HRP960313B1 - Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) - Google Patents

Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)

Info

Publication number
HRP960313B1
HRP960313B1 HR960313A HRP960313A HRP960313B1 HR P960313 B1 HRP960313 B1 HR P960313B1 HR 960313 A HR960313 A HR 960313A HR P960313 A HRP960313 A HR P960313A HR P960313 B1 HRP960313 B1 HR P960313B1
Authority
HR
Croatia
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
delta
Prior art date
Application number
HR960313A
Other languages
English (en)
Inventor
Ann T Mckenzie
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21696105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP960313(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HRP960313A2 publication Critical patent/HRP960313A2/hr
Publication of HRP960313B1 publication Critical patent/HRP960313B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
HR960313A 1995-07-17 1996-07-03 Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) HRP960313B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US145495P 1995-07-17 1995-07-17

Publications (2)

Publication Number Publication Date
HRP960313A2 HRP960313A2 (en) 1998-04-30
HRP960313B1 true HRP960313B1 (en) 2002-08-31

Family

ID=21696105

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960313A HRP960313B1 (en) 1995-07-17 1996-07-03 Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1)

Country Status (32)

Country Link
US (1) US6121461A (cs)
JP (1) JP3296563B2 (cs)
KR (1) KR100431039B1 (cs)
CN (1) CN1081632C (cs)
AT (1) ATE207465T1 (cs)
AU (1) AU725368B2 (cs)
BG (1) BG63629B1 (cs)
BR (1) BR9610567A (cs)
CA (1) CA2220458C (cs)
CO (1) CO4700442A1 (cs)
CZ (1) CZ294109B6 (cs)
DK (1) DK0848704T3 (cs)
EA (1) EA000505B1 (cs)
EE (1) EE03607B1 (cs)
ES (1) ES2166456T3 (cs)
GE (1) GEP20002028B (cs)
HR (1) HRP960313B1 (cs)
HU (1) HU223598B1 (cs)
ID (1) ID16158A (cs)
IL (3) IL122162A (cs)
MX (1) MX9708857A (cs)
MY (1) MY118398A (cs)
NO (1) NO309899B1 (cs)
NZ (1) NZ312906A (cs)
PE (1) PE1798A1 (cs)
PL (1) PL192244B1 (cs)
RO (1) RO120068B1 (cs)
SK (1) SK284201B6 (cs)
TW (1) TW401399B (cs)
UA (1) UA44796C2 (cs)
WO (1) WO1997003958A1 (cs)
ZA (1) ZA966045B (cs)

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IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
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WO2003004470A1 (en) * 2001-06-29 2003-01-16 Warner-Lambert Company Llc Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
MXPA04000889A (es) * 2001-07-30 2004-06-03 Reddys Lab Ltd Dr Formas cristalinas vi y vii de atorvastatina calcica.
US7074818B2 (en) 2001-07-30 2006-07-11 Dr. Reddy's Laboratories Limited Crystalline forms VI and VII of Atorvastatin calcium
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UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
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ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
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JP2006503024A (ja) * 2002-09-03 2006-01-26 モレペン、ラボラトリーズ、リミテッド Ｖｉ型アトルバスタチンカルシウムまたはその水和物
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CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
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KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
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CN102424663B (zh) * 2010-12-03 2013-08-14 天津滨江药物研发有限公司 一种阿托伐他汀氨基酸盐及其制备方法
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CN106432033B (zh) * 2016-10-21 2018-07-27 江苏阿尔法药业有限公司 一种无定形阿托伐他汀钙的制备方法
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Also Published As

Publication number Publication date
AU725368B2 (en) 2000-10-12
EA199800129A1 (ru) 1998-08-27
CA2220458C (en) 2002-09-24
GEP20002028B (en) 2000-04-10
HK1018053A1 (en) 1999-12-10
ES2166456T3 (es) 2002-04-16
EE9800016A (et) 1998-08-17
CN1190957A (zh) 1998-08-19
SK284201B6 (sk) 2004-10-05
BR9610567A (pt) 1999-07-06
CO4700442A1 (es) 1998-12-29
RO120068B1 (ro) 2005-08-30
IL122162A (en) 1999-07-14
CZ12398A3 (cs) 1998-06-17
NO980208L (no) 1998-01-16
JP3296563B2 (ja) 2002-07-02
TW401399B (en) 2000-08-11
HUP9901687A3 (en) 2000-04-28
HRP960313A2 (en) 1998-04-30
SK5998A3 (en) 1998-05-06
BG102186A (en) 1998-10-30
JPH11509229A (ja) 1999-08-17
PE1798A1 (es) 1998-03-04
IL177378A0 (en) 2006-12-10
US6121461A (en) 2000-09-19
MY118398A (en) 2004-10-30
AU6484196A (en) 1997-02-18
HU223598B1 (hu) 2004-10-28
KR19990029044A (ko) 1999-04-15
NZ312906A (en) 2000-12-22
PL324532A1 (en) 1998-06-08
UA44796C2 (uk) 2002-03-15
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IL128863A0 (en) 2000-01-31
NO309899B1 (no) 2001-04-17
IL122162A0 (en) 1998-04-05
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EA000505B1 (ru) 1999-10-28
KR100431039B1 (ko) 2004-08-25
CN1081632C (zh) 2002-03-27
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WO1997003958A1 (en) 1997-02-06
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