT (1) | ATE239481T1 (enExample) |
| AU (1) | AU738030B2 (enExample) |
| BR (1) | BR9807368A (enExample) |
| CA (1) | CA2277791C (enExample) |
| CO (1) | CO4920215A1 (enExample) |
| CY (1) | CY2480B1 (enExample) |
| CZ (1) | CZ298840B6 (enExample) |
| DE (1) | DE69814367T2 (enExample) |
| DK (1) | DK0966287T3 (enExample) |
| ES (1) | ES2199422T3 (enExample) |
| HU (1) | HU227807B1 (enExample) |
| ID (1) | ID22348A (enExample) |
| MY (1) | MY117582A (enExample) |
| NO (1) | NO327486B1 (enExample) |
| NZ (1) | NZ336946A (enExample) |
| PE (1) | PE58999A1 (enExample) |
| PL (1) | PL193332B1 (enExample) |
| PT (1) | PT966287E (enExample) |
| RU (1) | RU2201218C2 (enExample) |
| SK (1) | SK284503B6 (enExample) |
| TR (1) | TR199901804T2 (enExample) |
| TW (1) | TW529957B (enExample) |
| UY (1) | UY24888A1 (enExample) |
| WO (1) | WO1998035681A1 (enExample) |
| ZA (1) | ZA981205B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4920215A1 (es) * | 1997-02-14 | 2000-05-29 | Novartis Ag | Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones |
| GB9925962D0 (en) * | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| US6368628B1 (en) * | 2000-05-26 | 2002-04-09 | Pharma Pass Llc | Sustained release pharmaceutical composition free of food effect |
| WO2003053416A1 (en) | 2001-12-21 | 2003-07-03 | Pfizer Products Inc. | Directly compressible formulations of azithromycin |
| GB0221956D0 (en) * | 2002-09-20 | 2002-10-30 | Novartis Ag | Organic compounds |
| MXPA06002392A (es) | 2003-09-03 | 2006-06-20 | Novartis Ag | Uso de oxcarbazepina para el tratamiento de dolor neuropatico diabetico y la mejora del sueno. |
| PE20051156A1 (es) * | 2004-03-22 | 2006-02-13 | Novartis Ag | Formulaciones de matriz orales que comprenden licarbazepina |
| AR048672A1 (es) * | 2004-03-22 | 2006-05-17 | Novartis Ag | Tabletas de desintegracion que comprenden licarbazepina |
| US8367105B2 (en) | 2004-11-10 | 2013-02-05 | Teva Pharmaceutical Industries, Ltd. | Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| WO2007039420A1 (en) * | 2005-09-23 | 2007-04-12 | F. Hoffmann-La Roche Ag | Novel dosage formulation |
| DK2774925T3 (en) | 2005-11-08 | 2017-02-27 | Vertex Pharma | Heterocyclic modulators of ATP binding cassette transporters |
| CA2628716C (en) | 2005-11-10 | 2016-09-27 | Alphapharm Pty Ltd | Process to control particle size |
| AU2006313009B2 (en) * | 2005-11-10 | 2013-10-24 | Alphapharm Pty Ltd | Process to control particle size |
| CN101336105A (zh) * | 2006-01-31 | 2008-12-31 | 特瓦制药工业有限公司 | 奥卡西平药物制剂及其制备方法，其中奥卡西平具有宽且多峰的粒度分布 |
| EP2029118A2 (en) * | 2006-01-31 | 2009-03-04 | Teva Pharmaceutical Industries, Inc. | Oxcarbazepine pharmaceutical formulation and its method of preparation, wherein oxcarbazepine has a broad and multi-modal particle size distribution |
| AU2007242062A1 (en) * | 2006-04-21 | 2007-11-01 | Alphapharm Pty Ltd | Pharmaceutical compositions of oxcarbazepine with a median particle size of 15 to 30 microns |
| EP2018157A2 (en) | 2006-04-26 | 2009-01-28 | Astron Research Limited | Controlled release formulation comprising anti-epileptic drugs |
| CN101489560B (zh) * | 2006-04-26 | 2015-11-25 | 苏佩努斯制药公司 | 具有s形释放曲线的奥卡西平控释制剂 |
| US20080138403A1 (en) * | 2006-12-08 | 2008-06-12 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical dosage forms of oxcarbazepine |
| JP2010513324A (ja) | 2006-12-21 | 2010-04-30 | アルファファーム ピーティーワイ リミテッド | 医薬化合物および医薬組成物 |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| EP1970056A1 (en) * | 2007-03-15 | 2008-09-17 | Polichem S.A. | Time-specific delayed/pulsatile release dosage forms |
| WO2008141751A2 (en) * | 2007-05-23 | 2008-11-27 | Ratiopharm Gmbh | Pharmaceutical compositions comprising oxcarbazepine |
| US8372431B2 (en) | 2007-10-26 | 2013-02-12 | Bial-Portela & C.A., S.A. | Pharmaceutical composition comprising licarbazepine acetate |
| CN103626744B (zh) | 2007-12-07 | 2016-05-11 | 沃泰克斯药物股份有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
| EP2555755B2 (en) | 2010-04-07 | 2019-07-10 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyriodin-2-yl)benzoic acid and administration thereof |
| HRP20210516T2 (hr) | 2013-11-12 | 2021-10-01 | Vertex Pharmaceuticals Incorporated | Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr |
| CN103735527B (zh) * | 2013-12-24 | 2014-09-10 | 武汉人福药业有限责任公司 | 一种奥卡西平片剂及其制备方法 |
| WO2018208242A1 (en) | 2017-05-10 | 2018-11-15 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Formulation of deferasirox tablet for oral suspension composition with better processability |
| TW202444706A (zh) | 2019-05-16 | 2024-11-16 | 瑞士商諾華公司 | N-[4-(氯二氟甲氧基)苯基]-6-[(3r)-3-羥基吡咯啶-1-基]-5-(1h-吡唑-5-基)吡啶-3-甲醯胺之結晶形狀 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FI75561C (fi) * | 1979-10-30 | 1988-07-11 | Ciba Geigy Ag | Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter. |
| CH649080A5 (de) * | 1981-04-16 | 1985-04-30 | Ciba Geigy Ag | 5h-dibenz(b,f)azepin-5-carboxamide als mittel zur prophylaxe und behandlung von zerebraler leistungsinsuffizienz. |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| JPS6257467A (ja) * | 1985-09-06 | 1987-03-13 | Asahi Glass Co Ltd | コ−テイング剤組成物 |
| GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
| CH668187A5 (de) * | 1986-08-07 | 1988-12-15 | Ciba Geigy Ag | Therapeutisches system mit systemischer wirkung. |
| DD295760A5 (de) * | 1989-01-31 | 1991-11-14 | Martin-Luther-Universitaet Halle Wittenberg,De | Arzneistoffreigabesystem mit kotrollierter wirkstoffreisetzung |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5231089A (en) * | 1991-12-02 | 1993-07-27 | University Of Florida | Method of improving oral bioavailability of carbamazepine |
| FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
| FR2702148B1 (fr) * | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
| US5472714A (en) * | 1993-09-08 | 1995-12-05 | Ciba-Geigy Corporation | Double-layered oxcarbazepine tablets |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| US5478654A (en) * | 1994-05-06 | 1995-12-26 | Gencorp Inc. | Solventless carboxylated butadiene-vinylidene chloride adhesives for bonding rubber to metal |
| US5980942A (en) * | 1997-01-23 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release matrix tablet formulations of carbamazepine |
| US6296873B1 (en) * | 1997-01-23 | 2001-10-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Zero-order sustained release delivery system for carbamazephine derivatives |
| CO4920215A1 (es) * | 1997-02-14 | 2000-05-29 | Novartis Ag | Tabletas de oxacarbazepina recubiertas de una pelicula y metodo para la produccion de estas formulaciones |
-
1998
- 1998-02-05 CO CO98005805A patent/CO4920215A1/es unknown
- 1998-02-09 MY MYPI98000504A patent/MY117582A/en unknown
- 1998-02-11 PE PE1998000100A patent/PE58999A1/es not_active Application Discontinuation
- 1998-02-12 CN CNA200410075200XA patent/CN1626093A/zh active Pending
- 1998-02-12 JP JP10535347A patent/JP2000511935A/ja not_active Withdrawn
- 1998-02-12 RU RU99119599/14A patent/RU2201218C2/ru not_active IP Right Cessation
- 1998-02-12 DK DK98908091T patent/DK0966287T3/da active
- 1998-02-12 HU HU0000886A patent/HU227807B1/hu not_active IP Right Cessation
- 1998-02-12 BR BR9807368-0A patent/BR9807368A/pt not_active Application Discontinuation
- 1998-02-12 AT AT98908091T patent/ATE239481T1/de not_active IP Right Cessation
- 1998-02-12 CA CA002277791A patent/CA2277791C/en not_active Expired - Fee Related
- 1998-02-12 SK SK1098-99A patent/SK284503B6/sk not_active IP Right Cessation
- 1998-02-12 EP EP98908091A patent/EP0966287B1/en not_active Revoked
- 1998-02-12 AR ARP980100639A patent/AR011142A1/es not_active Application Discontinuation
- 1998-02-12 PL PL334959A patent/PL193332B1/pl unknown
- 1998-02-12 ID IDW990810A patent/ID22348A/id unknown
- 1998-02-12 ES ES98908091T patent/ES2199422T3/es not_active Expired - Lifetime
- 1998-02-12 AU AU66222/98A patent/AU738030B2/en not_active Ceased
- 1998-02-12 TR TR1999/01804T patent/TR199901804T2/xx unknown
- 1998-02-12 NZ NZ336946A patent/NZ336946A/en not_active IP Right Cessation
- 1998-02-12 CN CNB988024977A patent/CN1170542C/zh not_active Expired - Fee Related
- 1998-02-12 CZ CZ0287999A patent/CZ298840B6/cs not_active IP Right Cessation
- 1998-02-12 WO PCT/EP1998/000794 patent/WO1998035681A1/en not_active Ceased
- 1998-02-12 DE DE69814367T patent/DE69814367T2/de not_active Revoked
- 1998-02-12 PT PT98908091T patent/PT966287E/pt unknown
- 1998-02-13 UY UY24888A patent/UY24888A1/es not_active IP Right Cessation
- 1998-02-13 ZA ZA981205A patent/ZA981205B/xx unknown
- 1998-02-13 KR KR1019980004327A patent/KR19980071337A/ko not_active Ceased
- 1998-02-23 TW TW087102046A patent/TW529957B/zh not_active IP Right Cessation
-
1999
- 1999-08-13 NO NO19993919A patent/NO327486B1/no not_active IP Right Cessation
-
2004
- 2004-10-07 CY CY0400074A patent/CY2480B1/xx unknown
-
2005
- 2005-11-30 JP JP2005346338A patent/JP2006077029A/ja not_active Withdrawn
-
2006
- 2006-10-18 US US11/582,802 patent/US20070036863A1/en not_active Abandoned
-
2007
- 2007-07-17 US US11/879,329 patent/US20080014269A1/en not_active Abandoned
-
2009
- 2009-03-20 KR KR1020090024168A patent/KR20090037873A/ko not_active Ceased
-
2010
- 2010-02-26 JP JP2010041778A patent/JP2010132694A/ja active Pending
-
2012
- 2012-06-18 KR KR1020120065092A patent/KR20120079826A/ko not_active Ceased
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| MM4A | Lapse of definitive patent protection due to non-payment of fees |