HU199775B - Process for production of formed by fatty acids salts of amin acids and medical compositions containing them - Google Patents

Process for production of formed by fatty acids salts of amin acids and medical compositions containing them Download PDF

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Publication number
HU199775B
HU199775B HU881131A HU113188A HU199775B HU 199775 B HU199775 B HU 199775B HU 881131 A HU881131 A HU 881131A HU 113188 A HU113188 A HU 113188A HU 199775 B HU199775 B HU 199775B
Authority
HU
Hungary
Prior art keywords
lysine
acid
salt
mmol
formula
Prior art date
Application number
HU881131A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT49564A (en
Inventor
Nagy Peter Literati
Maria Boross
Jenoe Szilbereky
Istvan Racz
Gyoengyver Soos
Miklos Koller
Alan Pinter
Gabor Nemeth
Original Assignee
Nagy Peter Literati
Jenoe Szilbereky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagy Peter Literati, Jenoe Szilbereky filed Critical Nagy Peter Literati
Priority to HU881131A priority Critical patent/HU199775B/hu
Priority to CH820/89A priority patent/CH678851A5/de
Priority to AT0050989A priority patent/AT398073B/de
Priority to NL8900573A priority patent/NL8900573A/nl
Priority to LU87470A priority patent/LU87470A1/fr
Priority to JP1055241A priority patent/JP2751068B2/ja
Priority to GB8905384A priority patent/GB2216522B/en
Priority to IT8919705A priority patent/IT1229563B/it
Priority to ES8900861A priority patent/ES2010439A6/es
Priority to BE8900253A priority patent/BE1003663A3/fr
Priority to DE3907688A priority patent/DE3907688C2/de
Priority to CA000593269A priority patent/CA1339147C/en
Priority to SE8900827A priority patent/SE508603C2/sv
Priority to FI891144A priority patent/FI93949C/fi
Priority to KR1019890002919A priority patent/KR0140993B1/ko
Priority to FR898903084A priority patent/FR2628419B1/fr
Publication of HUT49564A publication Critical patent/HUT49564A/hu
Publication of HU199775B publication Critical patent/HU199775B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HU881131A 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them HU199775B (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU881131A HU199775B (en) 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them
CH820/89A CH678851A5 (de) 1988-03-09 1989-03-06
AT0050989A AT398073B (de) 1988-03-09 1989-03-07 Antiviral und immunstimulierend wirkende neue salze, sowie verfahren zu deren herstellung und verwendung der salze
NL8900573A NL8900573A (nl) 1988-03-09 1989-03-09 Nieuwe zout-type verbindingen, farmaceutische preparaten met dergelijke verbindingen erin en werkwijze voor de bereiding ervan.
LU87470A LU87470A1 (fr) 1988-03-09 1989-03-09 Nouveaux sels antiviraux,compositions pharmaceutiques les contenant et procede pour les preparer
JP1055241A JP2751068B2 (ja) 1988-03-09 1989-03-09 抗ウイルス剤およびそれを製造する方法
GB8905384A GB2216522B (en) 1988-03-09 1989-03-09 Amino acid salts of long chain unsaturated fatty acid
IT8919705A IT1229563B (it) 1988-03-09 1989-03-09 Composti tipo sali, composizioni farmaceutiche che li contengono e procedimento per la loro preparazione.
ES8900861A ES2010439A6 (es) 1988-03-09 1989-03-09 Procedimiento para la preparacion de nuevas sales antivirales y estimuladoras del sistema inmunologico.
BE8900253A BE1003663A3 (fr) 1988-03-09 1989-03-09 Nouveaux sels antiviraux, compositions pharmaceutiques les contenant et procede pour les preparer.
DE3907688A DE3907688C2 (de) 1988-03-09 1989-03-09 Salze von ungesättigten Fettsäuren mit Aminosäuren, Verfahren zu ihrer Herstellung sowie die Verwendung der ersteren und von weiteren derartigen Salzen
CA000593269A CA1339147C (en) 1988-03-09 1989-03-09 Salt-type compounds, pharmaceutical compositions containing them and process for preparing same
SE8900827A SE508603C2 (sv) 1988-03-09 1989-03-09 Nya föreningar av salttyp, farmaceutiska kompositioner som innehåller dem samt förfarande för framställning av dem
FI891144A FI93949C (fi) 1988-03-09 1989-03-09 Menetelmä uusien terapeuttisesti käyttökelpoisten suolayhdisteiden valmistamiseksi
KR1019890002919A KR0140993B1 (ko) 1988-03-09 1989-03-09 신규 염류 형태의 화합물, 이들을 함유하는 약학적 조성물 및 이 화합물을 제조하는 방법
FR898903084A FR2628419B1 (fr) 1988-03-09 1989-03-09 Nouveaux sels antiviraux, compositions pharmaceutiques les contenant et procede pour les preparer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU881131A HU199775B (en) 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them

Publications (2)

Publication Number Publication Date
HUT49564A HUT49564A (en) 1989-10-30
HU199775B true HU199775B (en) 1990-03-28

Family

ID=10952971

Family Applications (1)

Application Number Title Priority Date Filing Date
HU881131A HU199775B (en) 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them

Country Status (16)

Country Link
JP (1) JP2751068B2 (de)
KR (1) KR0140993B1 (de)
AT (1) AT398073B (de)
BE (1) BE1003663A3 (de)
CA (1) CA1339147C (de)
CH (1) CH678851A5 (de)
DE (1) DE3907688C2 (de)
ES (1) ES2010439A6 (de)
FI (1) FI93949C (de)
FR (1) FR2628419B1 (de)
GB (1) GB2216522B (de)
HU (1) HU199775B (de)
IT (1) IT1229563B (de)
LU (1) LU87470A1 (de)
NL (1) NL8900573A (de)
SE (1) SE508603C2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9381213B2 (en) 2004-12-03 2016-07-05 Sinnex Muszaki Fejleszto Es Tanacsado Kft Antiviral and immune stimulant pharmaceutical composition

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04279523A (ja) * 1991-01-11 1992-10-05 Nisshin Flour Milling Co Ltd 免疫賦活油脂加工品
CA2112399C (en) * 1991-06-24 2004-06-29 Antonio Ferrante Methods and compositions for treating malaria and other diseases
US5767156A (en) * 1993-10-06 1998-06-16 Peptide Technology Limited Polyunsaturated fatty acids and uses thereof
NL9401743A (nl) * 1994-10-20 1996-06-03 Prospa Bv Zouten van aminoalcoholen en farmaceutische formuleringen die deze bevatten.
AUPM906594A0 (en) * 1994-10-26 1994-11-17 Peptide Technology Limited Synthetic polyunsaturated fatty acid analogues
US5639858A (en) * 1995-03-22 1997-06-17 Tularik, Inc. Human signal transducer and binding assays
WO2007079394A2 (en) 2005-12-30 2007-07-12 Revance Therapeutics, Inc. Arginine heteromers for topical administration
MX384154B (es) * 2014-12-23 2025-03-14 Evonik Operations Gmbh Proceso para aumentar la estabilidad de una composición que comprende ácidos grasos omega-3 poliinsaturados.
EP3248467A1 (de) * 2016-05-25 2017-11-29 Evonik Technochemie GmbH Verfahren zur herstellung einer zusammensetzung enthaltend omega-3-fettsäure-l-lysin-salze
CN111032032B (zh) * 2017-08-15 2024-01-02 赢创运营有限公司 具有高活性成分含量的ω-3脂肪酸氨基酸盐的片剂
CN115397960A (zh) * 2020-01-30 2022-11-25 硅循环股份有限公司 制备多不饱和脂肪酸的固体中性氨基酸盐的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305553A1 (de) * 1972-02-04 1973-08-09 Univ Minnesota Arzneimittel zur behandlung von virusinfektionen
US4513008A (en) * 1982-07-30 1985-04-23 The Vinoxen Company, Inc. Virucidal compositions and therapy
GB8327911D0 (en) * 1983-10-19 1983-11-23 Ciba Geigy Ag Salts as corrosion inhibitors
US4537772A (en) * 1984-05-02 1985-08-27 Merck & Co., Inc. Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines
FR2587900B1 (fr) * 1985-10-01 1988-10-07 Morelle Jean Associations acides gras-acides amines basiques, douees de proprietes emollientes, emulsifiantes et antioxydantes, destinees a la cosmetique, la dermatologie et l'alimentation
JPS63230632A (ja) * 1987-03-20 1988-09-27 Nippon Oil & Fats Co Ltd リポキシゲナ−ゼ代謝刺激剤
DE3726299A1 (de) * 1987-06-26 1989-02-23 Dietl Hans Fettemulsion zur intravenoesen anwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9381213B2 (en) 2004-12-03 2016-07-05 Sinnex Muszaki Fejleszto Es Tanacsado Kft Antiviral and immune stimulant pharmaceutical composition

Also Published As

Publication number Publication date
FI891144A0 (fi) 1989-03-09
FR2628419B1 (fr) 1992-02-14
SE8900827D0 (sv) 1989-03-09
FR2628419A1 (fr) 1989-09-15
NL8900573A (nl) 1989-10-02
IT1229563B (it) 1991-09-04
DE3907688C2 (de) 1996-09-05
FI93949B (fi) 1995-03-15
LU87470A1 (fr) 1990-10-02
KR0140993B1 (ko) 1998-07-01
DE3907688A1 (de) 1989-09-21
IT8919705A0 (it) 1989-03-09
JPH024746A (ja) 1990-01-09
KR890014451A (ko) 1989-10-23
SE8900827L (sv) 1989-09-10
BE1003663A3 (fr) 1992-05-19
SE508603C2 (sv) 1998-10-19
FI93949C (fi) 1995-06-26
ATA50989A (de) 1994-01-15
AT398073B (de) 1994-09-26
CA1339147C (en) 1997-07-29
HUT49564A (en) 1989-10-30
CH678851A5 (de) 1991-11-15
ES2010439A6 (es) 1989-11-01
FI891144L (fi) 1989-09-10
GB8905384D0 (en) 1989-04-19
GB2216522B (en) 1992-01-02
GB2216522A (en) 1989-10-11
JP2751068B2 (ja) 1998-05-18

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee
HRH9 Withdrawal of annulment decision
HPC4 Succession in title of patentee

Owner name: BIOREX KUTATO-FEJLESZTOE KFT., HU

HPC4 Succession in title of patentee

Owner name: BIOREX KUTATO ES FEJLESZTOE RT., HU

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